Tag: 200-300

Ghasemi, Ashraf Sadat et al. published their research in Journal of Molecular Liquids in 2019 | CAS: 65350-59-6

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide

A study on the effect of 1-butyl-4-methylpyridinium bromide adsorption on the structural and electronic properties of B12N12 nano-cage was written by Ghasemi, Ashraf Sadat;Soltani, Alireza;Karimnia, Matin;Ashrafi, Fereydoun;Heidari, Fatemeh;Majidian, Mahtab. And the article was included in Journal of Molecular Liquids in 2019.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

In this study, adsorption of 1-butyl-4-methylpyridinium bromide (BMPB) on the B12N12 nano-cage have been investigated by d. functional theory (DFT) at 298.15 K. Provided data clearly indicate that the adsorption behavior of this ionic liquid on B12N12 nano-cage is electrostatic in nature with an energy of -0.283 eV. Furthermore, the value of dipole moment in B12N12 fullerene interacting with ionic liquid 1-butyl-4 methylpyridinium bromide was increased from zero to 13.64 Debye, while the dipole moment value in BMPB is 9.68 Debye. Thereupon, it is simulated to calculate the geometric optimized structure, electronic properties, NQR (NQR), NMR (NMR) studies and the natural bond orbital (NBO) anal. are conducted sep. for both B12N12-BMPB and BMPB. The sensitivity of B12N12 nano-cage to BMPB was investigated and the calculated data indicate that this nano-cage is sensitive to the presence of this ionic liquid In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Luo, Chaosheng et al. published their research in Journal of the American Chemical Society in 2019 | CAS: 175205-82-0

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of 2-Bromo-3-(trifluoromethyl)pyridine

Selective Defluoroallylation of Trifluoromethylarenes was written by Luo, Chaosheng;Bandar, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2019.Quality Control of 2-Bromo-3-(trifluoromethyl)pyridine This article mentions the following:

The authors report a fluoride-initiated coupling reaction between trifluoromethylarenes and allylsilanes to access allylated α,α-difluorobenzylic compounds This method’s utility is demonstrated through a 30 mmol scale reaction, a sequential allylation/derivatization protocol and multiple examples of site-selective trifluoromethylarene allylation. Initial mechanistic studies suggest a base-induced single electron transfer pathway is responsible for the high efficiency and selectivity of this novel C-F substitution process. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Quality Control of 2-Bromo-3-(trifluoromethyl)pyridine).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of 2-Bromo-3-(trifluoromethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chiellini, Emo et al. published their research in Chimica e l’Industria (Milan, Italy) in 1978 | CAS: 65350-59-6

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C10H16BrN

Polymeric reagents in organic chemistry. Catalytic activity of macromolecular matrixes with definite primary and secondary structures in polyphase reactions was written by Chiellini, Emo;Solaro, Roberto. And the article was included in Chimica e l’Industria (Milan, Italy) in 1978.COA of Formula: C10H16BrN This article mentions the following:

The alkylation of PhCH2CN by alkyl bromides was catalyzed by quaternary ammonium salts prepared from poly[4-(chloromethyl)styrene]; trialkylamines, pyridines, and poly(vinylpyridines) also catalyzed the reaction. The above catalysts were also effective in the reaction of PhCHO with CHCl3 to yield PhCH(OH)CO2H and in the cycloaddition reaction of PhCH:CH2 with :CCl2(from CHCl3). In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6COA of Formula: C10H16BrN).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C10H16BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Han, Ying-Feng et al. published their research in Organometallics in 2008 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Stepwise Formation of Molecular Rectangles of Half-Sandwich Rhodium and Ruthenium Complexes Containing Bridging Chloranilate Ligands was written by Han, Ying-Feng;Jia, Wei-Guo;Lin, Yue-Jian;Jin, Guo-Xin. And the article was included in Organometallics in 2008.Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

Binuclear complexes [Cp*2Rh2(μ-CA)Cl2] (2a) and [(p-cymene)2Ru2(μ-CA)Cl2] (2b) (CA = chloranilate) were obtained by the reactions of [Cp*RhCl(μ-Cl)]2 (1a) or [(p-cymene)RuCl(μ-Cl)]2 (1b) with H2CA in the presence of base, resp. Treatment of 2a or 2b with bidentate ligands (L) such as pyrazine, 4,4′-dipyridine (bpy), 2,5-bis(4-pyridyl)-1,3,5-oxadiazole (bpo), and E-1,2-bis(4-pyridyl)ethene (bpe) in the presence of AgOTf (OTf = CF3SO3) in CH3OH gave the corresponding tetranuclear complexes, with the general formulas [Cp*4Rh4(μ-CA)2(μ-L)2](OTf)4 (3a–d) and [(p-cymene)4Ru4(μ-CA)2(μ-L)2](OTf)4 (4a–d), resp. The mol. structures of [Cp*4Rh4(μ-CA)2(μ-bpy)2](OTf)4 (3b), [(p-cymene)4Ru4(μ-CA)2(μ-bpy)2](OTf)4 (4b), and [(p-cymene)4Ru4(μ-CA)2(μ-bpe)2](OTf)4 (4d) have been determined by single-crystal x-ray anal. and revealed that the metal centers were connected by pyridyl ligands and bis-bidentate chloranilate (CA) ligands to construct a rectangular cavity with different dimensions and strong π interactions between independent mols. to form rectangle channels in the solid state. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mehrdad, Abbas et al. published their research in Journal of Chemical Thermodynamics in 2017 | CAS: 65350-59-6

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide

Effect of 1-butyl-4-methylpyridinium and 1-butyl-3-methylimidazolium halide ionic liquids on the interactions of lactic acid in the aqueous solutions of polyethylene glycol was written by Mehrdad, Abbas;Shekaari, Hemayat;Noorani, Narmin. And the article was included in Journal of Chemical Thermodynamics in 2017.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

In this study, effect of some ionic liquids on the thermodn. and transport properties of L(+)-lactic acid in aqueous polyethylene glycol solutions have been investigated. D., speed of sound, and viscosity of L(+)-lactic acid in the aqueous solutions of polyethylene glycol, polyethylene glycol +1-butyl-3-methylimidazolium bromide, polyethylene glycol +1-butyl-3-methylimidazolium chloride, polyethylene glycol +1-butyl-4-methylpyridinium bromide, and polyethylene glycol +1-butyl-4-methylpyridinium chloride were measured at T/K = (288.15, 298.15, 308.15 and 318.15). Infinite dilution apparent molar volumes, transfer apparent molar volume, infinite dilution apparent molar isentropic compressibility and viscosity B-coefficient of L(+)-lactic acid were calculated using exptl. data and were discussed in terms of solute-solute and solute-solvent interactions. The results reveal that solute-solvent interactions were decreased with increasing temperature, size of halide anion. Also solute-solvent interactions in the presence pyridinium ionic liquids are stronger than those of imidazolium ionic liquids The obtained results from spectroscopic reveal that λmax of imidazolium based ionic liquids were red shifted in the presence of lactic acid and this behavior confirmed existence hydrogen bound between lactic acid and imidazolium based ionic liquids In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Han, Dongyang et al. published their research in Chemistry – A European Journal in 2020 | CAS: 175205-82-0

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C6H3BrF3N

Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive was written by Han, Dongyang;Li, Sasa;Xia, Siqi;Su, Mincong;Jin, Jian. And the article was included in Chemistry – A European Journal in 2020.COA of Formula: C6H3BrF3N This article mentions the following:

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodol. features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides RX (R = 4-methanesulfonylphenyl, 3-cyanopyridin-2-yl, 1,3-benzoxazol-2-yl, etc.; X = Br, Cl) were coupled successfully with primary and secondary alkyl amines and anilines such as cyclohexanamine, pyrrolidine, 4-methylaniline, etc. in good to excellent yields RR1 [R1 = cyclohexylaminyl, pyrrolidin-1-yl, (4-methylphenyl)aminyl, etc.]. Similarly, benzophenone imine gave the corresponding N-arylation product N-(4-(methylsulfonyl)phenyl)-1,1-diphenylmethanimine in an excellent yield. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0COA of Formula: C6H3BrF3N).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C6H3BrF3N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nuriev, Vyatsheslav N. et al. published their research in ARKIVOC (Gainesville, FL, United States) in 2005 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 15420-02-7

Synthetic pathways to a family of pyridine-containing azoles-promising ligands for coordination chemistry was written by Nuriev, Vyatsheslav N.;Zyk, Nikolay V.;Vatsadze, Sergey Z.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2005.SDS of cas: 15420-02-7 This article mentions the following:

A series of pyridine-containing pyrazoles, isoxazoles, imidazoles, oxazoles, thiazoles, oxadiazoles, triazoles, and 1,3,4-triazepines were synthesized as potential conjugated building blocks for the construction of coordination compounds In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7SDS of cas: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Han, Ying-Feng et al. published their research in Dalton Transactions in 2011 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 15420-02-7

Discrete half-sandwich Ir, Rh-based organometallic molecular boxes: synthesis, characterization, and their properties was written by Han, Ying-Feng;Lin, Yue-Jian;Jin, Guo-Xin. And the article was included in Dalton Transactions in 2011.SDS of cas: 15420-02-7 This article mentions the following:

The treatment of binuclear complexes [Cp*2M2(μ-QA)Cl2] (M = Ir, 2a; M = Rh, 2b) (H2QA = 1,4-dihydroxyanthraquinone) with pyrazine or bifunctional pyridyl-based ligands (4,4′-dipyridine (bpy), E-1,2-bis(4-pyridyl)ethene (bpe), 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (bpo), and 2,5-bis(4-pyridyl)-1,3,4-thiadiazole (bpt)) in the presence of AgOTf (OTf = CF3SO3) in CH3OH, gave the corresponding tetra-nuclear complexes, with a general formula of [Cp*4M4(μ-QA)2(μ-L)2](OTf)4 (M = Ir, 3a–7a; M = Rh, 3b–7b), resp. The mol. structure of [Cp*4Ir4(μ-QA)2(μ-pyrazine)2](OTf)4 (3a) has been determined by single-crystal x-ray anal., revealing that the metal centers were connected by pyrazine and bis-bidentate QA2- ligands to construct a rectangular cavity with the dimension of 7.30 × 8.41 × 6.92 Å. Complexes 3a and 3b were found to exhibit selective trapping of halocarbons properties. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7SDS of cas: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ko, Kwangseok et al. published their research in Journal of Medicinal Chemistry in 2018 | CAS: 203794-33-6

5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application In Synthesis of 5,6-Dichloro-3-nitropyridin-2-amine

Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis was written by Ko, Kwangseok;Kim, Hye-Jung;Ho, Pil-Su;Lee, Soon Ok;Lee, Ji-Eun;Min, Cho-Rong;Kim, Yu Chul;Yoon, Ju-Han;Park, Eun-Jung;Kwon, Young-Jin;Yun, Jee-Hun;Yoon, Dong-Oh;Kim, Jung-Sook;Park, Woul-Seong;Oh, Seung-Su;Song, Yu-Mi;Cho, Woon-Ki;Morikawa, Kazumi;Lee, Kyoung-June;Park, Chan-Hee. And the article was included in Journal of Medicinal Chemistry in 2018.Application In Synthesis of 5,6-Dichloro-3-nitropyridin-2-amine This article mentions the following:

The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient agents controlling both pruritus and inflammation in AD have been developed yet. Here, we have discovered a novel class of orally available H4R antagonists showing strong anti-itching and anti-inflammation activity as well as excellent selectivity against off-targets. A pharmacophore-based virtual screening system constructed in house successfully identified initial hit compound 9, and the subsequent homol. model-guided optimization efficiently led us to discover pyrido[2,3-e]tetrazolo[1,5-a]pyrazine analog 48 as a novel chemotype of a potent and highly selective H4R antagonist. Importantly, orally administered compound 48 exhibits remarkable efficacy on antipruritus and anti-inflammation with a favorable pharmacokinetic (PK) profile in several mouse models of AD. Thus, these data strongly suggest that our compound 48 is a promising clin. candidate for treatment of AD. In the experiment, the researchers used many compounds, for example, 5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6Application In Synthesis of 5,6-Dichloro-3-nitropyridin-2-amine).

5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application In Synthesis of 5,6-Dichloro-3-nitropyridin-2-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Siddiq, Muhammad et al. published their research in Pakistan Journal of Scientific and Industrial Research in 1988 | CAS: 13472-81-6

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C5H3Br2NO

The effect of the substituents on the carbonyl absorptions of 2H-pyrid-2-ones and 2H-thiopyran-2-ones was written by Siddiq, Muhammad. And the article was included in Pakistan Journal of Scientific and Industrial Research in 1988.Synthetic Route of C5H3Br2NO This article mentions the following:

The IR spectra of a number of substituted 2H-pyrid-2-ones and 2H-thiopyran-2-ones have been measured in the carbonyl stretching vibration region and interpreted in terms of the chem. effect of the substituents. In general, the presence of electron withdrawing substituents at the 1-, 3-, or 3,5-positions and electron donating substituents at the 1-, 4-, or 5-positions of the 2-pyridone have been found to raise and lower the carbonyl absorption, resp. The substituted 2H-thiopyran-2-ones show an appreciable decrease in their carbonyl absorptions as compared to the corresponding 2-pyridones. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Synthetic Route of C5H3Br2NO).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C5H3Br2NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem