Tag: M.W=100-150

Pyridine is colorless, but older or impure samples can appear yellow. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Formula: C6H8N2.

Tran, Khoa M.;Ho, Nhat T.;Le, Trang T. T.;Nguyen, Tung T.;Phan, Nam T. S. research published 《 Copper-Mediated (2-Methylthio)aniline Directed Annulation of sp² C-H Bonds with Primary Anilines》, the research content is summarized as follows. A method for copper-mediated, directed functionalization of sp² C-H bonds in benzamides with primary anilines toward synthesis of indazolones I [R = H, 6-OMe, 4-F, etc.; Ar = Ph, 4-BrC₆H₄, 2-pyridyl, etc.] was reported. Successful transformations relied on the use of a bidentate 2-methylthio aniline directing group. Functionalities including halogen, methylthio, cyano, ester, protected alc., and tertiary amine groups were compatible with reaction conditions. The method featured a rare example for directed annulation of sp² C-H bonds with amines.

Formula: C6H8N2, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Synthetic Route of 1603-41-4.

Uysal, Sirin;Soyer, Zeynep;Saylam, Merve;Tarikogullari, Ayse H.;Yilmaz, Sinem;Kirmizibayrak, Petek Ballar research published 《 Design, synthesis and biological evaluation of novel naphthoquinone-4-aminobenzensulfonamide/carboxamide derivatives as proteasome inhibitors》, the research content is summarized as follows. A series of novel 4-aminobenzensulfonamide/carboxamide derivatives I [R = 2-ethylanilino, (2-chloro-3-pyridyl)amino, 1-naphthylamino, etc.] and II [R¹ = anilino, 2-thiazolylamino, 4-nitroanilino, etc.] were designed, sythesized and evaluated for their proteasome inhibitory and antiproliferative activities against human breast cancer cell line (MCF-7). The structures of the synthesized compounds I and II were confirmed by spectral and elemental analyses. The proteasome inhibitory activity studies were carried out using cell-based assay. The antiproteasomal activity results revealed that most of the compounds exhibited inhibitory activity with different percentages against the caspase-like (C-L, β1 subunit), trypsin-like (T-L, β2 subunit) and chymotrypsin-like (ChT-L, β5 subunit) activities of proteasome. Among the tested compounds, compound I [R = (5-chloro-2-pyridyl)amino] was the most active compound in the series and displayed higher inhibition with IC₅₀ values of 9.90 ± 0.61, 44.83 ± 4.23 and 22.27 ± 0.15μM against ChT-L, C-L and T-L activities of proteasome compared to the lead compound PI-083 (IC₅₀ = 12.47 ± 0.21, 53.12 ± 2.56 and 26.37 ± 0.5μM), resp. The antiproliferative activity were also determined by MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay in-vitro. According to the antiproliferative activity results, all of the compounds I and _II exhibited cell growth inhibitory activity in a range of IC₅₀ = 1.72 ± 0.14-20.8 ± 0.5μM and compounds I [R = (5-methyl-2-pyridyl)amino] and II [R¹ = (4-methyl-2-pyridyl)amino] were found to be the most active compounds with IC₅₀ values of 1.79 ± 0.21 and 1.72 ± 0.14μM, resp. Furthermore, mol. modeling studies were carried out for the compounds I [R = (5-methyl-2-pyridyl)amino, (5-chloro-2-pyridyl)amino] and II [R¹ = (4-methyl-2-pyridyl)amino] to investigate the ligand-enzyme binding interactions.

Synthetic Route of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Product Details of C6H8N2.

Verevkin, Sergey P.;Zherikova, Kseniya V.;Martynenko, Evgeniya A. research published 《 Molecular versus ionic liquids: Development of a thermodynamic framework for predicting vaporization thermodynamics》, the research content is summarized as follows. Ionic liquids based on the pyridinium and quinolinium cations show good result in desulfurization of fuels. The knowledge of their vaporisation thermodn. is of practical importance. The standard molar enthalpies of vaporization of pyridinium based ionic liquids were derived from the vapor pressure temperature dependences measured by the quartz-crystal microbalance method. We have collected available primary exptl. results on vapor pressures, and enthalpies of phase transitions (solid-solid, crystal-gas, and liquid-gas) of analogus mol. species – substituted pyridines and quinolines. These data were evaluated using the structure-property correlations. The consistent sets of evaluated thermodn. data on the mol. and ionic liquids were used to develop the ′′centerpiece′′ based group-additivity method for predicting enthalpies of vaporization of mol. and ionic compounds The general transferability of the contributions to the enthalpy of vaporization from the mol. liquids to the ionic liquid has been established.

Product Details of C6H8N2, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Electric Literature of 1603-41-4.

Sun, Chaofan;Lu, Ju-You;Lu, Jian research published 《 Pd-Catalyzed Selective B(6)-H Phosphorization of nido-Carboranes via Cascade Deboronation/B-H Activation from closo-Carboranes》, the research content is summarized as follows. Efficient Pd-catalyzed regioselective B(6)-H phosphorization of nido-carboranes via cascade deboronation/B-H activation of readily available C-substituted o-carboranes with various phosphines using 3-methylpyridine or isoquinoline as a directing group in combination with pyridine ligands was developed, affording unprecedented B(6)-phosphinated nido-carborane derivatives with high selectivity in a simple 1-pot process.

Electric Literature of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Formula: C6H8N2.

Sugihara, Naoki;Suzuki, Kensuke;Nishimoto, Yoshihiro;Yasuda, Makoto research published 《 Photoredox-Catalyzed C-F Bond Allylation of Perfluoroalkylarenes at the Benzylic Position》, the research content is summarized as follows. Site-selective and direct C-F bond transformation of perfluoroalkylarenes was achieved with allylic stannanes via an iridium photoredox catalyst system. The present defluoroallylation proceeds exclusively at the benzylic position through perfluoroalkyl radicals generated by a single-electron transfer from an excited photoredox catalyst to perfluoroalkylarenes. A variety of perfluoroalkyl groups are applicable: linear perfluoroalkyl-substituted arenes such as Ar-ⁿC₄F₉ and Ar-ⁿC₆F₁₃ and heptafluoroisopropylarenes (Ar-CF(CF₃)₂) underwent site-selective defluoroallylation. DFT calculation studies revealed that the in situ generated Bu₃SnF traps F^– to prevent a retroreaction from the unstable perfluoroalkyl radical intermediate, and the radical intermediate favorably reacts with allylic stannanes. The synthesis of a bis(trifluoromethyl)methylene unit containing compound, which is an analog that is useful as a pharmaceutical agent for the prophylaxis or treatment of diabetes and inflammatory diseases, demonstrated the utility of this reaction.

Formula: C6H8N2, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. COA of Formula: C6H8N2.

Sagar, Sneha R.;Singh, Devendra Pratap;Das, Rajesh D.;Panchal, Nirupa B.;Sudarsanam, Vasudevan;Nivsarkar, Manish;Vasu, Kamala K. research published 《 Investigations on substituted (2-aminothiazol-5-yl)(imidazo[1,2-a]pyridin-3-yl)methanones for the treatment of Alzheimer’s disease》, the research content is summarized as follows. Herein authors report of a new series of substituted (2-aminothiazol-5-yl)(imidazo[1,2-a]pyridin-3-yl)methanones I (R¹ = H, Me; R² = H, Me, Ph, NMe₂). The designed compounds were synthesized and characterized by spectral data. In vivo anti-inflammatory activity was carried out for screening of anti-inflammatory potential of synthesized compounds All the compounds were tested for acute inflammatory activity by using carrageenan induced acute inflammation model. Compounds I (R¹ = 8-Me, R² = NMe₂; R¹ = 7-Me, R² = NMe₂; R¹ = 7-Me, R² = H) had shown promising acute anti-inflammatory activity and they were further tested for formalin induced chronic inflammation model. Compound I (R¹ = 7-Me, R² = NMe₂)10c showed both acute and chronic anti-inflammatory activity. Compound I also showed promising results in AlCl3 induced AD model. Studies on various behavioral parameters suggested improved amnesic performance of compound I treated rats. Compound I treated rats also exhibited excellent antioxidant and neuroprotective effect with inherent gastrointestinal safety.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, COA of Formula: C6H8N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Product Details of C6H8N2.

Shareef, Sumbulunnisan;Saigal;Khizr, Mohammad;Sahoo, Subash C.;Musawwer Khan, Md. research published 《 Microwave assisted novel one-pot three-component reaction for synthesis of 3-aminoimidazopyridines using molecular iodine》, the research content is summarized as follows. An expedient, cost-effective and metal-free green protocol was developed for the preparation of 3-aminoimidazopyridines by the three-component reaction of arylglyoxal monohydrates, aromatic amines and 2-aminopyridines. This multicomponent reaction was executed under microwave irradiation in presence of catalytic amount of mol. iodine in ethanol, involving the formation of three new C-N bonds via imine intermediate. Environmentally benign catalyst, eco-friendly medium, good yields, short reaction time and purification by simple crystallization are some distinguished features of this protocol. In addition, presented method is sustainable since produced water only as by product, avoidance of toxic catalyst and good amenability with principle of green chem.

Product Details of C6H8N2, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Formula: C6H8N2.

Sharma, Richa;Yadav, Lalit;Yadav, Ravi Kant;Chaudhary, Sandeep research published 《 Oxidative cross-dehydrogenative coupling (CDC) via C(_SP²)-H bond functionalization: tert-butyl peroxybenzoate (TBPB)-promoted regioselective direct C-3 acylation/benzoylation of 2H-indazoles with aldehydes/benzyl alcohols/styrenes》, the research content is summarized as follows. An efficient, cost-effective, transition-metal-free, oxidative C(_SP²)-H/C(_SP²)-H cross-dehydrogenative coupling via a C(_SP²)-H bond functionalization protocol for the regioselective direct C-3 acylation/benzoylation of substituted 2H-Indazoles I (R = H, F, Cl, OMe; R¹ = H, Me; RR¹ = -OCH₁O-; R² = H, Cl, Me, OMe; X = CH, N) with substituted aldehydes R³CHO (R³ = Me, Ph, pyrrol-2-yl, etc;)/benzyl alcs. R³CH₂OH/styrenes R³CH=CH₂ is reported. The operationally simple protocol proceeds in the presence of tert-Bu peroxybenzoate (TBPB) as an oxidant in chlorobenzene (PhCl) as a solvent at 110°C for 24 h under an inert atm., which furnished a diverse variety of substituted 3-(acyl/benzoyl)-2H-indazoles II in up to 87% yields. The reaction involves a free-radical mechanism and proceeds via the addition of an in situ generated acyl radical (from aldehydes /benzyl alcs./styrenes) on 2H-indazoles. The functional group tolerance, broad substrate scope, control/competitive experiments and gram-scale synthesis and its application to the synthesis of anti-inflammatory agent III and novel indazole-fused diazepine IV further signify the versatile nature of the developed methodol.

Formula: C6H8N2, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Name: 2-Amino-5-methylpyridine.

Shashikala, K.;Praveena, D.;Ramesh, M.;Laxminarayana, E. research published 《 FeF₃ mediated synthesis of 3,4-dihydro-3-pyridyl-2H-naphtha[2,1-e][1,3]oxazine derivatives》, the research content is summarized as follows. Biol. active 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives I [R = 4-pyridyl, 5-methyl-2-pyridyl, 4-methyl-2-pyridyl, etc.] were synthesized using environmentally benign and economically feasible Lewis acid FeF₃.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Name: 2-Amino-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Name: 2-Amino-5-methylpyridine.

Silva, Daniel G.;Junker, Anna;de Melo, Shaiani M. G.;Fumagalli, Fernando;Gillespie, J. Robert;Molasky, Nora;Buckner, Frederick S.;Matheeussen, An;Caljon, Guy;Maes, Louis;Emery, Flavio S. research published 《 Synthesis and Structure-Activity Relationships of Imidazopyridine/Pyrimidine- and Furopyridine-Based Anti-infective Agents against Trypanosomiases》, the research content is summarized as follows. Neglected tropical diseases remain among the most critical public health concerns in Africa and South America. The drug treatments for these diseases are limited, which invariably leads to fatal cases. Hence, there is an urgent need for new antitrypanosomal drugs. To address this issue, a large number of diverse heterocyclic compounds were prepared Straightforward synthetic approaches tolerated pre-functionalized structures, giving rise to a structurally diverse set of analogs. We report on a set of 57 heterocyclic compounds with selective activity potential against kinetoplastid parasites. In general, 29 and 19 compounds of the total set could be defined as active against Trypanosoma cruzi and T. brucei brucei, resp. (antitrypanosomal activities <10μM). The present work discusses the structure-activity relationships of new fused-ring scaffolds based on imidazopyridine/pyrimidine and furopyridine cores. This library of compounds shows significant potential for anti-trypanosomiases drug discovery.

Name: 2-Amino-5-methylpyridine, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem