Tag: 200-300

HPLC of Formula: 29682-15-3In 2019 ,《New pyridine based liquid crystalline esters with different terminal chains》 appeared in Journal of Molecular Structure. The author of the article were Karanlik, Gurkan; Ocak, Hale; Bilgin Eran, Belkiz. The article conveys some information:

The synthesis, structural and mesomorphic characterization of new pyridine-based Me esters carrying a n-alkoxy chain or 3,7-dimethyloctyloxy branched group at terminal I [R = C8H17, C10H21, C12H25, (4S)-4,8-dimethylnonyl, 4,8-dimethylnonyl] have been presented. The liquid crystalline properties of the new pyridine-based calamitic mols. have been investigated by polarized optical microscopy and differential scanning calorimetry. New compounds exhibit enantiotropic smectic A mesophase at a variable mesomorphic range depending on alkoxy chain length and branching at terminal. The presence of a branched terminal group in chiral or racemic form gives rise to a sharply increase in mesomorphic range as well as decrease in crystallization points by preserving mesophase type. The experimental process involved the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3HPLC of Formula: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheng, Peter T. W.; Kaltenbach, Robert F.; Zhang, Hao; Shi, Jun; Tao, Shiwei; Li, Jun; Kennedy, Lawrence J.; Walker, Steven J.; Shi, Yan; Wang, Ying; Dhanusu, Suresh; Reddigunta, Ramesh; Kumaravel, Selvakumar; Jusuf, Sutjano; Smith, Daniel; Krishnananthan, Subramaniam; Li, Jianqing; Wang, Tao; Heiry, Rebekah; Sum, Chi Shing; Kalinowski, Stephen S.; Hung, Chen-Pin; Chu, Ching-Hsuen; Azzara, Anthony V.; Ziegler, Milinda; Burns, Lisa; Zinker, Bradley A.; Boehm, Stephanie; Taylor, Joseph; Sapuppo, Julia; Mosure, Kathy; Everlof, Gerry; Guarino, Victor; Zhang, Lisa; Yang, Yanou; Ruan, Qian; Xu, Carrie; Apedo, Atsu; Traeger, Sarah C.; Cvijic, Mary Ellen; Lentz, Kimberley A.; Tirucherai, Giridhar; Sivaraman, Lakshmi; Robl, Jeffrey; Ellsworth, Bruce A.; Rosen, Glenn; Gordon, David A.; Soars, Matthew G.; Gill, Michael; Murphy, Brian J. published an article in 2021. The article was titled 《Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases》, and you may find the article in Journal of Medicinal Chemistry.Safety of 2,5-Dibromopyridine The information in the text is summarized as follows:

The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1 (LPA1) antagonist, with a human LPA1Kb of 6.9 nM. The structure-activity relationship (SAR) studies starting from the LPA1 antagonist clin. compound BMS-986020 (1), which culminated in the discovery of 33, are discussed. The detailed in vitro and in vivo preclin. pharmacol. profiles of 33, as well as its pharmacokinetics/metabolism profile, are described. On the basis of its in vivo efficacy in rodent chronic lung fibrosis models and excellent overall ADME (absorption, distribution, metabolism, excretion) properties in multiple preclin. species, 33 was advanced into clin. trials, including an ongoing Phase 2 clin. trial in patients with lung fibrosis (NCT04308681). After reading the article, we found that the author used 2,5-Dibromopyridine(cas: 624-28-2Safety of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Safety of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Richardson, Jeffery; Mutton, Simon P. published 《Improved Substrate Scope in the Potassium Hexacyanoferrate(II)-Based Cyanation for the Synthesis of Benzonitriles and Their Heterocyclic Analogues》.Journal of Organic Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

The use of Pd(DPEPhos)Cl2 (P26) as a catalyst for the formation of benzonitriles and their heterocyclic analogs provides excellent complementarity to existing catalysts, allowing highly electron-deficient heterocyclic aryl halides to be efficiently converted to the corresponding nitriles using K4[Fe(CN)6] as cyanide source. This catalyst significantly enhances the scope of this reaction to include a number of substrates that are highly relevant for pharmaceutical and agrochem. applications. Importantly, not only does this cyanation method employ a nontoxic cyanide source, simple semiquant. testing suggests that, unlike many other methods, no free cyanide is present in the reaction mixture or during a variety of potential workups, thus improving the safety aspects of this method from initial setup through to product isolation. Finally, developing and testing a series of convenient cyanation kits has allowed facile application and broader adoption of this method in our laboratories In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2008,Kimball, F. Scott; Romero, F. Anthony; Ezzili, Cyrine; Garfunkle, Joie; Rayl, Thomas J.; Hochstatter, Dustin G.; Hwang, Inkyu; Boger, Dale L. published 《Optimization of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase》.Journal of Medicinal Chemistry published the findings.Recommanded Product: 29682-15-3 The information in the text is summarized as follows:

A series of α-ketooxazoles, e.g., I, containing conformational constraints in the flexible C2 acyl side chain of II (OL-135) and representative oxazole C5 substituents were prepared and examined as inhibitors of fatty acid amide hydrolase (FAAH). Exceptionally potent and selective FAAH inhibitors emerged from the series (e.g., 6, Ki = 200 and 260 pM for rat and rhFAAH). With simple and small C5 oxazole substituents, each series bearing a biphenylethyl, phenoxyphenethyl, or (phenoxymethyl)phenethyl C2 side chain was found to follow a well-defined linear relationship between -log Ki and Hammett σp of a magnitude (ρ = 2.7-3.0) that indicates that the substituent electronic effect dominates, confirming its fundamental importance to the series and further establishing its predictive value. Just as significantly, the nature of the C5 oxazole substituent substantially impacts the selectivity of the inhibitors whereas the effect of the C2 acyl chain was more subtle but still significant even in the small series examined Combination of these independent features, which display generalized trends across a range of inhibitor series, simultaneously improves FAAH potency and selectivity and can provide exquisitely selective and potent FAAH inhibitors. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte published their research in Journal of Medicinal Chemistry on August 12 ,2004. The article was titled 《Fluorescent Pirenzepine Derivatives as Potential Bitopic Ligands of the Human M1 Muscarinic Receptor》.Application of 1028-86-0 The article contains the following contents:

Following a recent description of fluorescence resonance energy transfer between enhanced green fluorescent protein (EGFP)-fused human muscarinic M1 receptors and Bodipy-labeled pirenzepine, the authors synthesized seven fluorescent derivatives of this antagonist in order to further characterize ligand-receptor interactions. These compounds carry Bodipy [558/568], Rhodamine Red-X [560/580], or Fluorolink Cy3 [550/570] fluorophores connected to pirenzepine through various linkers. All mols. reversibly bind with high affinity to M1 receptors (radioligand and energy transfer binding experiments) provided that the linker contains more than six atoms. The energy transfer efficiency exhibits modest variations among ligands, indicating that the distance separating EGFP from the fluorophores remains almost constant This also supports the notion that the fluorophores may bind to the receptor protein. Kinetic analyses reveal that the dissociation of two Bodipy derivatives (10 or 12 atom long linkers) is sensitive to the presence of the allosteric modulator brucine, while that of all other mols. (15-24 atom long linkers) is not. The data favor the idea that these analogs might interact with both the acetylcholine and the brucine binding domains. The experimental part of the paper was very detailed, including the reaction process of N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0Application of 1028-86-0)

N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application of 1028-86-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Magee, Thomas V.; Brown, Matthew F.; Starr, Jeremy T.; Ackley, David C.; Abramite, Joseph A.; Aubrecht, Jiri; Butler, Andrew; Crandon, Jared L.; Dib-Hajj, Fadia; Flanagan, Mark E.; Granskog, Karl; Hardink, Joel R.; Huband, Michael D.; Irvine, Rebecca; Kuhn, Michael; Leach, Karen L.; Li, Bryan; Lin, Jian; Luke, David R.; MacVane, Shawn H.; Miller, Alita A.; McCurdy, Sandra; McKim, James M.; Nicolau, David P.; Nguyen, Thuy-Trinh; Noe, Mark C.; O’Donnell, John P.; Seibel, Scott B.; Shen, Yue; Stepan, Antonia F.; Tomaras, Andrew P.; Wilga, Paul C.; Zhang, Li; Xu, Jinfeng; Chen, Jinshan Michael published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections》.Quality Control of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate The author mentioned the following in the article:

The authors report novel polymyxin analogs with improved antibacterial in vitro potency against polymyxin resistant recent clin. isolates of Acinetobacter baumannii and Pseudomonas aeruginosa. In addition, a human renal cell in vitro assay (hRPTEC) was used to inform structure-toxicity relationships and further differentiate analogs. Replacement of the Dab-3 residue with a Dap-3 in combination with a relatively polar 6-oxo-1-phenyl-1,6-dihydropyridine-3-carbonyl side chain as a fatty acyl replacement yielded analog 5x, which demonstrated an improved in vitro antimicrobial and renal cytotoxicity profiles relative to polymyxin B (PMB). However, in vivo PK/PD comparison of 5x and PMB in a murine neutropenic thigh model against P. aeruginosa strains with matched MICs showed that 5x was inferior to PMB in vivo, suggesting a lack of improved therapeutic index in spite of apparent in vitro advantages. The experimental part of the paper was very detailed, including the reaction process of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3Quality Control of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate)

Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Quality Control of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylateThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guagnini, Francesca; Pedrini, Alessando; Dalcanale, Enrico; Massera, Chiara published their research in Chemistry – A European Journal in 2021. The article was titled 《Multidentate, V-Shaped Pyridine Building Blocks as Tectons for Crystal Engineering》.Name: 2,6-Dibromopyridine The article contains the following contents:

The formation of supramol. structural units through self-assembly is a powerful method to design new architectures and materials endowed with specific properties. With the aim of adding a group of versatile tectons to the toolkit of crystal engineers, 4 new V-shaped building blocks characterized by an aryl acetylene scaffold comprising 3 substituted pyridine rings connected by 2 triple bonds were have devised and synthesized. The judicious choice of different substituents on the pyridine rings provides these tectons with distinctive steric, electrostatic and self-assembly properties, which influence their crystal structures and their ability to form co-crystals. Co-crystals of the tectons with tetrafluorodiiodobenzene were obtained both via traditional and mechanochem. crystallization strategies, proving their potential use in crystal engineering. The energetic contributions of the supramol. interactions at play in the crystal lattice also were evaluated to better understand their nature and strength and to rationalize their role in designing mol. crystals. After reading the article, we found that the author used 2,6-Dibromopyridine(cas: 626-05-1Name: 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Influence of Ligand and Nuclearity on the Cytotoxicity of Cyclometallated C-N-C Platinum(II) Complexes》 was written by Kergreis, Angelique; Lord, Rianne M.; Pike, Sarah J.. Product Details of 626-05-1 And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

A series of cyclometalated mono- and di-nuclear platinum(II) complexes [(C-N-C)PtL] (2-3, L = DMSO, PPh3) and the parent organic ligand, 2,6-diphenylpyridine (1, HC-N-CH), have been synthesized and characterized. This library of compounds includes [(C-N-C)PtII(L)] (2, 3; L = DMSO, PPh3) and [(C-N-C)2Pt2(μ-L1)] (4-6; L1 = pyrazine, 4,4′-bipyridine, dppb). Their cytotoxicity was assessed against four cancerous cell lines and one normal cell line, with results highlighting significantly increased antiproliferative activity for the dinuclear complexes 4-6, when compared to the mononucleated species 2 and 3. Complex 6 is the most promising candidate, displaying very high selectivity towards cancerous cells, with selectivity index (SI) values >29.5 (A2780) and >11.2 (A2780cisR), and outperforming cisplatin by >4-fold and >18-fold, resp. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Product Details of 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Product Details of 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate》 was written by Cinelli, Maris A.; Reidl, Cory T.; Li, Huiying; Chreifi, Georges; Poulos, Thomas L.; Silverman, Richard B.. Related Products of 31106-82-8 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing these diseases. Several classes of 2-aminoquinoline-based nNOS inhibitors were developed previously, but these compounds had drawbacks including off-target promiscuity, low activity against human nNOS, and only modest selectivity for nNOS over related enzymes. In this study, new nNOS inhibitors based on 7-phenyl-2-aminoquinoline were synthesized and assayed them against rat and human nNOS, human eNOS, and murine and (in some cases) human iNOS. Compounds with a meta-relationship between the aminoquinoline and a pos. charged tail moiety were potent and had up to nearly 900-fold selectivity for human nNOS over human eNOS. X-ray crystallog. indicates that the amino groups of some compounds occupy a water-filled pocket surrounding an nNOS-specific aspartate residue (absent in eNOS). This interaction was confirmed by mutagenesis studies, making 7-phenyl-2-aminoquinolines the first aminoquinolines to interact with this residue. In the experimental materials used by the author, we found 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Related Products of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Related Products of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and Molecular Structure of a Chiral Bipyridine-Menthol Ether》 was published in Journal of Structural Chemistry in 2020. These research results belong to de Carvalho, A. B.; Diogo, G. M.; Correa, R. S.; Taylor, J. G.. Synthetic Route of C5H3Br2N The article mentions the following:

This paper presents the synthesis and structural characterization of 6,6′-bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-[2,2′]bipyridine obtained by homocoupling of chiral 2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-pyridine. The two-step synthetic procedure afforded chiral bipyridine in a good yield and the structure of the compound is determined by X-ray diffraction. It crystallizes in a non-centrosym. chiral crystal structure type (P21 a = 10.7543(8) Å, b = 8.4488(6) Å, c = 15.8964(10) Å, β = 104.035(7)°, V = 1401.24(17) Å3, Z = 2). Moreover, the compound is characterized by FTIR, high resolution mass spectrometry and its complexation capacity to transition metals is studied by UV-Vis spectroscopy. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1Synthetic Route of C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem