Tag: 200-300

《Synthesis of pyridine-bridged bisferrocene and its pH value adjustable photoelectric properties》 was written by Ma, Jingjing; Zhai, Yali; Chen, Jiahui; Zhou, Xiang; Shi, Weimin; Zhang, Jianye; Li, Gaiping; Hou, Hong wei. Application In Synthesis of 2,6-Dibromopyridine And the article was included in Tetrahedron in 2020. The article conveys some information:

Four bisferrocenyl pyridine derivatives 2, 6-bis(ferrocenylethynyl) pyridine (3), 2, 6-bis (ferrocenylbutadiynyl) pyridine (8), 2, 6-bis (ferrocenylhexyltriynyl) pyridine (9), 2, 5-bis (ferrocenylbutadiynyl) pyridine (14) were synthesized and photoelec. properties of these compounds were studied. UV-visible spectroscopic, 3rd-order nonlinear optical property and electrochem. studies revealed that the photoelec. properties of these compounds would change significantly by adjusting pH. Compared with neutral conditions, lower-energy metal-to-ligand charge transfer (MLCT) transition was stronger, the oxidation potential shift neg., a luminescence increase and 3rd-order nonlinear optical properties were stronger under acidic conditions. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Application In Synthesis of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Odingo, Joshua; Bailey, Mai A.; Files, Megan; Early, Julie V.; Alling, Torey; Dennison, Devon; Bowman, Julie; Dalai, Suryakanta; Kumar, Naresh; Cramer, Jeffrey; Masquelin, Thierry; Hipskind, Philip A.; Parish, Tanya published 《In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis》.ACS Omega published the findings.Safety of Methyl 5-bromopicolinate The information in the text is summarized as follows:

Nitazoxanide has antiparasitic and antibiotic activities including activity against Mycobacterium tuberculosis. We prepared and evaluated a set of its analogs to determine the structure-activity relationship, and identified several amide- and urea-based analogs with low micromolar activity against M. tuberculosis in vitro. Pharmacokinetics in the rat suggested a path forward to obtain bioavailable compounds The series had a good microbiol. profile with bactericidal activity in vitro against replicating and nonreplicating M. tuberculosis. Analogs had limited activity against other Gram-pos. bacteria but no activity against Gram-neg. bacteria. Our studies identified the key liability in this series as cytotoxicity. Future work concentrating on identifying the target(s) could assist in removing activity against eukaryotic cells. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《Synthesis, Characterization, and Structural Transformation of Picolyl-Functionalized Polynuclear Silver(I)- and Gold(I)-N-Heterocyclic Carbene Complexes》 was published in Organometallics. The article was written by Li, Xin; Zhao, Jing; Shi, Wen-jie; Bai, Sha; Han, Ying-feng. The article contains the following contents:

Three coinage-metal (AgI, CuI, and AuI) NHC complexes featuring picolyl-functionalized NHC ligands were synthesized and fully characterized by NMR spectroscopy and single-crystal X-ray diffraction analyses. The obtained complexes exhibit different geometries depending on the diversified coordination modes of the multidentate ligand toward different metal ions. The trinuclear AgI complex [Ag3(L)2](PF6)3 was directly synthesized by the one-step reaction of picolyl-functionalized diimidazolium salts with Ag2O. Further, transmetalation of [Ag3L2](PF6)3 with CuCl and Au(THT)Cl (THT = tetrahydrothiophene) led to the formation of the unexpected copper(I)-NHC complex {[CuL(CH3CN)Cl]PF6}n with one-dimensional chain structure and the tetranuclear gold(I) complex [Au4L2]Cl(PF6)3, resp. Interestingly, the two trinuclear AuI-NHC complexes [Au3L2]2(2,6-nds)3 and [Au3L2]2(1,5-nds)3 (nds = naphthalenedisulfonate) were further obtained through an anion-induced structural transformation of [Au4L2]Cl(PF6)3. Complexes [Au3L2]2(2,6-nds)3 and [Au3L2]2(1,5-nds)3 were also characterized by mass spectrometry and single-crystal X-ray diffraction studies. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Category: pyridine-derivatives)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Li, Jia-Yi; Wang, Li; Yin, Li-Ping; Jiang, Xin-Meng; Guo, Kai; Zhang, Chun; Yu, Shan-Shan; Yu, Xiao-Qi; Wang, Qin published an article in ChemistryOpen. The title of the article was 《A Racemic Naphthyl-Coumarin-Based Probe for Quantitative Enantiomeric Excess Analysis of Amino Acids and Enantioselective Sensing of Amines and Amino Alcohols》.Product Details of 31106-82-8 The author mentioned the following in the article:

A new racemic naphthyl-coumarin-based probe was found to bind covalently with amino acids in MeOH-KOH system and thereby generates distinct CD responses. The induced strong CD signals allowed quant. enantiomeric excess anal. of amino acids and enantioselective sensing of amines and amino alcs. The mechanism for the reaction of the coumarin-aldehyde probe with an amino acid was investigated by CD, UV-Vis, NMR, ESI-MS analyses and ECD calculation2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis, and in-vitro evaluation of hydroxybenzimidazole-donepezil analogues as multitarget-directed ligands for the treatment of Alzheimer’s disease》 was written by Chaves, Silvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; Capriati, Vito; Pereira-Santos, A. Raquel; Cardoso, Sandra M.; Santos, M. Amelia. HPLC of Formula: 31106-82-8 And the article was included in Molecules in 2020. The article conveys some information:

A series of multi-target-directed ligands (MTDLs), obtained by attachment of a hydroxyphenylbenzimidazole (BIM) unit to donepezil (DNP) active mimetic moiety (benzyl-piperidine/-piperazine) was designed, synthesized, and evaluated as potential anti-Alzheimer’s disease (AD) drugs in terms of biol. activity (inhibition of acetylcholinesterase (AChE) and β-amyloid (Aβ) aggregation), metal chelation, and neuroprotection capacity. Among the DNP-BIM hybrids studied herein, the structural isomerization did not significantly improve the biol. properties, while some substitutions, namely a fluorine atom in each moiety or the methoxy group in the benzyl ring, evidenced higher cholinergic AChE activity. All the compounds were able to chelate Cu and Zn metal ions through their bidentate BIM moieties; but compound I, containing a three-dentate chelating unit, is the strongest Cu(II) chelator. Concerning the viability on neuroblastoma cells, compounds II (R1 = 5-MeO, R2 = H; R1 = H, R2 = 2-F) displayed the highest reduction of Aβ-induced cell toxicity. In silico calculations of some pharmacokinetic descriptors indicate that all the compounds but the nitro derivatives have good potential oral-bioavailability. Overall, it can be concluded that most of the studied DNP-BIM conjugates showed quite good anti-AD properties, therefore deserving to be considered in further studies with the aim of understanding and treating AD. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8HPLC of Formula: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. HPLC of Formula: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Continuous Flow as Enabling Technology: Synthesis of Heteroaromatic Sulfinates as Bench Stable Cross-Coupling Partners》 was written by Lima, Fabio; Andre, Jerome; Marziale, Alexander; Greb, Andreas; Glowienke, Susanne; Meisenbach, Mark; Schenkel, Berthold; Martin, Benjamin; Sedelmeier, Joerg. Quality Control of 2,6-Dibromopyridine And the article was included in Organic Letters in 2020. The article conveys some information:

An enabling continuous flow setup for handling of unstable organolithium intermediates and synthesis of heteroaryl sulfinates on a multigram scale is described. The developed continuous flow process allows for the synthesis and simple isolation of heteroaryl sulfinates which are otherwise challenging to access in classical batch mode. The lithium sulfinate salts prepared by this method were shown to be efficient reaction partners in palladium catalyzed C(sp2)-C(sp2) cross-coupling to access medicinally relevant bis-heteroaryl motifs. In addition to this study using 2,6-Dibromopyridine, there are many other studies that have used 2,6-Dibromopyridine(cas: 626-05-1Quality Control of 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Quality Control of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of α-Heteroaryl Propionic Esters by Palladium-Catalyzed α-Heteroarylation of Silyl Ketene Acetals》 was written by Li, Bowen; Luo, Bangke; Blakemore, Caroline A.; Smith, Aaron C.; Widlicka, Daniel W.; Berritt, Simon; Tang, Wenjun. Recommanded Product: Methyl 5-bromopicolinateThis research focused ontrimethylsiloxy propene tertiary butoxy heteroaryl bromide palladium catalyst heteroarylation; tertiary butyl pyridinyl propanoate preparation. The article conveys some information:

A practical and efficient synthesis of α-heteroaryl propionic esters was developed by employing palladium-catalyzed α-heteroarylation of silyl ketene acetals, forming a wide variety of α-heteroaryl propionic esters with various substituents and functionalities in high yields. The success of this transformation was credited to the development of the bulky P,P=O ligand. This method provided an efficient synthesis of α-heteroaryl propionic acids. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H3Br2NIn 2020 ,《Regioselective, stereoselective, and living polymerization of divinyl pyridine monomers using rare earth catalysts》 appeared in Polymer Chemistry. The author of the article were Yan, Chao; Liu, Zhao-Xuan; Xu, Tie-Qi. The article conveys some information:

The first regioselective, stereoselective, and living polymerization of divinyl pyridine monomers, mediated by simple rare earth catalysts, is reported. The polymerization by Ln(CH2SiMe3)3(L)2 (Ln = Sc, Y, Lu, Dy; L = THF, Py) is perfectly regioselective for a 2,5-divinylpyridine (DVP) monomer, and the process only concerned the double bond at the 2-position of DVP and the C=C bond at the 5-position selectively remained unreacted. In contrast, the polymerization of DVP by La(CH2SiMe3)3(THF)2 is not regioselective, producing a crosslinking network. The polymerization by Lu(CH2SiMe3)3(Py)2/B(C6F5)3 is most stereoselective, yielding perfect isotactic PDVP with mmmm >99%. The isoselectivity (mm) of the polymers could be controlled in a range of 31% to 99% by adjusting the amount of THF added. The DVP polymerization is controlled by Lu[CH(C5H4N)CH2CH2SiMe3]3 (formed via in situ mixing of Lu(CH2SiMe3)3(THF)2 and 2-vinylpyridine), with the mol. weight (Mn) matching the theor. value of monomer conversion and a narrow dispersity. The stereoblock polymerization of DVP with 2-vinylpyridine was achieved by adding the monomer sequentially. The post-functionalization of stereoblock polymers containing vinyl groups has been achieved by the thiol-ene “”click”” reaction in which all the C=C double bonds are quant. converted to thioether bonds. The experimental process involved the reaction of 2,5-Dibromopyridine(cas: 624-28-2COA of Formula: C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yang, Mingxue; Zhao, Tian-Xiang; Ji, Si-Chao; Tao, Xiao-Dong; Chen, Xu-Lin; Meng, Lingyi; Liang, Dong; Lu, Can-Zhong published an article in Nanomaterials. The title of the article was 《Voltage-Dependent Emission Varying from Blue to Orange-Red from a Nondoped Organic Light-Emitting Diode with a Single Emitter》.Reference of 2,5-Dibromopyridine The author mentioned the following in the article:

Organic light-emitting diodes (OLEDs) with tunable emission colors, especially white OLEDs, have rarely been observed with a single emitter in a single emissive layer. In this paper, we report a new compound featuring a D-A-D structure, 9,9′-(pyrimidine-2,5-diylbis(2,1-phenylene))bis(3,6-di-tert-butyl-9H-carbazole) (PDPC). A nondoped OLED using this compound as a single emitter exhibits unique voltage-dependent dual emission. The emission colors range from blue to orange-red with an increase in voltage, during which white electroluminescence with a Commission Internationale De L′Eclairage (CIE) coordinate of (0.35, 0.29) and a color render index (CRI) value of 93 was observed A comparative study revealed that the dual emission simultaneously originates from the monomers and excimers of the emitter. This study provides insight into understanding the multimer-excited mechanism and developing novel color-tunable OLEDs. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromopyridine(cas: 624-28-2Reference of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Reference of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Iridium-Catalyzed ortho-C-H Borylation of Thioanisole Derivatives Using Bipyridine-Type Ligand》 was written by Zeng, Jialin; Naito, Morio; Torigoe, Takeru; Yamanaka, Masahiro; Kuninobu, Yoichiro. Safety of 2,5-Dibromopyridine And the article was included in Organic Letters in 2020. The article conveys some information:

A simple iridium catalytic system was developed that allows for a variety of 2-borylthioanisoles, e.g. I, to be easily synthesized via ortho-selective C-H borylation of thioanisole derivatives Once introduced, boryl and methylthio groups were converted by palladium-catalyzed transformations. D. functional theory calculations revealed that weak interactions, such as hydrogen bonding between the C-H bond of the SCH3 group and the oxygen atom of the boryl ligand, control the ortho-selectivity. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Safety of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Safety of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem