Tag: 200-300

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors was written by Demont, Emmanuel H.;Chung, Chun-wa;Furze, Rebecca C.;Grandi, Paola;Michon, Anne-Marie;Wellaway, Chris;Barrett, Nathalie;Bridges, Angela M.;Craggs, Peter D.;Diallo, Hawa;Dixon, David P.;Douault, Clement;Emmons, Amanda J.;Jones, Emma J.;Karamshi, Bhumika V.;Locke, Kelly;Mitchell, Darren J.;Mouzon, Bernadette H.;Prinjha, Rab K.;Roberts, Andy D.;Sheppard, Robert J.;Watson, Robert J.;Bamborough, Paul. And the article was included in Journal of Medicinal Chemistry in 2015.COA of Formula: C10H13ClN2O2 This article mentions the following:

Overexpression of ATAD2 (ATPase family, AAA domain containing 2) has been linked to disease severity and progression in a wide range of cancers, and is implicated in the regulation of several drivers of cancer growth. Little is known of the dependence of these effects upon the ATAD2 bromodomain, which has been categorized as among the least tractable of its class. The absence of any potent, selective inhibitors limits clear understanding of the therapeutic potential of the bromodomain. Here, the authors describe the discovery of a hit from a fragment-based targeted array. Optimization of this produced the first known micromolar inhibitors of the ATAD2 bromodomain, e.g. I. In the experiment, the researchers used many compounds, for example, (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1COA of Formula: C10H13ClN2O2).

(2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C10H13ClN2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel heteroaryl replacements of aromatic 3-tetrafluoroethoxy substituents in trifluoro-3-(tertiary amino)-2-propanols as potent inhibitors of cholesteryl ester transfer protein was written by Massa, M. A.;Spangler, D. P.;Durley, R. C.;Hickory, B. S.;Connolly, D. T.;Witherbee, B. J.;Smith, M. E.;Sikorski, J. A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Related Products of 175205-82-0 This article mentions the following:

A series of novel N,N-disubstituted trifluoro-3-amino-2-propanols, e.g., I, has been prepared as potent inhibitors of cholesteryl ester transfer protein. Modifying the aromatic 3-tetrafluoroethoxy group in the lead mol. (II) with various heteroaryl moieties produced new 2-furyl analogs with submicromolar potency in vitro. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Related Products of 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rapid generation of N,N’-diacylhydrazines by I₂ or Br₂/hydrazine hydrate: a facile route to 1,3,4-oxadiazoles was written by Pamar, Malavath Geeta;Gannimani, Ramesh;Govender, Patrick;Ramjugernath, Deresh;Nanjundaswamy, Hemmaragala Marishetty. And the article was included in Organic Chemistry: An Indian Journal in 2014.Recommanded Product: 15420-02-7 This article mentions the following:

The rapid preparation of sym. azines and N,N’-Diacylhydrazines by NH₂NH₂.H₂O in presence of mol. iodine or bromine at 0-10°C is described. This method afforded an exceedingly convenient route to 1,3,4-Oxadiazoles. The reactions are safe, affording excellent yields of high purity products in shorter durations and the workup procedure involves no solvent extraction, which is environmentally acceptable. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Characterization, and Second-Order Optical Nonlinearity of a Polyurethane Structure Functionalized with a Hemicyanine Dye was written by Moon, Ki-Jeong;Shim, Hong-Ku;Lee, Kwang-Sup;Zieba, Jaroslaw;Prasad, Paras N.. And the article was included in Macromolecules in 1996.HPLC of Formula: 65350-59-6 This article mentions the following:

A new polyurethane structure with a hemicyanine dye attached to the polymer side chain was synthesized by the step growth polymerization in a reaction between (E)-N-butyl-4-[2-[4-[bis(2-hydroxyethyl)amino]ethenyl]pyridinium tetraphenylborate and 2,4-toluene diisocyanate. The mol. weight of the final product was determined to be M_n = 12,000 and M_w/M_n = 1.67. The polymer is soluble in DMF and can be processed into optical quality films by spin casting. No evidence of melting was detected by differential scanning calorimetry, suggesting that this polymer presents an amorphous phase. It shows a glass transition temperature of 121°. The macroscopic second-order hyperpolarizability χ⁽²⁾ of this polyurethane was determined by measuring the second harmonic generation for a thin polymer film. The χ⁽²⁾ value was in the range 1.8 × 10^-7 to 5.0 × 10^-7 esu, depending upon poling conditions. This high second-order activity seems to prove the earlier prediction about a possible enhancement in the nonlinear second-order properties of organic materials triggered by utilizing the strong electron-accepting nature of the pyridinium group. The alignment of the nonlinear chromophore moieties induced by elec. poling exhibits an extended temporal stability, due to the stabilizing function of the H bridges formed between the neighboring polyurethane chains, preventing the relaxation of oriented mol. dipoles. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6HPLC of Formula: 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Functionalized Imidazalium Carboxylates for Enhancing Practical Applicability in Cellulose Processing was written by Xu, Airong;Chen, Lin;Wang, Jianji. And the article was included in Macromolecules (Washington, DC, United States) in 2018.Formula: C10H16BrN This article mentions the following:

Developing cellulose-based products is highly important because of their low-cost, reproducibility, and biodegradability. However, extensive application for cellulose was actually hindered due to its well-known insolubility Herein, some 22 novel functionalized imidazalium carboxylates exhibit tremendously enhanced dissolution capacity for cellulose even without extra energy consumption and are much superior to the previously reported solvents so far. Systematic investigations reveal that the powerful dissolution capacity for cellulose mainly results from the contribution of the imidazolium skeleton cation, not replacing acidic H atoms in imidazolium skeleton by alkyl, binding more allyl in N atoms of imidazolium cation, and binding an electron-donating group in carboxylate anion. Of particular importance, porous cellulose materials with varying micro-morphol., for the first time, are reported by tuning the anionic and/or cationic structures of an IL. Moreover, the regenerated cellulose material retains sufficient thermal stability and chem. structure. Therefore, this investigation provides a viable strategy for practical application in cellulose conversion into valuable products even without extra heating. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Formula: C10H16BrN).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C10H16BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Poly(1,3,4-oxadiazoles). IV. Poly(1,3,4-oxadiazoles) containing pyridine rings was written by Iwakura, Yoshio;Uno, Keikichi;Hara, Shigeyoshi. And the article was included in Makromolekulare Chemie in 1967.SDS of cas: 15420-02-7 This article mentions the following:

Poly(1,3,4-oxadiazoles), which have both thermostability and solubility in organic solvents, are formed by the polycondensation of pyridine dicarboxylic dihydrazides in fuming H2SO4 or polyphosphoric acid (I). The resulting polymers contain pyridine rings and have low mol. weight Thus, 4 g. isocinchomeronic dihydrazide was dissolved with gradual heating in 60 g. I. Heating was continued for 2 hrs. at 120° and 6 hrs. at 180°. The mixture turned dark brown in color. The product was precipitated and washed in H2O, allowed to stand overnight in dilute Na2CO3 solution, H2O-washed, and vacuum dried at 70° to yield 3.2 g. poly(pyridine-5,2-diyl-1,3,4-oxadiazole-2,5-diyl) (II), sp. viscosity 0.16 (0.2 g./100 ml. 95% H2SO4, 30°). [TABLE OMITTED] Similar polymers were prepared from the solution polycondensation of dinicotinic, 2,6-dimethyldinicotinic, dipicolinic, and dipicolinic terephthalic dihydrazides. Polycondensation in fuming H2SO4 gave considerably lower yields. Differences were observed between the ir spectrum of II and that of authentic II prepared by the cyclodehydration of poly(isocinchomeronic hydrazide) in fuming H2SO4. The ir spectrum of II relatively agreed with that of a model compound, 2,5-di-3-pyridyl-1,3,4-oxadiazole, m. 185-5.5°, prepared by condensing nicotinic acid with hydrazine sulfate in fuming H2SO4. Another model compound, 2,5-di-4-pyridyl-1,3,4-oxadiazole, m. 184.5-5°, was similarly prepared from isonicotinic acid. Brittle films of the various polymers were cast from ClCHCO2H and showed moderate solubility in H2SO4 and HCO2H. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7SDS of cas: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Parallel microwave-assisted synthesis of ionic liquids and screening for denitrogenation of straight-run diesel feed by liquid-liquid extraction was written by Ceron, Miguel A.;Guzman-Lucero, Diego J.;Palomeque, Jorge F.;Martinez-Palou, Rafael. And the article was included in Combinatorial Chemistry & High Throughput Screening in 2012.Related Products of 65350-59-6 This article mentions the following:

Fifty-six ionic liquids were efficiently synthesized in parallel format under one-pot, solvent-free microwave-assisted synthesis. These compounds were evaluated as extracting agents of nitrogen-containing compounds from a real Diesel feed before being submitted to the hydrodesulfurization process to obtain ultralow sulfur Diesel. Our results showed that halogenated ionic liquids are an excellent alternative due to these ionic liquids are relatively inexpensive, presenting a high selectivity for the extraction of nitrogen-containing compounds and can be regenerated and recycled. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Related Products of 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Related Products of 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and fungicidal activity of novel methoximinoacetates containing phenylpyridine moieties was written by Mao, Dajie;Hu, Chongbo;Liu, Jianhua;Du, Xiaohua;Xu, Zhenyuan. And the article was included in Nongyaoxue Xuebao in 2014.Safety of 2-Bromo-3-(trifluoromethyl)pyridine This article mentions the following:

Twenty-four novel methoximinoacetate compounds containing phenylpyridine moieties were synthesized from (3-hydroxyphenyl) boronic acid and substituted bromopyridines via Suzuki cross-coupling reaction and nucleophilic substitution. The structures of all compounds were confirmed by ¹H-NMR, ESI-MS and IR. Bioactivity tests showed that most of the compounds had moderate to good fungicidal activity and compounds 5i, 5r and 5t exhibited more than 80% inhibition against Pseudoperonospora cubensis at 50 mg/L, which meant that the title compounds were potential as the fungicidal lead compounds In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Safety of 2-Bromo-3-(trifluoromethyl)pyridine).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of 2-Bromo-3-(trifluoromethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem