Tag: 200-300

Sonavane, Sachin; Deshmukh, Ganesh; Wakchaure, Satish; Deshmukh, Sharayu published their research in Heterocyclic Letters in 2021. The article was titled 《An improved, practical, reliable and scalable synthesis of 2,5-dibromopyridine》.Product Details of 624-28-2 The article contains the following contents:

A convenient and scalable process for preparation of 2,5-dibromopyridine has been developed. Total yield of 83% has been achieved from 2-aminopyridine. The process is convenient and could be easily scaled up. Byproduct dibromide pyridine is separated and 2-amino-5-bromopyridine is converted by modified Sandmeyer conditions to synthesize 2,5-dibromopyridine from its diazonium salt in presence of bromine instead of conventional copper halide such as CuBr as reagents or catalysts. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromopyridine(cas: 624-28-2Product Details of 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cavity-directed nitroaromatics sensing within a carbazole-based luminescent supramolecular M2L3 cage》 was published in Chinese Chemical Letters in 2020. These research results belong to Feng, Tianchi; Li, Xuezhao; Wu, Jinguo; He, Cheng; Duan, Chunying. Quality Control of 2,5-Dibromopyridine The article mentions the following:

The design and preparation of luminescent M2L3 metal-organic cage via the coordination-driven self-assembly of carbazole-based ligand with a V-shaped geometry is described. The cage Zn-L1 with an open cavity which equipped aromatic rich ligands shows the highest emission quenching efficiency towards picric acid than other nitroarom. explosives. The quenching ability depended on whether there formed the host-guest mols. are well explored by electrospray ionization mass spectrometry (ESI-MS), and isothermal titration microcalorimetry (ITC). The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Quality Control of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR》 was published in ACS Infectious Diseases in 2020. These research results belong to Kim, Seung Min; Park, Jongmin; Kim, Myun Soo; Song, Heebum; Jo, Ala; Park, Hankum; Kim, Tae Sung; Choi, Sang Ho; Park, Seung Bum. Formula: C5H3Br2N The article mentions the following:

An antivirulence agent against Vibrio vulnificus named quoromycin (QM, I) was discovered by a phenotype-based elastase inhibitor screening. Using the fluorescence difference in two-dimensional gel electrophoresis (FITGE) approach, SmcR, a quorum-sensing master regulator and homolog of LuxR, was identified as the target protein of QM. We confirmed that the direct binding of QM to SmcR inhibits the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviates the virulence of V. vulnificus in vitro and in vivo. I can be regarded as a novel antivirulence agent for the treatment of V. vulnificus infection. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Formula: C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fiore, Gina L.; Goguen, Brenda N.; Klinkenberg, Jessica L.; Payne, Sarah J.; Demas, J. N.; Fraser, Cassandra L. published an article in Inorganic Chemistry. The title of the article was 《Ruthenium Tris(bipyridine) Complexes with Sulfur Substituents: Model Studies for PEG Coupling》.Recommanded Product: 138219-98-4 The author mentioned the following in the article:

Ruthenium polypyridyl complexes are incorporated into polymers for sensing and light emitting materials applications. Coupling reactions between metal complexes and polymers are one route to polymeric metal complexes. In an effort to increase conjugation efficiency, tune materials properties, and introduce a responsive crosslink, ruthenium tris(bipyridine) derivatives with sulfur substituents were synthesized and compared to oxygen analogs. Difunctional thiols, thioesters, thioethers, and disulfides, as well as hexafunctional nonpolymeric model systems, were explored. Upon exposure to oxygen, the thiol derivative was readily oxidized. These studies guided Ru(bpy)3 PEG coupling reactions with disulfide and thioether linkages, which proceeded to ∼80% and ∼60% yield, resp. The luminescence properties of the Ru PEG derivatives and model systems were investigated. The emission spectra and lifetimes for all complexes in CH3CN under an inert atm. are comparable to [Ru(bpy)3]Cl2. Lifetime data for nonpolymeric analogs fit to a single exponential decay indicating heterogeneity, suggesting sample homogeneity, whereas data for polymers fit to a multiexponential decay. In contrast to certain [Ru(bpy)3]2+/thiol mixtures, no intramol. quenching by the sulfide is observed for [Ru(bpy)2{bpy(CH2SH)2}](PF6)2. Emission spectra red shift and multiexponential decay are noted for the oxidized Ru thiol product. The rates of oxygen quenching are slower for Ru PEG derivatives than those for nonpolymeric analogs, which may be attributed to shielding effects of the polymer chain. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Recommanded Product: 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Recommanded Product: 138219-98-4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Single-component white polymer light-emitting diode (WPLED) based on a binary tris-pyrazolonate-Sm-complex》 was written by Liu, Jiaxiang; Li, Wentao; Wang, Baowen; He, Yani; Miao, Tiezheng; Lu, Xingqiang; Fu, Guorui. Synthetic Route of C5H3Br2NThis research focused ontrispyrazolonate samerium complex white polymer light emitting diode. The article conveys some information:

Based on the doping of the binary tris-pyrazolate-Sm3+ complex [Sm(tba-PMP)3(5-Br-2,2′-bpy)] (1; 5-Br-2,2′-bpy = 5-bromo-2,2′-bipyridine and (Htba-PMP = 1-phenyl-3-methyl-4-(tert-butylacetyl)-5-pyrazolone)) with an efficient orange-light into the PVK (poly(N-vinylcarbazole)) host, the obtained PVK@1 films exhibit the dichromatic color-tuning (white-light to purplish-pink and to pink) characters strictly relative to the Sm3+-doping content and the λex wavelength. Further using the PVK@1 film (10:1; wt/wt) with the straightforward white-light (φPL = 5.8%) as the emitting layer, its single-component solution-processed WPLED gives the electroluminescent performance (LMax of 157 cd/m2, ηMaxc of 0.65 cd/A and the white-light-emitting stability) satisfactory enough for portable full-color flat displays. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Synthetic Route of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Synthetic Route of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《An improved synthesis of (hydroxymethyl)bipyridines》 was written by Smith, Adam P.; Corbin, Perry S.; Fraser, Cassandra L.. Formula: C12H10Cl2N2 And the article was included in Tetrahedron Letters on April 15 ,2000. The article conveys some information:

Quick and efficient syntheses of 4,4′-bis(hydroxymethyl)-2,2′-bipyridine and 4-(hydroxymethyl)-2,2′-bipyridine are described starting from 4,4′-dimethyl-2,2′-bipyridine and 4-methyl-2,2′-bipyridine, resp., via (trimethylsilyl)methyl-, bromomethyl-, and acetoxymethyl intermediates. After reading the article, we found that the author used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Formula: C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Formula: C12H10Cl2N2 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2008,Synthetic Communications included an article by Dai, Liyan; Fan, Dongbo; Wang, Xiaozhong; Chen, Yingqi. Product Details of 153476-68-7. The article was titled 《Improved synthetic approach to tenatoprazole》. The information in the text is summarized as follows:

An improved synthetic approach to tenatoprazole I was described. It started from 2,3,5-trimethyl-4-nitropyridine-N-oxide with acetic anhydride via rearrangement and hydrolysis to give 2-hydroxymethyl-3,5-dimethyl-4-nitropyridine, chlorination with SOCl2 yielded 2-chloromethyl-3,5-dimethyl-4-nitropyridine hydrochloride (II), then II condensed with 2-mercapto-5-methoxyimidazole[4,5-b]pyridine to give 5-methoxy-2-[(4-nitro-3,5-dimethyl-2-pyridinyl)methylthio]imidazole[4,5-b]pyridine (III). At last the title compound I was produced by two methods: the compound III was oxidized with MCPBA and then methoxylated with CH3ONa to give I and III was first methoxylated with CH3ONa and then oxidized with MCPBA to give I. The overall yield was around 26% for both five-step syntheses. In the part of experimental materials, we found many familiar compounds, such as 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7Product Details of 153476-68-7)

2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 153476-68-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridineOn May 3, 2010 ,《Surface Catalysis of Water Oxidation by the Blue Ruthenium Dimer》 appeared in Inorganic Chemistry. The author of the article were Jurss, Jonah W.; Concepcion, Javier C.; Norris, Michael R.; Templeton, Joseph L.; Meyer, Thomas J.. The article conveys some information:

Single-electron activation of multielectron catalysis is viable in catalytic H2O oxidation with stepwise proton-coupled electron transfer, leading to high-energy catalytic precursors. For the blue dimer, cis,cis-[(bpy)2(H2O)RuIIIORuIII(H2O)(bpy)2]4+, the 1st well-defined mol. catalyst for H2O oxidation, stepwise 4e-/4H+ oxidation occurs to give the reactive precursor [(O)RuVORuV(O)]4+. This key intermediate is kinetically inaccessible at an unmodified metal oxide surface, where the only available redox pathway is electron transfer. The authors report here a remarkable surface activation of In-Sn oxide (In2O3:Sn) electrodes toward catalytic H2O oxidation by the blue dimer at electrodes derivatized by surface phosphonate binding of [Ru(4,4′-((HO)2P(O)CH2)2bpy)2(bpy)]2+. Surface binding dramatically improves the rate of surface oxidation of the blue dimer and induces H2O oxidation catalysis. The experimental process involved the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Encapsulation of Phosphorescent Pt(II) Complexes in Zn-Based Metal-Organic Frameworks toward Oxygen-Sensing Porous Materials》 was written by Knedel, Tim-Oliver; Buss, Stefan; Maisuls, Ivan; Daniliuc, Constantin G.; Schluesener, Carsten; Brandt, Philipp; Weingart, Oliver; Vollrath, Annette; Janiak, Christoph; Strassert, Cristian A.. Name: 2,6-Dibromopyridine And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

In this work, two tailored phosphorescent Pt(II) complexes are synthesized bearing a cyclometalating tridentate thiazole-based C^N*N pincer luminophore (L) and exchangeable chlorido ([PtCl(L)]) or cyanido ([PtCN(L)]) coligands. While both complexes showed photoluminescence from metal-perturbed ligand-centered triplet states (3MP-LC), [PtCN(L)] reached the highest phosphorescence quantum yields and displayed a significant sensitivity toward quenching by 3O2. They were encapsulated into two Zn-based metal-organic frameworks, namely, MOF-5 and ZIF-8. The incorporation of the organometallic compounds in the resulting composites [PtCl(L)]@ZIF-8, [PtCN(L)]@ZIF-8, [PtCl(L)]@MOF-5 and [PtCN(L)]@MOF-5 was verified by powder X-ray diffractometry, SEM, time-resolved photoluminescence spectroscopy and microscopy, as well as N2- and Ar-gas sorption studies. The amount of encapsulated complex was determined by graphite furnace at. absorption spectroscopy, showing a maximum loading of 3.7 wt %. If compared with their solid state forms, the solid-solution composites showed prolonged 3O2-sensitive excited state lifetimes for the complexes at room temperature, reaching up to 18.4μs under an Ar atm., which is comparable with the behavior of the complex in liquid solutions or even frozen glassy matrixes at 77 K. Two tailored phosphorescent Pt(II) complexes were synthesized bearing a cyclometalating tridentate thiazole-based C^N*N pincer luminophore and exchangeable coligands. They were encapsulated into two Zn-based metal-organic frameworks, namely, MOF-5 and ZIF-8. If compared with their liquid solutions, the solid-solution composites showed prolonged 3O2-sensitive excited state lifetimes for the complexes at room temperature, reaching up to 18.4μs under an Ar atm., which is comparable with the behavior of the complex in frozen glassy matrixes at 77 K.2,6-Dibromopyridine(cas: 626-05-1Name: 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Name: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria》 were Chen, Peng; Zhang, Yinyong; Shi, Chenghui; Meng, Xin; Yang, Yushe; Zhou, Xianli; Guo, Bin. And the article was published in Journal of Chemical Research in 2019. Recommanded Product: 2,5-Dibromopyridine The author mentioned the following in the article:

An improved process for the synthesis of potent oxazolidinone candidate I against multi-drug resistant bacteria was developed. Compared with the original synthetic route, this new approach was two steps shorter, and all of the steps involved simple purifications without column chromatog. More importantly, it avoided the use of explosive azide compounds and expensive metal catalysts. The new reaction conditions were mild and safe, which was more suitable for the scalable synthesis of YG-056SP for preclin. studies. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Recommanded Product: 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem