Tag: 200-300

In 2019,ChemSusChem included an article by Gholinejad, Mohammad; Oftadeh, Erfan; Shojafar, Mohammad; Sansano, Jose M.; Lipshutz, Bruce H.. Synthetic Route of C6H7Br2N. The article was titled 《Synergistic Effects of ppm Levels of Palladium on Natural Clinochlore for Reduction of Nitroarenes》. The information in the text is summarized as follows:

The modified naturally occurring clay clinochlore with ppm amounts of palladium that leads to a new and very effective reagent for the reduction of numerous aromatic nitro species RNO2 (R = H3CC(O)NHC6H4, naphthalen-1-yl, pyridin-2-yl, etc.) has been augmented. When palladium nanoparticles are supported on pyridyltriazole-modified clinochlore, iron within clinochlore acts synergistically with palladium to catalyze the reduction of a wide variety of nitroarenes at room temperature in aqueous media. Based on E-factor calculations, the catalyst system is found to be in line with green chem. standards and can be recycled up to five times. In the experiment, the researchers used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Dyes and Pigments included an article by Yan, Zhengquan; Wei, Gang; Guang, Shanyi; Xu, Manman; Ren, Xia; Wu, Rongliang; Zhao, Gang; Ke, Fuyou; Xu, Hongyao. Formula: C6H7Br2N. The article was titled 《A multidentate ligand chromophore with rhodamine-triazole-pyridine units and its acting mechanism for dual-mode visual sensing trace Sn2+》. The information in the text is summarized as follows:

A multidentate ligand chromophore, combining rhodamine, triazole, and pyridine units, was identified and developed for the 1st time. Using triazole and pyridine rings as coordinating functional recognition groups, it was expected to selectively recognize Sn2+ to form some stable 5-member or 6-member rings with nitrogen and oxygen atoms. Under the optimized conditions, the ligand chromophore could selectively react with trace Sn2+ in CH3CN/H2O (99/1, volume/volume), accompanying with obvious changes in fluorescent spectrum, UV-visible spectrum and visual color. For fluorescent anal., a turn-on fluorescence at 587 nm was found and increased linearly at 1.2-6.2 × 10-7 mol L-1 Sn2+ from colorless to orange. For UV-visible one, a new absorption peak at 560 nm emerged with a linear range of 2.0-11.0 × 10-7 mol L-1 Sn2+ from colorless to pink. The action mechanism between the ligand chromophore and Sn2+ was confirmed basing on UV-visible titration, 1H NMR titration, Job’s plot, binding constants and theor. calculation In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2009,Xiao, Fangliang; Liu, Yu; Hu, Zhengyong; Gan, Quan; Wang, Lei; Wen, Zhonglin; Zhu, Meixiang; Zhu, Weiguo published 《Synthesis of bicyclometalated iridium complex containing 1,3,4-oxadiazole-based picolinic acid derivative and its optoelectronic properties in polymer light-emitting devices》.Synthetic Metals published the findings.Formula: C7H6BrNO2 The information in the text is summarized as follows:

A picolinic acid (Pic) derivative I bearing a 1,3,4-oxadiazole unit and its bicyclometalated iridium complex (PhOXD)2Ir(BuPhOXD-Pic) were synthesized and characterized, in which BuPhOXD-Pic (I) is 5-(4′-(5”-(4-tert-butylphenyl)-1”,3”,4”-oxadiazol-2”-yl) phenyl) picolinic acid and PhOXD is 2,5-diphenyl-1,3,4-oxadiazole. The optoelectronic properties of this iridium complex were studied in the double-layer polymer light-emitting devices using a blend of poly (9,9-dioctylfluorene) and 5-biphenyl-2-(4-tert-butyl) phenyl-1,3,4-oxadiazole as a host matrix. This complex exhibited a maximum luminance efficiency of 7.7 cd/A at 5.6 mA/cm2 and a peak brightness of 5288 cd/m2 at 153.7 mA/cm2 in the devices. Compared to the (PhOXD)2Ir(Pic) complex, the (PhOXD)2Ir(BuPhOXD-Pic) complex displays better optoelectronic properties in the devices. This study provides a convenient way to improve the optoelectronic properties of iridium complexes by modifying an ancillary ligand of picolinic acid with an 1,3,4-oxadiazole unit. The experimental process involved the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Formula: C7H6BrNO2)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Yinghua; Ding, Xufen; Ma, Hongxing; Chu, Youqun; Ma, Chunan published an article in Electrochimica Acta. The title of the article was 《Selective hydrodechlorination of 3,5,6-trichloropicolinic acid at an activated silver cathode: Synthesis of 3,5-dichloropicolinic acid》.Related Products of 40360-44-9 The author mentioned the following in the article:

Electrochem. reduction of 3,5,6-trichloropicolinic acid (3,5,6-T) at glassy carbon, Ni, Cu, and Ag cathodes in aqueous solutions at different pH values was studied. Probably the selectivity of the reduction strongly depends on the cathode materials used and the pH of the aqueous solutions A high selectivity for the hydrodechlorination of 3,5,6-T to 3,5-dichloropicolinic acid (3,5-D) was achieved exclusively at an activated Ag cathode and at pH 3: a selectivity of 95% at 42% conversion under potentiostatic mode and a selectivity of 89% at 88% conversion under intentiostatic mode. An explanation is proposed for this high selectivity. After reading the article, we found that the author used 3,5,6-Trichloropicolinic acid(cas: 40360-44-9Related Products of 40360-44-9)

3,5,6-Trichloropicolinic acid(cas: 40360-44-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Related Products of 40360-44-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Yuan, Yan-Qiu; Yuan, Feng-Ling; Li, Fei-Long; Hao, Zhi-Min; Guo, Jun; Young, David J.; Zhang, Wen-Hua; Lang, Jian-Ping published 《A cuboidal [Ni4O4] cluster as a precursor for recyclable, carbon-supported nickel nanoparticle reduction catalysts》.Dalton Transactions published the findings.SDS of cas: 29682-15-3 The information in the text is summarized as follows:

Cuboidal [Ni4O4] clusters supported by a pyridine alkoxide ligand have been developed. One of these clusters was selected as a precursor for carbon-hosted Ni nanoparticles (NiNPs/C) which were efficient catalysts for the conversion of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) at room temperature In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3SDS of cas: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Hayashi, Minoru; Nishimura, Yasunobu; Watanabe, Yutaka published 《Syntheses of 3-oxo-λ5-benzophospholes by an intramolecular cyclization of phosphorus-ylide》.Chemistry Letters published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

Three synthetic procedures were developed for a new class of P ylide containing conjugate heterocycles, 3-oxo-λ5-benzophospholes. The key to the formation of the heterocycle is unusual intramol. acylation of a P ylide forming an endocyclic ylide. Several types of 2-substituted benzophospholes were synthesized, some of which show fluorescence. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C12H10Cl2N2On September 19, 2000 ,《Synthesis of Thermochromic Iron(II) Tris(bipyridine)-Centered Star-Shaped Polyoxazolines and Their Bipyridine-Centered Macroligand Counterparts》 was published in Macromolecules. The article was written by McAlvin, John E.; Scott, Sarah B.; Fraser, Cassandra L.. The article contains the following contents:

Iron tris(bipyridine) complexes [Fe{4,4′-bis(chloromethyl)-2,2′-bipyridine}3], I, and the corresponding iodide analog generated in situ using NaI, II, were used as initiators for the polymerization of a series of 2-R-2-oxazoline monomers (R = Et, EtOX; Me, MeOX; Ph, PhOX; and undecyl, UnOX). The resulting labile core, red-violet Fe-centered star polymers fragment during mol. weight anal. by gel permeation chromatog. (GPC). Thus, samples were subjected to chem. cleavage in aqueous K2CO3 to generate metal-free bipyridine-centered polyoxazolines, bpyPROX2. When combined with ferrous ammonium sulfate, these bpyPROX2 macroligands chelate to Fe(II), regenerating the [Fe(bipyridine)3]2+ chromophores. Both preparative and anal. kinetics experiments generally produce polymers with reasonably narrow mol. weight distribution (∼1.1 – 1.5). Mol. weight vs. percent monomer conversion plots with either the iodide or chloride initiating system were nearly linear for all monomers ; however, only PEOX and PUOX products show good correlation with Mn(calculated) based on monomer/initiator loading. For most monomers, reactions with iodide initiators are faster than the chlorides, and linear first-order kinetics plots were observed Polymerization of oxazolines with 4,4′-bis(halomethyl)-2,2′-bipyridines produced polymers with narrow mol. weight distribution but with mol. weight higher than targeted based on monomer loading. The 1H NMR data indicate that termination with dipropylamine is efficient for EtOX polymerizations Thermal anal. by DSC and TGA reveal few differences between Fe-centered stars and their bpy-centered PROX macroligand counterparts. Variable-temperature UV/vis data of Fe-centered PEOX thin film illustrate the bleaching of the metal to ligand charge transfer band at about 535 nm of an Fe-centered PEOX film heated under N; cooling and reheating revealed that this process is at least partially reversible for all [Fe-(bpyPROX2)3]2+. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Synthetic Route of C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Synthetic Route of C12H10Cl2N2 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidOn March 31, 1995, Monge, A.; Martinez-Merino, V.; Simon, M. A.; Sanmartin, C. published an article in Arzneimittel-Forschung. The article was 《New 5H-[1,3]thiazolo[3,2-a]pyrido[3,2-e]pyrimidin-5-one derivatives as diuretics》. The article mentions the following:

A series of new 5H-[1,3]thiazolo[3,2-a]pyrido[3.2-3]pyrimidin-5-ones 3-substituted and/or 8,9-hydrogenated was prepared and tested for their diuretic, natriuretic and kaliuretic activities on male Wistar rats at a dosage of 25 mg/kg or less. Diuretic and saliuretic activities were strongly influenced by substituents in 3-position. Quant. structure-activity relationships show that electron withdrawn substituents in 3-position enhance both diuretic and saliuretic activities at 25 mg/kg. Global anal. of the variations introduced on pyridine, pyrimidine and thiazole rings of this tricyclic system showed an increases of diuretic and natriuretic activities when the formal charge on N9a and C9b increases. Potassium ion excretion also increases, although not as drastically a in the earlier cases. Regression equations were calculated by partial least squares method (PLS) and validated by the cross-validation (leave-one-out) technique. The results came from multiple reactions, including the reaction of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid)

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Electrocatalytic dechlorination of chloropicolinic acid mixtures by using palladium-modified metal cathodes in aqueous solutions》 was written by Ma, Hongxing; Xu, Yinghua; Ding, Xufen; Liu, Qi; Ma, Chun-An. Formula: C6H2Cl3NO2 And the article was included in Electrochimica Acta on August 20 ,2016. The article conveys some information:

In China, chloropicolinic acid (ClPA) mixtures comprising 3,5,6-trichloropicolinic acid, 3,6-dichloropicolinic acid (3,6-D), 3-ClPA, and 6-ClPA are discharged as organic wastes at a rate of ∼300 tons per yr. The authors developed an aqueous phase electrocatalytic hydrogenation (ECH) system based on Pd catalyst to dechlorinate the ClPA mixtures into picolinic acid (PA) at room temperature Firstly, the authors evaluated the influence of cathode support and Pd loading on the catalytic performance of cathodes, as well as the effects of operating parameters on the intermediate product selectivity and dechlorination efficiency of the ECH process with 3,6-D as the target compound Secondly, the authors analyzed the ECH dechlorination mechanism of 3,6-D with regard to the surface condition of cathode and catholyte pH, and the rate-limiting step of the dechlorination process is also discussed. Finally, the authors assessed the practicability of the ECH system to dechlorinate the ClPA mixtures into PA by using a plate-and-frame cell. Pd/Ni foam cathodes with Pd loading of 2.25-3.6 mg cm-2 exhibited the optimum ECH dechlorination performance, and the basic aqueous solution and high 3,6-D concentration favored the ECH process. The ClPA mixtures with 47 g L-1 concentration (the total concentration of ClPAs was ∼250 mM) can be selectively dechlorinated into PA with 99% yield, 76.3% current efficiency, and 2.47 kW h kg-1 PA specific elec. energy consumption at a c.d. of 208 A m-2 in a 1.25 M NaOH aqueous solution In addition to this study using 3,5,6-Trichloropicolinic acid, there are many other studies that have used 3,5,6-Trichloropicolinic acid(cas: 40360-44-9Formula: C6H2Cl3NO2) was used in this study.

3,5,6-Trichloropicolinic acid(cas: 40360-44-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C6H2Cl3NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: Methyl 5-bromopicolinateIn 2012 ,《Synthesis of Highly Oxidized Quinolizidine via Reduction of Acylpyridinium Cations, and Total Syntheses of Quinolizidines 207I and 1-epi-207I》 appeared in Organic Letters. The author of the article were Tsukano, Chihiro; Oimura, Atsuko; Enkhtaivan, Iderbat; Takemoto, Yoshiji. The article conveys some information:

A new strategy for synthesizing quinolizidine skeletons by reductive cyclization via acylpyridinium cations was developed. Several functional groups, including carbonyl, silyl, and acetal, were tolerated under mild reaction conditions. For example, reacting the acylpyridinium cations derived from I (R = Me, Ph, Br, CF3) with Ghosez’s reagent and Hantzch ester in the presence of 4Å mol. sieves gave quinolizidines II. The reaction was successfully extended to a one-pot synthesis of a bicyclic compound, and the synthetic strategy was applied to concise total syntheses of quinolizidines 207I and 1-epi-207I, without protecting groups. The experimental part of the paper was very detailed, including the reaction process of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem