Tag: M.W=100-150

In 2019.0 ANTI-CANCER AGENT ME published article about ACRIDINE-DERIVATIVES; ANTIOXIDANT; POTENT; AGENTS in [Kalirajan, R.; Gaurav, K.; Pandiselvi, A.; Gowramma, B.; Sankar, S.] Deemed Univ, Constituent Coll JSS Acad Higher Educ & Res, Dept Pharmaceut Chem, JSS Coll Pharm, Udhagamandalam 643001, Tamil Nadu, India in 2019.0, Cited 26.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Name: 3-Pyridinecarboxaldehyde

Background: 9-anilinoacridines are acting as DNA-intercalating agents which plays an important role as antitumor drugs, due to their anti-proliferative properties. Some anticancer agents contain 9-anilinoacridines such as amsacrine (m-AMSA), and nitracrine (Ledakrine) have been already developed. Methods: In this study, novel 9-anilinoacridines substituted with thiazines 4a-r were designed, synthesized, characterized by physical and spectral data and their cytotoxic activities against DLA cell lines were evaluated. Results: Among those compounds, 4b, c, e, g, i, j, k, m, o, p, q, r exhibited significant short term in vitro cytotoxic activity against Daltons lymphoma ascites (DLA) cells with CTC50 value of 0.18 to 0.31 mu M. The compounds 4b, c, e, g, y j, k, m, o, p, q, r are also exhibited significant long term in vitro anti-tumour activity against human tumor cell lines, HEp-2 (laryngeal epithelial carcinoma) by Sulforhodamine B assay with CTC50 value of 0.20 to 0.39 mu M. The compounds 4b, i, j exhibited significant in vivo antitumor activity with % Increase in Life Span (ILS) 48-82%. Conclusion: Results obtained in this study clearly demonstrated that many of the thiazine substituted 9-anilinoacridines exert interesting anti-tumour activity. The compounds 4b, i, j have significant anti-tumour activity and useful drugs after further refinement. The above derivatives will encourage to design future antitumor agents with high therapeutic potentials.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 ORG BIOMOL CHEM published article about DONOR-ACCEPTOR CYCLOPROPANES; ENANTIOSELECTIVE SYNTHESIS; ALLYLIC ALCOHOLS; CHEMISTRY; FLUORINE; ACID; DERIVATIVES; OLEFINS; ROUTE; ZINC in [Kazia, Armands; Melngaile, Renate; Mishnev, Anatoly; Veliks, Janis] Latvian Inst Organ Synth, Aizkraukles 21, LV-1006 Riga, Latvia in 2020.0, Cited 44.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Formula: C6H5NO

Johnson-Corey-Chaykovsky fluorocyclopropanation of double activated alkenes utilizing S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium tetrafluoroborate is an efficient approach to obtain a range of monofluorocyclopropane derivatives. So far, fluoromethylsulfonium salts have displayed the broadest scope for direct fluoromethylene transfer. In contrast to more commonly used fluorohalomethanes or freon derivatives, diarylfluoromethylsulfonium salts are bench stable, easy-to use reagents useful for the direct transfer of a fluoromethylene group to alkenes giving access to the challenging products – fluorocyclopropane derivatives. Interplay between the reactivity of the starting materials and stability of the fluorocyclopropanes formed determines the outcome of the process.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Structure-Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents WOS:000495757700001 published article about CAFFEIC ACID-ESTERS; ANTILEISHMANIAL ACTIVITIES; TRYPANOSOMA-BRUCEI; PHENOLIC-COMPOUNDS; IN-VITRO; ASSAY; ESTERIFICATION; RHODESIENSE; SENSITIVITY; CATALYSTS in [Bernal, Freddy A.; Schmidt, Thomas J.] Westfalische Wilhelms Univ Munster, IPBP, Corrensstr 48, D-48149 Munster, Germany; [Kaiser, Marcel] Swiss Trop & Publ Hlth Inst Swiss TPH, Socinstr 57, CH-4051 Basel, Switzerland; [Kaiser, Marcel] Univ Basel, Peterspl 1, CH-4003 Basel, Switzerland; [Wuensch, Bernhard] Westfalische Wilhelms Univ Munster, Inst Pharmazeut & Med Chem, Corrensstr 48, D-8149 Munster, Germany in 2020.0, Cited 51.0. Recommanded Product: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Protozoal infections are still a global health problem, threatening the lives of millions of people around the world, mainly in impoverished tropical and sub-tropical regions. Thus, in view of the lack of efficient therapies and increasing resistances against existing drugs, this study describes the antiprotozoal potential of synthetic cinnamate ester analogues and their structure-activity relationships. In general, Leishmania donovani and Trypanosoma brucei were quite susceptible to the compounds in a structure-dependent manner. Detailed analysis revealed a key role of the substitution pattern on the aromatic ring and a marked effect of the side chain on the activity against these two parasites. The high antileishmanial potency and remarkable selectivity of the nitro-aromatic derivatives suggested them as promising candidates for further studies. On the other hand, the high in vitro potency of catechol-type compounds against T. brucei could not be extrapolated to an in vivo mouse model.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis of novel 4,5-dihydropyrrolo[1,2-a]quinoxalines, pyrrolo[1,2-a]quinoxalin]-2-ones and their antituberculosis and anticancer activity published in 2020.0, Reprint Addresses Rode, HB (corresponding author), CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, Telangana, India.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

A facile strategy was developed for the synthesis of biologically important 4,5-dihydropyrrolo[1,2-a]quinoxalines and pyrrolo[1,2-a]quinoxalin]-2-ones by treating 2-(1H-pyrrol-1-yl)anilines with imidazo[1,2-a]pyridine-3-carbaldehyde or isatin, using amidosulfonic acid (NH3SO3) as a solid catalyst in water at room temperature. The protocol has been extended to electrophile ninhydrin. The catalyst could be recycled for six times without the loss of activity. The compounds were evaluated for their antituberculosis, antibacterial, and anticancer activities. It is worth noting that compounds3dand3edemonstrated a minimum inhibitory concentration value of 6.25 mu M againstMycobacterium tuberculosisH37Rv, whereas compounds3d,3g,5d,5e, and5ishowed a remarkable inhibition of A549, DU145, HeLa, HepG2, MCF-7, and B16-F10 cell lines, respectively.Staphylococcus aureuswas inhibited by compounds5b,5e,5d,5g, and5lat 32 mu g/ml.

Category: pyridine-derivatives. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines WOS:000470996600117 published article about MULTICOMPONENT REACTIONS; CHEMISTRY; ISOCYANIDES; DISCOVERY; MECHANISM; REVEALS; BIOLOGY; IMINES in [Galli, Ubaldina; Hysenlika, Rejdia; Del Grosso, Erika; Tron, Gian Cesare] Univ Piemonte Orientale, Dipartimento Sci Farmaco, I-28100 Novara, Italy; [Meneghetti, Fiorella] Univ Milan, Dipartimento Sci Farmaceut, I-20133 Milan, Italy; [Pelliccia, Sveva; Novellino, Ettore; Giustiniano, Mariateresa] Univ Napoli Federico II, Dipartimento Farm, I-80131 Naples, Italy in 2019.0, Cited 38.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 500-22-1

A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine derivatives in excellent yields. The imidazole nitrogen atom was able to intercept the nascent nitrilium ion, channeling the reaction toward to the sole formation of imidazopyrazines, suppressing the competitive formation of other possible side products deriving from the reaction with the high-energy nitrilium ion. The number of examples and the variability of the nature of isocyanides, aldehydes, and amine components herein employed, witness the robustness of this novel methodology.

Recommanded Product: 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Galli, U; Hysenlika, R; Meneghetti, F; Del Grosso, E; Pelliccia, S; Novellino, E; Giustiniano, M; Tron, GC or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of 3-Pyridinecarboxaldehyde. I found the field of Biochemistry & Molecular Biology very interesting. Saw the article N-Benzyl Derivatives of Long-Chained 4-Amino-7-chloro-quionolines as Inhibitors of Pyocyanin Production in Pseudomonas aeruginosa published in 2019.0, Reprint Addresses Opsenica, DM; Senerovic, L (corresponding author), Univ Belgrade, Inst Mol Genet & Genet Engn, Vojvode Stepe 444a, Belgrade 11010, Serbia.; Opsenica, DM (corresponding author), Univ Belgrade, ICTM, Ctr Excellence Environm Chem & Engn, Belgrade 11000, Serbia.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Pseudomonas aeruginosa is a leading cause of nosocomial infections that are becoming increasingly difficult to treat due to the occurrence of antibiotic resistant strains. Since P. aeruginosa virulence is controlled through quorum sensing, small molecule treatments inhibiting quorum sensing signaling pathways provide a promising therapeutic option. Consequently, we synthesized a series of N-octaneamino-4-aminoquinoline derivatives to optimize this chemotype’s antivirulence activity against P. aeruginosa via inhibition of pyocyanin production. The most potent derivative, which possesses a benzofuran substituent, provided effective inhibition of pyocyanin production (IC50 = 12 mu M), biofilm formation (BFIC50 = 50 mu M), and motility. Experimentally, the compound’s activity is achieved through competitive inhibition of PqsR, and structure-activity data were rationalized using molecular docking studies.

Welcome to talk about 500-22-1, If you have any questions, you can contact Aleksic, I; Jeremic, J; Milivojevic, D; Ilic-Tomic, T; Segan, S; Zlatovic, M; Opsenica, DM; Senerovic, L or send Email.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Kazemnejadi, M; Sharafi, Z; Mahmoudi, B; Zeinali, A; Nasseri, MA in SPRINGER published article about ONE-POT SYNTHESIS; FRIEDLANDER SYNTHESIS; NANOPARTICLES; COMPLEX; SURFACE; ACID; NANOCATALYST; DERIVATIVES; QUINOLINES; PHOSPHINE in [Kazemnejadi, Milad; Zeinali, Atefeh; Nasseri, Mohammad Ali] Univ Birjand, Dept Chem, Fac Sci, Birjand 97175615, Iran; [Sharafi, Zeinab] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran; [Mahmoudi, Boshra] Sulaimani Polytech Univ, Res Ctr, Sulaimani 46001, Kurdistan Regio, Iraq in 2020.0, Cited 48.0. Computed Properties of C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A new, cheap, and accessible method has been used for the preparation of nano-belts from the chemical decomposition (top-down approach) of a cheap stainless steel screw and found as an efficient magnetically recyclable nanocatalyst for the preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild reaction conditions. The nano-belts, Fe-Cr-Ni oxide alloy, was prepared in a two-step synthesis and characterized with various instrumental methods. Due to magnetic property of the screw (a ferritic-alloy), the resultant nano-belts is magnetic. Magnetic Fe-Cr-Ni alloy nano-belts were applied toward efficient preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild conditions. The catalyst could be readily recovered and recycled for several consecutive runs, while it suffers from a very low metal leaching and subsequently efficiency drop. Graphic abstract

Welcome to talk about 500-22-1, If you have any questions, you can contact Kazemnejadi, M; Sharafi, Z; Mahmoudi, B; Zeinali, A; Nasseri, MA or send Email.. Computed Properties of C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 J MED CHEM published article about NATURAL-PRODUCTS; INTRACELLULAR ZINC; CORRELATION-ENERGY; IRON CHELATORS; CELL-GROWTH; DNA-DAMAGE; APOPTOSIS; COMPLEXES; DEPLETION; ANALOGS in [Galiana-Rosello, Cristina; Gonzalez, Jorge; Martinez-Camarena, Alvaro; Garcia-Espana, Enrique] Univ Valencia, Inst Ciencia Mol ICMol, Dept Quim Inorgan, Valencia 46980, Spain; [Galiana-Rosello, Cristina; Eugenia Gonzalez-Rosende, Maria] Univ CEU Cardenal Herrera, Fac Ciencias Salud, Dept Farm, C Ramon y Cajal S-N, Valencia 46115, Spain; [Galiana-Rosello, Cristina; Fernandez de Mattos, Silvia; Villalonga, Priam] Univ Illes Balears, Inst Univ Invest Ctencies Salut IUNICS, Canc Cell Biol Lab, Illes Balears 07122, Spain; [Galiana-Rosello, Cristina; Fernandez de Mattos, Silvia; Villalonga, Priam] Inst Invest Sanitaria Illes Balears IdISBa, Illes Balears 07122, Spain; [Villalonga, Ruth] Univ Illes Balears, Dept Quim, Illes Balears 07122, Spain; [Fernandez de Mattos, Silvia] Univ Illes Balears, Dept Biol Fonamental, Illes Balears 07122, Spain; [Soriano, Concepcion; Llinares, Jose] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain in 2020.0, Cited 79.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Category: pyridine-derivatives

In vitro viability assays against a representative panel of human cancer cell lines revealed that polyamines L1a and L5a displayed remarkable activity with IC50 values in the micromolar range. Preliminary research indicated that both compounds promoted G1 cell cycle arrest followed by cellular senescence and apoptosis. The induction of apoptotic cell death involved loss of mitochondrial outer membrane permeability and activation of caspases 3/7. Interestingly, L1a and L5a failed to activate cellular DNA damage response. The high intracellular zinc-chelating capacity of both compounds, deduced from the metal specific Zinquin assay and ZnL2+ stability constant values in solution, strongly supports their cytotoxicity. These data along with quantum mechanical studies have enabled to establish a precise structure-activity relationship. Moreover, L1a and L5a showed appropriate drug-likeness by in silico methods. Based on these promising results, L1a and L5a should be considered a new class of zinc-chelating anticancer agents that deserves further development.

Category: pyridine-derivatives. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 RUSS CHEM B+ published article about HYDRAZONES in [Gorodnicheva, N. V.; Vasil’eva, O. S.; Ostroglyadov, E. S.; Baichurin, R. I.; Makarenko, S. V.] Herzen State Pedag Univ Russia, 48 Nab R Moiki, St Petersburg 191186, Russia; [Karamov, F. A.] Kazan Natl Res Tech Univ, 10 Ul K Marksa, Kazan 420111, Russia; [Lodochnikova, O. A.; Litvinov, I. A.] Russian Acad Sci, Kazan Sci Ctr, Fed Res Ctr, AE Arbuzov Inst Organ & Phys Chem, 8 Ul Akad Arbuzova, Kazan 420088, Russia in 2020.0, Cited 25.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. SDS of cas: 500-22-1

4-Het(aryl)-2-pyrrolidone-3(5)-carboxylic acid hydrazides react with aromatic aldehydes, acetone, and acetophenone to give new representatives of N ‘-alkyl(hetaryl)idenecarbohydrazides of (3R*,4S*)-4-het(aryl)-2-pyrrolidone-3- and (4R*,5R*)-4-het(aryl)-2-pyrrolidone-5-carboxylic acids.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Gorodnicheva, NV; Vasil’eva, OS; Ostroglyadov, ES; Baichurin, RI; Makarenko, SV; Karamov, FA; Lodochnikova, OA; Litvinov, IA or concate me.. SDS of cas: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Microwave-assisted synthesis and antibacterial propensity of N ‘-s-benzylidene-2-propylquinoline-4-carbohydrazide and N ‘-((s-1H-pyrrol-2-yl)methylene)-2-propylquinoline-4-carbohydrazide motifs WOS:000505076000135 published article about QUINOLINE DERIVATIVES; ESCHERICHIA-COLI; BINDING; MECHANISMS; RESISTANCE; DOCKING; OVENS in [Ajani, Olayinka O.; Iyaye, King T.; Aderohunmu, Damilola V.; Olanrewaju, Ifedolapo O.] Covenant Univ, Dept Chem, CST, Km 10 Idiroko Rd,PMB 1023, Ota, Ogun State, Nigeria; [Germann, Markus W.; Bello, Babatunde L.] Georgia State Univ, Dept Chem, Atlanta, GA 30302 USA; [Olorunshola, Shade J.] Covenant Univ, Dept Biol Sci, CST, Km 10 Idiroko Rd,PMB 1023, Ota, Ogun State, Nigeria in 2020.0, Cited 53.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

Microwave-assisted approach was utilized as green approach to access a series of 2-pro pylquinoline-4-carbohydrazide hydrazone derivatives 10a-j of aromatic and heteroaromatic aldehydes in highly encouraging yields. It involved four steps reaction which was initiated with ring opening reaction of isatin in a basified environment and subsequent cross-coupling with pentan-2-one to produce compound 7. Esterification of 7 in acid medium led to the formation of compound 8 which was reacted with hydrazine hydrate to access 9 which upon microwave-assisted condensed with aromatic and heteroaromatic aldehydes furnished the targeted compounds 10a-j. The structures of 10aj were confirmed by physico-chemical, elemental analyses and spectroscopic characterization which include UV, FT-IR, H-1 and C-13 NMR as well as DEPT-135. The targeted compounds 10a-j, alongside with gentamicin clinical standard, were investigated for their antibacterial efficacies using agar diffusion method. 2-Propyl-N’-(pyridine-3-ylmethylene) quinoline-4-carbohydrazide 10j emerged as the best antibacterial hydrazide-hydrazone with lowest MIC value of 0.39 +/- 0.02 – 1.56 +/- 0.02 mu g/ mL across all the organisms screened. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.

Welcome to talk about 500-22-1, If you have any questions, you can contact Ajani, OO; Iyaye, KT; Aderohunmu, DV; Olanrewaju, IO; Germann, MW; Olorunshola, SJ; Bello, BL or send Email.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem