Tag: M.W=100-150

Empel, Anna published the artcileTowards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine, the main research area is lung breast cancer SAR anticancer tertiary phenothiazine quinoline; antibacterial activity; antiproliferative activity; azaphenothiazines; lipophilicity; pharmacophore mapping; phenothiazine; similarity-activity landscape index.

A series of new tertiary phenothiazine derivatives containing a quinoline and a pyridine fragment was synthesized by the reaction of 1-methyl-3-benzoylthio-4-butylthioquinolinium chloride with 3-aminopyridine derivatives bearing various substituents on the pyridine ring. The direction and mechanism of the cyclization reaction of intermediates with the structure of 1-methyl-4-(3-pyridyl)aminoquinolinium-3-thiolate was related to the substituents in the 2- and 4-pyridine position. The structures of the compounds were analyzed using 1H, 13C NMR (COSY, HSQC, HMBC) and X-ray anal., resp. Moreover, the antiproliferative activity against tumor cells (A549, T47D, SNB-19) and a normal cell line (NHDF) was tested. The antibacterial screening of all the compounds was conducted against the reference and quality control strain Staphylococcus aureus ATCC 29213, three clin. isolates of methicillin-resistant S. aureus (MRSA). In silico computation of the intermol. similarity was performed using principal component anal. (PCA) and hierarchical clustering anal. (HCA) on the pool of structure/property-related descriptors calculated for the novel tetracyclic diazaphenothiazine derivatives The distance-oriented property evaluation was correlated with the exptl. anticancer activities and empirical lipophilicity as well. The quant. shape-based comparison was conducted using the CoMSA method in order to indicate the potentially valid steric, electronic and lipophilic properties. Finally, the numerical sampling of similarity-related activity landscape (SALI) provided a subtle picture of the SAR trends.

International Journal of Molecular Sciences published new progress about Antibacterial agents. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kulathooran, S. published the artcileSynthesis and biological activities of novel heterocyclic chalcone derivatives by two different methods using anhydrous potassium carbonate as an efficient catalyst, SDS of cas: 71255-09-9, the main research area is acetyl dimethylfuran aryl aldehyde potassium carbonate catalyst microwave irradiation; chalcone preparation diastereoselective green chem antibacterial antifungal activity SAR.

A series of twenty 3-(aryl)-1-(2,5-dimethylfuran-3-yl)prop-2-en-1-one I [R = 2,5-(F)2-C6H3, 2-naphthyl, 2-biphenyl, etc.] were synthesized by using conventional and microwave irradiation methods in the presence of anhydrous potassium carbonate as an safe, inexpensive and efficient basic catalyst. Synthesized compounds were evaluated for their in-vitro antimicrobial activity against variety of microbial strains and it was characterized by IR, NMR (1H & 13C) and mass spectral anal. The biol. screening results indicated that some of the compounds showed significant antibacterial and antifungal activities. Compound I [R = 3-methyl-2-thiophenyl] displayed excellent antimicrobial activity against various microbial strains. The newly synthesized high potent compound I [R = 3-methyl-2-thiophenyl] was subjected to thermogravimetric anal. (TGA), differential scanning calorimetric (DSC) and single crystal XRD.

Pharma Chemica published new progress about Antibacterial agents. 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, SDS of cas: 71255-09-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sakai, Hiroki published the artcileSecond basic pKa: An overlooked parameter in predicting phospholipidosis-inducing potential of diamines, Quality Control of 149489-32-7, the main research area is phospholipidosis pos diamine second basic pKa PLIP; Diamine; Phospholipidosis; Second basic pKa.

In this paper, we present the phospholipidosis-inducing potential (PLIP) of forty fragment-sized diamines derived from N-benzyl-4-(methylamino)piperidine and discuss the relationship between their PLIP and the physicochem. properties. Our results demonstrate that the previously reported methods are not suitable for predicting the PLIP of fragment-sized diamines; the second basic pKa can distinguish PLIP-pos. diamines from PLIP-neg. diamines more accurately than ClogP or most basic pKa. To the best of our knowledge, this is the first report describing the relationship between PLIP and second basic pKa.

Bioorganic & Medicinal Chemistry Letters published new progress about Chemical potential (phospholipidosis-inducing potential (PLIP)). 149489-32-7 belongs to class pyridine-derivatives, name is 2-(Chloromethyl)-3-fluoropyridine, and the molecular formula is C6H5ClFN, Quality Control of 149489-32-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Youcan published the artcileCopper-catalyzed carbonylative synthesis of pyrrolidine-containing amides from γ,δ-unsaturated aromatic oxime esters, Related Products of pyridine-derivatives, the main research area is pyrrolidine containing amide preparation regioselective copper catalyst; unsaturated aromatic oxime ester amine carbonylative cyclization.

A new method of low-cost copper-catalyzed carbonylative cyclization for preparing pyrrolidine-containing amides I (R = H, R’ = t-Bu, Ph, 2-Py, etc; R1 = Me, Et, Ph, R2 =Me, Allyl, CHC6H5; Ar = Ph, 3-MeC6H4, 2-thiophenenyl, 2-Naph, etc.; R3, R4 = H, Me;) from γ,δ-unsaturated aromatic oxime esters II and amines has been described. A range of readily available amines were examined, including primary, secondary, and heterocycle amines, giving over 60 examples of targeted N-heterocycle substituted amides with broad functional group tolerance, good chem. selectivity and moderate to excellent yields.

Organic Chemistry Frontiers published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Related Products of pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Giri, T. published the artcileSynthesis and antibacterial activity of novel 4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}-benzohydrazide derivatives, Computed Properties of 71255-09-9, the main research area is methylaminothienopyrimidinyl benzohydrazide derivative preparation antibacterial agent.

A series of novel 4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}benzohydrazide derivatives were synthesized and evaluated for their antibacterial activity. Most of the compounds demonstrated high activity towards Escherichia coli, Pseudomonas, Staphylococcus aureus, and Bacillus. Structures of all synthesized compounds were confirmed by spectral anal.

Russian Journal of General Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, Computed Properties of 71255-09-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Murphy, Rebecca A. published the artcileDirect Methoxypyridine Functionalization Approach to Magellanine-Type Lycopodium Alkaloids, Application of 2-Methoxynicotinaldehyde, the main research area is enantioselective synthesis tetracyclic core magellanine Lycopodium alkaloid; Hajos Parrish reaction enantioselective synthesis magellanine Lycopodium alkaloid; palladium catalyzed pyridine functionalization enantioselective synthesis magellanine Lycopodium alkaloid.

A concise enantioselective approach to the tetracyclic core of the magellanine-type Lycopodium alkaloids is reported. Key to this approach is the use of the Hajos-Parrish reaction to set a challenging quaternary stereocenter, thereby guiding the stereoselectivity for the remainder of the synthesis, as well as the use of a palladium-mediated direct pyridine functionalization reaction to forge the tetracyclic core.

Organic Letters published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation) (Lycopodium). 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, Application of 2-Methoxynicotinaldehyde.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Savarimuthu, Sebastian Antony published the artcileSodium Tertiary Pentoxide as a Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols, COA of Formula: C7H7NO2, the main research area is carbonyl compound phenylacetylene sodium tertiary pentoxide promoter green coupling; propargyl alc preparation.

This report confirmed that sodium tertiary-pentoxide was a very effective base for the nucleophilic addition of acetylenes to aldehydes and ketones in 1,4-dioxane at room temperature These mild and operationally simple procedures were working well with a variety of aromatic and heteroaromatic aldehydes and also equally working well with aliphatic, aromatic and heteroaromatic ketones. A very clean product of secondary and tertiary propargylic alcs. were obtained from 70-94% yield. This process was explored in bulk scale synthesis on selected mols. and also adapted the column free purification for most of the substrates.

ChemistrySelect published new progress about Alcohols, propargyl Role: SPN (Synthetic Preparation), PREP (Preparation). 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Dingzhong published the artcileIndustrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles-catalyzed hydrogenation of nitroarenes, Application of 2-Chloro-4-methylpyridin-3-amine, the main research area is cunninghamia lanceolata carbon support iron hydroxide oxide catalyst preparation; nitroarene iron hydroxide oxide catalyst hydrogenation; aryl amine green preparation.

An industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles process for the synthesis of aryl amines with good yields via hydrogenation of nitroarenes was reported. Nine key anti-cancer drug intermediates were successfully achieved with protocol. And Osimertinib intermediate could be smoothly synthesized at a 2.67 kg-scale with >99.5% HPLC purity. This protocol featured cheap carbon source, highly catalytic activity, simple operation, kilogram-scalable and recyclable catalysts (eight times without observable losing activity).

Catalysis Communications published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Application of 2-Chloro-4-methylpyridin-3-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rogers, David A. published the artcileAmplification of Trichloroisocyanuric Acid (TCCA) Reactivity for Chlorination of Arenes and Heteroarenes via Catalytic Organic Dye Activation, Recommanded Product: 2-Methoxynicotinaldehyde, the main research area is chlorination arene heteroarene trichloroisocyanuric acid brilliant green catalyst.

Heteroarenes and arenes that contain electron-withdrawing groups are chlorinated in good to excellent yields (scalable to gram scale) using trichloroisocyanuric acid (TCCA) and catalytic Brilliant Green (BG). Visible-light activation of BG serves to amplify the electrophilic nature of TCCA, providing a mild alternative approach to acid-promoted chlorination of deactivated (hetero)aromatic substrates. The utility of the TCCA/BG system is demonstrated through comparison to other chlorinating reagents and by the chlorination of pharmaceuticals including caffeine, lidocaine, and phenazone.

Organic Letters published new progress about Aryl chlorides Role: SPN (Synthetic Preparation), PREP (Preparation). 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, Recommanded Product: 2-Methoxynicotinaldehyde.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Miura, Hiroki published the artcileRuthenium-Catalyzed Intermolecular Hydroacylation of Internal Alkynes: The Use of Ceria-Supported Catalyst Facilitates the Catalyst Recycling, HPLC of Formula: 71255-09-9, the main research area is conjugated enone preparation; ceria supported ruthenium hydroacylation alkyne aldehyde.

Intermol. hydroacylation of internal alkynes by aromatic aldehydes, catalyzed by Ru/CeO2 or [RuCl2(p-cymene)]2 in the presence of sodium formate and Xantphos, gave conjugated enones. E.g., in presence of Ru/CeO2, hydroacylation of PhCCPh by PhCHO gave 52% enone I (64:36 E/Z). The solid Ru/CeO2 continued to show catalytic activity and gave enones without significant decreases in yields for at least three times.

Chemistry – A European Journal published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, HPLC of Formula: 71255-09-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem