Tag: 200-300

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase was written by Feng, Danqing;Biftu, Tesfaye;Romero, F. Anthony;Kekec, Ahmet;Dropinski, James;Kassick, Andrew;Xu, Shiyao;Kurtz, Marc M.;Gollapudi, Anantha;Shao, Qing;Yang, Xiaodong;Lu, Ku;Zhou, Gaochao;Kemp, Daniel;Myers, Robert W.;Guan, Hong-Ping;Trujillo, Maria E.;Li, Cai;Weber, Ann;Sebhat, Iyassu K.. And the article was included in ACS Medicinal Chemistry Letters in 2018.Product Details of 203794-33-6 This article mentions the following:

5′-Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of mammalian energy homeostasis and has been implicated in mediating many of the beneficial effects of exercise and weight loss including lipid and glucose trafficking. As such, the enzyme has long been of interest as a target for the treatment of Type 2 Diabetes Mellitus. The authors describe the optimization of 灏?-selective, liver-targeted AMPK activators and their evolution into systemic pan-activators capable of acutely lowering glucose in mouse models. Identifying surrogates for the key acid moiety in early generation compounds proved essential in improving 灏?-activation and in balancing improvements in plasma unbound fraction while avoiding liver sequestration. In the experiment, the researchers used many compounds, for example, 5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6Product Details of 203794-33-6).

5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 203794-33-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morphology, surface properties and photocatalytic activity of the bismuth oxyhalides semiconductors prepared by ionic liquid assisted solvothermal method was written by Bielicka-Gieldon, Aleksandra;Wilczewska, Patrycja;Malankowska, Anna;Szczodrowski, Karol;Ryl, Jacek;Zielinska-Jurek, Anna;Siedlecka, Ewa Maria. And the article was included in Separation and Purification Technology in 2019.Synthetic Route of C10H16BrN This article mentions the following:

This is the first report of the effect of the ILs cation type (imidazolium, pyridinium and pyrrolidinium) on the morphol., surface properties and photoactivity of BiOX semiconductors type obtained by solvothermal method in glycerol. The various ionic liquids (IL) cation type as a halogen source and templating agent for the synthesis of the bismuth oxyhalides nanoparticles has been systematically investigated. The role of ILs in synthesis of the semiconductors was loosening of the structure and increasing the particle size of semiconductors. It was also found that ILs increased sp. surface area and pore volume of bismuth oxyhalides. Rhodamine B and 5-fluorouracil were used as the model contaminates to evaluate the adsorption capacity and photooxidation performance of studied BiOX. Removal of chromium (VI) from acidic solution were demonstrated photoreduction ability of BiOX. Generally the activity of bismuth oxyhalides was better for the samples prepared with ILs, although the increase in activity was different for various ionic liquids The changes of band gap structure were major causes of the enhanced photocatalytic activity of bismuth oxyhalides with ILs as the halogen source. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Synthetic Route of C10H16BrN).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C10H16BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridinium and imidazolium 1,3,4-oxadiazole ionic liquid crystals: a thermal and photophysical systematic investigation was written by Westphal, Eduard;Henrique da Silva, Danilo;Molin, Fernando;Gallardo, Hugo. And the article was included in RSC Advances in 2013.Product Details of 15420-02-7 This article mentions the following:

The authors present the synthesis and complete structural characterization of twenty five 1,3,4-oxadiazole mols. (ionic and nonionic) with some systematic structural variations, such as number of counterions, number of alkoxy chains, alkyl chain size, type of counterion and its position on the mol. The thermal and photophys. properties for all compounds were studied allowing a complete and interesting simultaneous study of the effect of structural changes on these properties. Every parameter studied affected both the thermal and photophys. properties. For these bent core mols., the liquid crystalline behavior was observed only for compounds containing one counterion, SmA (monolayer or bilayer) being the predominant phase. The neutral (nonionic) compounds and the imidazolium derivatives showed emission at 閳?60 nm and a high quantum yield, while most of the pyridinium derivatives showed emission at 閳?30 nm, a low quantum yield and a complex photophys. behavior. In all cases, the quantum yield for the different counterions follows the sequence ClO₄^– > BF₄^– > DS^– > NO₃^– > Br^–(I^–). In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Product Details of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gel polymer electrolyte based on polyvinylidenefluoride-co-hexafluoropropylene and ionic liquid for lithium ion battery was written by Yang, Pei Xia;Liu, Lei;Li, Li Bo;Hou, Jun;Xu, Yan Ping;Ren, Xuefeng;An, Mao Zhong;Li, Ning. And the article was included in Electrochimica Acta in 2014.Recommanded Product: 65350-59-6 This article mentions the following:

Gel-type polymer electrolytes with 1-butyl-4-methylpyridinium bis(trifluoromethanesulfonyl)imide (B4MePyTFSI) ionic liquid are formed by the solution casting method. The conductivity and transference number measurements are carried out to study conductivity and charge transport in the gel polymer electrolytes. The conductivity of the samples increases when the amount of B4MePyTFSI ionic liquid is increased. The Li ion ionic conductivity reaches the maximum value (2.01 鑴?10^-4 S cm^-1) when GPE contains 33.3% B4MePyTFSI. The electrochem. stability window of ILGPE is 閳?.5 V vs. Li⁺/Li at 20鎺? meeting the basic requirement of rechargeable Li batteries. Discharge performance of Li battery using this ILGPE membrane shows a capacity of 閳?60 mAh g^-1. The excellent performance with higher capacity, good cycle stability and compatibility are observed for the Li/ILGPE/LiFePO₄ cells. The interfacial resistances between ILGPE and electrodes have the less change after 10 cycles. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Recommanded Product: 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and characterization of new coordination polymers generated from oxadiazole-containing ligands and IIB metal ions was written by Cheng, Jun-Yan;Dong, Yu-Bin;Huang, Ru-Qi;Smith, Mark D.. And the article was included in Inorganica Chimica Acta in 2005.Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

The coordination chem. of the oxadiazole-containing rigid bidentate ligands 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (L1) and 2,5-bis(3-pyridyl)-1,3,4-oxadiazole (L2) with inorganic IIB metal salts were studied. Five new coordination polymers (1–5) were prepared by solution reactions and fully characterized by IR spectroscopy, elemental anal., and single-crystal x-ray diffraction. Cd(L1)₂(MeCN)₂(ClO₄)₂璺?MeCN)₂ (1) crystallized in the monoclinic space group P2₁/c, a 8.4028(5), b 21.3726(13), c 10.5617(7) 鑴? 灏?95.1200(10)鎺? and Z = 2. In the solid state, it adopts an infinite two-dimensional polymeric structural motif with effective cross section of 閳?4.31 鑴?14.31 鑴? Cd(L2)(H₂O)(NO₃)₂ (2) crystallized in the monoclinic Ia, a 7.1203(5), b 22.2475(15), c 20.2652(16) 鑴? 灏?90.6080(10)鎺? and Z = 8. In the solid state, the two Cd(II) centers are connected to each other by L2 ligands and bridging nitrates into a two-dimensional network. [ZnCl₂(L1)] (3) and [HgI₂(L1)]璺疢eCN (4) crystallized in the monoclinic crystal system (3: space group P2₁/c, a 5.3702(3), b 20.4800(11), c 12.4093(7) 鑴? 灏?94.7930(10)鎺? and Z = 4; 4: space group P2/n, a 17.2733(11), b 5.2173(3), c 20.4069(13) 鑴? 灏?102.8690(10)鎺? and Z = 4). In the solid state, Zn(II) and Hg(II) metal centers are connected to each other by L1 ligands into a zigzag chain motif. Compound 5 (HgBr₂(L2) is different from 3 and 4, monoclinic, P2(1)/n, a 5.470(4), b 16.271(13), c 16.486(12) 鑴? 灏?93.197(15)鎺? and Z = 4) and adopts a novel 1-dimensional helical chain motif which resulted from the relative different coordinated orientation of the two N-donors on L2 ligand. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oxidative Condensations To Form Benzimidazole-Substituted Potassium Organotrifluoroborates was written by Molander, Gary A.;Ajayi, Kehinde. And the article was included in Organic Letters in 2012.Quality Control of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde This article mentions the following:

A library of benzimidazole-substituted potassium organotrifluoroborates was prepared via the condensation of various potassium formyl-substituted aryl- and heteroaryltrifluoroborates with aromatic 1,2-diamines under oxidative conditions. The efficient Suzuki-Miyaura cross-coupling of products thus formed to various aryl and heteroaryl bromides was achieved in good yields. The method allows the facile preparation of benzimidazole-containing triarom. products in two steps from simple potassium formyl substituted aryl- or heteroaryltrifluoroborates. In the experiment, the researchers used many compounds, for example, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (cas: 1073354-14-9Quality Control of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde).

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (cas: 1073354-14-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cobalt(III)-Catalyzed Directed C-H Coupling with Diazo Compounds: Straightforward Access towards Extended 锜?Systems was written by Zhao, Dongbing;Kim, Ju Hyun;Stegemann, Linda;Strassert, Cristian A.;Glorius, Frank. And the article was included in Angewandte Chemie, International Edition in 2015.Recommanded Product: 54151-74-5 This article mentions the following:

The first highly efficient and scalable cobalt-catalyzed directed C-H functionalization with carbene precursors is presented. This methodol. provides a modular route towards a new class of conjugated polycyclic hydrocarbons with tunable emission wavelengths both in solution and in the solid state. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Recommanded Product: 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective O-methylation of phenols and benzyl alcohols in simple pyridinium based ionic liquids was written by Das, Pranab Jyoti;Das, Jupitara. And the article was included in Journal of Molecular Liquids in 2015.Application In Synthesis of 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

Synthesis of pyridinium based ionic liquids were reported and applied as catalyst for the selective O-methylation of phenols and benzyl alcs. The reactions were carried out by using dimethylcarbonate (DMC) as the methylating agent. High selectivity, high yield and recyclability of the ionic liquids were important features of the reactions. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Application In Synthesis of 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery was written by Erlanson, Daniel A.;Arndt, Joseph W.;Cancilla, Mark T.;Cao, Kathy;Elling, Robert A.;English, Nicki;Friedman, Jessica;Hansen, Stig K.;Hession, Cathy;Joseph, Ingrid;Kumaravel, Gnanasambandam;Lee, Wen-Cherng;Lind, Ken E.;McDowell, Robert S.;Miatkowski, Konrad;Nguyen, Christine;Nguyen, Thinh B.;Park, Sophia;Pathan, Nuzhat;Penny, David M.;Romanowski, Michael J.;Scott, Daniel;Silvian, Laura;Simmons, Robert L.;Tangonan, Bradley T.;Yang, Wenjin;Sun, Lihong. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Application In Synthesis of 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid This article mentions the following:

We report the use of a fragment-based lead discovery method, Tethering with extenders, to discover a pyridinone fragment that binds in an adaptive site of the protein PDK1. With subsequent medicinal chem., this led to the discovery of the potent and highly selective inhibitor of PDK1 33 (I), which binds in the ‘DFG-out’ conformation. In the experiment, the researchers used many compounds, for example, 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (cas: 1001413-01-9Application In Synthesis of 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid).

1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (cas: 1001413-01-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKC胃 inhibitors: Part I was written by Subrath, Joan;Wang, Daniel;Wu, Biqi;Niu, Chuansheng;Boschelli, Diane H.;Lee, Julie;Yang, Xiaoke;Brennan, Agnes;Chaudhary, Divya. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Application of 1073354-14-9 This article mentions the following:

We earlier reported that 3-pyridinecarbonitriles with a 4-methylindolyl-5-amino group at C-4 and a Ph group at C-5 were inhibitors of PKC胃. Keeping the group at C-4 of the pyridine core constant, we varied the water solubilizing group on the Ph ring at C-5 and then replaced the C-5 Ph ring with several monocyclic heteroaryl rings, including furan, thiophene and pyridine. Analog 6e (I) with a 4-methylindol-5-ylamino group at C-4 and a 5-[(4-methylpiperazin-1-yl)methyl]-2-furyl group C-5 had an IC₅₀ value of 4.5 nM for the inhibition of PKC胃. In the experiment, the researchers used many compounds, for example, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (cas: 1073354-14-9Application of 1073354-14-9).

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (cas: 1073354-14-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 蟺-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 蟽 bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application of 1073354-14-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem