Tag: 200-300

Investigation of the solute-solute and solute-solvent interactions in ternary {saccharide + ionic liquid + water} systems was written by Zafarani-Moattar, Mohammed Taghi;Shekaari, Hemayat;Mazaher Haji Agha, Elnaz. And the article was included in Journal of Molecular Liquids in 2018.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

The aim of this work is to investigate the salt effect resulted by addition of ionic liquids to aqueous saccharide solutions To achieve this goal, systematic studies have been made on ternary {saccharide + ionic liquid + water} system using the available vapor-liquid equilibrium (VLE) data published recently. Vapor pressure depression, osmotic and activity coefficient data for the ionic liquids and saccharides in the binary solutions are used to investigate ionic liquid-water and saccharide-water interactions. For ternary solutions, the calculated activity coefficient of saccharides in presence of ionic liquids, transfer Gibbs energies, pair and triplet interaction parameters and salting constants are used to investigate saccharide-ionic liquid interactions.. The aforementioned properties were also calculated for these new systems. In this article, the effect of stereochem. of sugar, cation (imidazolium or pyridinium), chain length and anion of ionic liquids on vapor-liquid equilibrium behavior of these ternary systems and saccharide-ionic liquid interactions have been discussed. Generally, we found that there is a relationship between soluting-in or soluting-out behavior of ionic liquids and their hydration so that soluting-in effect is observed in ionic liquids with longer chain length and with anions having smaller values of osmotic coefficient From the VLE results we conclude that soluting-out effect of ionic liquids also depends on the hydration of saccharides and is observed in saccharides with high tendency to interact with water. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Self-assembled half-sandwich Ir, Rh-based organometallic molecular boxes for reversible trapping of halocarbon molecules was written by Han, Ying-Feng;Fei, Yue;Jin, Guo-Xin. And the article was included in Dalton Transactions in 2010.Category: pyridine-derivatives This article mentions the following:

Reactions of [Cp^*MCl(μ-Cl)]₂ (M = Ir or Rh) with 6,11-dihydroxy-5,12-naphthacenedione (H₂DHNA) in the presence of a base, gave the corresponding binuclear complexes [Cp^*₂M₂(μ-DHNA)Cl₂] (M = Ir (1a); M = Rh (1b)), resp. Treatment of 1a or 1b with bidentate ligands (L) such as pyrazine, 4,4′-dipyridine (bpy), E-1,2-bis(4-pyridyl)ethene (bpe) or 2,5-bis(4-pyridyl)-1,3,5-oxadiazole (bpo) in the presence of AgOTf (OTf = CF₃SO₃) in MeOH, gave the corresponding tetranuclear complexes, [Cp^*₄M₄(μ-DHNA)₂(μ-L)₂](OTf)₄ (M = Ir, L = pyrazine (3a), bpy (4a), bpe (5a), bpo (6a); M = Rh , L = pyrazine (3b), bpy (4b), bpe (5b), bpo (6b)), resp. X-ray analyses of 3a, 3b, 4a, 4b, 5a and 5b revealed that each of the half-sandwich metal centers was connected by DHNA and bidentate bridging ligands to construct a rectangular cavity with different dimensions, and strong π-π interactions between independent mols. to form rectangular channels in the solid-state. Complexes 3a and 3b based on H₂DHNA and pyrazine spacing ligands exhibit selective and reversible small organic mols. adsorption properties. Intercalated supramol. arrays were obtained by introducing Cl₂C:CCl₂ templates into the middle of the 1-dimensional lines of 3b. The 2-dimensional framework was stabilized due to weak C-H···Cl interactions and the displaced face-to-face π···π interactions between the planes of the monomeric complexes. The hollow cavities in the 2-dimensional frameworks still exhibit selective and reversible CH₂Cl₂ adsorption properties. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Category: pyridine-derivatives).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt To Synthesize the Indenopyridine Core of Haouamine was written by Idzik, Tomasz J.;Borzyszkowska-Ledwig, Aleksandra;Struk, Lukasz;Sosnicki, Jacek G.. And the article was included in Organic Letters in 2019.COA of Formula: C5H3Br2NO This article mentions the following:

An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R₃MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized conditions, is described. Following the developed protocol, rare C4a-aryl substituted indeno[2,1-b]pyridones (e.g. I), resembling the core of haouamine, were obtained. The protocol offering the one-pot synthesis directly from 2-pyridone is also described. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6COA of Formula: C5H3Br2NO).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C5H3Br2NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Solvothermal synthesis of two new coordination polymers: in situ heterocycle conversion and N-alkylation, network topologies and luminescence properties was written by Fang, Zhenlan;Yang, Wenbin;He, Jiangang;Ding, Kaining;Wu, Xiaoyuan;Zhang, Qisheng;Yu, Rongmin;Lu, Canzhong. And the article was included in CrystEngComm in 2012.COA of Formula: C12H8N4O This article mentions the following:

Two new copper complexes [Cu^I₄(L2)I₅]_n (1, L2 = 3,5-bis(1-ethylpyridinium-4-yl)-1,2,4-triazol-4-ide) and [Cu^I₆(L3)₃Br₃]_n (2, L3 = 3,5-bis(4-pyridyl)-1,2,4-triazolate) were obtained from the solvothermal reactions of different copper halides with 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (L1) in the presence of aqueous ammonia. The x-ray diffraction, IR spectrum and elemental analyses of 1 and 2 clearly show that the 1,3,4-oxadiazole ligand L1 has transformed into the triazolate ligands L2 and L3. Most fascinatingly, 1 represents the first example of an integrated reaction system involving heterocyclic conversion from oxadiazole to triazolate, N-alkylation, and further self-assembly of the in situ generated ligand L2 with metal cations to form a coordination polymer in one solvothermal spot. The possible formation mechanism of 1 is proposed, and in addition, the interesting topologies and luminescence properties of 2 were studied based on the results of the DFT calculations In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7COA of Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. COA of Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity was written by Lawson, Marie;Hamze, Abdallah;Peyrat, Jean-Francois;Bignon, Jerome;Dubois, Joelle;Brion, Jean-Daniel;Alami, Mouad. And the article was included in Organic & Biomolecular Chemistry in 2013.Application of 175205-82-0 This article mentions the following:

The synthesis of 2-α-styrylpyridines has been carried out by using the coupling of polyoxygenated N-tosylhydrazones with various 2-halopyridines. We demonstrated that the use of a catalytic amount of PdCl₂(MeCN)₂ in combination with a bidentate ferrocene DPPF or a monodentate alkyl phosphine ^tBu₂MeP-HBF₄ constitutes an efficient protocol for this coupling, providing 2-α-styrylpyridines in satisfactory to good yields. Among evaluated, compound I was found to exhibit excellent antiproliferative and antimitotic activities comparable to that of the reference compound isoCA-4. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Application of 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application of 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and biological activity of aryl thiazole piperidine amide compounds was written by Ding, Chengrong;Pan, Yayun;Tan, Chengxia. And the article was included in Youji Huaxue in 2020.Recommanded Product: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate This article mentions the following:

In order to find a novel biol. active compound containing aromatic thiazole piperidine structure, 15 novel aryl thiazole piperidine amide derivatives were designed and synthesized. The structures of the target compounds were fully characterized by ¹H NMR, ¹³C NMR and HRMS spectra. The bioactivity test showed that some target compounds had good fungicidal and insecticidal activity. For example, the inhibition rate of 5-(3-bromophenyl)-4-methyl-2-(1-((4-nitrophenyl) sulfonyl) piperidin-4-yl) thiazole (6b) shown in I against Pseudoperonospora cubensis was 100% better than azoxystrobin, and the inhibition rate of 5-(4-bromophenyl)-2-(1-((4-chlorophenyl) sulfonyl) piperidin-4-yl)-4-methylthiazole (6c) shown in II against Rhizoctonia solani was 58.86% comparable to azoxystrobin at 200μg/mL. The lethal rate of (4-(5-(3-bromophenyl)-4-methylthiazol-2-yl) piperidin-1-yl) (m-tolyl) methanone (6h) shown in III against Mythimna separata was 100% at 500μg/mL. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Recommanded Product: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Syntheses of the piperidine alkaloids (±)-cassine, (±)-spectaline, (±)-spicigerine methyl ester and of (±)-azimic acid and (±)-carpamic acid was written by Hasseberg, Hans Albrecht;Gerlach, Hans. And the article was included in Liebigs Annalen der Chemie in 1989.Formula: C5H3Br2NO This article mentions the following:

The title compounds I, II, III, IV (n = 5, 7), resp., were prepared from 2,6-dibromo-3-pyridinol via coupling of the pyridine V with Grignard agents in presence of dichloro[bis(diphenylphosphino)propane]nickel. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Formula: C5H3Br2NO).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C5H3Br2NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rapid synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under microwave irradiation was written by Bentiss, Fouad;Lagrenee, Michel;Barbry, Didier. And the article was included in Synthetic Communications in 2001.Recommanded Product: 15420-02-7 This article mentions the following:

A number of sym. 2,5-disubstituted 1,3,4-oxadiazoles I (Ar = Ph, 2-ClC₆H₄, 4-pyridyl, etc.) are quickly prepared by the reaction of aromatic acids ArCO₂H with hydrazine dihydrochloride in a mixture of orthophosphoric acid and phosphorus pentoxide under microwave irradiation In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity was written by Micheli, Fabrizio;Cugola, Alfredo;Donati, Daniele;Missio, Andrea;Pecunioso, Angelo;Reggiani, Angelo;Tarzia, Giorgio. And the article was included in Bioorganic & Medicinal Chemistry in 1997.Application of 203794-33-6 This article mentions the following:

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive glycine binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of glycine antagonists in vivo. In the experiment, the researchers used many compounds, for example, 5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6Application of 203794-33-6).

5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 203794-33-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis was written by Yang, Shao-Qian;Wang, Yi-Fan;Zhao, Wei-Cheng;Lin, Guo-Qiang;He, Zhi-Tao. And the article was included in Journal of the American Chemical Society in 2021.Related Products of 917023-06-4 This article mentions the following:

Herein we describe a protocol for the unprecedented stereodivergent synthesis of tertiary fluoride-tethered allenes bearing a stereogenic center and stereogenic axis via Cu/Pd synergistic catalysis. A broad scope of conjugated enynes are coupled with various α-fluoroesters in high yields with high diastereoselectivities and generally >99% ee. In addition, the four stereoisomers of the allene products ensure precise access to the corresponding four stereoisomers of the fluorinated hydrofurans via a novel stereodivergent axial-to-central chirality transfer process. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Related Products of 917023-06-4).

Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 917023-06-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem