Tag: 200-300

《Four congenetic zinc(II) MOFs from delicate solvent-regulated strategy: Structural diversities and fluorescent properties》 was written by Wen, Gui-Lin; Liu, Bo; Liu, Dao-Fu; Wang, Feng-Wu; Li, Li; Zhu, Liang; Song, Dong-Mei; Huang, Chao-Xiu; Wang, Yao-Yu. COA of Formula: C5H3Br2NThis research focused onzinc carboxylphenyl pyridine MOF preparation crystal structure thermal stability; fluorescence zinc carboxylphenyl pyridine MOF. The article conveys some information:

Four new congenetic zinc(II) MOFs, namely [Zn5(bdcpp)3(DMF)(H2O)4]n·x(solvent) (1), [Zn2(bdcpp)(Hbdcpp)]n·y(solvent) (2), [Zn2(bdcpp)(DMF)(H2O)2]n (3), and [Zn2(bdcpp)(NMP)(H2O)2]n (4) (H4bdcpp = 2,6-bis(2′,4′-dicarboxylphenyl)pyridine, DMF = N,N’-dimethylformamide, NMP = N-methyl-2-pyrrolidone), were synthesized solvothermally with different solvent systems. Stabilized by Zn2(COO)4 paddle-wheel building blocks, the resulting MOFs 1-4 represent diverse structural features. Structurally, 1 is a rarely 3,4-c binodal 2D bilayered framework, 2 possesses a 4-c 2D (4,4) sql planar network accommodating two kinds of hetero chiral helix chains, 3 and 4 are isostructural 1D loop ladder chains except different solvent mols. occupying the axial terminals of Zn2(COO)4 paddle-wheels. This approach based on solvent-regulated strategy aiming to allow the structural fine-tuning provides a good role model in reticular chem. Complexes 1-3 display excellent solid-state photoluminescence stemming from the metal-to-ligand charge transfer or intraligand charge transmission. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1COA of Formula: C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.COA of Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C5H3Br2NIn 2019 ,《The development of improved syntheses of PPARγ-sparing, insulin sensitizing thiazolidinedione-ketones》 was published in Tetrahedron Letters. The article was written by Tanis, Steven P.; Colca, Jerry R.; Parker, Timothy T.; Artman, Gerald D. III; Larsen, Scott D.; Gadwood, Robert C.; Zeller, James R.. The article contains the following contents:

Ketones I [R = H, OMe; R1 = H, Et; Y = C(O); X = CH, N] were selected for clin. development, however their initial syntheses were considered suboptimal for application deep into clin. trials. Direct ketone introduction/maintenance was desired for maximum efficiency and convergence was found to be critically dependent upon the acidity of the nucleophilic species I [R = OMe; R1 = H; X = CH; Y = CHOH] and 1-(5-Ethyl-2-pyridinyl)-ethanone and the use of pre- or post-alkylative oximino-ether/oxime protection. Improvements in overall yield for the syntheses of compound I [R = H; R1 = Et; Y = C(O); X = N] from 20% to 44% and compound I [R = OMe; R1 = H; Y = C(O); X = CH] from 31% to 59% were realized. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Formula: C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H7Br2NIn 2021 ,《Evaluating Metal-Ligand Interactions of Metal-Binding Isosteres Using Model Complexes》 was published in Inorganic Chemistry. The article was written by Seo, Hyeonglim; Prosser, Kathleen E.; Kalaj, Mark; Karges, Johannes; Dick, Benjamin L.; Cohen, Seth M.. The article contains the following contents:

Bioisosteres are a useful approach to address pharmacokinetic liabilities and improve drug-like properties. Specific to developing metalloenzyme inhibitors, metal-binding pharmacophores (MBPs) have been combined with bioisosteres, to produce metal-binding isosteres (MBIs) as alternative scaffolds for use in fragment-based drug discovery (FBDD). Picolinic acid MBIs have been reported and evaluated for their metal-binding ability, pharmacokinetic properties, and enzyme inhibitory activity. However, their structural, electronic, and spectroscopic properties with metal ions other than Zn(II) have not been reported, which might reveal similarities and differences between MBIs and the parent MBPs. To this end, [M(TPA)(MBI)]+ (M = Ni(II) and Co(II), TPA = tris(2-pyridylmethyl)amine) is presented as a bioinorganic model system for investigating picolinic acid, four heterocyclic MBIs, and 2,2′-bipyridine. These complexes were characterized by x-ray crystallog. as well as NMR, IR, and UV-vis spectroscopies, and their magnetic moments were accessed. In addition, [(TpPh,Me)Co(MBI)] (TpPh,Me = hydrotris(3,5-phenylmethylpyrazolyl)borate) was used as a second model compound, and the limitations and attributes of the two model systems are discussed. These results demonstrate that bioinorganic model complexes are versatile tools for metalloenzyme inhibitor design and can provide insights into the broader use of MBIs. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Electric Literature of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 624-28-2In 2022 ,《Effect of the nuclearity on the catalytic performance of a series of Pd(II) complexes in the Suzuki-Miyaura reaction》 appeared in Journal of Catalysis. The author of the article were Kurpik, Gracjan; Walczak, Anna; Gilski, Miroslaw; Harrowfield, Jack; Stefankiewicz, Artur R.. The article conveys some information:

Development of well-defined multivalent systems with densely packed multiple functional groups located within a single mol. structure provides an excellent opportunity to generate catalysts of enhanced activity. A series of mono-, di- and trinuclear Pd(II) complexes based on polyketonate ligands allied with 2,2′-bipyridine was designed, synthesized and fully characterized in both solution and solid state. The mono-, di- and tritopic β-diketonate mols. serve as scaffolds for Pd(II) active sites which, in the two latter cases, are forced into close proximity. Application of the complexes as catalysts in Suzuki-Miyaura cross-coupling as a model reaction revealed significant differences in reaction yields and a trend in reactivity reflecting their nuclearity. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Application of 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《One-Pot Synthesis of a Linear [4]Catenate Using Orthogonal Metal Templation and Ring-Closing Metathesis》 was published in Inorganic Chemistry in 2020. These research results belong to Colley, Nathan D.; Nosiglia, Mark A.; Li, Lei; Amir, Faheem; Chang, Christy; Greene, Angelique F.; Fisher, Jeremy M.; Li, Ruihan; Li, Xuesong; Barnes, Jonathan C.. SDS of cas: 624-28-2 The article mentions the following:

The efficient synthesis of well-defined, linear oligocatenanes possessing multiple mech. bonds remains a formidable challenge in the field of mech. interlocked mols. Here, a one-pot synthetic strategy is described to prepare a linear [4]catenate using orthogonal metal templation between a macrocycle precursor, composed of terpyridine and phenanthroline ligands spaced by flexible glycol linkers, and a closed phenanthroline-based mol. ring. Implementation of two simultaneous ring-closing metathesis reactions after metal complexation resulted in the formation of three mech. bonds. The linear [4]catenate product was isolated in 55% yield as a mixture of topol. diastereomers. The intermediate metal complexes and corresponding interlocked products (with and without metals) were characterized by NMR, mass spectrometry, gel permeation chromatog., and UV-vis absorption spectroscopy. We envision that this general synthetic strategy may pave the way for the synthesis of higher order linear oligocatenates/catenanes with precise mol. weights and four or more interlocking mol. rings. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromopyridine(cas: 624-28-2SDS of cas: 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Pang, Lijuan; Bezencon, Jacqueline; Kleeb, Simon; Rabbani, Said; Sigl, Anja; Smiesko, Martin; Sager, Christoph P.; Eris, Deniz; Schwardt, Oliver; Ernst, Beat published 《FimH antagonists – solubility vs. permeability》.Carbohydrate Chemistry published the findings.HPLC of Formula: 29682-15-3 The information in the text is summarized as follows:

Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most prevalent infections worldwide. Since frequent antibiotic treatment favors the emergence of antibiotic resistance, efficient non-antibiotic strategies are urgently needed. The first step of the pathogenesis of UTI is the bacterial adherence to urothelial host cells, a process mediated by the mannose-binding adhesin FimH located at the tip of bacterial pili. In a preliminary study, biphenyl α-D-mannopyranosides with an electron-withdrawing carboxylate on the aglycon were identified as potent FimH antagonists. Although passive permeability could be established by masking the carboxylate as an ester, insufficient solubility and fast hydrolysis did not allow to maintain the therapeutic concentration in the bladder for the requested period of time. By modifying the substitution pattern, mol. planarity and symmetry of the biphenyl aglycon could be disrupted leading to improved solubility In addition, when heteroatoms were introduced to the aglycon, antagonists with further improved solubility, metabolic stability as well as passive permeability were obtained. The best representative, the pyrrolylphenyl mannoside 42f exhibited therapeutic urine concentration for up to 6 h and is therefore a promising oral candidate for UTI prevention and/or treatment. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3HPLC of Formula: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Chapman, Michael R.; Kwan, Maria H. T.; King, Georgina E.; Kyffin, Benjamin A.; Blacker, A. John; Willans, Charlotte E.; Nguyen, Bao N. published 《Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions》.Green Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

A novel, rapid and efficient route to imidazo[1,2-a]pyridines I [R = H, 7-CH3, 6-NO2, etc.] under ambient, aqueous and metal-free conditions was reported. The NaOH-promoted cycloisomerization of N-propargylpyridiniums gave quant. yield in a few minutes (10 g scale). A comparison of common green metrics to current routes showed clear improvements, with at least a one order of magnitude increase in space-time-yield. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Category: pyridine-derivatives)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Sharma, Sanjeev; Kim, Hyungjun; Lee, Young Hoon; Kim, Taewon; Lee, Yoon Sup; Lee, Min Hyung published 《Heteroleptic Cyclometalated Iridium(III) Complexes Supported by Triarylborylpicolinate Ligand: Ratiometric Turn-On Phosphorescence Response upon Fluoride Binding》.Inorganic Chemistry published the findings.Synthetic Route of C7H6BrNO2 The information in the text is summarized as follows:

Heteroleptic cyclometalated iridium(III) complexes (CN̂)2Ir(Bpic) (4-6) (CN̂ = dfppy (4), ppy (5), btp (6)) supported by triarylborylpicolinate (Bpic) ancillary ligand were synthesized and characterized. X-ray diffraction (XRD) study of 5 confirmed NÔ chelation of the Bpic ligand to the iridium center forming an (CN̂)2Ir-borane conjugate. While the UV/vis absorption bands of 4-6 remained almost unchanged in the low-energy region upon fluoride addition, a ratiometric turn-on phosphorescence response was observed for 4 and 5. In contrast, the phosphorescence of 6 was little affected by fluoride binding. Exptl. and theor. studies suggest that the LUMO in neutral 4 and 5 is dominated by the Bpic ligand, which makes the weakly emissive 3ML’CT/3LL’CT (L = CN̂; L’ = Bpic) states as the lowest-energy triplet excited state, while the fluoride binding to 4 and 5 induces the highly emissive 3MLCT/3ππ* states centered on the (CN̂)2Ir moiety. Thermally induced conversion from the 3MLCT/3ππ* to the 3ML’CT/3LL’CT states is suggested to be responsible for the low-energy weak phosphorescence in 4 and 5. In addition to this study using Methyl 5-bromopicolinate, there are many other studies that have used Methyl 5-bromopicolinate(cas: 29682-15-3Synthetic Route of C7H6BrNO2) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Synthetic Route of C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C5H3Br2NIn 2021 ,《Stimuli-responsive cyclometalated platinum complex bearing bent molecular geometry for highly efficient solution-processable OLEDs》 was published in Chinese Chemical Letters. The article was written by Wei, Zhenhua; Zhang, Kai; Kim, Chan Kyung; Tan, Shuai; Wang, Shaojie; Wang, Lin; Li, Jun; Wang, Yafei. The article contains the following contents:

Smart materials, such as stimuli-responsive luminescence, have attracted much attentions due to their potential application in semiconductor filed. In this context, Pt complexes of (dfppy-DC)Pt(acac) and (dfppy-O-DC)Pt(acac) were prepared and characterized, in which (2-(4′,6′-difluorophenyl)pyridinato-N,C2′)(2,4-pentanedionato-O,O)Pt(II) was used as the planar emission core and 9-(4-(phenylsulfonyl)phenyl)-9H-carbazole (d.c.) was regard as the bent pendent. Both Pt complexes showed bright emission in solution and solid state, concomitant with charming external-stimuli-responsive emission under mech. grinding, organic solvent vapors and pressure. The change emission color spanned from yellow to near-IR region. Using the Pt complexes as the dopant, solution processable organic light-emitting diodes (OLEDs) were fabricated and a maximum external quantum efficiency of -18% was achieved, which is the highest value among the reported solution-processable OLEDs based on external-stimuli-responsive luminescence. This research demonstrated that Pt complex can show promising stimuli responsive emission via ingenious mol. design, indicating a novel way for developing the smart materials in semiconductor filed. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Formula: C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wolinska, Ewa; Rozbicki, Przemyslaw; Branowska, Danuta published an article in Monatshefte fuer Chemie. The title of the article was 《Chiral pyridine oxazoline and 1,2,4-triazine oxazoline ligands incorporating electron-withdrawing substituents and their application in the Cu-catalyzed enantioselective nitroaldol reaction》.Formula: C5H3Br2N The author mentioned the following in the article:

Eight pyridine-containing and four 1,2,4-triazine-containing chiral oxazoline ligands incorporating electron-withdrawing substituents have been oxazolines I (R1 = Ph, t-Bu; R2 = H, F; R3 = H, Cl; R4 = H, F, Cl, nitro; R5 = H, Br), II and III synthesized by two-step route including Buchwald-Hartwig amination. Enantio-inducing activity of the ligands has been assessed in the copper-catalyzed asym. nitroaldol reactions and the influence of the electron-withdrawing substituents on the ligands’ activity has been investigated. In the experiment, the researchers used 2,6-Dibromopyridine(cas: 626-05-1Formula: C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem