Tag: 200-300

《LaIII and ZnII Cooperatively Template a Metal-Organic Capsule》 was published in Journal of the American Chemical Society in 2020. These research results belong to Yang, Dong; Greenfield, Jake L.; Ronson, Tanya K.; von Krbek, Larissa K. S.; Yu, Le; Nitschke, Jonathan R.. Product Details of 624-28-2 The article mentions the following:

An organic subcomponent was designed with 2-formyl-8-aminoquinoline and triazole-pyridine ends. The relative orientations and geometries of these two ends enabled this subcomponent to assemble together with ZnII and LaIII cations to generate a heterobimetallic tetrahedral capsule. The LaIII cations each template three imine bonds that hold together a 3-fold-sym. metallo-ligand, defining the center of each tetrahedron face. The ZnII cations occupy the other ends of these C3 axes, defining the vertices of the tetrahedron. This is the first example where subcomponent self-assembly brought into being the faces of a polyhedron, as opposed to the vertices. Host-guest studies show pos. cooperative binding toward ReO4-, the encapsulation of which also resulted in the quenching of capsule fluorescence. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Product Details of 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Sekioka, Ryuichi; Honda, Shugo; Honjo, Eriko; Suzuki, Takayuki; Akashiba, Hiroki; Mitani, Yasuyuki; Yamasaki, Shingo. Formula: C7H6BrNO2 The article mentions the following:

Gamma-secretase modulators (GSMs) are promising disease-modifying drugs for Alzheimer’s disease because they can selectively decrease pathogenic amyloid-β42 (Aβ42) levels. Here we report the discovery of orally active N-ethylpyridine-2-carboxamide derivatives as GSMs. The isoindolinone moiety of 5-[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]-2-ethyl-2,3-dihydro-1H-isoindol-1-one hydrogen chloride (1a) was replaced with a picolinamide moiety. Optimization of the benzyl group significantly improved GSM activity and mouse microsomal stability. 5-{8-[([1,1′-Biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-ethylpyridine-2-carboxamide hydrogen chloride (1v) potently reduced Aβ42 levels with an IC50 value of 0.091μM in cultured cells without inhibiting CYP3A4. Moreover, 1v demonstrated a sustained pharmacokinetic profile and significantly reduced brain Aβ42 levels in mice.Methyl 5-bromopicolinate(cas: 29682-15-3Formula: C7H6BrNO2) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Building an electron push-pull system of linear conjugated polymers for improving photocatalytic hydrogen evolution efficiency》 were Wang, Zijian; Mao, Na; Zhao, Yongbo; Yang, Tongjia; Wang, Feng; Jiang, Jia-Xing. And the article was published in Polymer Bulletin (Heidelberg, Germany) in 2019. Recommanded Product: 624-28-2 The author mentioned the following in the article:

Abstract: A series of linear conjugated polymers with different acceptor units has been synthesized and applied as photocatalysts for hydrogen evolution from water splitting. It was found that the introduction of nitrogen atom into the polymer skeleton could efficiently improve the photocatalytic performance due to the improvement in charge carriers’ transport and separation, and the enhanced interfacial wettability from the hydrogen-bonding interaction between nitrogen atom and water mol. The replacement position of nitrogen atom also has a big influence on the photocatalytic performance due to the enhanced internal dipole orientation. A high hydrogen evolution rate of 18.7 μmol h-1 was achieved by PyPm with strong acceptor unit of pyrimidine. The results demonstrate that the construction of an electronic push-pull system is an efficient strategy to produce linear conjugated polymer photocatalysts with high photocatalytic performance. Graphical abstract: [Figure not available: see full text.]. The experimental process involved the reaction of 2,5-Dibromopyridine(cas: 624-28-2Recommanded Product: 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Combining structure- and property-based optimization to identify selective FLT3-ITD inhibitors with good antitumor efficacy in AML cell inoculated mouse xenograft model》 were Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai. And the article was published in European Journal of Medicinal Chemistry in 2019. COA of Formula: C7H6BrNO2 The author mentioned the following in the article:

FLT3 mutation is among the most common genetic mutations in acute myeloid leukemia (AML), which is also related with poor overall survival and refractory in AML patients. Recently, FLT3 inhibitors have been approved for AML therapy. Herein, a series of new compounds with pyrazole amine scaffold was discovered, which showed potent inhibitory activity against FLT3-ITD and significant selectivity against both FLT3-ITD and AML cells expressing FLT3-ITD. Compound 46, possessing the most promising cellular activity, blocked the autophosphorylation of FLT3 pathway in MV4-11 cell line. Furthermore, the apoptosis and down regulation of P-STAT5 were also observed in tumor cells extracted from the MV4-11 cell xenografts model upon compound 46 treatment. Compound 46 was also metabolically stable in vitro and suppressed tumor growth significantly in MV4-11 xenografts model in vivo. Compound 46 showed no toxicity to the viscera of mice and caused no decrease in body weight of mice. In conclusion, the results of this study could provide valuable insights into discovery of new FLT3 inhibitors, and compound 46 was worthy of further development as potential drug candidate to treat AML.Methyl 5-bromopicolinate(cas: 29682-15-3COA of Formula: C7H6BrNO2) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Excimer Disaggregation Enhanced Emission: A Fluorescence “”Turn-On”” Approach to Oxoanion Recognition》 were Yang, Jian; Dong, Chao-Chen; Chen, Xu-Lang; Sun, Xin; Wei, Jin-Yan; Xiang, Jun-Feng; Sessler, Jonathan L.; Gong, Han-Yuan. And the article was published in Journal of the American Chemical Society in 2019. Safety of 2,6-Dibromopyridine The author mentioned the following in the article:

A new approach to anion sensing that involves excimer disaggregation induced emission (EDIE) is reported. It involves the anion-mediated disaggregation of the excimer formed from a cationic macrocycle. This leads to an increase in the observed fluorescence intensity. The macrocycle in question, cyclo[1]N2,N6-dimethyl-N2,N6-bis(6-(1H-imidazolium-1-yl)pyridin-2-yl)pyridine-2,6-diamine[1]1,4-dimethylbenzene (12+; prepared as its PF6- salt), is obtained in ca. 70% yield via a simple cyclization. X-ray diffraction analyses of single crystals revealed that, as prepared, this macrocycle exists in a supramol. polymeric form in the solid state. Macrocycle 12+ is weakly fluorescent in acetonitrile. The emission intensity is concentration dependent, with the maximum intensity being observed at [12+] ≈ 0.020 mM. This finding is ascribed to formation of an excimer, followed possibly by higher order aggregates as the concentration of 12+ is increased. Addition of tetrabutylammonium pyrophosphate (HP2O73-) to 12+ (0.020 mM in acetonitrile) produces a ca. 200-fold enhancement in the emission intensity (λex = 334 nm; λem = 390-650 nm). These findings are rationalized in terms of the HP2O73- serving to break up essentially non-fluorescent excited-state dimers of 12+ through formation of a highly fluorescent anion-bound monomeric complex, 12+·HP2O73-. A turn-on in the fluorescence intensity is also seen for H2PO4- and, to a lesser extent, HCO3-. Little (HSO4-, NO3-) or essentially no (N3-, SCN-, F-, Cl-, Br- and I-) response is seen for other anions. Solid-state structural anal. of single crystals obtained after treating 12+ with HP2O73- in the presence of water revealed a salt form wherein a H2P2O72- anion sits above the cone-like macrocycle. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Safety of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nau, Jennifer; Bruening, Vincent; Biesen, Lukas; Knedel, Tim-Oliver; Janiak, Christoph; Mueller, Thomas J. J. published an article in 2022. The article was titled 《Synthesis and Electronic Properties of Conjugated syn,syn-Dithienothiazine Donor-Acceptor-Donor Dumbbells》, and you may find the article in European Journal of Organic Chemistry.Category: pyridine-derivatives The information in the text is summarized as follows:

A series of conjugated syn,syn-dithienothiazine donor-acceptor-donor dumbbells was readily synthesized by Suzuki coupling or a one-pot α-lithiation-zincation-Negishi coupling sequence in moderate to good yield. The title compounds were all electron-rich reversible oxidizable redox systems with a relatively narrow range of oxidation potentials according to cyclic voltammetry. UV/Vis and fluorescence spectroscopy however showed a significant effect of the electronic nature of the conjugated bridging system on absorption and emission characteristics. Furthermore, a highly polar excited state was corroborated by Lippert-Mataga anal. of the emission solvatochromicity as well as by TD-DFT calculation of absorption and emission maxima, which classified these dumbbell systems as redox active, luminescent low band gap chromophores with exptl. determined optical band gaps between 2.20 and 2.50 eV. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Category: pyridine-derivatives)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

McConnell, Danielle L.; Blades, Alisha M.; Rodrigues, Danielle Gomes; Keyes, Phoebe V.; Sonberg, Justin C.; Anthony, Caitlin E.; Rachad, Sofia; Simone, Olivia M.; Sullivan, Caroline F.; Shapiro, Jonathan D.; Williams, Christopher C.; Schafer, Benjamin C.; Glanzer, Amy M.; Hutchinson, Holly L.; Thayaparan, Ashley B.; Krevlin, Zoe A.; Bote, Isabella C.; Haffary, Yasin A.; Bhandari, Sambat; Goodman, Jack A.; Majireck, Max M. published an article in 2021. The article was titled 《Synthesis of Bench-Stable N-Quaternized Ketene N,O-Acetals and Preliminary Evaluation as Reagents in Organic Synthesis》, and you may find the article in Journal of Organic Chemistry.Category: pyridine-derivatives The information in the text is summarized as follows:

In this report, a general synthetic approach to a variety of bench-stable N-quaternized ketene N,O-acetals I (R = H, 2-Ph, 4-Me, 2,6-Cl2, etc.; X = OTf, NTf2) via treatment of pyridine II or aniline bases with acetylenic ethers R1CC (R1 = OEt, 4-methoxyphenyl) and an appropriate Bronsted or Lewis acid (triflic acid, triflimide, or scandium(III) triflate) have been described. The resulting pyridinium I and anilinium salts C6H5N+((CH3)CH2)C(=CH2)R1 X- can be used as reagents or synthetic intermediates in multiple reaction types. For example, N-(1-ethoxyvinyl)pyridinium or anilinium salts can thermally release highly reactive O-Et ketenium ions for use in acid catalyst-free electrophilic aromatic substitutions. N-(1-ethoxyvinyl)-2-halopyridinium salts I (R = 2-Cl, 2-Br) can be employed in peptide couplings as a derivative of Mukaiyama reagent (2-chloro-1-methylpyridinium iodide) or react with phenylmethanamine in nucleophilic aromatic substitutions under mild conditions. These preliminary reactions illustrate the broad potential of these currently understudied compounds in organic synthesis. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rani, Chekuri Sharmila; Reddy, Alugubelli Gopi; Susithra, E.; Mak, Kit-Kay; Pichika, Mallikarjuna Rao; Reddymasu, Sreenivasulu; Rao, Mandava Venkata Basaveswara published their research in Medicinal Chemistry Research in 2021. The article was titled 《Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines》.Computed Properties of C5H3Br2N The article contains the following contents:

Abstract: A novel series of amide functionalized imidazo[1,2-a]pyridine (14a-14j) derivatives were synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB-231), lung (A549), and prostate (DU-145) cancer cell lines using MTT assay with etoposide as the standard reference drug. Among them, compound 14 showed highest potency in anticancer activities against MCF-7, MDA-MB-231, A549, and DU-145 cell lines with IC50 values of 0.021 ± 0.0012μM, 0.95 ± 0.039μM, 0.091 ± 0.0053μM, and 0.24 ± 0.032μM, resp. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kirilov, Plamen; Matondo, Hubert; Vicendo, Patricia; Garrigues, Jean-Christophe; Baboulene, Michel; Nguyen, Hoang-Phuong; Rico-Lattes, Isabelle published an article on February 28 ,2006. The article was titled 《Synthesis and photophysical properties of novel amphiphilic ruthenium(II) complexes containing 4,4′-dialkyl-aminomethyl-2,2′-bipyridyl ligands》, and you may find the article in Applied Organometallic Chemistry.HPLC of Formula: 138219-98-4 The information in the text is summarized as follows:

The synthesis of new 2,2′-bipyridine ligands (L = 4,4′-dialkyl-aminomethyl-2,2′-bipyridine; alkyl = octyl, dodecyl, octadodecyl) functionalized with bulky amino side groups is reported. Three homoleptic polypyridyl ruthenium(II) complexes [Ru(L)3]2+(PF6-)2 have been synthesized. These compounds were characterized and their photophys. properties examined The electronic spectra of three complexes show pyridyl π → π* transitions in the UV region and metal-to-ligand charge transfer bands in the visible region. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4HPLC of Formula: 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. HPLC of Formula: 138219-98-4The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duan, Yu-Hao; Zhu, Xiao-Zhao; Zhang, Qian; Yang, Yang published an article in Inorganic Chemistry Communications. The title of the article was 《Molecular enantiopure homometallic Zn14L24 cubic cages with luminescence properties》.Product Details of 1214363-66-2 The author mentioned the following in the article:

Chiral homometallic high-nuclearity cages are rare and of synthetic challenge. Herein, the authors report the syntheses and structures of a pair of enantiopure homometallic high-nuclearity [Zn14L24]28+ cages. The mol. cage has a cubic framework with pseudo-O symmetry and encloses a large void inside. The chirality of the framework is directed by the point chirality of the chiral amine applied, which is verified by the crystal structure and CD studies. The formation processes are probed by NMR and CD studies. The cage complexes also possess blue luminescence properties. They represent the first enantiopure homometallic cubic cages and rare examples of high-nuclearity enantiopure cages. In the experimental materials used by the author, we found [3,4′-Bipyridine]-6-carboxylic acid(cas: 1214363-66-2Product Details of 1214363-66-2)

[3,4′-Bipyridine]-6-carboxylic acid(cas: 1214363-66-2) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Product Details of 1214363-66-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem