Tag: 200-300

Loss of isocyanic acid from the internal oxadiazole ring of protonated molecules of some 2,5-diaryl-1,3,4-oxadiazoles was written by Franski, Rafal;Schroeder, Grzegorz;Rybachenko, Volodymir;Szwajka, Oles P.. And the article was included in Rapid Communications in Mass Spectrometry in 2002.Formula: C12H8N4O This article mentions the following:

The fragmentation pattern of some protonated 2,5-diaryl-1,3,4-oxadiazoles is discussed. An unusual decomposition consisting of elimination of the isocyanic acid mol. from the internal oxadiazole ring was found. This fragmentation pathway was deduced on the basis of B/E linked scan mass spectra of metastable ions with liquid secondary ion mass spectrometry as the ionization method and also of low-energy CID mass spectra where electrospray was used as the ionization technique. High resolution measurements were also performed. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG) was written by Tsagris, Denise J.;Birchall, Kristian;Bouloc, Nathalie;Large, Jonathan M.;Merritt, Andy;Smiljanic-Hurley, Ela;Wheldon, Mary;Ansell, Keith H.;Kettleborough, Catherine;Whalley, David;Stewart, Lindsay B.;Bowyer, Paul W.;Baker, David A.;Osborne, Simon A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Product Details of 214834-18-1 This article mentions the following:

A series of trisubstituted thiazoles have been identified as potent inhibitors of Plasmodium falciparum (Pf) cGMP-dependent protein kinase (PfPKG) through template hopping from known Eimeria PKG (EtPKG) inhibitors. The thiazole series has yielded compounds with improved potency, kinase selectivity and good in vitro ADME properties. These compounds could be useful tools in the development of new anti-malarial drugs in the fight against drug resistant malaria. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Product Details of 214834-18-1).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Product Details of 214834-18-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2-(Anilinomethyl)imidazolines as α_1A Adrenergic Receptor Agonists: 2′-Heteroaryl and 2′-Oxime Ether Series was written by Navas, Frank;Bishop, Michael J.;Garrison, Deanna T.;Hodson, Stephen J.;Speake, Jason D.;Bigham, Eric C.;Drewry, David H.;Saussy, David L.;Liacos, James H.;Irving, Paul E.;Gobel, M. Jeffrey. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.HPLC of Formula: 175205-82-0 This article mentions the following:

A series of 2′-heteroaryl and 2′-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human α_1A, α_1B, and α_1D receptor subtypes. Potent and selective α_1A agonists have been identified in these series. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0HPLC of Formula: 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of 1,3,6-Trisubstituted Azulenes was written by Leino, Teppo O.;Baumann, Marcus;Yli-Kauhaluoma, Jari;Baxendale, Ian R.;Wallen, Erik A. A.. And the article was included in Journal of Organic Chemistry in 2015.Product Details of 65350-59-6 This article mentions the following:

We have developed a short, general synthetic route to 1,3,6-trisubstituted azulenes. The key intermediate, 6-methylazulene, was synthesized from readily available and inexpensive starting materials in 63% yield over two steps. The Me group of 6-methylazulene was then used as a synthetic handle to introduce different substituents at the 6-position via two different methods. Subsequently, the 1- and 3-positions were substituted with addnl. functional handles, such as formyl, chloromethyl ketone, and iodide. The efficiency of the synthetic route was demonstrated by preparing a collection of three different products with the best demonstrated yield 33% over seven steps. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Product Details of 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Studies on 2,5-disubstituted-1,3,4-oxadiazoles. Part-I. Preparation and antimicrobial activity of 2-aryl-5-(4′-benzenesulfonamidophenyl)/(4′-pyridyl)-1,3,4-oxadiazoles was written by Pachhamia, V. L.;Parikh, A. R.. And the article was included in Journal of the Indian Chemical Society in 1989.Reference of 15420-02-7 This article mentions the following:

Fifty-two title compounds I and II (R = Ph, substituted Ph, cinnamyl, 4-hydroxycinnamyl, 3-pyridyl, 4-pyridyl) were prepared by cyclocondensation of 4-(PhSO₂NH)C₆H₄CONHNH₂ or isoniazide (III) with RCO₂H in POCl₃. Most of the compounds showed good activity against different strains of bacteria and fungi. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Reference of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Reference of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of Decahydrocyclobuta[cd]indene Skeletons: Rhodium(III)-Catalyzed Hydroarylation and Relay Thiophene-Promoted Intramolecular [2+2] Cycloaddition was written by Gao, Dingding;Wang, Feng;Liu, Xing-Yu;Feng, Kai-Rui;Zhao, Jia-Ying;Wang, Yu-Hui;Yang, Xiao-Di;Tian, Ping;Lin, Guo-Qiang. And the article was included in Advanced Synthesis & Catalysis in 2020.Related Products of 54151-74-5 This article mentions the following:

The preparation of decahydrocyclobuta[cd]indene skeleton was accomplished through rhodium(III)-catalyzed hydroarylation and relay thiophene-promoted intramol. [2+2] cycloaddition This tandem reaction exhibited broad substrate scope (24 examples) and good functional group compatibility. Control experiments revealed the important role of sulfur (S) heteroatom, thus a tentative mechanism with thiophene-promoted double Michael additions was proposed to explain this formal [2+2] cycloaddition Moreover, the resulting polycyclic products displayed potent anti-cancer activities against breast cancer cell lines MDA-MB-468. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Related Products of 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

4-Dimensional observation ER-mitochondria interaction in living cells under nanoscopy by a stable pyridium salt as biosensor was written by Zhu, Fenfang;Yang, Zhenghui;Wang, Fei;Li, Dandan;Cao, Hongzhi;Tian, Yupeng;Tian, Xiaohe. And the article was included in Sensors and Actuators, B: Chemical in 2020.Reference of 65350-59-6 This article mentions the following:

Intracellular membrane-bounded organelles are phys. associated and play critical roles in many physiol. processes. However, real-time monitoring of their interaction at the nanoscale in three-dimension (xyz-t or 4D imaging) remains considerable difficulties due to limitations of the current super-resolution probe toolbox. Here, we developed a novel cell-permeable pyridium salt derivative (TpsPym) with red-emission and large Stock-shift. Interestingly, TpsPym demonstrated a high specificity to mitochondria and endoplasmic reticulum (ER) with different fluorescent intensity. This offered the possibility to utilize this probe to label dual-organelles (ER-mitochondria) under stimulated emission depletion nanoscopy (STED). We successfully monitored the dynamic interactions in real-time between mitochondria and ER in three dimension during starvation-induced autophagy. It suggested ER-mitochondria contacting area might play an essential factor during autophagic cell death (ACD). Our study not only expanding the nanoscopic probe kit but also provide new understanding for ER-mitochondrial interaction at the nanoscale during correlated physiol. conditions. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Reference of 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New supramolecular complexes generated from Mn^II, Fe^II, Co^II, Zn^II, Fe^III with a bent dipyridyl ligand: metal- and anion-directed assembly was written by Du, Miao;Li, Cheng-Peng;You, Yan-Ping;Jiang, Xiu-Juan;Cai, Hua;Wang, Qian;Guo, Jian-Hua. And the article was included in Inorganica Chimica Acta in 2007.Computed Properties of C12H8N4O This article mentions the following:

Assemblies of an angular dipyridyl ligand 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (4-bpo) with metal perchlorate afford five new supramol. complexes of [M(4-bpo)₂(H₂O)₄]·(4-bpo)₂·(anion)·(solvent), in which M = Mn^II for 1, Fe^II for 2, Co^II for 3, Zn^II for 4, and Fe^III for 5. Although similar mol. structures and compositions are found for these mononuclear complexes, they display two types of supramol. lattices. Complexes 1, 4 and 5 similarly crystallize in space group P2/n or P2/c. The complex cations, free 4-bpo and lattice H₂O are linked to generate two-dimensional layered frameworks with the aid of H bonding, and the counteranions are located within and between (also MeOH in 5) these two-dimensional arrays. However, complexes 2 and 3 are isostructural in space group P1̅. Two types of alternate 2-dimensional layers consisting of complex cations and free 4-bpo components, resp., are observed with the anions and lattice H₂O locating between them. These motifs are interlinked by complicated H-bonding to form a three-dimensional intercalated network. Also, when Co(NO₃)₂ was used instead of Co(ClO₄)₂ in the assembly of 3, a 1-dimensional polymeric chain complex {[Co(4-bpo)(H₂O)₂(NO₃)₂](H₂O)₃}_n (6) is generated. The choice of metal ion and anion exerts a significant influence on governing the target complexes. A comparison of the structural features for all metal perchlorate complexes with 4-bpo is also briefly discussed. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Computed Properties of C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Computed Properties of C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

From discrete metallacycle, cage to infinite chain: tuning the coordination frameworks by variation of the metal center or ligand functionality was written by Du, Miao;Zhao, Xiao-Jun;Guo, Jian-Hua. And the article was included in Inorganic Chemistry Communications in 2005.Related Products of 15420-02-7 This article mentions the following:

Self-assembly of the angular dipyridyl-type ligand 2,5-bis(3-pyridyl)-1,3,4-oxadiazole (L¹) with Cu^II(BF₄)₂ or Cu^I(ClO₄) affords a bimetallic macrocyclic compound [Cu₂(L¹)₂(H₂O)₆](BF₄)₄·(H₂O)₃·(MeOH)_0.5 (1) (similar to its Cu^II(ClO₄)₂ complex) or a novel trigonal-prismatic cage-shape species [(H₂O)⊂ Cu₂(L¹)₃(MeCN)₂](ClO₄)₂ (2), resp. However, substituting L¹ with its analogous 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (L²) to react with Cu^I(BF₄) yields a 1-dimensional infinite chain array {[Cu(L²)₂(MeCN)](BF₄)·(H₂O)_1.5}_n (3), being similar to its Cu^I(ClO₄) compound These results unequivocally suggest that the nature of the metal center and ligand functionality play the key role in formation of the coordination supramol. frameworks of 1–3. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Related Products of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium(II)-Catalyzed Formal [4+1]-Cycloaddition of Pyridotriazoles and Propargyl Alcohols: Synthesis of 2,5-Dihydrofurans was written by Lv, Xinxin;Yang, Haijian;Shi, Taoda;Xing, Dong;Xu, Xinfang;Hu, Wenhao. And the article was included in Advanced Synthesis & Catalysis in 2019.Quality Control of Methyl 2-(5-bromopyridin-2-yl)acetate This article mentions the following:

A rhodium-catalyzed formal [4+1]-cycloaddition of pyridotriazoles, e.g., I and aryl propargyl alcs. ArCCCH₂OH (Ar = 4-methylphenyl, naphth-1-yl, 2-bromophenyl, etc.) is reported, providing an effective access to 2-pyridyl-substituted 2,5-dihydrofuran derivatives II (R = Me, Et, t-Bu; Ar¹ = 6-chloropyridin-2-yl, 4,5-diphenyloxazol-2-yl, 3-bromopyridin-2-yl, etc.) in moderate to high yields. Mechanistically, the proposed oxonium ylide intermediate in this catalytic alkyne carbocyclization transformation is verified by an interception experiment for the first time. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Quality Control of Methyl 2-(5-bromopyridin-2-yl)acetate).

Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of Methyl 2-(5-bromopyridin-2-yl)acetate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem