Tag: M.W=100-150

Xu, Shenzhen; Carter, Emily A. published the artcile< Optimal functionalization of a molecular electrocatalyst for hydride transfer>, SDS of cas: 3796-23-4, the main research area is optimal functionalization mol electrocatalyst hydride transfer; carbon dioxide reduction; catalyst functionalization; hydride transfer.

Optimization of hydride transfer (HT) catalysts to enhance rates and selectivities of (photo)electroreduction reactions could be a crucial component of a sustainable chem. industry. Here, the authors analyze how ring functionalization of the adsorbed transient intermediate 2-pyridinide (2-PyH) and predicted to form in situ from pyridine (Py) in acidified H2O at a cathode surface and to be the key to selective reduction and enhanced catalytic activity. Reducing the electron d. on 2-PyH could limit this protonation, with the trade-off that it may become less active for HT from 2-PyH. The authors explore here how Py functionalization affects the electron distribution and in turn tunes the catalytic performance of 2-PyH*. The authors indeed find that electron-withdrawing groups could enhance the stability of 2-PyH by reducing its electron d. on the ring. Also, the change in the number of electrons on the substituting group of the hydride donor is a good descriptor for both the stability against protonation and the magnitude of the HT barrier. The authors studied the effect of substituent on the process.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Electrochemical reaction catalysts. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, SDS of cas: 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Guo-Xing; Hu, Xiafei; He, Gang; Chen, Gong published the artcile< Photoredox-mediated remote C(sp3)-H heteroarylation of free alcohols>, Application of C7H7NO2, the main research area is alc heteroaryl preparation regioselective chemoselective; heteroarene aliphatic alc heteroarylation.

An efficient and economical method for remote δ C(sp3)-H heteroarylation of free aliphatic alcs., e.g., cyclobutaneethanol using a hypervalent iodine PFBI-OH oxidant under photoredox catalysis has been reported. The reaction sequence involves in situ alcoholysis of PFBI-OH with alc., generation of an alkoxy radical intermediate by SET reduction, 1,5-HAT, and Minisci-type C-C bond formation. This method uses a slight excess of alcs., can facilitate reaction at δ Me and methylene positions, and has been successfully applied to modification of complex drug mols.

Chemical Science published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xue; Wang, Yun; Li, Xiaoqing; Dai, Yejia; Wang, Qinghao; Wang, Guoyou; Liu, Depeng; Gu, Xuezhu; Yu, Dingrong; Ma, Yinlian; Zhang, Cun published the artcile< Treatment mechanism of Gardeniae fructus and its carbonized product against ethanol-induced gastric lesions in rats>, Reference of 93-60-7, the main research area is Gardeniae gastric lesions gastroprotective; Gardeniae Fructus; carbonized Gardeniae Fructus; ethanol-induced gastric lesion; gastroprotective; metabolomics; processed.

Gardeniae Fructus (GF) and carbonized GF (GFC) have been shown to exert a gastrointestinal protective effect and are frequently used in clin. practice for the treatment of hemorrhage and brown stool. In this study, we employed a combination of pharmacol. methods and metabolomics in a rat model of ethanol-induced acute stomach ulcer to investigate the gastroprotective effect of GF and GFC water extracts and the potential mechanism involved in this process. The levels of nitric oxide (NO) and interleukin 6 (IL-6) in the plasma of rats were determined The results showed that both GF and GFC reduced the ethanol-induced gastric lesions and expression of NO and IL-6 in these rats. Of note, 16 and 11 feature metabolites were filtered and identified in the GF and GFC groups, resp. Both GF and GFC act by restoring the biosynthesis of valine, leucine, and isoleucine, and the metabolism of glycerophospholipids. Moreover, histol. evaluation revealed that heat processing of GF to create GFC enhanced the gastric mucosa protective effect. Furthermore, heat processing converted the main pathway from alanine, aspartate, and glutamate metabolism, associated with GF, to histidine metabolism, associated with GFC. GF and GFC ameliorated gastric mucosa lesions in rats via reductions in NO production and inflammatory cytokine secretion, and the induction of prostaglandin E2.

Frontiers in Pharmacology published new progress about Biomarkers. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rani, Pooja; Gauri; Husain, Ahmad; Bhasin, K. K.; Kumar, Girijesh published the artcile< A Doubly Interpenetrated CuII Metal-Organic Framework for Selective Molecular Recognition of Nitroaromatics>, COA of Formula: C6H8N2, the main research area is copper pyridinylnaphthalenecarboxamide oxybisbenzoate MOF preparation thermal stability fluorescent sensor; crystal structure copper pyridinylnaphthalenecarboxamide oxybisbenzoate MOF.

Herein, we report the design, synthesis, and structural characterization of a novel 2-fold interpenetrated CuII metal-organic framework Cu-MOF-1 [{Cu2(L)(oba)2}·DMF·H2O]α (where, L = N2,N6-di(pyridin-4-yl)naphthalene-2,6-dicarboxamide and oba2- is 4,41-oxybis(benzoic acid) anion). A single-crystal X-ray anal. reveals that Cu-MOF-1 exhibits a doubly (1 + 1) interpenetrated three-dimensional structure with 6-connected mab topol. Moreover, Cu-MOF-1 showed high fluorescence stability in methanol solution and selectively detected nitroaroms. with high quenching constants and low detection limits of 0.31 × 105 M-1 and 22.65μM for 2,4,6-TNP; 1.34 × 105 M-1 and 18.7μM for 4-NPH; and 1.49 × 105 M-1 and 14.07μM for 4-NA. Notably, ligand L itself did not display any type of recognition for any nitroaroms. in methanol solution The sensing of NACs by Cu-MOF-1 followed mostly the resonance energy transfer mechanism; however, in the case of 4-NPH and 2,4,6-TNP an electron transfer mechanism also exists. Importantly, Cu-MOF-1 shows recyclability up to five cycles without any significant loss in quenching efficiency.

Crystal Growth & Design published new progress about Aromatic nitro compounds Role: ANT (Analyte), ANST (Analytical Study). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gardell, Stephen J.; Hopf, Meghan; Khan, Asima; Dispagna, Mauro; Hampton Sessions, E.; Falter, Rebecca; Kapoor, Nidhi; Brooks, Jeanne; Culver, Jeffrey; Petucci, Chris; Ma, Chen-Ting; Cohen, Steven E.; Tanaka, Jun; Burgos, Emmanuel S.; Hirschi, Jennifer S.; Smith, Steven R.; Sergienko, Eduard; Pinkerton, Anthony B. published the artcile< Boosting NAD+ with a small molecule that activates NAMPT>, Formula: C6H8N2, the main research area is lung carcinoma cell NAMPT SBI797812 NAD.

Pharmacol. strategies that boost intracellular NAD+ are highly coveted for their therapeutic potential. One approach is activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase production of NMN (NMN), the predominant NAD+ precursor in mammalian cells. A high-throughput screen for NAMPT activators and hit-to-lead campaign yielded SBI-797812, a compound that is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 shifts the NAMPT reaction equilibrium towards NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate byproduct, and blunts feedback inhibition by NAD+. These effects of SBI-797812 turn NAMPT into a “”super catalyst”” that more efficiently generates NMN. Treatment of cultured cells with SBI-797812 increases intracellular NMN and NAD+. Dosing of mice with SBI-797812 elevates liver NAD+. Small mol. NAMPT activators such as SBI-797812 are a pioneering approach to raise intracellular NAD+ and realize its associated salutary effects.

Nature Communications published new progress about Biomarkers. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zeng, Liyao; Yang, Huaxin; Zhao, Menglong; Wen, Jialin; Tucker, James H. R.; Zhang, Xumu published the artcile< C1-Symmetric PNP Ligands for Manganese-Catalyzed Enantioselective Hydrogenation of Ketones: Reaction Scope and Enantioinduction Model>, Application In Synthesis of 350-03-8, the main research area is ferrocene chiral PNP ligand manganese preparation ketone enantioselective hydrogenation.

A family of ferrocene-based chiral PNP ligands I (R = t-Bu, cyclohexyl, Ph, R’ = Ph; R = Ph, R’ = H, i-Pr, PhCH2) has been reported. These tridentate ligands were successfully applied in Mn-catalyzed asym. hydrogenation of ketones with high enantioselectivities (92-99% ee for aryl alkyl ketones) as well as high efficiencies (TON up to 2000). In addition, dialkyl ketones could also be hydrogenated smoothly. Manganese intermediates that might be involved in the catalytic cycle were analyzed. DFT calculation was carried out to help understand the chiral induction model. The Mn/PNP catalyst could discriminate two groups with different steric properties by deformation of the phosphine moiety in the flexible 5-membered ring.

ACS Catalysis published new progress about Density functional theory. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mahmoudi, Maedeh; Bayat, Amir-Hossein; Boroujeni, Mahdi Eskandarian; Abdollahifar, Mohammad Amin; Ebrahimi, Vahid; Danyali, Samira; Heidari, Mohammad Hassan; Aliaghaei, Abbas published the artcile< Curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is cerebellar ataxia purkinje neuron curcumin motor function; 3-Acethylpyridine; Cerebellar ataxia; Curcumin; Neuroprotection; Purkinje cells.

Cerebellar ataxias comprise a group of terminal illnesses with ataxia as the main symptom. Curcumin as a yellow polyphenol was extracted from the rhizome of Curcuma longa. Owing to its antioxidant, anti-inflammatory, anti-fibrotic and anti-tumor features, curcumin is considered as a potential therapeutic agent. In this study, we aim to investigate the neuroprotective effects of oral administration of curcumin on a rat model of cerebellar ataxia induced by neurotoxin 3-acetylpyridine. The animals were randomly separated into three groups (control, 3-acetylpyridine, and curcumin + 3-acetylpyridine). Next, motor performance and muscle electromyog. activity were assessed. Then, in the mol. part of the study, the anti-apoptotic role of curcumin in cerebellar ataxia and its relationship to protection of Purkinje cells were investigated. Curcumin treatment improved motor coordination and muscular activity, reduced cleaved caspase-3, and increased glutathione level in 3-AP-lesioned rats as well as total volumes of cerebellar granular and mol. layers.the present study implies that curcumin might have neuroprotective effects to counteract neurotoxicity of 3-AP-induced ataxia.

Journal of Chemical Neuroanatomy published new progress about Electromyography. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Jiacheng; Siang Tan, Suan; Kyne, Sara Helen; Chan, Philip Wai Hong published the artcile< Minisci-Type Alkylation of N-Heteroarenes by N-(Acyloxy)phthalimide Esters Mediated by a Hantzsch Ester and Blue LED Light>, Safety of 3-(Trifluoromethyl)pyridine, the main research area is alkylated quinoline preparation; quinoline acyloxy phthalimide ester Minisci type alkylation HE mediated; isoquinoline alkylated preparation; acyloxy phthalimide ester isoquinoline Minisci type alkylation HE mediated; pyridine alkylated preparation; phthalimide ester acyloxy pyridine Minisci type alkylation HE mediated.

A synthetic method that enabled the Hantzsch ester (HE)-mediated Minisci-type C2-alkylation of quinolines, isoquinolines and pyridines by N-(acyloxy)phthalimide esters (NHPI) to afford alkylated N-heterocyclic products, e.g., I, under blue LED (light emitting diode) light (456 nm) was described. Achieved under mild reaction conditions at room temperature, the metal-free synthetic protocol was shown to be applicable to primary, secondary and tertiary NHPIs to give the alkylated N-heterocyclic products in yields of 21-99%. On introducing a chiral phosphoric acid, an asym. version of the reaction was also realized and provided product enantiomeric excess (ee) values of 53-99%.

Advanced Synthesis & Catalysis published new progress about Alkylation. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Safety of 3-(Trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nallagonda, Rajender; Karimov, Rashad R. published the artcile< Copper-Catalyzed Regio- and Diastereoselective Additions of Boron-Stabilized Carbanions to Heteroarenium Salts: Synthesis of Azaheterocycles Containing Contiguous Stereocenters>, Name: 3-(Trifluoromethyl)pyridine, the main research area is nonaromatic nitrogen heterocycle preparation diastereoselective addition boron carbanion heteroarenium.

Nucleophilic addition of diborylalkyl reagents to N-alkyl or N-acylpyridinium and related heteroarenium salts has been developed as a key step for the synthesis of nonaromatic nitrogen heterocycles that contain contiguous stereogenic centers. Derivatization of the dihydropyridine products for the synthesis of tetrahydropyridines and piperidines have also been described.

ACS Catalysis published new progress about Boranes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkyl). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Name: 3-(Trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Guo Cheng; Li, Yan; Chi, Jie; Xu, Na; Wang, Xiu Li; Lin, Hong Yan; Chen, Yong Qiang published the artcile< Multi-functional fluorescent responses of cobalt complexes derived from functionalized amide-bridged ligand>, Quality Control of 3731-53-1, the main research area is cobalt methylenepyridinylnaphthalenedicarboxamide dicarboxylate coordination polymer preparation fluorescent indicator; crystal structure cobalt methylenepyridinylnaphthalenedicarboxamide dicarboxylate coordination polymer.

Multi-functional fluorescent detection for inorganic pollutants and biol. protein is important but challenging. Five multi-functional luminescent coordination polymers (LCPs), [Co2(L)2(PDA)2]·H2O (1), [Co(L)(TPD)(H2O)2]·8H2O (2), [Co(L)(1,3-BDC)]·2H2O (3), [Co(L)(MIP)]·H2O (4) and [Co3(L)3(HIPA)3] (5) [H2PDA = 1,3-phenylenediacetic acid, H2TPD = 2,5-thiophenedicarboxylic acid, 1,3-H2BDC = 1,3-benzenedicarboxylic acid, H2MIP = 5-methylisophthalic acid and H2HIPA = 5-hydroxyisophthalic acid] were successfully synthesized from a naphthalene-dicarboxamide [N,N’-bis(4-methylenepyridin-4-yl)-1,4-naphthalene dicarboxamide (L)] with multi-functional spacers. 1 And 2 show 4-c sql networks. 3-5 display mab, pcu and hxg 3-dimensional frameworks, resp. The title complexes exhibit multi-functional fluorescent responses towards metal ion (Fe3+), anions (CrO42-, Cr2O72- and MnO4-) and biol. protein (bovine serum albumin).

Dyes and Pigments published new progress about Bovine serum albumin Role: ANT (Analyte), ANST (Analytical Study). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem