Tag: 300-400

On March 31, 2012, Raghu, M. S.; Basavaiah, K.; Ramesh, P. J.; Abdulrahman, Sameer A. M.; Vinay, K. B. published an article.SDS of cas: 132-20-7 The title of the article was Development and validation of a UV-spectrophotometric method for the determination of pheniramine maleate and its stability studies. And the article contained the following:

A sensitive, precise, and cost-effective UV-spectrophotometric method is described for the determination of pheniramine maleate (PAM) in bulk drug and tablets. The method is based on the measurement of absorbance of a PAM solution in 0.1 N HCl at 264 nm. As per the International Conference on Harmonization (ICH) guidelines, the method was validated for linearity, accuracy, precision, limits of detection (LOD) and quantification (LOQ), and robustness and ruggedness. A linear relationship between absorbance and concentration of PAM in the range of 2-40 μg/mL with a correlation coefficient (r) of 0.9998 was obtained. The LOD and LOQ values were found to be 0.18 and 0.39 μg/mL PAM, resp. The precision of the method was satisfactory: the value of relative standard deviation (RSD) did not exceed 3.47%. The proposed method was applied successfully to the determination of PAM in tablets with good accuracy and precision. Percentages of the label claims ranged from 101.8% to 102.01% with the standard deviation (SD) from 0.64% to 0.72%. The accuracy of the method was further ascertained by recovery studies via a standard addition procedure. In addition, the forced degradation of PAM was conducted in accordance with the ICH guidelines. Acidic and basic hydrolysis, thermal stress, peroxide, and photolytic degradation were used to assess the stability-indicating power of the method. A substantial degradation was observed during oxidative and alk. degradations No degradation was observed under other stress conditions. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate determination uv spectrophotometry stability, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.SDS of cas: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 15, 2013, Youngvises, Napaporn; Chaida, Thanatcha; Khonyoung, Supada; Kuppithayanant, Nattawan; Tiyapongpattana, Warawut; Itharat, Arunporn; Jakmunee, Jaroon published an article.Category: pyridine-derivatives The title of the article was Greener liquid chromatography using a guard column with micellar mobile phase for separation of some pharmaceuticals and determination of parabens. And the article contained the following:

In this research, a greener chromatog. employing a short column, Zorbax SB C18 cartridge (12.5 × 4.6 mm, 5 μm) commonly used as a guard column in a reverse phase high performance liquid chromatog. (RP-HPLC), was utilized as the anal. column in conjunction with a more eco-friendly micellar mobile phase of sodium dodecyl sulfate (SDS) for separation tertiary mixtures of local anesthetics and antihistamines; and binary mixture of colds drugs; and quaternary mixture of some parabens with different separation conditions. The chromatog. behavior of these analytes was studied to demonstrate separation efficiency of this guard column in a micellar mobile phase. Moreover, this column and SDS mobile phase was exploited for determination of parabens in 64 samples of cosmetic product, both those that were produced locally in the community and those that were com. manufactured Linear calibration graphs of the parabens as detected at 254 nm were obtained in the range of 1-100 μmol L-1 with R2>0.9990. Percentage recoveries were 92.4-109.2 with %RSD<3, and the limit of detection and quantitation were 0.04-0.10 and 0.20-0.80 μmol L-1, resp. This anal. system is not only greener but also faster and employing simpler sample preparation than a conventional liquid chromatog. system. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives

The Article related to green liquid chromatog micelle mobile pharmaceutical paraben, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sawant, Sakshi; Borkar, Nitin published an article in 2015, the title of the article was Validation of high performance liquid chromatographic method for the simultaneous determination of common cough and cold ingredients in multicomponent oral drug products.HPLC of Formula: 132-20-7 And the article contains the following content:

This research was done to develop a potential, reliable fast and efficient anal. method for various dosage forms eg. Syrup, tablet, suspension etc which could estimate all the major components of a cough and cold multicomponent formulation and also this method was validated. All common used components like pheniramine maleate, phenylephrine hydrochloride, acetaminohen, dextromethorphan hydrobromide, guafenesin, chlorpheniramine maleate, diphenhydramine in cough and cold category of products also covering more than one dosage forms eg. Syrups, suspensions, tablet etc was used thus making the methodol. by and large universal for the entire range of cough and cold products. This would help in using almost a common method of anal. for separation of most of the components instead of using a lot of sep. methods for the same product or using a common method of anal. for a range of different dosage form of cough and cold category for a common set of components. This would save time and cost and ensure optimum usage of resources. Mobile phase of 0.01M 1-octane sulfonic acid sodium salt monohydrate pH adjusted to 2.80 with 0rthophosphoric acid: Acetonitrile in a gradient ratio was used with a flow rate of 1.0 mL/min on a C18, 25 × 4.6 mm id, 5μ column at a wavelength of 264nm. This method was validated for parameters as accuracy, repeatability, reproducibility, robustness, linearity, limit of detection and limit of quantification. This HPLC method was found to be specific, linear, precise,accurate, reproducible and robust and can be easily used for determination of common cough and cold analytes in a formulation as the results were found to be well within the acceptance range. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7

The Article related to cough cold ingredient high performance liquid chromatog, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.HPLC of Formula: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Raghu, M. S.; Basavaiah, K.; Prashanth, K. N.; Vinay, K. B. published an article in 2012, the title of the article was Acid-base titrimetric assay of pheniramine maleate in pharmaceuticals in hydro-alcoholic medium.Application of 132-20-7 And the article contains the following content:

Two simple titrimetric methods are described for the determination of pheniramine maleate (PAM) in pure form and in its dosage forms. The principle involved in the methods are simple acid-base reaction in which the carboxylic acid group of the drug was determined by titrating with an aqueous NaOH solution either visually using phenolphthalein as indicator (method A) or pH-metrically (method B) using glass-calomel electrode system. The methods were applicable over the range of 2-20 mg of PAM. The procedures were applied to the determination of PAM in tablets, injections, and the results were found to be in a good agreement with those obtained by the reference method. The precision results, expressed by intra-day and inter-day relative standard deviation values, were satisfactory (RSD ≤ 2.58%). The accuracy was satisfactory as well (RE ≤ 2.14%). Excipients used as additives in pharmaceutical formulations did not interfere in the proposed procedures as shown by placebo blank and synthetic mixture analyses and also by the recovery study via standard addition technique with percentage recoveries in the range 97.48 – 106.3% with a standard deviation of 1.76 – 3.42%. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application of 132-20-7

The Article related to pheniramine maleate determination acid base titrimetry, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Habyalimana, Vedaste; Mbinze, Jeremie Kindenge; Tshilombo, Nicodeme Kalenda; Dispas, Amandine; Loconon, Achille Yemoa; Sacre, Pierre-Yves; Widart, Joeelle; De Tullio, Pascal; Counerotte, Stephane; Ntokamunda, Justin-Leonard Kadima; Ziemons, Eric; Hubert, Philippe; Djang’eing’a, Roland Marini published an article in 2015, the title of the article was Analytical tools and strategic approach to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures: case study of antimalarial medicines.Synthetic Route of 132-20-7 And the article contains the following content:

Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in developing countries where drug quality assurance and regulatory systems for drug manufacturing, importation, distribution and sales are weak. A sustained vigilance on poor quality medicines that regroup counterfeit/falsified, substandard and degraded medicines is therefore required to ensure patient safety and genuine medicines integrity. A case situation is illustrated including a strategic approach and anal. tools that were found useful to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures against the spread of those harmful products. Several suspected medicines randomly sampled in several strategic Rwandan areas were firstly check-controlled by means of visual inspection and then applying several anal. techniques from simple to more complex ones. The following medicines were studied: quinine sulfate tablets, artemisinin-based combination tablets, and artesunate powders for injection. Taking into account the pharmaceutical forms and the chem. characteristics, the following tests were applied: uniformity of mass, friability, disintegration, fluorescence, identification and assay. They were followed by more complex anal. techniques that allowed more comprehension of abnormal findings among which the presence of a wrong active pharmaceutical ingredient in quinine sulfate tablets which is mainly discussed in this paper to illustrate a strategic approach and various anal. tools that can be used in detecting and identifying unknown component in poor quality medicines. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to antimalarial medicine drug quality assessment, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Synthetic Route of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sawant, Sakshi; Borkar, Nitin published an article in 2014, the title of the article was Method development of an simultaneous determination of common cough and cold ingredients by high performance liquid chromatography (HLPC) in multi component cough and cold oral drug products.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

A common simultaneous HPLC method has been developed for the quantification of common analytes used in cough and cold products. The seven analytes acetaminophen, guafenesin, pheniramine maleate, phenylephrine hydrochloride, diphenhydramine, chlorpheniramine maleate, dextromethorphan are separated out. HPLC separation was achieved on a C18 column with a gradient system optimized for all seven analytes with different chem. structures. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to cough cold high performance liquid chromatog, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Deconinck, E.; Sacre, P. Y.; Baudewyns, S.; Courselle, P.; De Beer, J. published an article in 2011, the title of the article was A fast ultra high pressure liquid chromatographic method for qualification and quantification of pharmaceutical combination preparations containing paracetamol, acetyl salicylic acid and/or antihistaminics.Recommanded Product: 132-20-7 And the article contains the following content:

A fully validated UHPLC method for the identification and quantification of pharmaceutical preparations, containing paracetamol and/or acetyl salicylic acid, combined with anti-histaminics (phenylephrine, pheniramine maleate, diphenhydramine, promethazine) and/or other additives as quinine sulfate, caffeine or codeine phosphate, was developed. The proposed method uses a Waters Acquity BEH C18 column (2 mm × 100 mm, 1.7 μm) with a gradient using an ammonium acetate buffer pH 4.0 as aqueous phase and methanol as organic modifier. The obtained method was fully validated based on its measurement uncertainty (accuracy profile) and robustness tests. Calibration lines for all components were linear within the studied ranges. The relative bias and the relative standard deviations for all components were resp. smaller than 1.5% and 2%, the β-expectation tolerance limits did not exceed the acceptance limits of 10% and the relative expanded uncertainties were smaller than 5% for all of the considered components. A UHPLC method was obtained for the identification and quantification of these kind of pharmaceutical preparations, which will significantly reduce anal. times and workload for the laboratories charged with the quality control of these preparations The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: 132-20-7

The Article related to nsaid antihistaminic uplc quality control, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Recommanded Product: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2011, Murahdharan, Balathandapani; Gopu, Gopalakrishnan; Laya, Saraswathy; Vedhi, Chinnapiyan; Manisankar, Paramasivam published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was A study on preparation and use of nano poly pyrrole and nano poly (3,4-ethylenedioxythiophene) coated glassy carbon electrode for the determination of antihistamine in pharmaceutical and urine sample. And the article contained the following:

Pheniramine maleate (PA), an antihistamine, was determined by Differential Pulse Stripping voltammetry using nano polypyrrole (Ppy) and nano poly (3,4-ethylenedioxythiophene) (PEDOT) modified glassy carbon electrodes. The cyclic voltammetric behavior of pheniramine was studied in aqueous acidic, neutral and alk. conditions. One well-defined oxidation peak was observed in the cyclic voltammograms at all pHs. The influence of pH, scan rate and concentration revealed irreversible electron transfer and the oxidation was diffusion controlled adsorption. The SEM anal. confirmed good accumulation of PA on the electrode surface. A systematic study of influence of various exptl. parameters that affect the stripping voltammetric response was carried out and the maximum peak current conditions were arrived at. Calibration was made under maximum peak current conditions. The range of study was 0.05 to 0.4 μg/mL on Ppy/GCE and 0.025 to 0.4 μg/mL on PEDOT/GCE and the lower limit of determination were 0.035 μg/mL on Ppy/GCE and 0.016 μg/mL on PEDOT/GCE. The suitability of the method for the determination of PA in pharmaceutical preparations and urine samples was also ascertained. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to polypyrrole ethylenedioxythiophene glassy carbon electrode nanoparticle antihistamine pheniramine maleate, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaya Oeztuerk, Dilara; Baki, Birol; Oeztuerk, Recep; Karayuecel, Sedat; Uzun Goeren, Guelsen published an article in 2019, the title of the article was Determination of growth performance, meat quality and colour attributes of large rainbow trout (Oncorhynchus mykiss) in the southern Black Sea coasts of Turkey.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

The aim of this study was to determine the growth performance, meat quality and color attributes of large rainbow trout (Oncorhynchus mykiss) in net cage systems in the southern Black Sea coasts of Turkey. In the study, large rainbow trout with an initial weight of 1,322.07 ± 57.72 g were reached to 3,385.30 ± 140.98 g and the survival rates were 95.69 ± 1.32% in 5-mo production period. Crude protein and crude fat values of fish meat were ranged between 16.75 ± 0.07-20.18 ± 0.90% and 9.22 ± 0.15-12.29 ± 0.42%, resp. (p < .05). The essential and non-essential amino acid values were between 12.92 ± 0.02-13.09 ± 0.01 g/100 g and 11.97 ± 0.14-11.47 ± 0.01 g/100 g, resp. (p > .05). C20:5n-3, C22:6n-3, ɷ3 and ɷ6 values in fish meat were between 4.32 ± 0.02-4.30 ± 0.08% (p < .05), 8.31 ± 0.10-7.72 ± 0.15% (p < .05), 13.41 ± 0.10-12.93 ± 0.23% (p < .05) and 21.85 ± 0.06%-19.74 ± 0.36 (p < .05), resp. As a result, it can be concluded that large rainbow trout cultured in the southern Black Sea coasts of Turkey is a rich source of food in terms of fatty and amino acid compositions and atherogenicity index, thrombogenicity index and hypocholesterolemic/hypercholesterolemic values. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to meat food quality color amino acid oncorhynchus turkey, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 2011, Raghu, M. S.; Basavaiah, K. published an article.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Two charge-transfer complexation reactions for spectrophotometric determination of pheniramine maleate using π-acceptors. And the article contained the following:

This study presents two simple, selective and rapid spectrophotometric methods for determination of pheniramine maleate (PAM) in pure form and in its formulations. Both methods are based on the formation of charge-transfer (CT) reaction of PAM with p-chloranilic acid (CAA) or 2,3-dichloro-5,6-dicyanoquinone (DDQ) in 1,4-dioxan-acetonitrile medium. CT complexes were quantified at 530 and 590 nm for CAA and DDQ methods, resp. Beer’s law is obeyed (concentrate ranges, 12.5-200 μg/mL-1 for CAA and 5-80 μg/mL-1 for DDQ method), with correlation coefficients (r) of 0.9999 and 0.9991. Apparent molar absorptivities are calculated to be 1.27 × 103 and 3.06 × 103 l/mol-1/cm-1, resp. and corresponding Sandell sensitivities are 0.281 and 0.112 μg/cm-2. Developed methods were successfully applied for determination of PAM in tablets and injections. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to charge transfer complexation spectrophotometric determination pheniramine maleate pi acceptor, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem