Tag: 200-300

COA of Formula: C7H6BrNO2In 2014 ,《Pyridine-N-Oxide 2-Carboxylic Acid: An Acceptor Group for Organic Sensitizers with Enhanced Anchoring Stability in Dye-Sensitized Solar Cells》 appeared in Asian Journal of Organic Chemistry. The author of the article were Cecconi, Bianca; Mordini, Alessandro; Reginato, Gianna; Zani, Lorenzo; Taddei, Maurizio; Fabrizi de Biani, Fabrizia; De Angelis, Filippo; Marotta, Gabriele; Salvatori, Paolo; Calamante, Massimo. The article conveys some information:

A D-π-A organic dye carrying a pyridine-N-oxide 2-carboxylic acid anchoring group (BC1) was synthesized together with two analogs lacking the N-oxide (BC2) or the carboxylic acid moiety (BC3). The distribution and energy of their MOs was determined, and modeling of their spectroscopic properties was performed through a TD-DFT computational study. The photo- and electrochem. properties of the dyes were assessed together with their desorption kinetics from nanocrystalline TiO2. In solution, the absorption spectra of dyes BC1 and BC3 were red-shifted compared with BC2, with the maximum absorption wavelength influenced by the dye protonation level. The 2-substituted carbonitrile dye BC3 was not adsorbed on the titania surface. On the other hand, the pseudo-first order desorption rate constants of BC1 and BC2 suggest that BC1 was removed from TiO2 more slowly than BC2 a reference cyanoacrylate dye, demonstrating that simultaneous use of the N-oxide and the carboxylic acid anchoring functions enhanced the stability of the dye/semiconductor assembly. When used as a photosensitizer for dye-sensitized solar cells, the photovoltaic performance of BC1 was better than BC2, which corresponds to approx. 66 % of that recorded with the reference dye. In addition to this study using Methyl 5-bromopicolinate, there are many other studies that have used Methyl 5-bromopicolinate(cas: 29682-15-3COA of Formula: C7H6BrNO2) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《1-Picolinyl-5-azido Thiosialosides: Versatile Donors for the Stereoselective Construction of Sialyl Linkages》 were Chen, Jian; Hansen, Thomas; Zhang, Qing-Ju; Liu, De-Yong; Sun, Yao; Yan, Hao; Codee, Jeroen D. C.; Schmidt, Richard R.; Sun, Jian-Song. And the article was published in Angewandte Chemie, International Edition in 2019. Computed Properties of C6H7Br2N The author mentioned the following in the article:

With the picolinyl (Pic) group as a C-1 located directing group and N3 as versatile precursor for C5-NH2, a novel 1-Pic-5-N3 thiosialyl donor was designed and synthesized, based on which a new sialylation protocol was established. In comparison to conventional sialylation methods, the new protocol exhibited obvious advantages, including excellent α-stereoselectivity in the absence of a solvent effect, broad substrate scope encompassing the challenging sialyl 8- and 9-hydroxy groups of sialic acid acceptors, flexibility in sialoside derivative synthesis, high temperature tolerance and easy scalability. In particular, the applicability to the synthesis of complex and bioactive N-glycan antennae when combined with the MPEP glycosylation protocol via the “”latent-active”” strategy has been shown. Mechanistically, the excellent α-stereoselectivity of the novel sialylation protocol could be attributed to the dramatic electron-withdrawing effect of the protonated Pic groups, which was supported by control reactions and DFT calculations After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Computed Properties of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Dalton Transactions included an article by Jacquot de Rouville, Henri-Pierre; Gourlaouen, Christophe; Heitz, Valerie. Category: pyridine-derivatives. The article was titled 《Self-complementary and narcissistic self-sorting of bis-acridinium tweezers》. The information in the text is summarized as follows:

A mol. tweezer incorporating two acridinium moieties linked by a 1,3-dipyridylbenzene spacer was synthesized in three steps. The formation of its self-complementary dimer in water was demonstrated as a result of π-π stacking and hydrophobic interactions. Moreover, a 1 : 1 mixture of this bis-acridinium tweezer with one built on a 2,6-diphenylpyridyl spacer evidenced its narcissistic self-sorting behavior in water. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Dziuganowska, Zofia A.; Slepokura, Katarzyna; Volle, Jean-Noel; Virieux, David; Pirat, Jean-Luc; Kafarski, Pawel published 《Structural Analogues of Selfotel》.Journal of Organic Chemistry published the findings.Application of 29682-15-3 The information in the text is summarized as follows:

A small library of phosphonopiperidylcarboxylic acids, analogs of NMDA antagonist selfotel (CGS 19755), was synthesized. First, the series of aromatic esters was obtained via a palladium-catalyzed cross-coupling reaction (Hirao coupling) of dialkyl phosphites with bromopyridinecarboxylates, followed by their hydrolysis. Then, hydrogenation of the resulting phosphonopyridylcarboxylic acids over PtO2 yielded the desired phosphonopiperidylcarboxylic acids. NMR studies indicated that the hydrogenation reaction proceeds predominantly by cis addition Several compounds were obtained as monocrystal structures. Preliminary biol. studies performed on cultures of neurons suggest that the obtained compounds possess promising activity toward NMDA receptors. In addition to this study using Methyl 5-bromopicolinate, there are many other studies that have used Methyl 5-bromopicolinate(cas: 29682-15-3Application of 29682-15-3) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fraser, Cassandra L.; Anastasi, Natia R.; Lamba, Jaydeep J. S. published their research in Journal of Organic Chemistry on December 26 ,1997. The article was titled 《Synthesis of Halomethyl and Other Bipyridine Derivatives by Reaction of 4,4′-Bis[(trimethylsilyl)methyl]-2,2′-bipyridine with Electrophiles in the Presence of Fluoride Ion》.Synthetic Route of C12H10Cl2N2 The article contains the following contents:

This report describes a new, high yield route to bipyridine derivatives via a trimethylsilyl (TMS) intermediate. 4,4′-Dimethyl-2,2′-bpy was reacted with lithium diisopropylamide, and the dianion thus formed was trapped with TMSCl to generate 4,4′-bis[(trimethylsilyl)methyl]-2,2′-bpy. The TMS group was removed using dry F- sources (TBAF/SiO2 in THF or CsF in DMF) in the presence of BrF2CCF2Br or Cl3CCCl3 to produce the bromide or chloride analogs of 4,4′-bis(halomethyl)-2,2′-bipyridine, resp. The CsF/DMF methodol. extends to other electrophiles, including benzaldehyde to give 4,4′-bis(2-hydroxy-2-phenethyl)-2,2′-bpy as well as to alkyl halides. Benzyl Br, dodecyl Br, and α-chloroacetonitrile gave mixtures of di- and monoalkylated products along with the diprotonated product, 4,4′-dimethyl-2,2′-bpy. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Synthetic Route of C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Synthetic Route of C12H10Cl2N2 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of Methyl 5-bromopicolinateIn 2011 ,《Fluorogenic N,O-chelates built on a C2-symmetric aryleneethynylene platform: Spectroscopic and structural consequences of conformational preorganization and ligand denticity》 appeared in Journal of Organometallic Chemistry. The author of the article were Park, Byung Gyu; Pink, Maren; Lee, Dongwhan. The article conveys some information:

Using π-extended aryleneethynylene as a rigid structural skeleton, a C2-sym. bis(picolinate) ligand I was prepared Binding of Zn(II) or Cd(II) ion to this formally tetradentate N2O2-chelate resulted in significant red shifts and enhancement in emission. The metal-ligand interaction responsible for such structural change was studied by isolation and characterization of a tetrazinc(II) complex, in which the picolinate group functions not only as terminal bidentate but also as bridging with its μ-1,3 carboxylate unit. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Reference of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhattarai, Rajan Sharma; Kumar, Virender; Romanova, Svetlana; Bariwal, Jitender; Chen, Hao; Deng, Shanshan; Bhatt, Vijaya R.; Bronich, Tatiana; Li, Wei; Mahato, Ram I. published an article in 2021. The article was titled 《Nanoformulation design and therapeutic potential of a novel tubulin inhibitor in pancreatic cancer》, and you may find the article in Journal of Controlled Release.HPLC of Formula: 626-05-1 The information in the text is summarized as follows:

Successful treatment of pancreatic cancer remains a challenge due to desmoplasia, development of chemoresistance, and systemic toxicity. Herein, we synthesized (6-(3-hydroxy-4-methoxylphenyl)pyridin-2-yl) (3,4,5-trimethoxyphenyl)methanone (CH-3-8), a novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance. CH-3-8 binding to the colchicine-binding site in tubulin protein was confirmed by tubulin polymerization assay and mol. modeling. CH-3-8 disrupted microtubule dynamics at the nanomolar concentration in MIA PaCa-2 and PANC-1 pancreatic cancer cell lines. CH-3-8 significantly inhibited the proliferation of these cells, induced G2/M cell cycle arrest, and led to apoptosis. CH-3-8 is hydrophobic with an aqueous solubility of 0.97 ± 0.16 μg/mL at pH 7.4. We further conjugated it with dodecanol through diglycolate linker to increase hydrophobicity and thus loading in lipid-based delivery systems. Hence, we encapsulated CH-3-8 lipid conjugate (LDC) into methoxy poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (mPEG-b-PCC-g-DC) polymeric nanoparticles (NPs) by solvent evaporation, resulting in a mean particle size of 125.6 ± 2.3 nm and drug loading of 10 ± 1.0% (weight/weight) while the same polymer could only load 1.6 ± 0.4 (weight/weight) CH-3-8 using the same method. Systemic administration of 6 doses of CH-3-8 and LDC loaded NPs at the dose of 20 mg/kg into orthotopic pancreatic tumor-bearing NSG mice every alternate day resulted in significant tumor regression. Systemic toxicity was negligible, as evidenced by histol. evaluations. In conclusion, CH-3-8 LDC loaded NPs have the potential to improve outcomes of pancreatic cancer by overcoming transporter-mediated chemoresistance and reducing systemic toxicity. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1HPLC of Formula: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Diiminepyridine-Supported Phosphorus(I) and Phosphorus(III) Complexes: Synthesis, Characterization, and Electrochemistry》 was written by Gray, Paul A.; Braun, Jason D.; Rahimi, Naser; Herbert, David E.. Recommanded Product: 626-05-1 And the article was included in European Journal of Inorganic Chemistry in 2020. The article conveys some information:

Diiminepyridines (DIP) are popular redox noninnocent ligands with widespread application in late, 1st-row transition metal mediated catalysis and coordination chem. Here, the authors report the isolation and characterization of a pair of P coordination complexes in the +1 and +3 oxidation states supported by the same ligand framework bearing sterically imposing and electron-releasing tBu substituents on the imine carbons of the DIP backbone. Electrochem. anal. demonstrates that the DIP scaffold can retain its ability to serve as an electron reservoir when coordinated to a reduced pnicogen center, with a reversible reduction observed for the PI complex. The experimental process involved the reaction of 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Raji, Idris; Ahluwalia, Kabir; Oyelere, Adegboyega K. published 《Design, synthesis and evaluation of antiproliferative activity of melanoma-targeted histone deacetylase inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Related Products of 29682-15-3 The information in the text is summarized as follows:

The clin. validation of histone deacetylase inhibition as a cancer therapeutic modality has stimulated interest in the development of new generation of potent and tumor selective histone deacetylase inhibitors (HDACi). With the goal of selective delivery of the HDACi to melanoma cells, we incorporated the benzamide, a high affinity melanin-binding template, into the design of HDACi to generate a new series of compounds 10a-b and 11a-b which display high potency towards HDAC1 and HDAC6. However, these compounds have attenuated antiproliferative activities relative to the untargeted HDACi. An alternative strategy furnished compound 14, a prodrug bearing the benzamide template linked via a labile bond to a hydroxamate-based HDACi. This pro-drug compound showed promising antiproliferative activity and warrant further study. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Related Products of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Sahu, Sumit; Zhang, Bo; Pollock, Christopher J.; Durr, Maximilian; Davies, Casey G.; Confer, Alex M.; Ivanovic-Burmazovic, Ivana; Siegler, Maxime A.; Jameson, Guy N. L.; Krebs, Carsten; Goldberg, David P. published 《Aromatic C-F Hydroxylation by Nonheme Iron(IV)-Oxo Complexes: Structural, Spectroscopic, and Mechanistic Investigations》.Journal of the American Chemical Society published the findings.Quality Control of 2-(Bromomethyl)pyridine hydrobromide The information in the text is summarized as follows:

The synthesis and reactivity of a series of mononuclear nonheme iron complexes that carry out intramol. aromatic C-F hydroxylation reactions is reported. The key intermediate prior to C-F hydroxylation, [FeIV(O)(N4Py2Ar1)](BF4)2 (1-O, Ar1 = -2,6-difluorophenyl), was characterized by single-crystal X-ray diffraction. The crystal structure revealed a nonbonding C-H···O=Fe interaction with a CH3CN mol. Variable-field Mössbauer spectroscopy of 1-O indicates an intermediate-spin (S = 1) ground state. The Mössbauer parameters for 1-O include an unusually small quadrupole splitting for a triplet FeIV(O) and are reproduced well by d. functional theory calculations With the aim of investigating the initial step for C-F hydroxylation, two new ligands were synthesized, N4Py2Ar2 (L2, Ar2 = -2,6-difluoro-4-methoxyphenyl) and N4Py2Ar3 (L3, Ar3 = -2,6-difluoro-3-methoxyphenyl), with -OMe substituents in the meta or ortho/para positions with respect to the C-F bonds. FeII complexes [Fe(N4Py2Ar2)(CH3CN)](ClO4)2 (2) and [Fe(N4Py2Ar3)(CH3CN)](ClO4)2 (3) reacted with iso-Pr 2-iodoxybenzoate to give the C-F hydroxylated FeIII-OAr products. The FeIV(O) intermediates 2-O and 3-O were trapped at low temperature and characterized. Complex 2-O displayed a C-F hydroxylation rate similar to that of 1-O. In contrast, the kinetics (via stopped-flow UV-vis) for complex 3-O displayed a significant rate enhancement for C-F hydroxylation. Eyring anal. revealed the activation barriers for the C-F hydroxylation reaction for the three complexes, consistent with the observed difference in reactivity. A terminal FeII(OH) complex (4) was prepared independently to investigate the possibility of a nucleophilic aromatic substitution pathway, but the stability of 4 rules out this mechanism. Taken together the data fully support an electrophilic C-F hydroxylation mechanism. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Quality Control of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Quality Control of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem