Lee, Dong-Hwan’s team published research in Green Chemistry in 12 | CAS: 197958-29-5

Green Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Recommanded Product: 2-Pyridinylboronic acid.

Lee, Dong-Hwan published the artcileHighly active and recyclable silica gel-supported palladium catalyst for mild cross-coupling reactions of unactivated heteroaryl chlorides, Recommanded Product: 2-Pyridinylboronic acid, the publication is Green Chemistry (2010), 12(11), 2024-2029, database is CAplus.

Silica gel-supported β-ketoiminatophosphane-Pd complex (Pd@O2) was shown to be a highly active and long-lived catalyst for aqueous Suzuki, Stille and Sonogashira coupling reactions of heteroaryl chlorides. A wide range of heteroaryl chlorides could be efficiently coupled with different nucleophilic partners in the presence of only 0.5 mol% catalyst and under mild conditions. This is one of the most powerful heterogeneous catalysts for the couplings of diverse heteroaryl chlorides. Furthermore, the catalyst could be reused with almost consistent activity.

Green Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Recommanded Product: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Krah, Sabrina’s team published research in ChemCatChem in 14 | CAS: 197958-29-5

ChemCatChem published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Krah, Sabrina published the artcileElectron-Rich Silicon Containing Phosphinanes for Rapid Pd-Catalyzed C-X Coupling Reactions, Formula: C5H6BNO2, the publication is ChemCatChem (2022), 14(16), e202200734, database is CAplus.

Novel silicon-containing phosphine, 4,1-phosphasilinane 2-TripC6H4P(CH2CH2)2SiMe2 (SabPhos, Trip = 2,4,6-iPr3C6H2) was prepared as a ligand for palladium-catalyzed coupling reactions. Palladium-catalyzed cross-coupling reactions are among the most useful and efficient methods for direct access to complex structures in organic synthesis. However, heteroatom-containing compounds can complicate such coupling reactions due to their competitive coordination with the palladium catalyst and electronic effects. As a result, good yields are often only obtained under harsher reaction conditions, such as high temperatures and long reaction times. Here the design of a highly active phosphine ligand is reported that provides excellent yields for C-N coupling reactions at ambient temperature Incorporation of the phosphorus atom into a cyclohexane ring maintains the pyramidal structure of the phosphorus while reducing steric hindrance. This, and a silicon atom in the cyclohexane moiety, results in an electron-rich phosphinane ligand. This novel silicon containing SabPhos ligand can be obtained in excellent yields in a straightforward synthesis. In palladium catalyzed reactions, this ligand facilitates the coupling of a broad range of heteroaryl chlorides via C-C bonds with boronic acids and C-N bonds with secondary amines in excellent yields under mild conditions.

ChemCatChem published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Malinowski, Marek’s team published research in Journal fuer Praktische Chemie (Leipzig) in 330 | CAS: 18437-58-6

Journal fuer Praktische Chemie (Leipzig) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, HPLC of Formula: 18437-58-6.

Malinowski, Marek published the artcileTitanium(0) reagents. III. A convenient preparation of 4-pyridinamine derivatives, HPLC of Formula: 18437-58-6, the publication is Journal fuer Praktische Chemie (Leipzig) (1988), 330(1), 154-8, database is CAplus.

Ti(0) slurry, easily accessible by the reduction of TiCl4 with LiAlH4 or Mg in THF, is an excellent reagent for the reduction of N-nitropyridine N-oxides, e.g., I (R = H, Me, F, Cl) to 4-aminopyridines, e.g., II. The reaction proceeds smoothly and fast at room temperature giving the amines in >90% yields.

Journal fuer Praktische Chemie (Leipzig) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, HPLC of Formula: 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sankar, Velayudham’s team published research in Advanced Synthesis & Catalysis in 362 | CAS: 18437-58-6

Advanced Synthesis & Catalysis published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Sankar, Velayudham published the artcileZinc-Catalyzed N-Alkylation of Aromatic Amines with Alcohols: A Ligand-Free Approach, Category: pyridine-derivatives, the publication is Advanced Synthesis & Catalysis (2020), 362(20), 4409-4414, database is CAplus.

An efficient zinc-catalyzed N-alkylation reaction of aromatic amines was achieved using aliphatic, aromatic and heteroaromatic alcs. as the alkylating reagent. A variety of aniline derivatives, including heteroaromatic amines, underwent the N-alkylation reaction and furnished N-alkyl amines in good to excellent yields. The application of reaction was also further demonstrated by the synthesis of 2-phenylquinoline from acetophenone and 2-aminobenzyl alc. Deuterium labeling experiments showed that the reaction proceeded via a borrowing hydrogen process.

Advanced Synthesis & Catalysis published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Graphakos, Basil J.’s team published research in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in | CAS: 18437-58-6

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Application In Synthesis of 18437-58-6.

Graphakos, Basil J. published the artcileHeterocycles in organic synthesis. Part 13. The reaction of 2,4-diphenylthiopyrylium perchlorate with amines, Application In Synthesis of 18437-58-6, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1980), 1345-6, database is CAplus.

2,4-Diphenylthiopyrylium perchlorate (I) [30235-02-0], prepared by sequential treatment of 4,6-diphenylthiopyran-2-thione [842-62-6] with 30% H2O2 (AcOH, 40°, 2 h) and 70% HClO4, reacted with aromatic amines and aminopyridines (EtOH, 40-4°, 2 h, 20°) to give the thiopyrylium dyes II (R = aminoaryl, aminopyridyl). Thus, 52% II (R = C6H4NH2-4) [75076-63-0] was obtained from PhNH2 [62-53-3] and I. Analogous treatment of I with MeNH2 [74-89-5] (EtOH, reflux, 2 h) gave 12% 1-methyl-2,4-diphenylpyridinium perchlorate [75076-60-7] and 45% 4,6-diphenyl-2H-thiopyran [75076-61-8].

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Application In Synthesis of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Lixia’s team published research in Chemistry Letters in 39 | CAS: 197958-29-5

Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C8H11BO2, HPLC of Formula: 197958-29-5.

Wang, Lixia published the artcileCross coupling of arylboronic acids with imidazoles by sulfonatocopper(II)(salen) complex in water, HPLC of Formula: 197958-29-5, the publication is Chemistry Letters (2010), 39(7), 764-765, database is CAplus.

A mild and clean protocol for the cross coupling reactions between imidazoles and arylboronic acids has been developed in good to excellent yields up to 98% in the presence of sulfonatocopper(II)(salen) catalyst in water without addition of other additives and bases.

Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C8H11BO2, HPLC of Formula: 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hansen, Marvin M.’s team published research in Organic Process Research & Development in 19 | CAS: 197958-29-5

Organic Process Research & Development published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Computed Properties of 197958-29-5.

Hansen, Marvin M. published the artcileBoronic Acids and Derivatives-Probing the Structure-Activity Relationships for Mutagenicity, Computed Properties of 197958-29-5, the publication is Organic Process Research & Development (2015), 19(11), 1507-1516, database is CAplus.

Despite a recent publication describing boronic acids as a “novel class of bacterial mutagen,” process and anal. chemists may not be aware of the potential worker exposure hazards, or of the need to assess boron compounds as potential genotoxic impurities (GTIs) per ICH M7. This publication provides new Ames data for 44 com. available boronic acids, boronic acid derivatives, and boron-containing reagents. Trends in the Ames data are discussed from a structure-activity perspective. Common reagents such as bis(pinacolato)diboron and bis-boronic acid were shown to be mutagenic in the Ames assay. Currently available in silico computational models were found to provide little value in predicting the outcome of the Ames assay for boronic acids and derivatives The authors propose oxygen-mediated oxidation of boron compounds to generate organic radicals as a potential mechanism for mutagenicity. It is hoped that this paper will result in increased awareness of this class of GTIs and prompt publication of addnl. Ames data for boronic acids and their derivatives that will lead to improved (Q)SAR models and an understanding of the mechanism of mutagenicity.

Organic Process Research & Development published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Moree, Wilna J.’s team published research in Bioorganic & Medicinal Chemistry Letters in 20 | CAS: 847225-56-3

Bioorganic & Medicinal Chemistry Letters published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C6H3FN2, Name: 4-Fluoropicolinonitrile.

Moree, Wilna J. published the artcileNovel benzothiophene H1-antihistamines for the treatment of insomnia, Name: 4-Fluoropicolinonitrile, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(7), 2316-2320, database is CAplus and MEDLINE.

SAR of lead benzothiophene H1-antihistamine I (R = 2-pyridyl) was explored to identify backup candidates with suitable pharmacokinetic profiles for an insomnia program. Several potent and selective H1-antihistamines with a range of projected half-lives in humans were identified. Had a suitable human half-life as demonstrated in a human microdose study, but variability in pharmacokinetic profile, attributed to metabolic clearance, prevented further development of this compound I (R = 1-pyrazolyl) demonstrated lower predicted clearance in preclin. studies, and may represent a more suitable backup compound

Bioorganic & Medicinal Chemistry Letters published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C6H3FN2, Name: 4-Fluoropicolinonitrile.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yonova, P. A.’s team published research in Dokladi na Bulgarskata Akademiya na Naukite in 52 | CAS: 18437-58-6

Dokladi na Bulgarskata Akademiya na Naukite published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H11BF3KO, Quality Control of 18437-58-6.

Yonova, P. A. published the artcileSynthesis of 1,1′-polymethylenebis-(3-substituted) ureas and related compounds of potential biological interest, Quality Control of 18437-58-6, the publication is Dokladi na Bulgarskata Akademiya na Naukite (1999), 52(3-4), 53-56, database is CAplus.

RNHCONH(CH2)nNHCONHR [I, R = Ph, 3-FC6H4, 4-FC6H4, 3-ClC6H4, 4-ClC6H4, n = 2-6; R = 2-thiazolyl, 4-pyridyl, 4-picolyl, 3,5-dichloro-4-pyridyl, n = 6] were pred. from RNCO and H2N(CH2)nNH2 or from RNH2 and H2N(CH2)6NH2. I have antisenescence activity comparable to that of PhNHCONHPh and putrescine.

Dokladi na Bulgarskata Akademiya na Naukite published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H11BF3KO, Quality Control of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zheng, Ke’s team published research in Journal of Medicinal Chemistry in 57 | CAS: 18437-58-6

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C15H24S, Product Details of C6H8N2.

Zheng, Ke published the artcileDesign and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives, Product Details of C6H8N2, the publication is Journal of Medicinal Chemistry (2014), 57(23), 10013-10030, database is CAplus and MEDLINE.

The c-jun N-terminal kinase 3 (JNK3) is expressed primarily in the brain. Numerous reports have shown that inhibition of JNK3 is a promising strategy for treatment of neurodegeneration. The optimization of aminopyrazole-based JNK3 inhibitors with improved potency, isoform selectivity, and pharmacol. properties by structure-activity relationship (SAR) studies utilizing biochem. and cell-based assays, and structure-based drug design is reported. These inhibitors had high selectivity over JNK1 and p38α, minimal cytotoxicity, potent inhibition of 6-OHDA-induced mitochondrial membrane potential dissipation and ROS generation, and good drug metabolism and pharmacokinetic (DMPK) properties for iv dosing. 26n was profiled against 464 kinases and was found to be highly selective hitting only seven kinases with >80% inhibition at 10 μM. Moreover, 26n showed good solubility, good brain penetration, and good DMPK properties. Finally, the crystal structure of 26k in complex with JNK3 was solved at 1.8 Å to explore the binding mode of aminopyrazole based JNK3 inhibitors.

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C15H24S, Product Details of C6H8N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem