Tag: M.W=0-100

Synthetic Route of 504-29-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 504-29-0, name is Pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Preparation 47 pyridine-2-amino-5-sulphonic Acid 2-Aminopyridine (80 g, 0.85 mol) was added portionwise over 30 minutes to oleum (320 g) and the resulting solution heated at 140 C. for 4 hours.. On cooling, the reaction was poured onto ice (200 g) and the mixture stirred in an ice/salt bath for a further 2 hours.. The resulting suspension was filtered, the solid washed with ice water (200 ml) and cold IMS (200 ml) and dried under suction to afford the title compound as a solid, (111.3 g). LRMS: m/z 175 (M+1)+.

According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc.; US6407114; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 108-99-6 ,Some common heterocyclic compound, 108-99-6, molecular formula is C6H7N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 2; The pelletized catalyst, TOSOH HSZ-690 HOD (SAR 203) with a silica binder, was ground to a coarse powder and screened to obtain a uniform size of 1-2 mm in diameter. A weight of 0.26 g of catalyst was charged into the reactor tube and glass wool (Pyrex) was used to secure it in place. Operating at a chlorine feed of 5 cc/min, a beta-picoline feed rate of 0.13 mg/min (10 cc/min N2 with a chiller temperature of 10 C.), the reagents were fed to the reactor at an initial temperature of 250 C. The system was initially ramped up to 325 C. and allowed to stablize. Under these conditions the product gases were 18.5% 3-trichloromethylpyridine (beta-tri ) and 65.4% beta-2-tet. When the system was allowed to stabilized at 350 C. the amount of beta-tri in the product gases was reduced to 2.6% and the conversion to beta-2-tet increased to 68.6% (see Table 2).; Example 3; The catalyst, TOSOH HSZ-690 HOD (SAR 203) with the silica binder, was sized to a uniform particle size of 1-2 mm in diameter. A weight of 0.26 g of catalyst was charged into the reactor tube and glass wool (Pyrex) was used to secure it in place. The reactor temperature was initially set to 250 C. prior to flowing chlorine at a rate of 5 cc/min. The beta-picoline feed rate was set to 0.13 mg/min (N2 flow 10 cc/min, chiller at 10 C.), while the reactor oven was ramped up to 350 C. over a one hour time period. At 350 C. the amount of beta-2-tet observed in the product gases was 65.6% (see Table 2).; Example 4; The catalyst, TOSOH HSZ-690 HOD (SAR 203) with the silica binder, was sized to a uniform particle size of 1-2 mm in diameter. A weight of 0.51 g of catalyst was charged into the reactor tube and glass wool (Pyrex) was used to secure it in place. The reactor temperature was initially set to 250 C. prior to flowing chlorine at a rate of 5 cc/min. The beta-picoline feed rate was set to 0.13 mg/min (chiller at 10 C.), with a nitrogen flow of 10 cc/min, while the reactor oven was ramped up to 350 C. over 2 hours. When the system had stabilized at 350 C. the amount of beta-2-tet observed in the product gases was 71.7% (see Table 2).; Example 5; The catalyst, TOSOH HSZ-690 HOD (SAR 203) with the silica binder, was sized to a uniform particle size of 1-2 mm. A weight of 0.51 g of catalyst was charged into the reactor tube and glass wool (Pyrex) was used to secure it in place. The reactor temperature was initially set to 250 C. prior to flowing chlorine at a rate of 5 cc/min. The beta-picoline feed rate was set to 0.25 mg/min (N2 at 10 cc/min, chiller at 20 C.), while the reactor oven was slowly ramped up to 350 C. over 2 hours. When the system had stabilized at 350 C. the amount of beta-2-tet observed in the product gases was 66.9% (see Table 2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-99-6, its application will become more common.

Reference:
Patent; Campbell, Kent Douglas; Livingston, Dana Alan; Wan, Hawk Suewah; Larson, Kenneth Michael; Schoeman, Brian John; Lakso, Steven Roy; US2005/240024; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 626-64-2 , The common heterocyclic compound, 626-64-2, name is Pyridin-4-ol, molecular formula is C5H5NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-Hydroxy pyridine (0.68g, 7.20mmol), 3,5-difluorobenzonitrile (0.5g, 3.60mmol), K2CO3 (1.73g, 12.6mmol) and DMF (15ml) were taken in a 50ml round bottom flask. The mixture was stirred constantly at 80C (Scheme 1). After 48h, heating was stopped and the reaction mixture was allowed to cool down at room temperature. After that, the mixture was poured into ice-cold water to obtain a white solid precipitate. It was filtered and air dried. Yield: 0.96g, (92%). SI-MS: [M+H], m/z: 290.0934 (100%) (calcd for C17H11N3O2, 289.0851) (Fig. S1). Anal. calcd. for C17H11N3O2: C, 70.59; H, 3.80; N, 14.53%. Found: C, 70.61; H, 3.82; N, 14.6% IR (cm-1, KBr pellet): 3426 (m), 3044 (m), 2943 (m) 2245 (m), 1651 (s), 1599 (s), 1443 (s), 1349 (s), 1248 (s), 1199 (s), 1090 (m), 892 (m), 843 (s), 690 (m), 557(m), 496 (m) (Fig. S2).

The synthetic route of 626-64-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Agarwal, Rashmi A.; De, Dinesh; Polyhedron; vol. 185; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 372-48-5 , The common heterocyclic compound, 372-48-5, name is 2-Fluoropyridine, molecular formula is C5H4FN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of diisopropylamine (104 g, 1 .03 mol) in dry THF (2.6 L) was added dropwise 2.5 M solution of pi-BuLi in hexane (392 mL, 0.98 mol) at -30 to -40C under N2. The resulting mixture was stirred at 0C for 35 min. The mixture was cooled to -70C and a solution of 2-fluoropyridine (I-25) (100 g, 1 .03 mol) in dry THF (800 mL) was added. After stirring at -70C for 2 hr, the mixture was added to a solution of l2 (261 .6 g, 1 .03 mol) in dry THF (800 mL) at -20C under N2. After the reaction was complete, the mixture was quenched with ice water (4 L). The mixture was diluted with EtOAc (4 L) and washed with aq. Na2S203 (500 mL) and brine (500 mL). The organic layer was dried over Na2S04 and concentrated in vacuo. The residue was purified by distillation in vacuum to afford 2-fluoro-3-iodopyridine (I-26) (140 g, 61 %) as a yellow solid.

The synthetic route of 372-48-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 504-29-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 504-29-0, name is Pyridin-2-amine, molecular formula is C5H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Aminopyridine (3.1g, 33mmol) and triethylamine(6.9mL, 49mmol) was dissolved in dichloromethane (40mL), 2,2-dimethylpropionyl chloride (4.5mL, 36mmol) was added on an ice bath, and the solution was stirred for 2 hours at the same temperature. Water was added thereto for extraction, the organic layer was sequentially washed with an aqueous solution of saturated sodium bicarbonate and brine, then, dried over anhydrous magnesium sulfate. The solvent was evaporated in vacuo, and the title compound (6.0g, 34mmol, 102%) was obtained as a white solid. 1H-NMR Spectrum (CDCl3) delta(ppm) :1.27 (9H, s), 7.03 (1H, ddd, J=1.1, 4.9, 7.3Hz), 7.68-7.72 (1 H, m), 8.02 (1 H, s), 8.23-8.27 (2H, m).

According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eisai Co., Ltd.; EP1669348; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-64-2, name is Pyridin-4-ol, the common compound, a new synthetic route is introduced below. SDS of cas: 626-64-2

General procedure: To a mixture of chlorinated derivatives of dihydropyrimidinonederivatives 4a-i (1 equiv.), potassium carbonate (2.5 equiv.) in acetonitrile,under 80 C was added different aryl/ heteroaryl alcohols(5a-k, 0.75 equiv.) and stirred under reflux till complete consumptionof the starting materials as determined by TLC. The solvent was thenremoved using rotary evaporator and extracted using ethyl acetate(25 mL×3) and water. The organic layer was concentrated under invacuo and the residue obtained was chromatographed on silica gel(elution with hexane/EtOAc=7:3-5:5) to provide the 2-oxo-6-(aryloxymethyl)-4-aryl/heteroaryl-1,2,3,4-tetrahydropyrimidine-5-carboxylatederivatives 6a-s in moderate to good yields.

The synthetic route of 626-64-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sana, Sravani; Tokala, Ramya; Bajaj, Deepti Madanlal; Nagesh, Narayana; Bokara, Kiran Kumar; Kiranmai, Gaddam; Lakshmi, Uppu Jaya; Vadlamani, Swapna; Talla, Venu; Shankaraiah, Nagula; Bioorganic Chemistry; vol. 93; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 108-99-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 108-99-6, name is 3-Methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

The catalyst was prepared by the method as described in Example 3 and process conditions were maintained as per Example 5 except that the process was carried out at large scale. The catalyst was packed as per Example 5 in a tubular reactor. Total volume of the reactor was 75 liters and equipped with heating and cooling arrangement. The catalyst bed was heated in the presence of air/nitrogen to 250 C. beta-picoline, water and air were fed separately through a vaporizer from top of the reactor. The molar feed ratio of oxygen:water:beta-picoline was 20:40:1 and WHSV was 0.05 hr-1. The nicotinic acid was isolated by the method as described in Example 4. The vent gases and scrubbed liquid obtained from secondary absorber and mother liquor of first absorber was recycled back in the process with optimum purge. The nicotinic acid obtained was white colored. Selectivity: 90.8%; beta-picoline conversion of 94.6%. Assay: 99.58%.

According to the analysis of related databases, 108-99-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JUBILANT LIFE SCIENCES LTD; US2012/65405; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 504-24-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 504-24-5 as follows.

A. 3-Iodopyridin-4ylamine. A solution of potassium iodide (19.48 g, 117.4 mmol) and iodine (18.37 g, 72.3 mmol) in water (77 ML) is added dropwise via an addition funnel to a refluxing solution of 4-aminopyridine (9.21 g, 97.8 mmol) and sodium carbonate (6.12 g, 57.7 mmol) in water (35 ML).Upon complete addition the mixture is stirred for 2 hours at reflux then cooled to room temperature and extracted with ethyl acetate.The combined organic layers are washed with saturated sodium thiosulfate solution (3*) and brine then dried over MgSO4, filtered and concentrated to give the title product (8.37 g, 38.0 mmol) and a trace of the di-iodo compound as an yellow/orange solid.This material is used in the subsequent step without further purification. 1H NMR (CDCl3, 300 MHz) delta8.70 (s, 1H), 8.10 (d, 1H), 6.55 (d, 1H), 4.60 (bs, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,504-24-5, its application will become more common.

Reference:
Patent; AVENTIS PHARMACEUTICALS INC.; US2004/102450; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 626-64-2, name is Pyridin-4-ol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H5NO

Step 36-1.; To a solution of 4-hydroxypyridine (T96-1, 7.0 g, 74 mmol) in CCl4 (360 mL) at rt was added NBS (26.2 g, 0.147 mol). The solution was stirred for 24 h in the dark (covered with aluminum foil). The mixture was concentrated under reduced pressure and the resulting residue triturated with MeOH, then with acetone to give 18.9 g (100%) of T96-2.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 626-64-2, Pyridin-4-ol.

Reference:
Patent; Marsault, Eric; Fraser, Graeme L.; Benakli, Kamel; St-Louis, Carl; Rouillard, Alain; Thomas, Helmut; US2010/93720; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 504-24-5, name is 4-Aminopyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H6N2

Example 25A 2,2-dimethyl-N-pyridin-4-ylpropanamide A mixture of 4-aminopyridine (10 g, 106 mmol) and pivaloyl chloride (12.9 g, 107 mmol) in 200 mL dichloromethane was cooled to 0 C. and treated slowly with triethylamine (10.9 g, 108 mmol), warmed to room temperature, stirred overnight, and diluted with water. The aqueous layer was extracted three times with dichloromethane and the combined extracts were washed with brine, dried (Na2SO4), filtered, and concentrated. The product was recrystallized from toluene to provide the desired product (14 g, 74%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 504-24-5, 4-Aminopyridine.

Reference:
Patent; Li, Qun; Woods, Keith W.; Zhu, Gui-Dong; Fischer, John P.; Gong, Jianchun; Li, Tongmei; Gandhi, Virajkumar; Thomas, Sheela A.; Packard, Garrick K.; Song, Xiaohong; Abrams, Jason N.; Diebold, Robert B.; Dinges, Jurgen; Hutchins, Charles W.; Stoll, Vincent S.; Rosenberg, Saul H.; Giranda, Vincent L.; US2003/199511; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem