Tag: M.W=100-150

Gao, Li; Wu, Datong; Tan, Wensheng; Pan, Fei; Xu, Jiale; Tao, Yongxin; Kong, Yong published the artcile< A facile synthesis of two ionized fluorescent carbon dots and selective detection toward Fe2+ and Cu2+>, Name: Pyridin-4-ylmethanamine, the main research area is iron copper carbon dot selective detection.

In this study, a facile synthesis of two ionized carbon dots (CDs-2 and CDs-3) is reported, in which different ionic pairs are formed at the surface of the carbon core. In contrast to CDs-3, the accumulation of carbon core can be clearly observed in the TEM image of CDs-2. This is due to the linkage of the dibromine alkyl group. Compared with naked CDs in the absence of the ionic pair, the maximum emission wavelength undergoes a red-shift of nearly 60 nm. Moreover, protic solvents (water, ethanol and N,N′-dimethyl formamide) have an apparent effect on the emission intensities of CDs-2 and CDs-3. The time-resolved average lifetimes of CDs-2 and CDs-3 are calculated as 56.34 ns and 54.50 ns, resp. Furthermore, they both have much better fluorescence stability in the solution with pH ranging from 2 to 11 due to the presence of the imidazolium cation. It is interesting to see that CDs-2 and CDs-3 have much different responses towards Cu2+ and Fe2+. The CDs-3 solution generates clear fluorescence quenching when treated with Fe2+. In brief, we believe that these findings can inspire more research developments in the synthesis and further application of functional CDs.

Nanoscale Advances published new progress about Carbon quantum dots. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Looga, A. M.; Ambassa, P.; Kamga, J.; Hortense, GK.; Ngadjui, B. T.; Ngameni, B. published the artcile< Synthesis and evaluation of antimicrobial properties of some novel indole pyridine based chalcones>, SDS of cas: 350-03-8, the main research area is chalcone indole pyridine diastereoselective preparation antibacterial antifungal; indolyl pyridinyl propenone preparation diastereoselective antibacterial antifungal activity.

A series of novel substituted indolylchalcone derivatives (E)-I (R = H, Me, Ar = pyridin-3-yl, pyridin-4-yl) were synthesized via Claisen-Schmidt condensation between indole-3-carbaldehyde and N-methylindole-3-carbaldehyde and 3- and 4-pyridinylacetophenones. All the compounds were screened for their antibacterial and antifungal activity against six different bacterial strains – Escherichia coli ATCC 25922, Klebsiella pneumonia ATCC 700603, Staphylococcus aureus ATCC 25923, Proteus mirabilis, Salmonella typhi, Pseudomonas aeruginosa – and against one fungal strain, Candida albicans. The results reveal that all the compounds exhibited moderate to good antibacterial and antifungal activities.

Austin Journal of Analytical and Pharmaceutical Chemistry published new progress about Antibacterial agents. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, SDS of cas: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duong, Thi-Mai Huong; Nobusue, Shunpei; Tada, Hirokazu published the artcile< Preparation of perovskite-derived one dimensional single crystals based on edge-shared octahedrons with pyridine derivatives>, HPLC of Formula: 3731-53-1, the main research area is lead pyridine derivative iodo complex perovskite preparation crystal structure; optical band gap lead pyridine derivative iodo complex perovskite.

Single crystals of hybrid materials based on 1D lead iodide perovskite networks with 2 pyridine (Py) derivatives, 4-Et (4Et)Py and 4-aminomethyl (4AM)Py, were prepared The compounds assembled into edge-shared lead iodide chains that formed needle-shaped crystals with lengths >1 cm. The crystal containing (4Et)Py formed in the triclinic system with P1 symmetry. The mols. were stacked along with the novel triple chain of 1D perovskite-derived networks. The crystal containing 4AMPy formed in the monoclinic system with P21/a symmetry. The amino group formed H bonds to I-. The optical band gaps for the 4EtPy-based and 4AMPy-based crystals are 2.73 eV and 2.64 eV, resp. The slight difference between the functional groups of the 2 mols. governed their crystal structures and hence optical properties.

Journal of Crystal Growth published new progress about Crystal structure. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Guoqi; Cheng, Jessica; Davis, Kezia; Bonifacio, Mary Grace; Zajaczkowski, Cynthia published the artcile< Practical and selective hydroboration of aldehydes and ketones in air catalysed by an iron(II) coordination polymer>, Product Details of C7H7NO, the main research area is hydroboration aldehyde ketone green chem iron coordination polymer catalyst.

The in air catalytic hydroboration of ketones and aldehydes with pinacolborane by an iron(II) coordination polymer (CP) is carried out under mild and solvent-free conditions. The precatalyst is highly active towards a wide range of substrates including functionalized ketones and aldehydes in the presence of KOtBu as an activator, achieving a high turnover number (TON) of up to 9500. Excellent chemoselectivity to aldehydes over ketones was also revealed, which is in sharp contrast with the results obtained under inert atm. using the same catalyst system. This catalyst observed here is not only highly efficient but also recyclable for reuse for at least 5 times without losing its effectiveness.

Green Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rechitskaya, E. D.; Kuratieva, N. V.; Lider, E. V.; Eremina, J. A.; Klyushova, L. S.; Eltsov, I. V.; Kostin, G. A. published the artcile< Tuning of cytotoxic activity by bio-mimetic ligands in ruthenium nitrosyl complexes>, Application In Synthesis of 93-60-7, the main research area is ruthenium nitrosyl isonicotinate nicotinate complex preparation cytotoxic activity; crystal structure ruthenium nitrosyl isonicotinate nicotinate complex.

Three novel ruthenium nitrosyl complexes [Ru(NO)Cl3(InicMe)2] (1b), [RuNOCl3(NicEt)2] (1c) and [RuNOCl3(NicMe)2] (1d) (InicMe = Me isonicotinate, NicEt = Et nicotinate, NicMe = = Me nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD anal. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: πarene-πarene and πCOO-πarene stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)2Cl3] (L = Py, γ-Pic, β-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex.

Journal of Molecular Structure published new progress about Antitumor agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duplantier, Allen J.; Becker, Stacey L.; Bohanon, Michael J.; Borzilleri, Kris A.; Chrunyk, Boris A.; Downs, James T.; Hu, Lain-Yen; El-Kattan, Ayman; James, Larry C.; Liu, Shenping; Lu, Jiemin; Maklad, Noha; Mansour, Mahmoud N.; Mente, Scot; Piotrowski, Mary A.; Sakya, Subas M.; Sheehan, Susan; Steyn, Stefanus J.; Strick, Christine A.; Williams, Victoria A.; Zhang, Lei published the artcile< Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potent D-Amino Acid Oxidase (DAAO) Inhibitors>, COA of Formula: C6H6N2O, the main research area is amino acid oxidase inhibitor hydroxyquinolinone preparation SAR.

3-Hydroxyquinolin-2(1H)-one (2) was discovered by high throughput screening in a functional assay to be a potent inhibitor of human DAAO, and its binding affinity was confirmed in a Biacore assay. Cocrystn. of 2 with the human DAAO enzyme defined the binding site and guided the design of new analogs. The SAR, pharmacokinetics, brain exposure, and effects on cerebellum D-serine are described. Subsequent evaluation against the rat DAAO enzyme revealed a divergent SAR vs. the human enzyme and may explain the high exposures of drug necessary to achieve significant changes in rat or mouse cerebellum D-serine.

Journal of Medicinal Chemistry published new progress about Cerebellum. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, COA of Formula: C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schubert, S.; Brans, R.; Reich, A.; Hansen, A.; Buhl, T.; Skudlik, C.; Mempel, M.; Schoen, M. P.; John, S. M.; Geier, J. published the artcile< Assessment of occupational exposure and spectrum of contact sensitization in metalworkers with occupational dermatitis: results of a cohort study within the OCCUDERM project>, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is occupational exposure contact sensitization dermatitis.

Background : Metalworkers occupationally exposed to metals, tools, metalworking fluids (MWFs), tech. oils, gloves, skin care products etc. frequently suffer from occupational dermatitis (OD). Objectives : To investigate occupational exposure and to identify relevant occupational sensitizers in metalworkers with OD, and to evaluate suitability of current German patch test recommendations for this occupational group. Patients and methods : As part of the OCCUDERM project, occupational exposure of 230 metalworkers with suspected OD patch tested in the departments of dermatol. in Goettingen and Osnabrueck (both Lower Saxony, Germany) in 2012-2017 was recorded by questionnaire. These data, as well as results, of patch testing with standardized allergens and with workplace material were analyzed. Results : Metalworking fluids and skin care products were the most important exposures. Among MWF allergens, most frequently sensitizations to formaldehyde and formaldehyde releasers, colophony/abietic acid and monoethanolamine were observed Sensitization to methylisothiazolinone (MI) was frequent, probably as part of the general European epidemic of contact allergy to MI in leave-on cosmetics. Sensitization to glove ingredients only played a minor role. Conclusions : The known occupational allergen spectrum could largely be confirmed. In order not to miss relevant sensitizations, patch testing with material from the patients workplaces in parallel to baseline and MWF series is recommended. Sensitizations diagnosed could not always be linked to particular occupational exposures.

Journal of the European Academy of Dermatology and Venereology published new progress about Allergic contact dermatitis. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mizukawa, Yuki; Ikegami-Kawai, Mayumi; Horiuchi, Masako; Kaiser, Marcel; Kojima, Masayoshi; Sakanoue, Seiki; Miyagi, Seiya; Nanga Chick, Christian; Togashi, Hiroyuki; Tsubuki, Masayoshi; Ihara, Masataka; Usuki, Toyonobu; Itoh, Isamu published the artcile< Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines>, Reference of 3731-53-1, the main research area is dimethoxyquinazolinediamine preparation antimalarial; Antimalarial drug; Derivatization; Quinazoline-2,4-diamines; SAR.

Quinazolines have long been known to exert varied pharmacol. activities that make them suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014, author’s have synthesized approx. 150 different 6,7-dimethoxyquinazoline-2,4-diamines and evaluated their antimalarial activity via structure-activity relationship studies. Here, author’s summarize the results and report the discovery of 6,7-dimethoxy-N4-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine, which exhibits high antimalarial activity as a promising antimalarial drug lead.

Bioorganic & Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Reference of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Beller, Matthias; Magerlein, Wolfgang; Indolese, Adriano F.; Fischer, Christine published the artcile< Efficient palladium-catalyzed alkoxycarbonylation of N-heteroaryl chlorides - A practical synthesis of building blocks for pharmaceuticals and herbicides>, Formula: C6H6ClNO, the main research area is butyl pyridinecarboxylate preparation; heteroaryl chloride alkoxycarbonylation palladium phosphine ligand catalyst; alkoxycarbonylation chloropyridine palladium catalyst.

The alkoxycarbonylation of various N-heteroaryl chlorides was examined in detail. Studies of the butoxycarbonylation of 2- and 3-chloropyridine revealed the importance of selecting both the right phosphine ligand and ligand concentration in order to obtain efficient conversion and selectivity. Amongst the different ligands tested, 1,4-bis(diphenylphosphino)butane (dppb) and 1,1′-bis(diphenylphosphino)ferrocene (dppf) led to the most efficient palladium catalyst systems for the conversion of 2- and 4-chloropyridines and similar heteroaryl chlorides. For e.g., Bu pyridine-2-carboxylate was prepared in 95% yield in the presence of dppf ligand. The best catalytic systems for the alkoxycarbonylation of less activated substrates, such as 3-chloropyridines, were found to be those containing 1,4-bis(dicyclohexylphosphino)butane. Good to excellent yields of a number of N-heterocyclic carboxylic acid esters were realized by applying the appropriate ligand in the right concentration at low catalyst loadings (0.005-0.5 mol% Pd). For the first time catalyst turnover numbers (TON) of up to 13,000 were obtained for the carbonylation of a (hetero)aryl chloride.

Synthesis published new progress about Alkoxycarbonylation. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Formula: C6H6ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Li; Wu, Datong; Tan, Wensheng; Pan, Fei; Xu, Jiale; Tao, Yongxin; Kong, Yong published the artcile< A facile synthesis of two ionized fluorescent carbon dots and selective detection toward Fe2+ and Cu2+>, Name: Pyridin-4-ylmethanamine, the main research area is iron copper carbon dot selective detection.

In this study, a facile synthesis of two ionized carbon dots (CDs-2 and CDs-3) is reported, in which different ionic pairs are formed at the surface of the carbon core. In contrast to CDs-3, the accumulation of carbon core can be clearly observed in the TEM image of CDs-2. This is due to the linkage of the dibromine alkyl group. Compared with naked CDs in the absence of the ionic pair, the maximum emission wavelength undergoes a red-shift of nearly 60 nm. Moreover, protic solvents (water, ethanol and N,N′-dimethyl formamide) have an apparent effect on the emission intensities of CDs-2 and CDs-3. The time-resolved average lifetimes of CDs-2 and CDs-3 are calculated as 56.34 ns and 54.50 ns, resp. Furthermore, they both have much better fluorescence stability in the solution with pH ranging from 2 to 11 due to the presence of the imidazolium cation. It is interesting to see that CDs-2 and CDs-3 have much different responses towards Cu2+ and Fe2+. The CDs-3 solution generates clear fluorescence quenching when treated with Fe2+. In brief, we believe that these findings can inspire more research developments in the synthesis and further application of functional CDs.

Nanoscale Advances published new progress about Carbon quantum dots. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem