Tag: M.W=100-150

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Visnagin and benzofuran scaffold-based molecules as selective cyclooxygenase-2 inhibitors with anti-inflammatory and analgesic properties: design, synthesis and molecular docking published in 2019.0. COA of Formula: C6H5NO, Reprint Addresses Arafa, RK (corresponding author), Zewail City Sci & Technol, Program Biomed Sci, Cairo 12578, Egypt.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A series of new visnagin and benzofuran scaffold-based molecules was designed and synthesized as anti-inflammatory and analgesic agents. Biological screening of these compounds showed that they exhibit potent anti-inflammatory/analgesic activity with a safer side effect profile in in vivo mouse models. In vitro cyclooxygenase (COX)inhibition assay showed that the compounds elicit their function through selective COX-2 inhibition. Molecular docking study also revealed the ability of the compounds to correctly recognize the active site and achieve noncovalent binding interactions with key residues therein. The best combined profile of anti-inflammatory, analgesic and COX-2 selective inhibition properties in association with low gastrotoxicity was displayed by the analogs 8, 11b and 19d, which can be considered as promising leads for further future optimization. [GRAPHICS] .

COA of Formula: C6H5NO. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 BIOORGAN MED CHEM published article about ALZHEIMERS-DISEASE; GSK-3 INHIBITORS; DESIGN; CANCER; GENE; COMBINATION; INDIRUBINS; METABOLISM; SIMULATION; EFFICIENT in [Lozinskaya, Natalia A.; Zaryanova, Ekaterina V.; Bezsonova, Elena N.; Borisov, Alexander V.; Tsymlyakov, Michael D.; Proskurnina, Marina V.] Lomonosov Moscow State Univ, Dept Chem, Leninskie Gory St 1, Moscow 119234, Russia; [Lozinskaya, Natalia A.; Anikina, Lada V.; Proskurnina, Marina V.] Russian Acad Sci, Inst Physiol Act Cpds, 1 Severnyi Proezd, Chernogolovka 142432, Russia; [Babkov, Denis A.; Zakharyascheva, Olga Yu.; Borisov, Alexander V.; Perfilova, Valentina N.; Tyurenkov, Ivan N.; Spasov, Alexander A.] Volgograd State Med Univ, Novorossiyskaya St 39, Volgograd 400087, Russia in 2019.0, Cited 49.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. SDS of cas: 500-22-1

Glycogen synthase kinase 3 beta (GSK-3 beta) is a widely investigated molecular target for numerous diseases including Alzheimer’s disease, cancer, and diabetes mellitus. Inhibition of GSK-3 beta activity has become an attractive approach for treatment of diabetes and cancer. We report the discovery of novel GSK-3 beta inhibitors of 3-arylidene-2-oxindole scaffold with promising activity. The most potent compound 3a inhibits GSK-3 beta with IC(50 )4.19 nM. In a cell-based assay 3a shows no significant leucocyte toxicity at 10 mu M and is moderately cytotoxic against A549 cells. Compound 3a demonstrated high antidiabetic efficacy in obese streptozotocin-treated rats improving glucose tolerance at a dose of 50 mg/kg body weight thus representing an interesting lead for further optimization.

SDS of cas: 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Lozinskaya, NA; Babkov, DA; Zaryanova, EV; Bezsonova, EN; Borisov, AV; Tsymlyakov, MD; Anikina, LV; Zakharyascheva, OY; Borisov, AV; Perfilova, VN; Tyurenkov, IN; Proskurnina, MV; Spasov, AA or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Microwave-assisted synthesis and antibacterial propensity of N ‘-s-benzylidene-2-propylquinoline-4-carbohydrazide and N ‘-((s-1H-pyrrol-2-yl)methylene)-2-propylquinoline-4-carbohydrazide motifs WOS:000505076000135 published article about QUINOLINE DERIVATIVES; ESCHERICHIA-COLI; BINDING; MECHANISMS; RESISTANCE; DOCKING; OVENS in [Ajani, Olayinka O.; Iyaye, King T.; Aderohunmu, Damilola V.; Olanrewaju, Ifedolapo O.] Covenant Univ, Dept Chem, CST, Km 10 Idiroko Rd,PMB 1023, Ota, Ogun State, Nigeria; [Germann, Markus W.; Bello, Babatunde L.] Georgia State Univ, Dept Chem, Atlanta, GA 30302 USA; [Olorunshola, Shade J.] Covenant Univ, Dept Biol Sci, CST, Km 10 Idiroko Rd,PMB 1023, Ota, Ogun State, Nigeria in 2020.0, Cited 53.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. COA of Formula: C6H5NO

Microwave-assisted approach was utilized as green approach to access a series of 2-pro pylquinoline-4-carbohydrazide hydrazone derivatives 10a-j of aromatic and heteroaromatic aldehydes in highly encouraging yields. It involved four steps reaction which was initiated with ring opening reaction of isatin in a basified environment and subsequent cross-coupling with pentan-2-one to produce compound 7. Esterification of 7 in acid medium led to the formation of compound 8 which was reacted with hydrazine hydrate to access 9 which upon microwave-assisted condensed with aromatic and heteroaromatic aldehydes furnished the targeted compounds 10a-j. The structures of 10aj were confirmed by physico-chemical, elemental analyses and spectroscopic characterization which include UV, FT-IR, H-1 and C-13 NMR as well as DEPT-135. The targeted compounds 10a-j, alongside with gentamicin clinical standard, were investigated for their antibacterial efficacies using agar diffusion method. 2-Propyl-N’-(pyridine-3-ylmethylene) quinoline-4-carbohydrazide 10j emerged as the best antibacterial hydrazide-hydrazone with lowest MIC value of 0.39 +/- 0.02 – 1.56 +/- 0.02 mu g/ mL across all the organisms screened. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.

COA of Formula: C6H5NO. Welcome to talk about 500-22-1, If you have any questions, you can contact Ajani, OO; Iyaye, KT; Aderohunmu, DV; Olanrewaju, IO; Germann, MW; Olorunshola, SJ; Bello, BL or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article The synthesis of blue emitting 3-Amino-l-hetarylfluorenes and their unprecedented alkylated derivatives WOS:000485335600003 published article about SELECTIVE HYDROGENATION; EFFICIENT SYNTHESIS; FLUORENE; ARYLIDENEMALONODINITRILES; NANOPARTICLES; REDUCTION; CATALYSTS; ALCOHOLS; NITRO in [Yalcin, Ergin] Iskenderun Tech Univ, Dept Engn Basic Sci, TR-31200 Antakya, Turkey; [Yalcin, Ergin; Duyar, Halil; Cakmaz, Deniz; Seferoglu, Zeynel] Gazi Univ, Dept Chem, TR-06500 Ankara, Turkey; [Sahin, Ertan] Ataturk Univ, Dept Chem, TR-25240 Erzurum, Turkey in 2019.0, Cited 38.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Safety of 3-Pyridinecarboxaldehyde

Novel 3-Amino-1-hetarylfluorene derivatives have medicinal uses and challenging transformation in organic synthesis have been synthesized via decyanation process. Surprisingly, the alkylated compounds derived from 3-Amino-1-hetarylfluorenes were obtained via further nucleophilic substitution to the 9-C and 3-N positions of the fluorene ring because of the harsh reaction condition employed. The synthesized compounds were characterized by spectroscopic techniques as well as X-ray single crystal diffraction analysis. This new family of blue emitting fluorene derivatives have low to moderate quantum yields (the largest value of Phi(F) = 0.52 for compound 15). (C) 2019 Elsevier Ltd. All rights reserved.

Safety of 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 500-22-1. Recently I am researching about FRUSTRATED LEWIS PAIRS; METAL-FREE HYDROGENATIONS; DERIVATIVES; ANTAGONISTS; REDUCTION; INSIGHTS; KETONES, Saw an article supported by the Natural Science Foundation of Zhejiang Province of ChinaNatural Science Foundation of Zhejiang Province [LY19B060011]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21676253, 21706234]. Published in WILEY in HOBOKEN ,Authors: Ling, F; Chen, JC; Xie, Z; Hou, HC; Pan, ZT; Feng, C; Shen, HW; Zhong, WH. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A metal-free method to construct quinoline derivatives via B(C6F5)(3)-catalyzed cyclization of anilines with aldehyde derivatives and pyruvates is described. This three-component cascade reaction provides an efficient approach for the easy access to various substituted quinoline-4-carboxylic esters with 71% to 92% yield. The utility of this methodology was further demonstrated by gram-scale formal synthesis of the antimalarial drug DDD107498.

SDS of cas: 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Ling, F; Chen, JC; Xie, Z; Hou, HC; Pan, ZT; Feng, C; Shen, HW; Zhong, WH or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Visnagin and benzofuran scaffold-based molecules as selective cyclooxygenase-2 inhibitors with anti-inflammatory and analgesic properties: design, synthesis and molecular docking published in 2019.0. COA of Formula: C6H5NO, Reprint Addresses Arafa, RK (corresponding author), Zewail City Sci & Technol, Program Biomed Sci, Cairo 12578, Egypt.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A series of new visnagin and benzofuran scaffold-based molecules was designed and synthesized as anti-inflammatory and analgesic agents. Biological screening of these compounds showed that they exhibit potent anti-inflammatory/analgesic activity with a safer side effect profile in in vivo mouse models. In vitro cyclooxygenase (COX)inhibition assay showed that the compounds elicit their function through selective COX-2 inhibition. Molecular docking study also revealed the ability of the compounds to correctly recognize the active site and achieve noncovalent binding interactions with key residues therein. The best combined profile of anti-inflammatory, analgesic and COX-2 selective inhibition properties in association with low gastrotoxicity was displayed by the analogs 8, 11b and 19d, which can be considered as promising leads for further future optimization. [GRAPHICS] .

COA of Formula: C6H5NO. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 BIOORGAN MED CHEM published article about ALZHEIMERS-DISEASE; GSK-3 INHIBITORS; DESIGN; CANCER; GENE; COMBINATION; INDIRUBINS; METABOLISM; SIMULATION; EFFICIENT in [Lozinskaya, Natalia A.; Zaryanova, Ekaterina V.; Bezsonova, Elena N.; Borisov, Alexander V.; Tsymlyakov, Michael D.; Proskurnina, Marina V.] Lomonosov Moscow State Univ, Dept Chem, Leninskie Gory St 1, Moscow 119234, Russia; [Lozinskaya, Natalia A.; Anikina, Lada V.; Proskurnina, Marina V.] Russian Acad Sci, Inst Physiol Act Cpds, 1 Severnyi Proezd, Chernogolovka 142432, Russia; [Babkov, Denis A.; Zakharyascheva, Olga Yu.; Borisov, Alexander V.; Perfilova, Valentina N.; Tyurenkov, Ivan N.; Spasov, Alexander A.] Volgograd State Med Univ, Novorossiyskaya St 39, Volgograd 400087, Russia in 2019.0, Cited 49.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. SDS of cas: 500-22-1

Glycogen synthase kinase 3 beta (GSK-3 beta) is a widely investigated molecular target for numerous diseases including Alzheimer’s disease, cancer, and diabetes mellitus. Inhibition of GSK-3 beta activity has become an attractive approach for treatment of diabetes and cancer. We report the discovery of novel GSK-3 beta inhibitors of 3-arylidene-2-oxindole scaffold with promising activity. The most potent compound 3a inhibits GSK-3 beta with IC(50 )4.19 nM. In a cell-based assay 3a shows no significant leucocyte toxicity at 10 mu M and is moderately cytotoxic against A549 cells. Compound 3a demonstrated high antidiabetic efficacy in obese streptozotocin-treated rats improving glucose tolerance at a dose of 50 mg/kg body weight thus representing an interesting lead for further optimization.

SDS of cas: 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Lozinskaya, NA; Babkov, DA; Zaryanova, EV; Bezsonova, EN; Borisov, AV; Tsymlyakov, MD; Anikina, LV; Zakharyascheva, OY; Borisov, AV; Perfilova, VN; Tyurenkov, IN; Proskurnina, MV; Spasov, AA or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of 3-Pyridinecarboxaldehyde. Prismawan, D; van der Vlag, R; Guo, H; Dekker, FJ; Hirsch, AKH in [Prismawan, Deka; van der Vlag, Ramon; Hirsch, Anna K. H.] Univ Groningen, Stratingh Inst Chem, Nijenborgh 7, NL-9747 AG Groningen, Netherlands; [Prismawan, Deka; Guo, Hao; Dekker, Frank J.] Univ Groningen, GRIP, Chem & Pharmaceut Biol, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands; [Hirsch, Anna K. H.] Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, Dept Drug Design & Optimizat, Campus Bldg E8-1, DE-66123 Saarbrucken, Germany; [Hirsch, Anna K. H.] Saarland Univ, Dept Pharm, DE-66123 Saarbrucken, Germany published Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry in 2019.0, Cited 21.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Human 15-lipoxygenase-1 (15-LOX-1) belongs to the class of lipoxygenases, which catalyze oxygenation of polyunsaturated fatty acids, such as arachidonic and linoleic acid. Recent studies have shown that 15-LOX-1 plays an important role in physiological processes linked to several diseases such as airway inflammation disease, coronary artery disease, and several types of cancer such as rectal, colon, breast and prostate cancer. In this study, we aimed to extend the structural diversity of 15-LOX-1 inhibitors, starting from the recently identified indolyl core. In order to find new scaffolds, we employed a combinatorial approach using various aromatic aldehydes and an aliphatic hydrazide tail. This scaffold-hopping study resulted in the identification of the 3-pyridylring as a suitable replacement of the indolyl core with an inhibitory activity in the micromolar range (IC50=16 +/- 6m) and a rapid and efficient structure-activity relationship investigation.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Formula: C6H5NO. In 2020.0 CHEM-US published article about MUKAIYAMA-MICHAEL REACTIONS; SILYL ENOL ETHERS; ASYMMETRIC ALDOL; INTERMOLECULAR ADDITION; PROTODEAURATION STEP; EFFICIENT SYNTHESIS; PROPARGYLIC ESTERS; CARBONYL-COMPOUNDS; REACTION 40YEARS; REACTIVITY in [Yuan, Teng; Ye, Xiaohan; Teng, Shun; Wang, Jin; Shan, Chuan; Wojtas, Lukasz; Jean, Jonathan; Shi, Xiaodong] Univ S Florida, Dept Chem, Tampa, FL 33620 USA; [Zhao, Pengyi; Chen, Hao] New Jersey Inst Technol, Dept Chem & Environm Sci, Newark, NJ 07102 USA; [Yi, Yaping] Tsinghua Univ, Dept Chem, Beijing, Peoples R China in 2020.0, Cited 93.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A synergistic gold-iron (Au-Fe) catalytic system was developed for sequential alkyne hydration and vinyl Au addition to aldehydes or ketones. Fe(acac)(3) was identified as an essential co-catalyst in preventing vinyl Au protodeauration and facilitating nucleophilic additions. Effective C-C bond formation was achieved under mild conditions (room temperature) with excellent regioselectivity and high efficiency (1% [Au], up to 95% yields). The intramolecular reaction was also achieved, giving successful macrocyclization (16-31 ring sizes) with excellent yields (up to 90%, gram scale) without extended dilution (0.2 M), which highlights the great potential of this new crossed aldol strategy in challenging target molecule synthesis.

Welcome to talk about 500-22-1, If you have any questions, you can contact Yuan, T; Ye, XH; Zhao, PY; Teng, S; Yi, YP; Wang, J; Shan, C; Wojtas, L; Jean, J; Chen, H; Shi, X or send Email.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 TETRAHEDRON LETT published article about ASYMMETRIC TRANSFER HYDROGENATION; NONCONVENTIONAL METHODOLOGIES; COUPLING REACTIONS; RADICAL-ADDITION; ALKYLATION; 4-ALKYL-1,4-DIHYDROPYRIDINES; TRIFLUOROMETHYLATION; ALKENYLATION; CLEAVAGE; ALCOHOLS in [Zhang, Siyu; Li, Yaming; Wang, Jiaao; Hao, Xinyu; Jin, Kun; Zhang, Rong; Duan, Chunying] Dalian Univ Technol, Sch Chem Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China in 2020.0, Cited 50.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

A photocatalyst-free stereoselectively photo-induced strategy for the denitroalkylation of beta-nitrostyrenes using 4-alkyl substituted Hantzsch esters as the alkyl source under xenon lamp irradiation is developed. The reaction proceeds at room temperature and affords the corresponding products in moderate to excellent yields. The oxidant di-t-butyl peroxide serves as an efficient radical initiator under irradiation of a Xenon lamp, initiating alkyl radicals from the 4-alkyl substituted Hantzsch esters. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Zhang, SY; Li, YM; Wang, JA; Hao, XY; Jin, K; Zhang, R; Duan, CY or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem