Tag: M.W=0-100

Recommanded Product: 1H-Pyrazole-5-carbaldehyde. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Unprecedented copper(II)-assisted acetal formation of a formyl-substituted bispyrazole. The x-ray structures of copper[1,2-bis(3′-dimethoxymethylpyrazol-1′-yl)ethane] dichloride and dibromide. Author is Koval, Iryna A.; Schuitema, Anna M.; Driessen, Willem L.; Reedijk, Jan.

The formation of two new acetal-containing ligands 1,2-bis(3′-dimethoxymethylpyrazol-1′-yl)ethane (bdmpe) and 1,2-bis(3′-diethoxymethylpyrazol-1′-yl)ethane (bdepe) in a Cu(II)-assisted alcoholysis of the initial ligand 1,2-bis(3′-formylpyrazol-1′-yl)ethane is described. The new ligands form polymeric complexes with Cu(II) salts, [Cu(L)X2]x, where L = bdmpe or bdepe, and X = Cl or Br. The single-crystal x-ray structures of [Cu(bdmpe)Cl2]x and [Cu(bdmpe)Br2]x show that two of the four oxygen atoms of the acetal fragments are axially semi-coordinated to the copper(II) ions, adjusting the coordination sphere around the metal ion to a very distorted octahedron. The coordination of the oxygen atoms of the acetal groups to the metal ion may well be the driving force for the transformation of the initial aldehyde groups into the acetal fragments. The equatorial plane in [Cu(bdmpe)Cl2]x is a trans-CuN2Cl2 chromophore, while in [Cu(bdmpe)Br2]x it is a cis-CuN2Br2 species with a large in-plane distortion.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and evaluation of novel 1-(((6-substituted benzo[d]thiazol-2-yl)amino)(heteroaryl)methyl)naphthalen-2-ol as pesticidal agents, published in 2022, which mentions a compound: 948552-36-1, Name is 1H-Pyrazole-5-carbaldehyde, Molecular C4H4N2O, Product Details of 948552-36-1.

To discover new agrochems. with prominent pesticidal properties, a series of novel β-naphthol derivatives containing benzothiazolylamino and various heteroaryl groups I (R = H, CF3, Cl; Het = pyrazol-5-yl, imidazol-2-yl, pyrimidin-5-yl, etc.) were efficiently synthesized via Betti reaction. The bioassay results showed that most of the synthesized compounds exhibited favorable insecticidal potentials, particularly towards oriental armyworm (50-100% at 200 mg·L-1) and diamondback moth (50-95% at 10 mg·L-1). Some compounds possessed LC50 values of 0.0988-5.8864 mg·L-1 against diamondback moth. Compounds I (R = H; Het = 2-phenyl-2H-1,2,3-triazol-4-yl), I (R = H; Het = 6-chloroimidazo[1,2-a]pyridin-3-yl), I (R = H; Het = 6-bromoimidazo[1,2-a]pyridin-3-yl) also displayed lethality rates of 30-90% against spider mite at the concentration of 100 mg·L-1. Overall, some compounds could be considered as new insecticidal/acaricidal leading structures for further investigation. The calcium imaging experiments revealed that compound I (R = H; Het = 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl), I (R = H; Het = 2-phenyl-2H-1,2,3-triazol-4-yl), and 1-((benzo[d]thiazol-2-ylamino)(4-methoxyphenyl)- Methyl)naphthalen-2-ol could activate the release of calcium ions in insect (M. separata) central neurons at a higher concentration (50 mg·L-1). The SAR anal. provided valuable information for further structural modifications.

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Rodriguez, Anabel M.; Molina, Francisco; Diaz-Requejo, M. Mar; Perez, Pedro J. published the article 《Copper-Catalyzed Selective Pyrrole Functionalization by Carbene Transfer Reaction》. Keywords: pyrrole preparation carbene transfer reaction copper catalyst.They researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).Application of 625-82-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:625-82-1) here.

1H-Pyrroles can be directly functionalized by means of the incorporation of carbene groups from diazo compounds, in a process catalyzed by TpxCu complexes (Tpx=hydrotrispyrazolylborate ligand). The reactions take place with a complete selectivity toward the formal insertion of the carbene into the Cα-H bond, leading to alkylated pyrroles, with no modification of the Cβ-H, N-H or C=C bonds of the pyrrole unit. Alkyl substituents at C-ring as well as alkyl, aryl, allyl or alkyne substitution at N atom are tolerated, the strategy affording 20 new pyrrole derivatives The observance of partial deuteration at the methylene group when the reaction is carried out with added D2O serves to discard the direct insertion of the carbene group into the Csp2-H bond, the alternative electrophilic attack to the pyrrole ring being feasible.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1H-Pyrazole-5-carbaldehyde( cas:948552-36-1 ) is researched.Quality Control of 1H-Pyrazole-5-carbaldehyde.Malik, M. Shaheer; Asghar, Basim H.; Syed, Riyaz; Alsantali, Reem I.; Morad, Moataz; Altass, Hatem M.; Moussa, Ziad; Althagafi, Ismail I.; Jassas, Rabab S.; Ahmed, Saleh A. published the article 《Novel pyran-linked phthalazinone-pyrazole hybrids: synthesis, cytotoxicity evaluation, molecular modeling, and descriptor studies》 about this compound( cas:948552-36-1 ) in Frontiers in Chemistry (Lausanne, Switzerland). Keywords: pyran phthalazinyl pyrazolyl preparation antitumor docking physiochem mol descriptor; anticancer activity; molecular descriptors; molecular modelling; multicomponent; phthalazinone; pyran; pyrazole hybrids. Let’s learn more about this compound (cas:948552-36-1).

A series of novel pyran-linked phthalazinone-pyrazole hybrids I (R = H, Me; R1 = H, Me; X = CN, COOEt) were designed and synthesized by a facile one-pot three-component reaction employing 3-(1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-3-oxopropanenitrile, 1H-pyrazole-5-carbaldehydes II, and active methylene compounds XCH2CN. Optimization studies led to the identification of L-proline and ethanol as efficient catalyst and solvent, resp. This was followed by evaluation of anticancer activity against solid tumor cell lines of lung and cervical carcinoma that displayed IC50 values in the range of 9.8-41.6μM. Mol. modeling studies were performed, and crucial interactions with the target protein were identified. The drug likeliness nature of the compounds and mol. descriptors such as mol. flexibility, complexity, and shape index were also calculated to understand the potential of the synthesized mols. to act as lead-like mol. upon further detailed biol. investigations as well as 3D-QSAR studies.

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Name: 2,4-Dimethyl-1H-pyrrole. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about A novel photosensitizer for lipid droplet-location photodynamic therapy. Author is Xia, Xiang; Wang, Ran; Hu, Yingqi; Liu, Wei Jian; Liu, Ting; Sun, Wen; Fan, Jiangli; Peng, Xiaojun.

Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biol. processes, which could be a potential target site for photodynamic therapy (PDT) of cancer. Herein, a lipid droplet-targeted photosensitizer (BODSeI) is developed, allowing for fluorescence imaging-guided PDT. Owing to the location of lipid droplets, BODSeI demonstrates enhanced PDT efficiency with an extremely low IC50 value (around 125 nM). Besides, BODSeI shows good biocompatibility and high photostability. Therefore, BODSeI is promising for droplet-location PDT, which may trigger wide interest for exploring the pathway of lipid droplet-location PDT.

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Lv, Kai; Wu, Shuo; Tao, Zeyu; Wang, Aoyu; Xu, Shijie; Yang, Lu; Gao, Qiang; Wang, Apeng; Qin, Xiaoyu; Jiang, Bin; Wu, Wenhao; Jia, Xuedong; Li, Yuhuan; Jiang, Jiandong; Liu, Mingliang published an article about the compound: 1H-Pyrazole-5-carbaldehyde( cas:948552-36-1,SMILESS:O=CC1=CC=NN1 ).Product Details of 948552-36-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:948552-36-1) through the article.

A series of GYH2-18 derivatives I [X = NHC(O), NHC(S), NHC(O)Me, etc.], II [n = 1,2; R = CN, Ph, 4,4-dimethyl-2-oxopyrrolidin-1-yl, etc. R1 = H, Me, cyclopropyl, benzyl; R2 = H; R3 = H, Me; R1R2 = -(CH2)6-] were designed, synthesized and evaluated for their anti-HBV activity. Two compounds II [n = 1; R = Ph, 4-(1,3-oxazol-2-yl)-2-oxopyrrolidin-1-yl; R1 = cyclopropyl; R2 = H; R3 = H] exhibited excellent anti-HBV activity, low cytotoxicity and accepted oral PK profiles. Chiral separation of II [n = 1; R = Ph, 4-(1,3-oxazol-2-yl)-2-oxopyrrolidin-1-yl; R1 = cyclopropyl; R2 = H; R3 = H] was conducted successfully and (6S)-cyclopropyl DPPC isomers II (S,R/S,S) [n = 1; R = Ph, 4-(1,3-oxazol-2-yl)-2-oxopyrrolidin-1-yl; R1 = cyclopropyl; R2 = H; R3 = H] were identified to be much more active than the corresponding (6R)-ones. The preliminary structure-activity relationship, particle gel assay and mol. modeling studies were also discussed, which provide useful indications for guiding the further rational design of new (6S)-cyclopropyl DPPC analogs.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called Simultaneous detection of carbon monoxide and viscosity changes in cells, Author is Robson, Jonathan A.; Kubankova, Marketa; Bond, Tamzin; Hendley, Rian A.; White, Andrew J. P.; Kuimova, Marina K.; Wilton-Ely, James D. E. T., which mentions a compound: 625-82-1, SMILESS is CC1=CNC(C)=C1, Molecular C6H9N, Synthetic Route of C6H9N.

A new family of robust, non-toxic, water-compatible ruthenium(II) vinyl probes allows the rapid, selective and sensitive detection of endogenous carbon monoxide (CO) in live mammalian cells under normoxic and hypoxic conditions. Uniquely, these probes incorporate a viscosity-sensitive BODIPY fluorophore that allows the measurement of microscopic viscosity in live cells via fluorescence lifetime imaging microscopy (FLIM) while also monitoring CO levels. This is the first example of a probe that can simultaneously detect CO alongside small viscosity changes in organelles of live cells.

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Pyridine – Wikipedia,
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Formula: C6H9N. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Construction of a red emission BODIPY-based probe for tracing lysosomal viscosity changes in culture cells. Author is Shen, Baoxing; Wang, Ling Feng; Zhi, Xu; Qian, Ying.

A red emission boron-dipyrromethene based lysosome-targeted viscosity probe was synthesized for monitoring lysosomal viscosity in live cells. The increase of viscosity can restrict the twisting of double bond between indole and boron-dipyrromethene fluorophore, also restrict the rotating of single bond between quinoline and boron-dipyrromethene, which lead to the enhancement of fluorescence intensity in high viscosity environment. The changes of fluorescence intensity exhibit a good linear relationship with viscosity values. Besides, lysosome-targeted viscosity probe is quite stable in various pH solvents with given viscosity, suggesting that lysosome-targeted viscosity probe is suitable for applying in a wide pH range. Moreover, lysosome-targeted viscosity probe can visualize the changes of lysosomal viscosity in live cells under the stimulus of dexamethasone. Bovine serum albumin titration experiment demonstrated that lysosome-targeted viscosity probe is stable in the presence of macromols. and proteins. Notably, the fluorescence lifetime of lysosome-targeted viscosity probe in large viscosity solvents is extremely high. These results indicate that lysosome-targeted viscosity probe is an excellent tool for detecing viscosity changes in vitro and live cells.

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Radi, Smaail; Tighadouini, Said; Bacquet, Maryse; Degoutin, Stephanie; Cazier, Francine; Zaghrioui, Mustapha; Mabkhot, Yahia N. published an article about the compound: 1H-Pyrazole-5-carbaldehyde( cas:948552-36-1,SMILESS:O=CC1=CC=NN1 ).Related Products of 948552-36-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:948552-36-1) through the article.

A new chelating matrix, SiNP, has been prepared by immobilizing 1.5-dimethyl-1H-pyrazole-3-carbaldehyde on silica gel modified with 3-aminopropyl-trimethoxysilane. This new chelating material was well characterized by elemental anal., FT-IR spectroscopy, cross polarization magic angle spinning solid state 13C-NMR, nitrogen adsorption-desorption isotherm, BET surface area, BJH pore size, and SEM (SEM). The new product exhibits good chem. and thermal stability as determined by thermogravimetry curves (TGA). The new prepared material was used as an adsorbent for the solid-phase extraction (SPE) of Pb(II), Cd(II), Cu(II) and Zn(II) from aqueous solutions using a batch method, prior to their determination by flame at. adsorption spectrometry. The adsorption capacity was investigated using kinetics and pH effects. Common coexisting ions did not interfere with separation and determination

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Reference:
Pyridine – Wikipedia,
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Related Products of 625-82-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about A novel dual-responsive fluorescent probe for the detection of copper(II) and nickel(II) based on BODIPY derivatives. Author is Song, Yuting; Tao, Jiayu; Wang, Yi; Cai, Zhengchun; Fang, Xianying; Wang, Shifa; Xu, Haijun.

A novel dual-responsive fluorescence probe 6 was constructed by introducing a dipicolyamine moiety on the BODIPY-based skeleton via Sonogashira coupling reaction and confirmed by 1H NMR, 13C NMR, elemental anal. and high-resolution mass spectroscopy (HRMS). The present probe 6 exhibited high selectivity and sensitivity toward Cu2+ and Ni2+ detection over other competitive metal ions by fluorescence quenching phenomena, resp. In addition, the detection limits (DLs) for Cu2+ and Ni2+ were calculated to be as low as both 0.1 μM resp., which were lower than the maximum allowable level of the World Health Organization (WHO) limit for the drinking water. The stoichiometric ratio of the probe 6 toward the Cu2+ or Ni2+ ions was determined to be 1:1 according to the result of the Job′s plot and HRMS anal. These results indicated that probe 6 can be used as a selective ′′turn-off′′ fluorescent sensor for the detection of Cu2+ and Ni2+.

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Pyridine – Wikipedia,
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