Tag: 200-300

Improved synthesis of 6-cyano-1-hydroxy-7-methyl-5-oxo-3,5-dihydro-indolizine-2-carboxylic acid methyl ester was written by Yang, Song;Zhang, Wannian;Zhou, Youjun;Yao, Jianzhong;Ji, Haitao. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2004.COA of Formula: C10H10N2O3 The following contents are mentioned in the article:

The synthesis of 6-cyano-1-hydroxy-7-methyl-5-oxo-3,5-dihydro-indolizine-2-carboxylic acid Me ester, an intermediate of the total synthesis of camptothecins, was improved. The yield of Et acetopyruvate was raised by controlling the speed of dropping and reaction time. The “one-pot procedure” was taken to prepare the title compound from Et acetopyruvate. The overall yield of the title compound was raised from 31% to 42.5%, and its structure of was confirmed by ¹H-NMR, MS and EA. The synthesis process was improved by the simplified operation, raised yield, shortened reaction time and the reduced usage of reagent. This study involved multiple reactions and reactants, such as Ethyl 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate (cas: 58610-61-0COA of Formula: C10H10N2O3).

Ethyl 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate (cas: 58610-61-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C10H10N2O3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Conformational change of organic cofactor PLP is essential for catalysis in PLP-dependent enzymes. was written by Ngo, Ho-Phuong-Thuy;Nguyen, Diem Quynh;Park, Hyunjae;Park, Yoon Sik;Kwak, Kiwoong;Kim, Taejoon;Lee, Jang Ho;Cho, Kyoung Sang;Kang, Lin-Woo. And the article was included in BMB reports in 2022.Synthetic Route of C8H10NO6P The following contents are mentioned in the article:

Pyridoxal 5′-phosphate (PLP)-dependent enzymes are ubiquitous, catalyzing various biochemical reactions of approximately 4% of all classified enzymatic activities. They transform amines and amino acids into important metabolites or signaling molecules and are important drug targets in many diseases. In the crystal structures of PLP-dependent enzymes, organic cofactor PLP showed diverse conformations depending on the catalytic step. The conformational change of PLP is essential in the catalytic mechanism. In the study, we review the sophisticated catalytic mechanism of PLP, especially in transaldimination reactions. Most drugs targeting PLP-dependent enzymes make a covalent bond to PLP with the transaldimination reaction. A detailed understanding of organic cofactor PLP will help develop a new drug against PLP-dependent enzymes. [BMB Reports 2022; 55(9): 439-446]. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Synthetic Route of C8H10NO6P).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C8H10NO6P

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A DFT study of the active role of the phosphate group of an internal aldimine in a transamination reaction was written by Yamabe, Shinichi;Tsuchida, Noriko;Yamazaki, Shoko. And the article was included in Organic & Biomolecular Chemistry in 2022.Synthetic Route of C8H10NO6P The following contents are mentioned in the article:

A transamination reaction from an internal aldimine ([PLP]) and (S)-alanine to pyridoxamine phosphate (PMP) and pyruvic acid was investigated by DFT calculations As [PLP], a model where the lysine (-Lys) part was approximated by -CH[-NH-C(=O)-CH₃]-C(=O)-NH-CH₃ was adopted. (H₂O)₄ was also included to trace reaction paths involving proton transfers. 13 elementary processes were obtained. For (the external aldimine 鈫?quinoid), (quinoid 鈫?ketimine) and (ketimine 鈫?carbinol amine) processes, the water dimer was found to connect a phosphate-group oxygen with the moving proton. The connection promoted the Grotthuss-type proton transfer in transition states. It was revealed that the phosphate group is not a mere substituent but has the central role in the transfer. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Synthetic Route of C8H10NO6P).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C8H10NO6P

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A DFT study of the active role of the phosphate group of an internal aldimine in a transamination reaction was written by Yamabe, Shinichi;Tsuchida, Noriko;Yamazaki, Shoko. And the article was included in Organic & Biomolecular Chemistry in 2022.Name: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate The following contents are mentioned in the article:

A transamination reaction from an internal aldimine ([PLP]) and (S)-alanine to pyridoxamine phosphate (PMP) and pyruvic acid was investigated by DFT calculations As [PLP], a model where the lysine (-Lys) part was approximated by -CH[-NH-C(=O)-CH₃]-C(=O)-NH-CH₃ was adopted. (H₂O)₄ was also included to trace reaction paths involving proton transfers. 13 elementary processes were obtained. For (the external aldimine 鈫?quinoid), (quinoid 鈫?ketimine) and (ketimine 鈫?carbinol amine) processes, the water dimer was found to connect a phosphate-group oxygen with the moving proton. The connection promoted the Grotthuss-type proton transfer in transition states. It was revealed that the phosphate group is not a mere substituent but has the central role in the transfer. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Name: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Name: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

GABA production and probiotic addition in Saccharina angustata (Hidakakombu) by fermentation of Lactiplantibacillus pentosus SN001 was written by Sekine, Tetsuya;Yamanushi, Mayu;Hamada-Sato, Naoko. And the article was included in Fisheries Science (Tokyo, Japan) in 2022.Synthetic Route of C8H10NO6P The following contents are mentioned in the article:

Saccharina angustata (Hidakakombu), commonly known as kelp, is an edible macroalgae mainly grown in the Hidaka region, Hokkaido. Hidakakombu is graded based on its shape and color. Low-grade Hidakakombu has low value and is distributed at a low price. Therefore, a method for adding value to low-grade Hidakakombu is needed. In this study, low-grade Hidakakombu was fermented by Lactiplantibacillus pentosus SN001 to add value. Fermentation of Hidakakombu was confirmed by an increase in the number of L. pentosus SN001 cells and a decrease in pH. Fermentation with pyridoxal 5′-phosphate (PLP) increased the GABA content. L. pentosus SN001 in fermented Hidakakombu remained viable in simulated gastric and intestinal juices. Hidakakombu fermented by L. pentosus SN001 was shown to be a source of GABA and probiotics. Therefore, fermentation by L. pentosus SN001 was found to be an effective means of adding high value to low-grade Hidakakombu. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Synthetic Route of C8H10NO6P).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C8H10NO6P

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

GABA production and probiotic addition in Saccharina angustata (Hidakakombu) by fermentation of Lactiplantibacillus pentosus SN001 was written by Sekine, Tetsuya;Yamanushi, Mayu;Hamada-Sato, Naoko. And the article was included in Fisheries Science (Tokyo, Japan) in 2022.Product Details of 54-47-7 The following contents are mentioned in the article:

Saccharina angustata (Hidakakombu), commonly known as kelp, is an edible macroalgae mainly grown in the Hidaka region, Hokkaido. Hidakakombu is graded based on its shape and color. Low-grade Hidakakombu has low value and is distributed at a low price. Therefore, a method for adding value to low-grade Hidakakombu is needed. In this study, low-grade Hidakakombu was fermented by Lactiplantibacillus pentosus SN001 to add value. Fermentation of Hidakakombu was confirmed by an increase in the number of L. pentosus SN001 cells and a decrease in pH. Fermentation with pyridoxal 5′-phosphate (PLP) increased the GABA content. L. pentosus SN001 in fermented Hidakakombu remained viable in simulated gastric and intestinal juices. Hidakakombu fermented by L. pentosus SN001 was shown to be a source of GABA and probiotics. Therefore, fermentation by L. pentosus SN001 was found to be an effective means of adding high value to low-grade Hidakakombu. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Product Details of 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Engineered production of pyridoxal 5鈥?phosphate in Escherichia coli BL21 was written by He, Min;Ma, Jian;Chen, Qingwei;Zhang, Qili;Yu, Ping. And the article was included in Preparative Biochemistry & Biotechnology in 2022.Quality Control of (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate The following contents are mentioned in the article:

Pyridoxal 5鈥?phosphate (PLP) is the coenzyme of more than 140 enzymes and is widely used in various fields. In this study, to enhance the production of PLP in Escherichia coli BL21, the recombinant strain E. coli BL21/pETDuet-1-pdxj-zwf-dxs was constructed. The concentration of PLP in this strain was 82.69 mg/L, which was increased by 1.38-fold as compared to that in E. coli BL21. Glucose, yeast extract, and pH had an obvious impact on the concentration of PLP, and their optimal levels were 34.89 g/L, 31.17 g/L, and 10.07, resp. The concentration of PLP under the optimal condition reached 2.23 g/L. The time-course anal. showed that the highest concentration of PLP was 2.32 g/L in recombinant strain after the induction for 12 h by 0.1 mM IPTG in a 1 L shake flask, which was increased by 38.76-fold as compared to that in E. coli BL21. This study provides a good basis for the efficient production of PLP in E. coli BL21. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Quality Control of (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Engineered production of pyridoxal 5鈥?phosphate in Escherichia coli BL21 was written by He, Min;Ma, Jian;Chen, Qingwei;Zhang, Qili;Yu, Ping. And the article was included in Preparative Biochemistry & Biotechnology in 2022.SDS of cas: 54-47-7 The following contents are mentioned in the article:

Pyridoxal 5鈥?phosphate (PLP) is the coenzyme of more than 140 enzymes and is widely used in various fields. In this study, to enhance the production of PLP in Escherichia coli BL21, the recombinant strain E. coli BL21/pETDuet-1-pdxj-zwf-dxs was constructed. The concentration of PLP in this strain was 82.69 mg/L, which was increased by 1.38-fold as compared to that in E. coli BL21. Glucose, yeast extract, and pH had an obvious impact on the concentration of PLP, and their optimal levels were 34.89 g/L, 31.17 g/L, and 10.07, resp. The concentration of PLP under the optimal condition reached 2.23 g/L. The time-course anal. showed that the highest concentration of PLP was 2.32 g/L in recombinant strain after the induction for 12 h by 0.1 mM IPTG in a 1 L shake flask, which was increased by 38.76-fold as compared to that in E. coli BL21. This study provides a good basis for the efficient production of PLP in E. coli BL21. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7SDS of cas: 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chitin biopolymer mediates self-sufficient biocatalyst of pyridoxal 5′-phosphate and L-lysine decarboxylase was written by Wei, Guoguang;Chen, Yan;Zhou, Ning;Lu, Qiuhao;Xu, Sheng;Zhang, Alei;Chen, Kequan;Ouyang, Pingkai. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Electric Literature of C8H10NO6P The following contents are mentioned in the article:

Enzyme cofactors are essential in biocatalysis for many enzymes. However, their high com. cost limits the industrial application of cofactor-dependent enzymes. We overcame this challenge by constructing a self-sufficient biocatalyst that co-immobilized pyridoxal 5′-phosphate (PLP) and L-lysine decarboxylase (LDC) using natural polymer chitin as the functional material. First, degree of deacetylation (DDA) of chitin was regulated to enhance PLP adsorption and immobilization. Then, the enzyme was immobilized via fusion of a chitin-binding domain. Chitin with 36% DDA efficiently co-immobilized LDC and PLP. Laser scanning confocal microscope and scanning electron microscope proved that the LDC and PLP were immobilized on the chitin. The self-sufficient biocatalyst retained over 55% of its original activity after five cycles. The proposed strategy provides a new way to achieve co-immobilization of PLP-dependent enzymes. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Electric Literature of C8H10NO6P).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 蟺-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 蟽 bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Electric Literature of C8H10NO6P

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chitin biopolymer mediates self-sufficient biocatalyst of pyridoxal 5′-phosphate and L-lysine decarboxylase was written by Wei, Guoguang;Chen, Yan;Zhou, Ning;Lu, Qiuhao;Xu, Sheng;Zhang, Alei;Chen, Kequan;Ouyang, Pingkai. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Related Products of 54-47-7 The following contents are mentioned in the article:

Enzyme cofactors are essential in biocatalysis for many enzymes. However, their high com. cost limits the industrial application of cofactor-dependent enzymes. We overcame this challenge by constructing a self-sufficient biocatalyst that co-immobilized pyridoxal 5′-phosphate (PLP) and L-lysine decarboxylase (LDC) using natural polymer chitin as the functional material. First, degree of deacetylation (DDA) of chitin was regulated to enhance PLP adsorption and immobilization. Then, the enzyme was immobilized via fusion of a chitin-binding domain. Chitin with 36% DDA efficiently co-immobilized LDC and PLP. Laser scanning confocal microscope and scanning electron microscope proved that the LDC and PLP were immobilized on the chitin. The self-sufficient biocatalyst retained over 55% of its original activity after five cycles. The proposed strategy provides a new way to achieve co-immobilization of PLP-dependent enzymes. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Related Products of 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem