Tag: M.W=100-150

Duroux, Romain published the artcileAntagonists of the adenosine A_2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity, Application In Synthesis of 197958-29-5, the publication is European Journal of Medicinal Chemistry (2018), 151-163, database is CAplus and MEDLINE.

The authors have recently reported a series of 2-furoyl-benzoxazoles as potential A_2A adenosine receptor (A_2AR) antagonists. Two hits were identified with interesting pharmacokinetic properties but were find to bind the hA_2AR receptor in the micromolar-range. Herein, to enhance affinity toward the hA_2AR, the authors explored the C5- and C7-position of the hits based on docking studies. These modifications led to compounds with nanomolar-range affinity (e.g., 6a (2,7-di(furan-2-yl)benzoxazol-5-amine), Ki = 40 nM) and high antagonist activity (e.g., 6a, IC₅₀ = 70.6 nM). Selected compounds also exhibited interesting in vitro DMPK (Drug Metabolism and Pharmacokinetics) properties including high solubility and low cytotoxicity. Therefore, the benzoxazole ring appears as a highly effective scaffold for the design of new A_2A antagonists.

European Journal of Medicinal Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Singh, Rahul published the artcileNickel-Catalyzed C-S Bond Formation: Synthesis of Aryl Sulfides from Arylsulfonyl Hydrazides and Boronic Acids, Computed Properties of 197958-29-5, the publication is Advanced Synthesis & Catalysis (2015), 357(6), 1181-1186, database is CAplus.

A practical nickel-catalyzed approach for the C-S bond formation through the cross-coupling of arylsulfonyl hydrazides RSO₂NHNH₂ [R = CH₃(CH₂)₇, C₆H₅, 4-O₂NC₆H₄, etc.] and aryl boronic acids R¹B(OH)₂ (R¹ = naphthalen-2-yl, 4-ClC₆H₄, pyridin-2-yl, etc.) has been developed. The report employs arylsulfonyl hydrazide as an aryl thiol equivalent and offers a mild and eco-safe synthesis of unsym. thioethers RSR¹ in good to excellent yields in air. The scope and versatility of the method has been successfully demonstrated with 22 examples.

Advanced Synthesis & Catalysis published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C17H16O2, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bagley, Mark C. published the artcileRapid Protium-Deuterium Exchange of 4-Aminopyridines in Neutral D₂O under Microwave Irradiation, Recommanded Product: 4-Amino-2-picoline, the publication is Synlett (2016), 27(17), 2467-2472, database is CAplus.

4-Aminopyridines underwent rapid and highly selective H/D exchange at C-2 and C-6 in neutral D₂O upon microwave irradiation at only 190° for two hours in a sealed vessel. This method contrasted and complemented the acid-mediated H/D exchange, required no catalyst, and was appropriate for the synthesis of deuterium isotopologues of N- and C-substituted 4-aminopyridines and other nitrogen heterocycles.

Synlett published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Recommanded Product: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Reference of 1603-41-4.

Zhang, Yi;Chen, Rener;Wang, Zhiming;Wang, Lei;Ma, Yongmin research published 《 I₂-Catalyzed Three-Component Consecutive Reaction for the Synthesis of 3-Aroylimidazo[1,2-a]-N-Heterocycles》, the research content is summarized as follows. A convenient one-pot, three-component reaction has been developed for the synthesis of 3-aroylimidazo[1,2-a]-N-heterocycles from aryl ketones and 2-amino-N-heterocycles using DMSO as a methylene donor. The reaction proceeds smoothly catalyzed by I₂ in the presence of K₂S₂O₈ and affords the desired products in moderate to good yields. This protocol offers significant superiority in accessing biol. active 3-aroylimidazo[1,2-a]-N-heterocycles with various substitution patterns.

Reference of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reference of 1603-41-4.

Zhou, Yong-Jun;Yang, Kai;Fang, Yong-Gan;Luo, Shi-He;Chen, Qi;Yu, Shi-Wei;Wang, Zhao-Yang research published 《 A NaHCO₃ Promoted Three-component Cyclization: Easy Access to Benzodisulfide Heterocycles》, the research content is summarized as follows. A facile route for the synthesis of benzodisulfide heterocyclic compounds I (R = H, 5-Cl, 5-Br, 6-F, 6-OMe; Ar = C₆H₅, 2-CH₃C₆H₄, 2-pyridyl, etc.) via a NaHCO₃-promoted three-component reaction between 2-halophenylacetic acids R¹-2-X-C₆H₃CH₂COOH (R¹ = H, 5-Cl, 5-Br, 4-F, 4-OMe; X = Cl, Br), elemental sulfur (S8) and amines ArNH₂ under metal-free conditions has been demonstrated. This transformation from available starting materials shows good functional group tolerance, and the target compounds I can be derivatized for further application.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Reference of 1603-41-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Quality Control of 1603-41-4.

Zhu, Kongyun;Liu, Qiutong;Dang, Chao;Li, Aimin;Zhang, Lei research published 《 Valorization of hydrothermal carbonization products by anaerobic digestion: Inhibitor identification, biomethanization potential and process intensification》, the research content is summarized as follows. Integrating hydrothermal carbonization (HTC) and anaerobic digestion for biorefinery-oriented full utilization of wet organic wastes is a promising emerging technol. The objectives of this study were to identify the potential inhibitory substances, evaluate the biomethane potential of mixed and aqueous products and explore process intensifying strategies. The results indicated that the high HTC temperature of 240 °C resulted in a significantly low methane yield of 60 ± 5 mL/g COD and a high Short chain fatty acid (SCFAs) accumulation of 4174 ± 76 mg/L. GC-MS anal. showed that the contents of inhibitory pyrazines, pyridines and ketones in aqueous fraction at 240 °C substantially increased from 13.14%, 0.4%, 0.55% at 180 °C to 23.34%, 2.89%, 5.13%, resp. When the aqueous products obtained from 240 °C-HTC was supplemented or pretreated by carbonaceous material, the methane yields were greatly improved and increased to 1.3-fold and 1.8-fold, resp. These finding could provide some valuable tech. information for HTC based biorefinery of organic waste.

Quality Control of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Related Products of 1603-41-4.

Zhang, Jie;Zhang, Yufeng;Zhang, Jian;Wu, Qingguo;Yang, Haifeng research published 《 Synthesis of C3-Cyanomethylated Imidazo[1,2-a]pyridines via Ultrasound-Promoted Three-Component Reaction under Catalyst- and Oxidant-Free Conditions》, the research content is summarized as follows. An efficient synthesis of C3-cyanomethylated imidazo[1,2-a]pyridines via ultrasound-promoted three-component reaction under catalyst-free, oxidant-free, and mild conditions has been developed. A series of C3-cyanomethylated imidazo[1,2-a]pyridines were rapidly prepared with satisfactory yields and good functional group compatibility. This strategy cloud also be applied to the synthesis of zolpidem and alpidem in short steps.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Related Products of 1603-41-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Recommanded Product: 2-Amino-5-methylpyridine.

Zhang, Ruizhong;Cheng, Jun;Yang, Liuqing;Wong, Jonathan M.;Ralph Adsetts, Jonathan;Wang, Ruiyao;Liu, Jiyan;Ding, Zhifeng;Wang, Hong-Bo research published 《 Optimizing the Electrochemiluminescence of Readily Accessible Pyrido[1,2-α]pyrimidines through “Green” Substituent Regulation》, the research content is summarized as follows. Bright and low-cost emitting organic mols. are very desirable for electrochemiluminescence (ECL). Here, we report a facile one-step, three-component reaction of readily available precursors to synthesize pyrido[1,2-α]pyrimidine derivatives (1-4), all which give off green photoluminescence (PL). In contrast, the electrochem. and ECL properties of these luminophores are affected by the extent of the conjugation and the nature of the peripheral substituents. D. functional theory (DFT) calculations identified the aromatic chain substitution could extend the conjugation of pyrido[1,2-α]pyrimidine core and stabilize the electrogenerated radicals required for generation of an excited state, affording pyrido[1,2-α]pyrimidine 3 the highest ECL activity among the studied samples. ECL in annihilation route confirmed weak emission, but great improvement was made using oxidizing co-reactant species (benzoate radical from benzoyl peroxide, BPO) with an efficiency of 43% relative to that of Ru(bpy)₃(PF₆)₂. The pyrido[1,2-α]pyrimidine 3/BPO system is more robust than those of reducing co-reactant species [tri-n-propylamine radical or 2-(dibutylamino) ethanol radical] and is one of the highest among the reported organic electrochemiluminophores. ECL spectroscopy revealed that the monomeric excited states were the main species to emit light. Their straightforward, one-step, green synthesis, and their structure tunability represent significant advantages in the development of readily accessible dyes for PL and especially ECL applications.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Recommanded Product: 2-Amino-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Computed Properties of 1603-41-4.

Yao, Hua;Zhong, Xiaoyang;Wang, Bingqing;Lin, Sen;Yan, Zhaohua research published 《 Cyanomethylation of the Benzene Rings and Pyridine Rings via Direct Oxidative Cross-Dehydrogenative Coupling with Acetonitrile》, the research content is summarized as follows. A novel and efficient approach for the amine-directed dehydrogenative C(sp₂)-C(sp₃) coupling of arylamines RNH₂ (R = Ph, 5-chloropyridin-2-yl, pyrazin-2-yl, etc.) with acetonitrile was reported by using FeCl₂ as the catalyst. Arylamines react with inactive acetonitrile to form the corresponding arylacetonitriles R¹CH₂CN (R¹ = 2-amino-5-chloropyridin-3-yl, 2-aminophenyl, 6-amino-1,3-benzothiazol-7-yl, etc.) in moderate to good yields. This protocol features nontoxic iron catalysis, efficient atom economy, nonprefunctionalized starting materials, good regioselectivity, and excellent compatibility of functional groups and aromatic rings, providing a novel, straightforward, and green approach toward arylacetonitriles.

Computed Properties of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Application In Synthesis of 1603-41-4.

Yuan, Yong;Zhou, Zhilin;Zhang, Lin;Li, Liang-Sen;Lei, Aiwen research published 《 Electrochemical Oxidative C3 Acyloxylation of Imidazo[1,2-a]pyridines with Hydrogen Evolution》, the research content is summarized as follows. The electrochem. oxidative C3 acyloxylation of imidazo[1,2-a]pyridines with carboxylic acids was demonstrated to obtain acyloxylated imidazo[1,2-a]pyridines I [R = Ph, 4-MeC₆H₄, cyclohexyl, etc.; R¹ = H, 6-Me, 8-F, 6-MeO; R² = t-Bu, Ph, 2-thienyl, etc.;]. Notably, by using electricity, the electrochem. oxidative C3 acyloxylation of imidazo[1,2-a]pyridines was carried out under mild conditions. Moreover, in addition to aromatic carboxylic acids, alkyl carboxylic acids were also competent substrates.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Application In Synthesis of 1603-41-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem