Tag: M.W=0-100

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Highly active binuclear Cu (II) catalyst bearing an unsymmetrical bipyridine-pyrazole-amine ligand for the azide-alkyne cycloaddition reaction.Related Products of 948552-36-1.

Ligands containing NH groups often show special characteristics. In this paper, a well-defined dinuclear Cu (II) complex bearing an unsym. bipyridine-pyrazole-amine ligand was synthesized by the condensation of N-H to release H2O. Using sodium L-ascorbate as a reductant, the binuclear complex showed excellent activity in 1,3-dipolar cycloaddition reactions between alkynes and azides to obtain 1,4-disubstituted triazoles in 95%-99% isolated yields.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 948552-36-1, is researched, SMILESS is O=CC1=CC=NN1, Molecular C4H4N2OJournal, Huaxue Yanjiu called Theoretical study on the proton transfer in 3-formylpyrazole, Author is Chen, Yuanli; Li, Baozong; Guo, Yongmin, the main research direction is aldehyde pyrazole proton transfer theor study.Safety of 1H-Pyrazole-5-carbaldehyde.

The mol. structures of 3-formylpyrazole tautomers with full geometry optimization were calculated by the B3LYP method at the 6-311G** level. The geometry and electronic structures of the tautomers of 3-formylpyrazole and their transition states were obtained. The four possible reaction pathways were studied including: (a) intramol. proton transfer; (b) water-assisted intermol. transfer; isomerization by double-proton transfer in the dimer; and (d) intermol. proton transfer via the complex formed. The results of the calculation indicated that the N1-H form of the anti conformer was more stable than that of the N2-H form, and the process in (d) has the lowest activation energy (61.09 kJ/mol), whereas the N2-H form of the syn conformer is more stable than that of the N1-H form and the process in (c) has the lowest activation energy (52.78 kJ/mol). Probably the hydrogen bonds formed in the complexes played an important role in proton transfer processes in the latter three reaction pathways.

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Pyridine – Wikipedia,
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Chinapang, Pondchanok; Iwami, Hikaru; Enomoto, Takafumi; Akai, Takuya; Kondo, Mio; Masaoka, Shigeyuki published the article 《Dirhodium-Based Supramolecular Framework Catalyst for Visible-Light-Driven Hydrogen Evolution》. Keywords: dirhodium supramol catalyst hydrogen evolution.They researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).Computed Properties of C6H9N. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:625-82-1) here.

The direct conversion of solar energy to clean fuels as alternatives to fossil fuels is an important approach for addressing the global energy shortage and environmental problems. Here, we introduce a new dirhodium-complex-based framework assembly as a heterogeneous mol.-based photocatalyst for hydrogen evolution using visible light. Two dirhodium complexes bearing visible-light-harvesting BODIPY (boron dipyrromethene, BDP) moieties were newly designed and synthesized. The obtained complexes were self-assembled to framework structures (supramol. framework catalysts), which are stabilized intermol. noncovalent interactions. These frameworks retained excellent visible-light-harvesting properties of BDP moieties. Investigation of the catalytic performance of the supramol. framework catalysts revealed that the supramol. framework catalyst with heavy atoms at BDP moieties exhibited excellent performance in the formation of hydrogen with a reaction rate of 275.8 μmol g-1 h-1 under irradiation of visible light, whereas the supramol. framework catalyst without heavy atoms at BDP moieties was inactive. Moreover, the system has the addnl. benefits of high durability (up to 96 h), reusability, and facile removal from the reaction mixture We also disclosed the effect of heavy atoms at BDP moieties on the catalytic activity and proposed a reaction mechanism.

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Pyridine – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 625-82-1, is researched, Molecular C6H9N, about Microtubule-Targeted Self-Assembly Triggers Prometaphase-Metaphase Oscillations Suppressing Tumor Growth, the main research direction is antimicrotubule mol self assembly metaphase oscillation antiproliferation; antimicrotubule; antiproliferation; cancer; molecular self-assembly; prometaphase−metaphase oscillation.Reference of 2,4-Dimethyl-1H-pyrrole.

Microtubules are highly strategic targets of cancer therapies. Small mol. antimitotic agents are so far the best chemotherapeutic medication in cancer treatment. However, the high rate of neuropathy and drug resistance limit their clin. usage. Inspired by the multicomponent-targeting feature of mol. self-assembly (MSA) overcoming drug resistance, we synthesized peptide-based rotor mols. that self-assemble in response to the surrounding environment to target the microtubule array. The MSAs self-adjust morphol. in response to the pH change and viscosity variations during Golgi-endosome trafficking, escape trafficking cargos, and eventually bind to the microtubule array phys. in a nonspecific manner. Such unrefined nano-bio interactions suppress regional tubulin polymerization triggering atypical prometaphase–metaphase oscillations to inhibit various cancer cells proliferating without inducing obvious neurotoxicity. The MSA also exerts potent antiproliferative effects in the s.c. cervix cancer xenograft tumor model equivalent to Cisplatin, better than the classic antimitotic drug Taxol.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 625-82-1, is researched, Molecular C6H9N, about Rational design of a lysosome-targeting and near-infrared absorbing Ru(II)-BODIPY conjugate for photodynamic therapy, the main research direction is lysosome nearIR ruthenium BODIPY conjugate preparation cancer PDT.COA of Formula: C6H9N.

A Ru(II)-BODIPY conjugate has been rationally designed and exhibits an intense absorption in the NIR region to boost lysosome-targeted PDT in vitro and in vivo. The advantages of Ru(II) and BODIPY were successfully instilled into the conjugate to yield highly effective PDT efficacy against malignant melanoma A375 cells (PI = 3448) and A375 mice xenografts.

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Application In Synthesis of 1H-Pyrazole-5-carbaldehyde. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Mild regioselective iodination of pyrazoles using n-butyltriphenylphosphonium peroxodisulfate. Author is Gorjizadeh, M.; Afshari, M.; Naseh, M..

A practical, efficient and inexpensive method of synthesis of iodopyrazoles by the reaction of pyrazoles with iodine using n-butyltriphenylphosphonium peroxodisulfate as an oxidant at room temperature is reported. The use of n-butyltriphenylphosphonium peroxodisulfate is feasible due to its easy preparation and handling, high stability and activity.

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Pyridine – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about A pyrazole-containing verdazyl radical ligand Meprv: structure of its precursor prvH3 and its bis(2,2′-bipyridine)ruthenium(II) complex, the main research direction is pyrazolyloxotetrazane preparation structure dehydrogenation; crystal structure pyrazolyloxotetrazane; ruthenium pyrazolyloxoverdazyl bipyridine complex preparation electrochem redox; verdazyl pyrazolyl ruthenium bipyridine complex preparation.Reference of 1H-Pyrazole-5-carbaldehyde.

Reaction between 1,1′-dimethyl carbonic dihydrazide and pyrazole-3-carboxaldehyde gave 1,5-dimethyl-3-(3′-pyrazolyl)-6-oxotetrazane (prvH3), which crystallizes in the orthorhombic space group Pca21, with a 10.7745(4), b 8.1745(2) and c 10.6625(3) Å. Dehydrogenation of prvH3 in methanol by 1,4-benzoquinone afforded the methylated radical 1,5-dimethyl-3-(1′-methyl-3′-pyrazolyl)-6-oxoverdazyl (Meprv), which reacted with cis-[Ru(bpy)2Cl2] and NaBPh4 to yield [Ru(bpy)2(Meprv)]2+ as its BPh4 salt. The absence of luminescence and the electrochem. behavior of this complex imply that the lowest 3MLCT (metal to ligand charge transfer) excited state is located on the electron-deficient Meprv ligand.

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Pyridine – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Activatable Photosensitizer for Smart Photodynamic Therapy Triggered by Reactive Oxygen Species in Tumor Cells, published in 2020-06-17, which mentions a compound: 625-82-1, Name is 2,4-Dimethyl-1H-pyrrole, Molecular C6H9N, Name: 2,4-Dimethyl-1H-pyrrole.

Photodynamic therapy (PDT) is a promising approach for the treatment of different kinds of cancers as well as some other diseases. By combining spatiotemporal light irradiation with photosensitizers (PS), PDT can be easily controlled by tuning illumination time and sites of irradiation However, how to reduce the phototoxicity of the PS to normal cells without sacrificing its effectiveness to cancer cells is still a challenge. Herein, we put forward a deactivation and reactivation strategy for PDT to reduce the undesired damage to normal cells under light irradiation First, by chem. modification of meso-(4-pyridinyl)-substitution BODIPY with phenylboronic acid pinacol ester moiety, the masked PS ProBODIPY-2I with low generation efficiency of singlet oxygen and good water solubility can be obtained. Moreover, ProBODIPY-2I can be reactivated at tumor microenvironment by reactive oxygen species (ROS), resuming their PDT efficiency. Meanwhile, ProBODIPY-2I showed low phototoxicity for the normal cells, due to the relatively low concentration of ROS. In this way, the safety and selectivity for the PDT can be greatly improved. It is anticipated that some other tumor biomarkers, such as proton, GSH and enzymes, can be employed for the smart PDT methods.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1H-Pyrazole-5-carbaldehyde(SMILESS: O=CC1=CC=NN1,cas:948552-36-1) is researched.Reference of tert-Butyl 5-bromo-1H-indazole-1-carboxylate. The article 《Photoisomerization and hydrogen-bonding-induced association in 2-(1H-diazol-2-ylmethylene)indane-1-ones and 2-(1H-diazol-2-ylmethylene)-1H-indene-1,3(2H)-diones.》 in relation to this compound, is published in Tetrahedron. Let’s take a look at the latest research on this compound (cas:948552-36-1).

The products of condensation of 2-imidazolyl-, 4-imidazolyl-, 3-pyrazolylcarbaldehydes with indan-1-one 1-3 and 1H-indene-1,3(2H)-dione 4-6 were synthesized. The E-isomers of 1-3 undergo UV-induced isomerization to the Z-isomers stabilized by intramol. NH···O=C hydrogen bond with the pyrrolic-type NH group. Theor. anal. of all isomers, tautomers and rotamers showed that the degree of conjugation between the diazolyl group and the C=O group decreases in the order 1 > 2>3. Spectroscopic study of 1-6 performed before and after UV irradiation allowed to conclude on the nature of the associates formed. A remarkably different association of the 2- and 4-imidazolyl derivatives 4 and 5 was revealed by X-ray and confirmed theor., leading to the formation of the chelate rings closed by NH···O=C hydrogen bond in 4 or by N-H …Npyridinic hydrogen bond in 5. Both chelate rings include two bifurcate H-bonds with bifurcation on the carbonyl oxygen and the pyrrolic NH hydrogen.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ) is researched.Product Details of 625-82-1.Karges, Johannes; Blacque, Olivier; Gasser, Gilles published the article 《Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy》 about this compound( cas:625-82-1 ) in Inorganica Chimica Acta. Keywords: metal dipyrrin complex photosensitizer photodynamic therapy. Let’s learn more about this compound (cas:625-82-1).

Over the last decades, the use of photodynamic therapy (PDT) for the treatment of various types of cancer as well fungal, viral and bacterial infections has received increasing attention. Despite its clin. success, the currently approved photosensitizers (PSs) are associated with poor water solubility, aggregation, low photostability and a long excretion time. To overcome these limitations, much research is devoted towards the development of PSs based on transition metal complexes. However, the majority of metals used for this purpose are rare and expensive. Therefore, it would be of high interest to develop effective PDT PSs based on cheap and abundant metals. In this article, the use of Cu(II) and Ni(II) dipyrrin complexes as potential PDT PSs against cancer is presented. As required for PDT applications, these complexes were found to have a strong absorption in the green spectrum and to be stable in an aqueous solution in the dark as well as upon light irradiation Biol. studies revealed that the complexes have a very low cytotoxic effect in the dark with a slight effect upon irradiation at 510 nm in human cervical carcinoma (HeLa) cells.

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Reference:
Pyridine – Wikipedia,
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