Tag: M.W=100-150

Bernard, Sylvain published the artcileEfficient synthesis of nevirapine analogs to study its metabolic profile by click fishing, HPLC of Formula: 133627-45-9, the main research area is nevirapine analog preparation azide coupling click.

Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chem. was developed.

Bioorganic & Medicinal Chemistry Letters published new progress about nevirapine analog preparation azide coupling click. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, HPLC of Formula: 133627-45-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grozinger, K. G. published the artcileSynthesis of nevirapine and its major metabolite, COA of Formula: C6H7ClN2, the main research area is nevirapine preparation metabolite.

Several synthetic methods were developed during the process optimization for the large scale synthesis of nevirapine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. The synthesis of its putative major metabolite 11-cyclopropyl-5,11-dihydro-4-hydroxymethyl-6H-[3,2-b:2′,3′-e][1,4]diazepin-6-one and its oxidation to the corresponding aldehyde, were described.

Journal of Heterocyclic Chemistry published new progress about nevirapine preparation metabolite. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, COA of Formula: C6H7ClN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Talik, Tadeusz published the artcile2-Fluoronitro-derivatives of pyridine and picolines, Name: 6-Methylpyridine-2,5-diamine, the main research area is pyridine fluoro nitro; picoline fluoro nitro; diazotization aminopyridine.

6-Fluoro derivatives from 4-nitro- and 3,5- and 3,4-dinitropyridine, 3- and 5-nitro- and 3,5-dinitro-4-picoline, 3- and 5-nitro- and 3,5-dinitro-2-picoline, and 5-nitro-3-picoline as well as 2-fluoro-5-nitro-3-picoline were prepared in 52.5-85% yields by diazotization of the corresponding amino derivatives in 65% HF.

Roczniki Chemii published new progress about pyridine fluoro nitro; picoline fluoro nitro; diazotization aminopyridine. 6992-84-3 belongs to class pyridine-derivatives, name is 6-Methylpyridine-2,5-diamine, and the molecular formula is C6H9N3, Name: 6-Methylpyridine-2,5-diamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Tony Y. published the artcileRegioselective synthesis of 2-chloro-3-pyridinecarboxylates, COA of Formula: C6H7ClN2, the main research area is chloropyridinecarboxylate regioselective preparation; pyridinecarboxylate chloro regioselective preparation.

2-Chlorocyanoacetate undergoes base-catalyzed Michael addition to α,β-unsaturated ketones or aldehydes, e.g., acrolein, to afford 5-oxopentenenitrile derivatives, e.g., OHCCH2CH2CCl(CN)CO2Et. In the presence of anhydrous HCl, these compounds cyclize to yield 2-chloro-3-pyridinecarboxylates, e.g., I. The process is highly regiospecific and useful in the synthesis of 2,3-disubstituted pyridines.

Tetrahedron published new progress about chloropyridinecarboxylate regioselective preparation; pyridinecarboxylate chloro regioselective preparation. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, COA of Formula: C6H7ClN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Q. Chan published the artcileValidation of a high-performance liquid chromatography method for the assay of and determination of related organic impurities in nevirapine drug substance, Application In Synthesis of 133627-45-9, the main research area is HPLC impurity determination nevirapine; liquid chromatog nevirapine impurity determination.

Nevirapine (Viramune), a dipyridiodiazepinone, is a potent and highly specific nonnucleoside inhibitor of HIV-1 reverse transcriptase. This study described the validation of a specific, sensitive, and a stability-indicating HPLC method for the determination of related organic impurities in nevirapine drug substance. This method used a Supelcosil LC-ABZ column, a mobile phase of 20:80 MeCN-pH 5.0 25-mM NH4H2PO4 and UV detection at 220 nm. This method was validated for specificity, linearity, accuracy, repeatability, detection limit, quantitation limit, stability of analyte solutions, robustness, and intermediate precision. Nevirapine was completely separated from all impurities. The method was linear with coefficients of determination >0.999. Average accuracy was 100.4% with a relative standard deviation of 0.7% for the assay. Accuracy ranges from 100.1 to 102.6% for related organic impurities. The repeatability was good, with relative standard deviations �.4%. The detection limit and the quantitation limit were 0.001 and 0.003%, resp. Relative response factors of known organic impurities were determined, permitting the use of nevirapine at the 0.1% level as an external standard for the quantitation of these impurities. Analyte solutions were stable for at least 2 days at ambient temperature The method was validated as robust, and intermediate precision was high. A system suitability test was developed and validated, and requirements were set. (c) 2000 Preston Publications.

Journal of Chromatographic Science published new progress about HPLC. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Application In Synthesis of 133627-45-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wollinger, Wagner published the artcileSimultaneous Determination of Assay and Related Substances in Nevirapine Suspension by HPLC, Name: 2-Chloro-4-methylpyridin-3-amine, the main research area is nevirapine impurity suspension HPLC UV detection.

The USP HPLC method for quant. determination of nevirapine in suspension formulations was evaluated to determine its ability to resolve nevirapine and its major related impurities. The method was modified and an overall satisfactory resolution for all components was obtained by changing the column temperature to 25°, the organic modifier to methanol, the mobile phase ratio to 50 %, adding 1% HCl into the diluents, decreasing the flow rate from 1.5 to 1.2 mL mL-1 and using an isocratic mode. The related organic impurities were synthesized in high yield. The method is shown to be linear with coefficient of determination around 0.999 to nevirapine (Nvp) and related impurities were resolved using a mobile phase of potassium phosphate/phosphoric acid buffer (pH 2.5; 10 mM)/methanol (50:50, volume/volume) on a BDS Hypersil C18 5 μm, 250 × 4.6 mm column. Accuracy ranged from 100.2 to 101.1 % and 100.0 to 100.5 % for nevirapine and related impurities, resp. Repeatability from all experiments achieved RSD values <0.95 %. The detection and quantification limits were determined in the level of ng mL-1. This method easily separated all known impurities synthesized and can be employed for routine anal. of suspension containing nevirapine in the presence of its impurities. Chromatographia published new progress about HPLC. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Name: 2-Chloro-4-methylpyridin-3-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wadsworth, Harry published the artcileExploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein-potential novel positron emitting tomography imaging agents, Formula: C7H7NO2, the main research area is PET imaging diaryl anilide preparation translocator protein ligand SAR.

A series of novel ligands based on the diaryl anilide (DAA) class of translocator protein (TSPO) ligands was synthesized and evaluated as potential positron emitting tomog. (PET) ligands for imaging TPSO in vivo. Fluorine-18 labeling of the mols. was achieved using direct radiolabelling or synthon based labeling approaches. Several of the ligands prepared have promising profiles as potential TSPO PET imaging ligands and will be evaluated further as potential clin. imaging agents.

Bioorganic & Medicinal Chemistry Letters published new progress about Brain. 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Weidmann, Klaus published the artcile2-[(2-Pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K+-ATPase inhibitors, SDS of cas: 149489-32-7, the main research area is pyridylmethylsulfinylthienoimidazole preparation inhibitor ATPase; stomach acid secretion inhibitor pyridylmethylsulfinylthienoimidazole; gastric acid secretion inhibitor pyridylmethylsulfinylthienoimidazole.

2-[(2-Pyridylmethyl)sulfinyl]thienoimidazoles I (R = H, Me, Ac, Ph, MeO2C, 4-MeOC6H4; R1 = H, Me, MeO2C; R2 = H, Me, MeO, F, Cl, Br, fluoroalkoxy; R3 = H, Me, alkoxy, and substituted alkoxy, benzyloxy, and phenoxy; R4 = H, Me, MeO, F, Cl, Br) and II (R, R1 = H, MeO2C; R2 = H, MeO) were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The [3,4-d] isomers of the two possible thienoimidazole series were found to be potent inhibitors of gastric acid secretion in vitro and in vivo. Structure-activity relationships indicate that especially lipophilic alkoxy, benzyloxy, and phenoxy substituents with addnl. electron-demanding properties in the 4-position of the pyridine moiety combined with an unsubstituted thieno[3,4-d]imidazole lead to highly active compounds with a favorable chem. stability. Various substitution patterns in the thieno[3,4-d]imidazole moiety result in lower biol. activity. Saviprazle [HOE 731, I; R-R2 = R4 = H, R3 = F3C(CF2)2CH2O] was selected for further development and is currently undergoing clin. evaluation. Comprehensive pharmacol. studies indicate a pharmacodynamic profile different to omeprazole, the first H+/K+-ATPase blocker introduced on the market.

Journal of Medicinal Chemistry published new progress about Stomach. 149489-32-7 belongs to class pyridine-derivatives, name is 2-(Chloromethyl)-3-fluoropyridine, and the molecular formula is C6H5ClFN, SDS of cas: 149489-32-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kucharska, E. published the artcileMolecular and crystal structure, IR and Raman spectra, and quantum chemical calculations for 2-hydroxy-3-cyano-4-methylpyridine, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine, the main research area is hydroxycyanomethylpyridine crystallog mol structure IR Raman spectroscopy.

The paper presents the mol. and XRD structures as well as room temperature IR and Raman studies of 2-hydroxy-3-cyano-4-methylpyridine. The nature and assignment of the vibrational modes have been discussed on the basis of the quantum chem. calculations performed with the use of B3LYP/6-311G(d,p) basis set. The role of the hydrogen bonds in the stabilization of the structure has been analyzed. The quantum chem. calculations have been performed for the monomer as well as for the dimer coupled via the hydrogen bonds. A possible application of this compound in the hybrid formation technol. is discussed.

Vibrational Spectroscopy published new progress about Crystal structure. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Gang published the artcileExperimental Study on Seawater Applications in Organic Reactions, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine, the main research area is organic reaction seawater application industrial production.

Background: Total water resources account for only 2.5% of freshwater on earth, and only 1% of total water resources can be exploited by humans. The development of practical methods of seawater desalination and comprehensive utilization technol. can help address the shortage of freshwater resources in the world, and achieve sustainable use of water resources to ensure sustainable development in a society. Direct seawater utilization currently involves industrial cooling water, water for agricultural irrigation, and flushing water. Applications in aqueous phase organic reactions, particularly the direct use of seawater in industrial organic synthesis reactions, are seldom reported. Methods: we used seawater instead of freshwater in selected basic organic chem. reactions. The application of seawater in aqueous phase organic reactions was systematically investigated. Six types of reactions were studied using freshwater and seawater, namely, preparation of acetanilide, synthesis of mandelic acid, Cannizzaro reaction, Hofmann degradation reaction, preparation of quinazolin-4-one, and preparation of adipic acid. Results: Seven organic compounds were produced. Results show that some organic reactions could directly use seawater or treated seawater as an alternative to freshwater. The yields of the reactions using seawater could be compared with literature values, or were even better than literature values. Conclusion: This research provides new opportunities for the comprehensive utilization of seawater. Some organic reactions could directly use seawater or treated seawater instead of freshwater. The use of seawater instead of freshwater for organic reactions in industrial production may greatly conserve freshwater resources and protect the environment.

Letters in Organic Chemistry published new progress about Cannizzaro reaction. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem