Tag: M.W=100-150

Maidich, Luca published the artcileElectronic and Steric Effects in Rollover C-H Bond Activation, Application In Synthesis of 197958-29-5, the publication is Organometallics (2015), 34(5), 817-828, database is CAplus.

Steric and electronic factors in rollover C-H bond activation of substituted 2,2′-bipyridines, mediated by Pt(II), were studied by comparing the influence of two substituents, CH₃ and CF₃, on the progress of the reaction. The substituents were chosen to have similar steric hindrance but different electronic effects and were placed in position 6 (i.e., near one of the N atoms) or in position 5, which allows, in part, electronic and steric influence to be distinguished. The ligands studied, 6-methyl-2,2′-bipyridine, 5-methyl-2,2′-bipyridine, 6-trifluoromethyl-2,2′-bipyridine, and 5-trifluoromethyl-2,2′-bipyridine, were compared to unsubstituted 2,2′-bipyridine in the reaction with the electron-rich complex [Pt(Me)₂(DMSO)₂]. The electron-withdrawing CF₃ group has a significant effect in accelerating the cyclometalation reaction. The substituent in position 6 influences the stability of the intermediate adduct [Pt(N,N)(Me)₂] (N,N = chelated bipyridine), as indicated by d. functional theory calculations The steric hindrance of substituted bipyridines was also evaluated by defining and measuring the angle ζ in [Pt(N,N)(Me)₂] adducts. The presence of a substituent in position 6 causes destabilization of the adduct, acceleration of the cyclometalation reaction, and regioselectivity of C-H bond activation.

Organometallics published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shen, Hong C. published the artcileDiscovery of Biaryl Anthranilides as Full Agonists for the High Affinity Niacin Receptor, Application In Synthesis of 197958-29-5, the publication is Journal of Medicinal Chemistry (2007), 50(25), 6303-6306, database is CAplus and MEDLINE.

Biaryl anthranilides are reported as potent and selective full agonists for the high affinity niacin receptor GPR109A. The SAR presented outlines approaches to reduce serum shift and both CYPCYP2C8 and CYP2C9 liabilities, while improving PK and maintaining excellent receptor activity. Compound 2i (I) exhibited good in vivo antilipolytic efficacy while providing a significantly improved therapeutic index over vasodilation (flushing) with respect to niacin in the mouse model.

Journal of Medicinal Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C6H10O7, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cui, Jiaxin published the artcileDiscovery of bis-aryl urea derivatives as potent and selective Limk inhibitors: Exploring Limk1 activity and Limk1/ROCK2 selectivity through a combined computational study, HPLC of Formula: 18437-58-6, the publication is Bioorganic & Medicinal Chemistry (2015), 23(23), 7464-7477, database is CAplus and MEDLINE.

Lim kinase (Limk), a proline/serine-rich sequence, can regulate the polymerization of the actin filaments by phosphorylating, and it is found to be highly involved in various human diseases. In this paper, 47 reported Limk1 inhibitors with bis-aryl urea scaffold were used to design potent and selective Limk inhibitors by computational approaches. Firstly, the structure-Limk1 activity relationship models (3D-QSAR) and structure-Limk1/ROCK2 selectivity relationship models (3D-QSSR) were developed and both 3D-QSAR and 3D-QSSR models showed good correlative and predictive abilities. Then, the mol. docking and mol. dynamics (MD) simulations were employed to validate the optimal docking conformation and explore the binding affinities. Finally, five new compounds were designed and all of them exhibited good Limk1 inhibition and Limk1/ROCK2 selectivity after synthesis and biol. evaluation, which demonstrated that the obtained information from computational studies were valuable to guide Limk inhibitors’ design.

Bioorganic & Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, HPLC of Formula: 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kuduk, Scott D. published the artcileTetrabutylammonium salt induced denitration of nitropyridines: synthesis of fluoro-, hydroxy-, and methoxypyridines, Safety of 4-Fluoropicolinonitrile, the publication is Organic Letters (2005), 7(4), 577-579, database is CAplus and MEDLINE.

An efficient method for the synthesis of fluoropyridines by the fluorodenitration reaction is reported. The reaction was mediated by tetrabutylammonium fluoride under mild conditions without undue regard to the presence of water. The fluorodenitration was general for 2- or 4-nitro-substituted pyridines, while 3-nitropyridines required attendant electron-withdrawing groups for the reaction to proceed efficiently. Nitropyridines also underwent hydroxy- and methoxydenitration under mild conditions in the presence of the corresponding tetrabutylammonium species.

Organic Letters published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C6H3FN2, Safety of 4-Fluoropicolinonitrile.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rheault, Tara R. published the artcileHeteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties, Recommanded Product: 2-Pyridinylboronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(15), 4587-4592, database is CAplus and MEDLINE.

Potent inhibitors of PLK1 with acceptable solubility, mouse iv clearance, and reduced CYP450 inhibition were identified. Drug-like properties were improved using a heteroaryl ring as a functional handle for manipulation of inhibitors’ physiochem. and DMPK properties.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Recommanded Product: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dunn, A. D. published the artcileBromination of Pyridines. II. Bromination of aminopicolines, Computed Properties of 18437-58-6, the publication is Journal fuer Praktische Chemie (Leipzig) (1989), 331(3), 369-74, database is CAplus.

The bromination of all 10 possible aminopicolines was investigated. In general, the major brominated product was that corresponding to electrophilic attack at the site para or ortho to the amino group.

Journal fuer Praktische Chemie (Leipzig) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Computed Properties of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yule, Ian A. published the artcilePyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity, Recommanded Product: 4-Amino-2-picoline, the publication is European Journal of Medicinal Chemistry (2014), 31-38, database is CAplus and MEDLINE.

The development of antibacterial drugs based on novel chemotypes is essential to the future management of serious drug resistant infections. We herein report the design, synthesis and SAR of a novel series of N-ethylurea inhibitors based on a pyridine-3-carboxamide scaffold targeting the ATPase sub-unit of DNA gyrase. Consideration of structural aspects of the GyrB ATPase site has aided the development of this series resulting in derivatives that demonstrate excellent enzyme inhibitory activity coupled to potent Gram pos. antibacterial efficacy.

European Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H12N2O, Recommanded Product: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Liang published the artcileRapid, Sustainable, and Gram-Scale Synthesis of Phenols Catalyzed by a Biodegradable Deep Eutectic Mixture in Water, SDS of cas: 197958-29-5, the publication is Asian Journal of Organic Chemistry (2013), 2(12), 1040-1043, database is CAplus.

Mild, rapid, recyclable, gram-scale synthesis of phenols via oxidative hydroxylation of arylboronic acids catalyzed by a biodegradable deep eutectic mixture in water was reported. A broad substrate compatibility, metal- and additive-free conditions, as well as gram-scale synthesis made this procedure more environmentally benign.

Asian Journal of Organic Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is 0, SDS of cas: 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rombouts, Frederik J. R. published the artcileDiscovery of N-(4-[¹⁸F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer, Synthetic Route of 18437-58-6, the publication is Journal of Medicinal Chemistry (2019), 62(6), 2974-2987, database is CAplus and MEDLINE.

In Alzheimer’s disease, the d. and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure-activity relationship exploration around an isoquinoline hit, followed by an exploration of tolerated fluorination positions, allowed us to identify 9 (JNJ-64326067), a potent and selective binder to aggregated tau with a favorable pharmacokinetic profile and no apparent off-target binding. This was confirmed in rat and monkey positron emission tomog. studies using [¹⁸F]9.

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Synthetic Route of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lim, Chae Jo published the artcileSynthesis and structure-activity relationship of naphtho[1,2-b]furan-2-carboxamide derivatives as melanin concentrating hormone receptor 1 antagonists, SDS of cas: 197958-29-5, the publication is Chemical & Pharmaceutical Bulletin (2013), 61(12), 1239-1247, database is CAplus and MEDLINE.

Synthesis and structure-activity relationship of naphtho[1,2-b]furan-2-carboxamides I (n = 2-5; R = H, Br, Ph, 4-MeC₆H₄, 3-ClC₆H₄, 2-pyridyl, 3-furyl, 3-thienyl, etc.) containing linked piperidinylphenylacetamide groups as melanin concentrating hormone receptor 1 (MCH-R1) antagonists are described. The structure activity relationship (SAR) study, probing members of this family that contain a variety of aryl and heteroaryl groups at C-5 of I skeleton and having different chain linker lengths, led to the identification of the 5-(4-pyridinyl)-substituted analog I (n = 2; R = pyridin-4-yl) as a highly potent MCH-R1 antagonist with an IC₅₀ value of 3nM. This compound also displayed excellent metabolic stability and did not significantly inhibit cytochrome P 450 (CYP450) enzymes.

Chemical & Pharmaceutical Bulletin published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, SDS of cas: 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem