Tag: 200-300

Application In Synthesis of 2,6-DibromopyridineIn 2020 ,《Synthesis of polystyrene-supported Pd(II)-containing macrocyclic complex as a reusable catalyst for chemoselective Suzuki-Miyaura coupling reaction》 appeared in Tetrahedron Letters. The author of the article were Yamamoto, Koji; Nameki, Riku; Sogawa, Hiromitsu; Takata, Toshikazu. The article conveys some information:

A polystyrene-supported Pd complex bearing a cyclic pyridine-2,6-bisiamide ligand was synthesized and its catalytic activity in the Suzuki-Miyaura coupling reaction of 2,6-bromopyridine with 4-methoxyphenylboronic acid in aqueous media was investigated. The solid-supported catalyst exhibited catalytic activity and chemoselectivity that were comparable to those of homogeneous catalyst. The reusability of the solid-supported catalyst was also examined The experimental process involved the reaction of 2,6-Dibromopyridine(cas: 626-05-1Application In Synthesis of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lin, Shengjie; Zhou, Ping; Xu, Tingting; Fan, Lihui; Wang, Xinxin; Yue, Lianglan; Jiang, Zhenzhen; Zhang, Yuanbin; Zhang, Zhengyi; He, Yabing published their research in Inorganic Chemistry in 2021. The article was titled 《Modulation of Topological Structures and Adsorption Properties of Copper-Tricarboxylate Frameworks Enabled by the Effect of the Functional Group and Its Position》.Safety of Methyl 5-bromopicolinate The article contains the following contents:

To push forward the structural development and fully explore the potential utility, it is highly desired but challenging to regulate in a controllable manner the structures and properties of MOFs. The authors reported the structural and functional modulation of Cu(II)-tricarboxylate frameworks by employing a strategy of engineering the functionalities and their positions. Two pairs of unsym. biaryl tricarboxylate ligands modified with a Me group and a pyridinic-N atom at distinct positions were logically designed and synthesized, and their corresponding Cu(II)-based MOFs were solvothermally constructed. Diffraction analyses revealed that the variation of functionalities and their positions furnished three different types of topol. structures, which the authors ascribed to the steric effect exerted by the Me group and the chelating effect involving the pyridinic-N atom. Also, gas adsorption studies showed that three of them are potential candidates as solid separation media for acetylene (C2H2) purification, with the separation potential tailorable by altering functionalities and their locations. At 106.7 kPa and 298 K, the C2H2 uptake capacity varies from 64.1 to 132.4 cm3 (STP) g-1, while the adsorption selectivities of C2H2 over its coexisting components of CO2 and CH4 fall at 3.28-4.60 and 14.1-21.9, resp. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Xiang-Jing; Zheng, He-Gen published their research in Dalton Transactions in 2021. The article was titled 《The difference in the CO2 adsorption capacities of different functionalized pillar-layered metal-organic frameworks (MOFs)》.Computed Properties of C5H3Br2N The article contains the following contents:

The excessive use of fossil energy has caused the CO2 concentration in the atm. to increase year by year. MOFs are ideal CO2 adsorbents that can be used in CO2 capture due to their excellent characteristics. Studies of the structure-activity relation between the small structural differences in MOFs and the CO2 adsorption capacities are helpful for the development of efficient MOF-based CO2 adsorbents. Therefore, a series of pillar-layered MOFs with similar structural and different functional groups were designed and synthesized. The CO2 adsorption tests were carried out at 273 K to explore the relation between the small structural differences in MOFs caused by different functional groups and the CO2 adsorption capacities. Significantly, compound 6 which contains a pyridazinyl group has a 30.9% increase in CO2 adsorption capacity compared to compound 1 with no functionalized group. The experimental process involved the reaction of 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lin, Na; Huang, Lei; Ding, Huan-huan; Zhang, Yue; Dong, Wen-jing; Xia, Bin-yuan; Ren, Wen-sheng; Zhao, Dong published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Synthesis of para-linked azacalix[n]pyridine[n]pyrazines and their uranyl ion binding properties》.Application of 626-05-1 The article contains the following contents:

Based on the fragment coupling strategy, the novel macrocycles, para-linked azacalix[n]pyridine[n]pyrazines (n = 2 and 4) with coexisting different heteroaromatics, were synthesized readily starting from 2,5-dibromopyrazine and 2,6-dibromopyridine. According to the X-ray diffraction anal., the macrocycle azacalix[4]pyridine[4]pyrazine adopted a unique boat-type conformation with a large rectangular cavity in the solid state. The complexation between the azacalix[n]pyridine[n]pyrazines and uranyl ions was investigated by DFT calculations and 1H NMR and UV-vis titration experiments It was found that they were strong host mols. to form 1 : 1 complexes with uranyl ions with an association constant of up to (1.38 +/= 0.04) x 105 M-1. After reading the article, we found that the author used 2,6-Dibromopyridine(cas: 626-05-1Application of 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application of 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A nitrogen-doped nanotube molecule with atom vacancy defects》 was written by Ikemoto, Koki; Yang, Seungmin; Naito, Hisashi; Kotani, Motoko; Sato, Sota; Isobe, Hiroyuki. Recommanded Product: 2,6-Dibromopyridine And the article was included in Nature Communications in 2020. The article conveys some information:

Nitrogen-doped carbon nanotubes have attracted attention in various fields, but lack of congeners with discrete mol. structures has hampered developments based on in-depth, chem. understandings. In this study, a nanotube mol. doped periodically with multiple nitrogen atoms has been synthesized by combining eight 2,4,6-trisubstituted pyridine units with thirty-two 1,3,5-trisubstituted benzene units. A synthetic strategy involving geodesic phenine frameworks is sufficiently versatile to tolerate pyridine units without requiring synthetic detours. Crystallog. analyses adopting aspherical multipole atom models reveal the presence of axially rotated structures as a minor disordered structure, which also provides detailed mol. and electronic structures. The nitrogen atoms on the nanotube serve as chem. distinct sites covered with neg. charged surfaces, and they increase the chance of electron injections by lowering the energy levels of the unoccupied orbitals that should serve as electron acceptors. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Mechanosynthesis of Noels-type NHC-Ruthenium Complexes and Applications in Ring-Opening Metathesis Polymerization》 was published in Organometallics in 2020. These research results belong to Quintin, Francois; Pinaud, Julien; Lamaty, Frederic; Bantreil, Xavier. Synthetic Route of C6H7Br2N The article mentions the following:

The use of ball-mills enabled the efficient mechanosynthesis of a variety of N-aryl,N-alkyl imidazolium salts and of corresponding NHC Ag(I) complexes. Transmetalation with Ru via mechanochem. allowed the rapid access (1.5 min to 1 h) to complexes having a similar structure to Noels-type precatalysts. Evaluation of the complexes in the ring-opening metathesis polymerization of norbornene in different solvent, including nontoxic ones, showed a high catalytic activity for one of them, comparable to the one of Noels catalyst.2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Construction of Nitrogen-containing Polycyclic Aromatic Compounds by Intramolecular Oxidative C-H/C-H Coupling of Bis(9H-carbazol-9-yl)benzenes and Their Properties》 were Taniguchi, Taisei; Itai, Yuhei; Nishii, Yuji; Tohnai, Norimitsu; Miura, Masahiro. And the article was published in Chemistry Letters in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Treatment of 1,3- and 1,4-bis(3,6-di-tert-butyl-9H-carbazol-9-yl)benzenes with an oxidizing system of Pd(II)/Ag(I) has been found to induce double intramol. C-H/C-H coupling to give the corresponding highly π-extended polycyclic compds I (X = CH, N), II and III. In contrast, a singly cyclized product IV in a different manner has been isolated from the reaction of 1,2-bis(3,6-di-tert-butyl-9H-carbazol-9-yl)benzene. Cardinal optoelectronic properties of the products have also been estimated2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Lemouzy, Sebastien; Jean, Marion; Giordano, Laurent; Herault, Damien; Buono, Gerard published 《The Hydroxyalkyl Moiety As a Protecting Group for the Stereospecific Alkylation of Masked Secondary Phosphine-Boranes》.Organic Letters published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

The synthesis of functionalized tertiary phosphine-boranes has been developed via a chemodivergent approach from readily accessible (hydroxymethyl) phosphine-boranes under mild conditions. O-Alkylation or decarbonylative P-alkylation product could be exclusively obtained. The P-alkylation reaction was found to proceed in moderate to very good yields and very high enantiospecificity (es >95%) using a variety of alkyl halides as electrophiles. The configurational stability of the sodium phosphido-borane intermediate was also investigated and allowed a deeper understanding of the reaction mechanism, furnishing secondary phosphine-boranes in moderate yield and enantiopurity. In the experimental materials used by the author, we found 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,ChemMedChem included an article by Doebelin, Christelle; Patouret, Remi; Garcia-Ordonez, Ruben D.; Chang, Mi Ra; Dharmarajan, Venkatasubramanian; Kuruvilla, Dana S.; Novick, Scott J.; Lin, Li; Cameron, Michael D.; Griffin, Patrick R.; Kamenecka, Theodore M.. Formula: C7H8BrNO. The article was titled 《N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists》. The information in the text is summarized as follows:

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-mol. repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein the authors describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure-activity studies reveal a critical linker region in these mols. as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) anal. of RORγ-ligand complexes help rationalize the observed results. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-3-methoxypyridine(cas: 889360-84-3Formula: C7H8BrNO)

2-(Bromomethyl)-3-methoxypyridine(cas: 889360-84-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Formula: C7H8BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2002,Organic Syntheses included an article by Smith, Adam P.; Lamba, Jaydeep J. S.; Fraser, Cassandra L.. Application of 138219-98-4. The article was titled 《Efficient synthesis of halomethyl-2,2′-bipyridines: 4,4′-bis(chloromethyl)-2,2′-bipyridine》. The information in the text is summarized as follows:

Silylation of 4,4′-dimethyl-2,2′-bipyridine with LDA followed by chlorotrimethylsilane gave 97% 4,4′-bis(trimethylsilylmethyl)-2,2′-bipyridine, treatment of which with Cl3CCCl3 and CsF in MeCN, gave 91% 4,4′-bis(chloromethyl)-2,2′-bipyridine. Among the 7 other halobipyridines similarly prepared were 98% 5-(chloromethyl)-2,2′-bipyridine 99% 4,4′-bis(bromomethyl)-2,2′-bipyridine. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application of 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Application of 138219-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem