Tag: 200-300

《Fluorescent recognition of L- and D-tryptophan in water by micelle probes》 was written by Du, Gengyu; Mao, Yifan; Abed, Mehdi A.; Pu, Lin. Recommanded Product: 31106-82-8This research focused onzinc tryptophan water fluorescent recognition micelle probe. The article conveys some information:

A series of BINOL-based monoaldehydes have been designed and synthesized as fluorescent probes for L- and D-tryptophan. It is found that in the presence of a diblock copolymer PEG-PLLA, these probes can be encapsulated into micelles which in combination with Zn2+ have exhibited chemo- and enantioselective fluorescent enhancement with tryptophan in aqueous media. In the experimental materials used by the author, we found 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of Methyl 5-bromopicolinateIn 2016 ,《A Convenient Process for the Preparation of Heteroaryl Trifluoromethyl Selenoethers》 was published in Chinese Journal of Chemistry. The article was written by Tian, Qinli; Weng, Zhiqiang. The article contains the following contents:

The preparation of heteroaryl trifluoromethyl selenoethers RSeCF3 (R = 3-methoxypyridin-5-yl, imidazo[1,2-a]pyrazin-6-yl, 6-methoxybenzo[d]thiazol-2-yl, etc.) by the trifluoromethylselenolation of heteroaryl bromides RBr with [(bpy)CuSeCF3]2 was investigated. A large number of trifluoromethylselenolated heterocyclic compounds were synthesized in good to excellent yields using this approach. It was demonstrated that this procedure tolerates a wide variety of functional groups. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2,5-DibromopyridineIn 2020 ,《Color-tunable white-light of binary tris-β-diketonate-(Dy3+, Gd3+x) complexes’ blend under single wavelength excitation》 appeared in Inorganic Chemistry Communications. The author of the article were Shi, Qi; Liu, Jiaxiang; Wang, Jia; Yang, Xiaohui; Zhang, Xingmei; Li, Shuna; Sun, Ping; Chen, Jin; Li, Beibei; Lu, Xingqiang. The article conveys some information:

Based on the Dy3+-centered yellow-light and the ligands-based blue-light of the iso-structural two complexes [Ln(acac)3(5-Br-2,2′-bpy)] (Ln3+ = Dy3+ (2) or Gd3+ (3); Hacac = acetylacetone, 5-Br-2,2′-bpy = 5-bromo-2,2′-bipyridine), resp., the stoichiometric fluorescence titrations of their tris-β-diketonate-(Dy3+, Gd3+x)-mixed complex, show that it is capable of the smooth color-tuning (yellow- to white- and to blue-light) under single wavelength excitation. Moreover, through the dichromatic integration, the binary tris-β-diketonate-(Dy3+, Gd3+x) complex exhibits the straightforward white-light in solid-state. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Safety of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Realization of Highly Efficient Red Phosphorescence from Bis-Tridentate Iridium(III) Phosphors》 were Gnanasekaran, Premkumar; Yuan, Yi; Lee, Chun-Sing; Zhou, Xiuwen; Jen, Alex K.-Y.; Chi, Yun. And the article was published in Inorganic Chemistry in 2019. Formula: C5H3Br2N The author mentioned the following in the article:

Bis-tridentate Ir(III) metal complexes bring forth interesting photophys. properties, among which the orthogonal arranged, planar tridentate chelates could increase the emission efficiency due to the greater rigidity and, in the meantime, allow strong interligand stacking that could deteriorate the emission efficiency. The authors bypassed this hurdle by design of 5 bis-tridentate Ir(III) complexes (1-5), to which both of their monoanionic ancillary and dianionic chromophoric chelate were functionalized derivative of 2-pyrazolyl-6-phenylpyridine, i.e. pzpyphH2 parent chelate. Hence, addition of Ph substituent to the pyrazolyl fragment of pzpyphH2 gave rise to the precursors of monoanionic chelate (A1H-A3H), on which the addnl. CMe3 and/or methoxy groups were introduced at the selected positions for tuning their steric and electronic properties, while precursors of dianionic chelates was judiciously prepared with an isoquniolinyl central unit on pziqphH2 in giving the red shifted emission (cf. L1H2 and L2H2). Factors affected their photophys. properties were discussed by theor. methods based on DFT and TD-DFT calculation, confirming that the T1 excited state of all studied Ir(III) complexes shows a mixed metal-to-ligand charge transfer (MLCT), intraligand charge transfer (ILCT), ligand-to-ligand charge transfer (LLCT), and ligand-centered (LC) transition character. But the poor quantum yield of 3 is due to the facilitation of the nonradiative decay in comparison to the radiative process. As for potential OLED applications, Ir(III) complex 2 gives superior performance with maximum efficiencies of 28.17%, 41.25 cd A-1 and 37.03 lm W-1, CIEx,y = 0.63, 0.37 at 50 mA cm-2, and small efficiency roll-off. Crystallog. data are given. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1Formula: C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis and docking studies of 1-(2-fluorophenyl)-3-(4-((pyridine-2-yl)methyl)piperazine-1-yl)-1H-indazole》 were Balaraju, V.; Kalyani, S.; Laxminarayana, E.. And the article was published in Rasayan Journal of Chemistry in 2019. Computed Properties of C6H7Br2N The author mentioned the following in the article:

Novel compound 1-(2-fluorophenyl)-3-(4-((pyridin-2-yl)methyl)piperazin-1-yl)-1H-indazole was synthesized in a simple and efficient process. All the synthesized compounds were characterized by spectral anal. Further, docking studies for this titled compound was also presented in this communication. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Computed Properties of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Ibrahim, Halliru; Bala, Muhammad Dabai published 《Earth abundant metal complexes of donor functionalised N-heterocyclic carbene ligands: synthesis, characterisation and application as amination catalysts》.New Journal of Chemistry published the findings.Computed Properties of C6H7Br2N The information in the text is summarized as follows:

Six new imidazolium salts of the form 3-R-1-picolylimidazolium bromide (1a: R = 4-nitrophenyl, 1b: R = 4-acetylphenyl, 1c: R = 4-cyanophenyl, 1d: R = allyl, 1e: R = butenyl, 1f: R = pentenyl) were synthesized and isolated in high yields. The corresponding Ag-NHC intermediate complexes 2a, 2d, and 2e were transmetalated to yield [M(NHC)2Cl2 M = Co, Ni] complexes in good to excellent yields. The Co-NHC (3a, 3d, 3e) and Ni-NHC (3a’, 3d’, 3e’) complexes were relatively stable in air, insoluble in chlorinated solvents but very soluble in methanol and DMSO. Poorly resolved NMR spectra and magnetic susceptibility values of 2.53 and 2.73 μB for 3d and 3e resp. suggest both to be paramagnetic cobalt complexes. All the imidazolium salts, isolated Ag-NHC complexes and the corresponding Co and Ni-NHC complexes were characterized by spectroscopic and anal. techniques. The complexes are active at low catalyst loading (1 mol%) for the C-N coupling of aniline with Ph bromide under mild reaction conditions. The in situ generated catalyst obtained from a mixture of NiCl2/1a (1:2 molar ratio) initiated the C-N coupling of several aryl amines with substituted aryl bromides bearing a wide variety of functional groups. Good to excellent yields of the desired diaryl amine products were obtained. The yields are comparable to data obtained with palladium catalysts or to data obtained under harsher temperature conditions of Cu mediated Ullman reactions. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Computed Properties of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carpenter, Joseph; Wu, Gang; Wang, Ying; Cook, Erica M.; Wang, Tao; Sitkoff, Doree; Rossi, Karen A.; Mosure, Kathy; Zhuo, Xiaoliang; Cao, Gary G.; Ziegler, Milinda; Azzara, Anthony V.; Krupinski, Jack; Soars, Matthew G.; Ellsworth, Bruce Alan; Wacker, Dean A. published 《Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis》.ACS Medicinal Chemistry Letters published the findings.Related Products of 29682-15-3 The information in the text is summarized as follows:

Herein we report the discovery and preclin. biol. evaluation of 6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)-7-azaspiro[3.5]non-1-en-7-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid, compound 1 (BMS-986318), a nonbile acid farnesoid X receptor (FXR) agonist. Compound 1 exhibits potent in vitro and in vivo activation of FXR, has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis. The overall profile of compound 1 supports its continued evaluation. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Related Products of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Hood, Jacob C.; Tshikaya, Yannick; Manz, Aaren R.; LaPorte, Marcus C.; Klumpp, Douglas A. published an article in Journal of Organic Chemistry. The title of the article was 《Double Addition Reactions Involving Vinyl-Substituted N-Heterocycles and Active Methylene Compounds》.Application of 626-05-1 The author mentioned the following in the article:

A series of conjugate addition reactions was performed with vinyl-substituted N-heterocycles with active methylene compounds such as 1,3-dicarbonyl compounds, cyano esters, a cyano sulfone and malonyl nitrile to provide dipyridyl and related heterocyclic products I [R1 = R2 = H, (pyridin-4-yl)ethyl, (pyridin-2-yl)ethyl, (pyrazin-2-yl)ethyl, (quinolin-2-yl)ethyl, (quinoxalin-2-yl)ethyl; n = 0, 1; X = O, CH2, NMe; R1 = H, Me, R2 = H, Ph, 4-(Me)2NC6H4, etc.] in acid-catalyzed conversions. The Michael accepting groups included vinyl-substituted pyridines, quinoline, and pyrazine. Double conjugate addition reactions was accomplished with 2,6-divinylpyridine and related systems. After reading the article, we found that the author used 2,6-Dibromopyridine(cas: 626-05-1Application of 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Xu, Guozhang; Liu, Zhijie; Wang, Xinkang; Lu, Tianbao; DesJarlais, Renee L.; Thieu, Tho; Zhang, Jing; Devine, Zheng Huang; Du, Fuyong; Li, Qiu; Milligan, Cynthia M.; Shaffer, Paul; Cedervall, Peder E.; Spurlino, John C.; Stratton, Christopher F.; Pietrak, Beth; Szewczuk, Lawrence M.; Wong, Victoria; Steele, Ruth A.; Bruinzeel, Wouter; Chintala, Madhu; Silva, Jose; Gaul, Michael D.; Macielag, Mark J.; Nargund, Ravi published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions》.Reference of 2,5-Dibromopyridine The author mentioned the following in the article:

Herein, activated factor XI (FXIa) inhibitors novel anticoagulants, discovery effort, utilizing nonclassical interactions to improve potency, cellular permeability, and oral bioavailability by enhancing the binding while reducing polar atoms was described. Beginning with literature-inspired pyridine N-oxide-based FXIa inhibitor 1, the imidazole linker was first replaced with a pyrazole moiety to establish a polar C-H···water hydrogen-bonding interaction. Then, structure-based drug design was employed to modify lead mol. I in the P1′ and P2′ regions, with substituents interacting with key residues through various nonclassical interactions. As a result, a potent FXIa inhibitor II (Ki = 0.17 nM) was discovered. This compound demonstrated oral bioavailability in preclin. species (rat 36.4%, dog 80.5%, and monkey 43.0%) and displayed a dose-dependent antithrombotic effect in a rabbit arteriovenous shunt model of thrombosis.2,5-Dibromopyridine(cas: 624-28-2Reference of 2,5-Dibromopyridine) was used in this study.

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Chuanfu; Sun, Shouneng; Liu, Ziqi; Zhang, Hui; Liu, Yue; An, Qi; Zhao, Jian; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi published an article in 2021. The article was titled 《Visible-Light-Induced Decarboxylative Acylation of Pyridine N-Oxides with α-Oxocarboxylic Acids Using Fluorescein Dimethylammonium as a Photocatalyst》, and you may find the article in Advanced Synthesis & Catalysis.Related Products of 626-05-1 The information in the text is summarized as follows:

The development of a visible-light-induced catalytic system achieved the decarboxylative acylation of pyridine N-oxides with α-oxocarboxylic acids, at room temperature and using the organic dye fluorescein dimethylammonium as a new type of photocatalyst was reported. A series of 2-arylacylpyridine N-oxides were selectively synthesized in moderate to good yields by controlling the polarity of the reaction solvent. The developed strategy was successfully applied in the synthesis of an important intermediate of the drug, acrivastine, on a gram scale. Notably, this is the first time that fluorescein dimethylammonium was used to catalyzed the Minisci-type C-H decarboxylative acylation reaction. The mechanism of decarboxylative acylation was studied by capturing adducts of acyl radicals and 1,1-diphenylethylene confirmed a radical mechanism. The disclosed catalytic system provided a green synthetic strategy for decarboxylative acylation without the use of addnl. oxidants or metal catalysts. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Related Products of 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem