Tag: 200-300

《Synthesis of Tridentate [1,2,4] Triazinyl-Pyridin-2-yl Indole Lewis Basic Complexants via Pd-Catalyzed Suzuki-Miyaura Cross-Couplingã€?was written by Gulledge, Zachary Z.; Tedder, Mariah L.; Lyons, Kyle R.; Carrick, Jesse D.. Synthetic Route of C5H3Br2NThis research focused ontriazinyl pyridinyl indole preparation; bromo triazinylpyridine indole boronicacid Suzuki Miyaura coupling palladium catalyst. The article conveys some information:

Full closure of the nuclear fuel cycle is predicated, in part, on defining efficient separations processes for the effective speciation of the neutron-absorbing lanthanides from the minor actinides post-PUREX. Pursuant to the aforementioned, a class of tridentate, Lewis basic procomplexants have been prepared leveraging a Pd-catalyzed Suzuki-Miyaura cross-coupling between 6-bromo-[1,2,4]-triazinylpyridine derivatives and various protected indole-boronic acids to afford functionalized 2-[6-(5,6-diphenyl-[1,2,4]triazin-3-yl)-pyridin-2-yl]-1H-indoles. A highly active catalyst/ligand system with low loadings was employed rapidly affording 26 examples in yields as high as 85%. Method optimization, substrate and indole scope, comparative anal. between coupling reagents, and a scale-up experiment are reported. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dibromopyridine(cas: 626-05-1Synthetic Route of C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Synthetic Route of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ohnishi, Ryuhei; Ohta, Hidetoshi; Mori, Shigeki; Hayashi, Minoru published their research in Organometallics in 2021. The article was titled 《Cationic Dirhodium Complexes Bridged by 2-Phosphinopyridines Having an Exquisitely Positioned Axial Shielding Group: A Molecular Design for Enhancing the Catalytic Activity of the Dirhodium Core》.HPLC of Formula: 626-05-1 The article contains the following contents:

This report describes a strategy to create highly electrophilic dirhodium catalysts. The electrophilicity of lantern-type dirhodium complexes is generally decreased by the coordination of a ligand to the axial site, which often causes a reduction in the catalytic activity. The authors designed and synthesized cationic dirhodium complexes bridged by 2-diarylphosphinopyridines having a bulky 2,4,6-triisopropylphenyl (Tip) group that can prevent the attack of external mols. to the closest axial site. Theor. calculations indicated that the Tip group weakly interacts with the axial site but hardly reduces the electrophilicity of the dirhodium core. The complexes served as excellent catalyst precursors for the dehydrogenative silylation of alcs. using hydrosilanes under mild conditions and a low metal loading, producing the silyl ethers in higher yields in comparison to conventional dirhodium complexes. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1HPLC of Formula: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. HPLC of Formula: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Structural isomers of 9-(pyridin-2-yl)-9H-carbazole in combination with 9’H-9,3′:6′,9”-tercarbazole and their application to high efficiency solution processed green TADF OLEDs》 was written by Hwang, Jinhyo; Yoon, Jiwon; Kim, Chae Yeong; Choi, Suna; Kang, Hyunchul; Kim, Jun Yun; Yoon, Dae-Wi; Han, Chang Wook; Park, Sungnam; Cho, Min Ju; Choi, Dong Hoon. Formula: C5H3Br2N And the article was included in Dyes and Pigments in 2020. The article conveys some information:

Two host materials, CzPy2TCz and CzPy3TCz, were designed as structural isomers and synthesized to achieve high efficiency thermally activated delayed fluorescence-organic light emitting diodes (TADF-OLEDs). The design strategy involved introducing a pyridine group into the core structure as an electron-withdrawing unit and varying the substitution position of tercarbazole (TCz). To realize green TADF-OLED, the 2 host materials synthesized in this study have excellent thermal stability and high excited triplet energy (T1 = 2.95-2.98 eV). The maximum external quantum efficiency and current efficiency values for CzPy2TCz were 23.81% and 80.2 cd/A, resp. and the resp. values for CzPy3TCz were 20.27% and 70.1 cd/A, resp. Structural isomers with carbazole (Cz) and TCz units at the 2,6-position of the pyridine core effectuate better device performance. Consequently, the host materials introduced in this study play an important role in implementing high performing solution-processed green TADF-OLED. The experimental process involved the reaction of 2,5-Dibromopyridine(cas: 624-28-2Formula: C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Qun; Li, Tian; Chen, Hekai; Kong, Jun; Zhang, Liwei; Yin, Hang published an article in 2021. The article was titled 《Design and optimisation of a small-molecule TLR2/4 antagonist for anti-tumour therapy》, and you may find the article in RSC Medicinal Chemistry.COA of Formula: C6H7Br2N The information in the text is summarized as follows:

A small-mol. co-inhibitor that targets the TLR2/4 signalling pathway were developed. After high-throughput screening of a compound library containing 14400 small mols., followed by hit-to-lead structural optimization, the compound I was finally obtained, which has effective inhibitory properties against the TLR2/4 signalling pathways. This compound was found to significantly inhibit multiple pro-inflammatory cytokines released by RAW264.7 cells. This was followed by compound I demonstrating promising efficacy in subsequent anti-tumor experiments The current results provided a novel understanding of the role of TLR2/4 in cancer and a novel strategy for anti-tumor therapy. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8COA of Formula: C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.COA of Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gong, Zhiming; Wang, Ru; Jiang, Yue; Kong, Xiangyu; Lin, Yue; Xu, Zhengjie; Zhou, Guofu; Liu, Jun-Ming; Kempa, Krzysztof; Gao, Jinwei published an article in 2021. The article was titled 《Novel D-A-D type small-molecular hole transport materials for stable inverted perovskite solar cells》, and you may find the article in Organic Electronics.HPLC of Formula: 624-28-2 The information in the text is summarized as follows:

Hole transport materials (HTMs), as a critical role in the hole extraction and transportation processes, highly influence the efficiency and stability of perovskite solar cells (PSCs). Despite that several efficient dopant-free HTMs have been reported, there is still no clear structure-property relationship that could give instructions for the rational mol. design of efficient HTMs. Thus, in this work, a series of donor-acceptor-donor (D-A-D) type carbazole-based small mols., TM-1 to TM-4, have been carefully designed and synthesized. By varing the electron acceptor unit from benzene to pyridine, pyrazine and diazine, their packing structure in single crystals, optical and electronic properties have shown a great difference. While as dopant-free HTM in p-i-n type PSCs, TM-2 improved the device photovoltaic performance with a power conversion efficiency from 15.02% (based on PEDOT:PSS) to 16.13%. Moreover, the unencapsulated device based on TM-2 retains about 80% of its initial efficiency after 500 h storage in ambient environment, showing the superior stability.2,5-Dibromopyridine(cas: 624-28-2HPLC of Formula: 624-28-2) was used in this study.

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. HPLC of Formula: 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C5H3Br2NIn 2019 ,《Extended π-conjugated quinazolinone derivatives with enhanced third-order nonlinear optical response》 appeared in Dyes and Pigments. The author of the article were Jia, Jianhong; Zhang, Jiuming; Zhou, Chunsong; Zheng, Mingming; Feng, Dong; Liang, Guanqiu; She, Yuanbin. The article conveys some information:

Quinazolinone derivatives were designed and synthesized based to the structure of donor-π-acceptor-π-donor (D-π-A-π-D). To obtain materials with good third-order nonlinear optical response that the authors have introduced some electron-donating groups such as triarylamine, cumene, and N,N-dimethylaniline into the 8- or 2,8- position of the quinazolinone. Compared with the parent QZ-1, the target compounds showed a significant red shift. Electrochem. data and theor. calculation showed that the introduction of the donor group that extended the conjugation length of the mol. and reduced the HOMO/LOMO band gap which promoted the intramol. charge transfer (ICT). Z-scan results demonstrated that as the electron-donating ability of the donor group increased, the synthetic materials exhibit stronger nonlinear optical response. Among them, QZB-1 incorporating with 2 triarylamine groups has a γ value of 34.616 × 10-32 esu, which is up to 38 times of the parent structure. The results of this study have guiding significance for the mol. design of nonlinear optical materials. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 2,5-DibromopyridineIn 2020 ,《Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes》 appeared in ChemMedChem. The author of the article were De Pascale, Martina; Iacopetta, Domenico; Since, Marc; Corvaisier, Sophie; Vie, Veronique; Paboeuf, Gilles; Hennequin, Didier; Perato, Serge; De Giorgi, Marcella; Sinicropi, Maria Stefania; Sopkova-De Oliveira Santos, Jana; Voisin-Chiret, Anne-Sophie; Malzert-Freon, Aurelie. The article conveys some information:

Pyridoclax is considered a promising anticancer drug, acting as a protein-protein interaction disruptor, with potential applications in the treatment of ovarian, lung, and mesothelioma cancers. Eighteen sensibly selected structural analogs of Pyridoclax were synthesized, and their physicochem. properties were systematically assessed and analyzed. Moreover, considering that drug-membrane interactions play an essential role in understanding the mode of action of a given drug and its eventual toxic effects, membrane models were used to investigate such interactions in bulk (liposomes) and at the air-water interface. The measured exptl. data on all original oligopyridines allowed the assessment of relative differences in terms of physicochem. properties, which could be determinant for their druggability, and hence for drug development. In the experiment, the researchers used 2,5-Dibromopyridine(cas: 624-28-2Quality Control of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Quality Control of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of Methyl 5-bromopicolinateIn 2021 ,《Synthesis and characterization of new pyridine-based chiral calamitic liquid crystals》 appeared in Liquid Crystals. The author of the article were Vardar, Deniz; Ocak, Hale; Akdas Kilic, Huriye; Jeannin, Olivier; Camerel, Franck; Eran, Belkiz Bilgin. The article conveys some information:

In this paper, novel chiral calamitic compounds, consisting of n-dodecyloxyphenyl substituted pyridine carboxylate core linked to one or two benzene rings through ester linkers was synthesized by multi-step procedures. The other end was varied by introducing a flexible (S)-2-methylbutyloxy or (S)-3,7-dimethyloctyloxy chiral chain. The liquid crystal properties of new compounds were investigated by various exptl. techniques such as DSC, POM and SAXS. The pyridine-based calamitic compounds exhibited enantiotropic chiral smectic mesophases such as SmC*, SmA or uncharacteristic mesophase depending on hetero aromatic rings such as nicotinate or picolinate cores, number of aromatic rings and the type of chiral-branched chain. In the experimental materials used by the author, we found Methyl 5-bromopicolinate(cas: 29682-15-3Reference of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ang, Mervin Chun-Yi; Dhar, Niha; Khong, Duc Thinh; Lew, Tedrick Thomas Salim; Park, Minkyung; Sarangapani, Sreelatha; Cui, Jianqiao; Dehadrai, Aniket; Singh, Gajendra Pratap; Chan-Park, Mary B.; Sarojam, Rajani; Strano, Michael published an article in 2021. The article was titled 《Nanosensor Detection of Synthetic Auxins In Planta using Corona Phase Molecular Recognition》, and you may find the article in ACS Sensors.Name: 2,5-Dibromopyridine The information in the text is summarized as follows:

Synthetic auxins such as 1-naphthalene acetic acid (NAA) and 2,4-dichlorophenoxyacetic acid (2,4-D) have been extensively used in plant tissue cultures and as herbicides because they are chem. more stable and potent than most endogenous auxins. A tool for rapid in planta detection of these compounds will enhance our knowledge about hormone distribution and signaling and facilitate more efficient usage of synthetic auxins in agriculture. In this work, we show the development of real-time and nondestructive in planta NAA and 2,4-D nanosensors based on the concept of corona phase mol. recognition (CoPhMoRe), to replace the current state-of-the-art sensing methods that are destructive and laborious. By designing a library of cationic polymers wrapped around single-walled carbon nanotubes with general affinity for chem. moieties displayed on auxins and its derivatives, we developed selective sensors for these synthetic auxins, with a particularly large quenching response to NAA (46%) and a turn-on response to 2,4-D (51%). The NAA and 2,4-D nanosensors are demonstrated in planta across several plant species including spinach, Arabidopsis thaliana (A. thaliana), Brassica rapa subsp. chinensis (pak choi), and Oryza sativa (rice) grown in various media, including soil, hydroponic, and plant tissue culture media. After 5 h of 2,4-D supplementation to the hydroponic medium, 2,4-D is seen to accumulate in susceptible dicotyledon pak choi leaves, while no uptake is observed in tolerant monocotyledon rice leaves. As such, the 2,4-D nanosensor had demonstrated its capability for rapid testing of herbicide susceptibility and could help elucidate the mechanisms of 2,4-D transport and the basis for herbicide resistance in crops. The success of the CoPhMoRe technique for measuring these challenging plant hormones holds tremendous potential to advance the plant biol. study. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromopyridine(cas: 624-28-2Name: 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Name: 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2017 ,《Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors》 was published in ChemMedChem. The article was written by Wuensch, Matthias; Senger, Johanna; Schultheisz, Philipp; Schwarzbich, Sabrina; Schmidtkunz, Karin; Michalek, Carmela; Klass, Michaela; Goskowitz, Stefanie; Borchert, Philipp; Praetorius, Lucas; Sippl, Wolfgang; Jung, Manfred; Sewald, Norbert. The article contains the following contents:

As histone deacetylases (HDACs) play an important role in the treatment of cancer, their selective inhibition has been the subject of various studies. These continuous investigations have given rise to a large collection of pan- and selective HDAC inhibitors, containing diverse US Food and Drug Administration (FDA)-approved representatives. In previous studies, a class of alkyne-based HDAC inhibitors was presented. We modified this scaffold in two previously neglected regions and compared their cytotoxicity and affinity toward HDAC1, HDAC6, and HDAC8. We were able to show that R-configured propargylamines contribute to increased selectivity for HDAC6. Docking studies on available HDAC crystal structures were carried out to rationalize the observed selectivity of the compounds Substitution of the aromatic portion by a thiophene derivative results in high affinity and low cytotoxicity, indicating an improved drug tolerance. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem