Tag: 200-300

In 2017,Vernia, Jennifer E.; Warmin, Mary R.; Krause, Jeanette A.; Tierney, David L.; Baldwin, Michael J. published 《Photochemistry and Anion-Controlled Structure of Fe(III) Complexes with an α-Hydroxy Acid-Containing Tripodal Amine Chelate》.Inorganic Chemistry published the findings.Computed Properties of C6H7Br2N The information in the text is summarized as follows:

The tripodal amine chelate with two pyridyl groups and an α-hydroxy acid (AHA) group, Pyr-TPA-AHA, was synthesized. Different Fe(III) complexes form with this chelate depending upon the counterion of the Fe(III) source used in the synthesis. A dinuclear complex, Fe(III)2(Pyr-TPA-AHA)2(μ-O), 1, and mononuclear complexes Fe(III)(Pyr-TPA-AHA)X (X = Cl- or Br-, 2 and 3, resp.) were synthesized. 2 Can be easily converted to 1 by addition of silver nitrate or a large excess of water. The structure of 1 was solved by x-ray crystallog. (C32H34N6O7Fe2·13H2O, a 14.1236(6), b 14.1236(6), c 21.7469(15) Å, α = β = γ 90.°, tetragonal, P42212, Z = 4). 2 And 3 each have simple quasireversible cyclic voltammograms with E1/2 (vs. aqueous Ag/AgCl) = +135 mV for 2 and +470 for 3 in acetonitrile. The cyclic voltammogram for 1 in acetonitrile has a quasireversible feature at E1/2 = -285 mV and an irreversible cathodic feature at -1140 mV. All three complexes are photochem. active upon irradiation with UV light, resulting in cleavage of the AHA group and reduction of the iron to Fe(II). Photolysis of 1 results in reduction of both Fe(III) ions in the dinuclear complex for each AHA group that is cleaved, while photolysis of 2 and 3 results in reduction of a single Fe(III) for each AHA cleavage. The quantum yields for 2 and 3 are significantly higher than that of 1. The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Computed Properties of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Unusual Recognition and Separation of Hydrated Metal Sulfates [M2(μ-SO4)2(H2O)n, M = ZnII, CdII, CoII, MnII] by a Ditopic Receptor》 was written by Ghosh, Tamal Kanti; Dutta, Ranjan; Ghosh, Pradyut. SDS of cas: 31106-82-8This research focused onzinc cadmium cobalt manganese pyridinylmethylaminoethylbutylurea sulfate complex preparation; binding constant transition metal pyridinylmethylaminoethylbutylurea sulfate; crystal structure transition metal pyridinylmethylaminoethylbutylurea sulfate. The article conveys some information:

A ditopic receptor L1, having metal binding bis(2-picolyl) donor and anion binding urea group, is synthesized and explored toward metal sulfate recognition via formation of dinuclear assembly, (L1)2M2(SO4)2. Mass spectrometric anal., 1H-DOSY NMR, and crystal structure anal. reveal the existence of a dinuclear assembly of MSO4 with two units of L1. 1H NMR study reveals significant downfield chem. shift of -NH protons of urea moiety of L1 selectively with metal sulfates (e.g., ZnSO4, CdSO4) due to second-sphere interactions of sulfate with the urea moiety. Variable-temperature 1H NMR studies suggest the presence of intramol. hydrogen bonding interaction toward metal sulfate recognition in solution state, whereas intermol. H-bonding interactions are observed in solid state. In contrast, anions in their tetrabutylammonium salts fail to interact with the urea -NH probably due to poor acidity of the tert-Bu urea group of L1. Metal sulfate binding selectivity in solution is further supported by isothermal titration calorimetric studies of L1 with different Zn salts in DMSO, where a binding affinity is observed for ZnSO4 (Ka = 1.23 × 106), which is 30- to 50-fold higher than other Zn salts having other counteranions in DMSO. Sulfate salts of CdII/CoII also exhibit binding constants in the order of ∼1 × 106 as in the case of ZnSO4. Pos. role of the urea unit in the selectivity is confirmed by studying a model ligand L2, which is devoid of anion recognition urea unit. Structural characterization of four MSO4 [M = ZnII, CdII, CoII, MnII] complexes of L1, i.e., complex 1, [(L1)2(Zn)2(μ-SO4)2]; complex 2, [(L1)2(H2O)2(Cd)2(μ-SO4)2]; complex 3, [(L1)2(H2O)2(Co)2(μ-SO4)2]; and complex 4, [(L1)2(H2O)2(Mn)2(μ-SO4)2], reveal the formation of sulfate-bridged eight-membered crownlike binuclear complexes, similar to one of the concentration-dependent dimeric forms of MSO4 as observed in solid state. Finally, L1 is found to be highly efficient in removing ZnSO4 from both aqueous and semiaq. medium as complex 1 in the presence of other competing ZnII salts via precipitation through crystallization Powder X-ray diffraction anal. has also confirmed bulk purity of complex 1 obtained from the above competitive crystallization experiment In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8SDS of cas: 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis》 was written by Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas. Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde And the article was included in Bioconjugate Chemistry on August 21 ,2019. The article conveys some information:

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets. After reading the article, we found that the author used 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde(cas: 1000340-35-1Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde)

4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde(cas: 1000340-35-1) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Oxidative electropolymerization of iron and ruthenium complexes containing aniline-substituted 2,2′-bipyridine ligands》 was written by Horwitz, Colin P.; Zuo, Qi. Formula: C12H10Cl2N2 And the article was included in Inorganic Chemistry on April 29 ,1992. The article conveys some information:

New bipyridine ligands with pendant aniline groups [4-CH2R-4′-CH2R’-2,2′-bipyridine, where R = NHPh and R’ = H (anilbpy) and R = R’ = NHPh (bis-anilbpy)] and the electrochem. properties of their Fe and Ru complexes, [Fe(anilbpy)3][PF6]2 (4), [Ru(bpy)2(anilbpy)][PF6]2 (5), and [Ru(bpy)2(bis-anilbpy)][PF6]2 (6) [where bpy = 4,4′-Me2-2,2′-bipyridine] are described. All complexes, except 5, form polymer films from an MeCN solution containing 0.1M Bu4NClO4 on Pt and glassy C electrodes; 1-4 are also polymerized onto NESA glass electrodes by repetitively cycling the electrode potential between 0 and 1.1 V or 0 and 1.5 V vs. SSCE. Two new redox couples arising from tail-to-tail and head-to-tail coupling of aniline groups on adjacent monomers are visible in the voltammograms during the film growth process carried out between 0 and 1.1 V. A broad, ill-defined redox couple for the tail-to-tail coupled aniline species is seen in polymer films grown at 1.5 V. The films exhibit voltammetric properties on all electrode materials expected for metal-centered oxidation and ligand-centered reductions when the coated electrodes are transferred to a MeCN solution containing only the supporting electrolyte. The visible spectra of the polymers on conductive glass electrodes show MLCT bands in the same region as the monomers with λmax ∼540 nm for poly-1 and poly-2 and λmax = 460 nm for poly-3 and poly-4. A new absorption band appears at λmax = 720 nm, assignable to a monocation of diphenylamine for films on the conductive glass oxidized to 0.9 V, and its intensity decreases with application of increasing pos. potentials, with a new band appearing at λmax ∼440 nm arising from the 2-electron oxidation products of diphenylamine and benzidine. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Formula: C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Formula: C12H10Cl2N2The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromideIn 2019 ,《Synthesis of Iridium(III) and Rhodium(III) Complexes Bearing C8-Metalated Theophylline Ligands by Directed C-H Activation》 was published in Organometallics. The article was written by Tan, Tristan Tsai Yuan; Hahn, F. Ekkehardt. The article contains the following contents:

The directed C-H activation at the C8 position of N-donor tethered theophylline with iridium(III) and rhodium(III) is presented. The donor strength of the N-tethered donor group has been varied. Proligands bearing a strongly donating imidazolin-2-ylidene or the weaker donating pyridine group were both metalated under similar conditions, suggesting that the electron d. at the metal center does not play a significant role in the C-H activation step, which was concluded to proceed via a carboxylate-assisted route. The synthesis and characterization of iridium(III) and rhodium(III) complexes bearing chelating CNHC^Cazolato ligands (M = Ir: [4], M = Rh: [5]) and Npyridine^Cazolato ligands (M = Ir: [7], M = Rh: [8]) are reported. In addition, the NHC complexes which are the precursors to the CNHC^Cazolato complexes (M = Ir: [2], M = Rh: [3]) were isolated and characterized. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H3Br2NIn 2019 ,《Synthesis of Tetracoordinate Boron-Fused Benzoaceanthrylene Analogs via Tandem Electrophilic C-H Borylation》 was published in Chemistry – An Asian Journal. The article was written by Oda, Susumu; Abe, Hiroaki; Yasuda, Nobuhiro; Hatakeyama, Takuji. The article contains the following contents:

Benzoaceanthrylene analogs with tetracoordinate B at the ring junction were synthesized through tandem electrophilic C-H borylation of 2,6-dinaphthylpyridine followed by nucleophilic substitution. Notably, the [5,6]-annulation occurred selectively over [6,6]-annulation with the assistance of N coordination of the pyridine ring. The x-ray crystallog. anal. revealed the polycyclic skeleton with a distorted tetracoordinate B atom and a unique packing structure with intermol. π-π interaction. The photophys. and electrochem. properties of these benzoaceanthrylene analogs were evaluated by UV-visible spectroscopy and differential pulse voltammetry. The electron affinity of the F-substituted derivative is 3.49 eV from the ionization potential and optical band gap. Thus, this derivative is expected to be a promising n-type semiconducting material. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1COA of Formula: C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. COA of Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C5H3Br2NIn 2020 ,《Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties》 appeared in Journal of Medicinal Chemistry. The author of the article were Chen, Hao; Deng, Shanshan; Wang, Yuxi; Albadari, Najah; Kumar, Gyanendra; Ma, Dejian; Li, Weimin; White, Stephen W.; Miller, Duane D.; Li, Wei. The article conveys some information:

We recently reported the crystal structure of tubulin in complex with a colchicine binding site inhibitor (CBSI), ABI-231, having 2-aryl-4-benzoyl-imidazole (ABI). Based on this and addnl. crystal structures, here we report the structure-activity relationship study of a novel series of pyridine analogs of ABI-231, with compound 4v being the most potent one (average IC50 ∼ 1.8 nM) against a panel of cancer cell lines. We determined the crystal structures of another potent CBSI ABI-274 and 4v in complex with tubulin and confirmed their direct binding at the colchicine site. 4v inhibited tubulin polymerization, strongly suppressed A375 melanoma tumor growth, induced tumor necrosis, disrupted tumor angiogenesis, and led to tumor cell apoptosis in vivo. Collectively, these studies suggest that 4v represents a promising new generation of tubulin inhibitors.2,6-Dibromopyridine(cas: 626-05-1Computed Properties of C5H3Br2N) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Feuerstein, Wolfram; Breher, Frank published an article in 2021. The article was titled 《Non-palindromic (C^C^D) gold(III) pincer complexes are not accessible by intramolecular oxidative addition of biphenylenes – an experimental and quantum chemical study》, and you may find the article in Dalton Transactions.Quality Control of 2-(Bromomethyl)pyridine hydrobromide The information in the text is summarized as follows:

Gold(I) complexes [(ArL)AuCl], [(ArL)Au(IPr)][SbF6] and [(Ar-NHC)2Au][SbF6] [ArL = 1-biphenylylmethylphosphine, 2-(1-biphenylyl)pyridine; IPr = 1,3-bis(2,6-diisopropylphenyl)-2-imidazolylidene; Ar-NHC = 1-(1-biphenylyl)-3-ethyl-2-imidazolylidene] were prepared by reaction of gold(I) precursors with donor-substituted biphenylenes. The oxidative addition of donor-substituted biphenylenes with gold(I) precursors to give gold(III) pincer CCD complexes was not observed unlike the known additions of unsubstituted biphenylenes; the reasons of this behavior are evaluated by DFT calculations We herein report on the synthesis of biphenylenes substituted with a pyridine (N), a phosphine (P) and a carbene (C’) donor as well as a carbene donor with addnl. pyridine in the lateral position. We describe the synthesis and structures of derived gold(I) complexes, which we tried to use for the synthesis of non-palindromic [(C-C-D)AuIII] pincer complexes by means of an intramol. oxidative addition of the strained biphenylene ring. However, the anticipated formation of gold(III) complexes failed due to kinetic and thermodn. reasons, which we extensively investigated by quantum chem. calculations Furthermore, we shed light on the oxidative addition of biphenylene to two different gold(I) systems reported in the literature. Our comprehensive quantum-chem. anal. is complemented by NMR experiments The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Quality Control of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Mechanistic Study on a BINOL-Coumarin-Based Probe for Enantioselective Fluorescent Recognition of Amino Acids》 was published in Journal of Organic Chemistry in 2020. These research results belong to Wu, Xuedan; Wang, Qin; Dickie, Diane; Pu, Lin. HPLC of Formula: 31106-82-8 The article mentions the following:

A detailed investigation was conducted on the reaction of a 1,1′-bi-2-naphthol-coumarin-based fluorescent probe with amino acids. On the basis of the studies, including fluorescence spectroscopy, 1H NMR, UV-vis, mass spectroscopy, single-crystal X-ray anal., and mol. modeling, it was found that the distinctively different fluorescent responses of the probe toward the amino acid at the two excitation wavelengths are due to two different reaction pathways that generate different intermediates and products. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8HPLC of Formula: 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chatterjee, Tanmay; Sarma, Monima; Das, Samar K. published their research in Tetrahedron Letters on December 29 ,2010. The article was titled 《Donor-acceptor amphiphilic 2,2′-bipyridine chromophores: synthesis, linear optical, and thermal properties》.Related Products of 138219-98-4 The article contains the following contents:

Two sym. and one unsym. push-pull amphiphilic 2,2′-bipyridine chromophores were synthesized through Horner-Wadsworth-Emmons and Knoevenagel reaction mechanized synthetic protocols and characterized by spectroscopy. The linear optical properties and thermal stability of the synthesized chromophores were studied. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Related Products of 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Related Products of 138219-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem