Tag: M.W=100-150

Zhang, Tian-Hua; Bai, Chao; Hu, Huai-Ming; Zhang, Jun-Lin; Li, Xuan-Yue; Wang, Xiaofang; Wang, Bo-Zhou published the artcile< Cadmium(II) and cobalt(II) coordination compounds based on a benzenesulfonic terpyridine ligand: Syntheses, structures, luminescent sensing and magnetic properties>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is cadmium cobalt terpyridinylbenzenesulfonate complex preparation luminescent probe; magnetic susceptibility cadmium cobalt terpyridinylbenzenesulfonate complex; crystal structure cadmium cobalt terpyridinylbenzenesulfonate complex.

Five coordination compounds based on a new ligand with terpyridyl and benzenesulfonyl groups, [Cd(STP)2]n (1), [Cd(STP)Cl(H2O)]n·2nH2O (2), [Cd(STP)Br(H2O)]n·2nH2O (3), [Co(STP)2]n (4), [Co(STP)2(H2O)4]·H2O (5) (HSTP = 2-(3,2′:6′,3”-terpyridin-4′-yl)benzenesulfonic acid) were synthesized and characterized by FT-IR, elemental anal., and single crystal X-ray diffraction. Compounds 1 and 4 exhibit a (3,6)-connected 2D layer structure with 3,6L40 topol. network and point symbol of {3·62}{66·96·123}. Compounds 2 and 3 display a 3D topol. network with fsc-3 network and point symbol of {4·6·8}{4·62·83}. Compound 5 shows a discrete mononuclear structure. The structural diversity of compounds 1-5 indicates that counter anions, pH values and coordination modes of STP- anions are significant influence on the final structures. Investigation of luminescent property indicates that compound 3 can be used as a recycled probe with high sensitivity and selectivity to detect acetone and Cr2O72- anion. The KSV of compound 3 for acetone and Cr2O72- anion are 1.295 x 104 M-1 and 5.79 x 102 M-1, resp. The PXRD and UV-Vis spectra indicates that the quenching mechanism of compound 3 toward Cr2O72- anion can be attributed to light competitive absorption. Addnl., magnetic property of compounds 4 and 5 was investigated. The difference of magnetic interactions between compounds 4 and 5 may be caused by different coordination fields.

Journal of Solid State Chemistry published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Esch, Patrick; Heiles, Sven published the artcile< Investigating C-C positions and hydroxylation sites in lipids using Paterno-Buechi functionalization mass spectrometry>, HPLC of Formula: 350-03-8, the main research area is double carbon bond lipid oxidation Paterno Buechi functionalization MS; Sacha inchi oil triglyceride oxidation Paterno Buechi functionalization MS.

Lipid oxidation plays a major role in biochem. processes and nutrition. Structural changes during oxidation can lead to alterations of lipid functions. Rancidification and production of secondary lipid messengers are well-known examples for the impact of oxidation on lipid function. Especially lipids with a high degree of unsaturation are prone to oxidize. In order to investigate structural changes of lipids upon oxidation, we here introduce a photochem. Paterno-Buechi functionalization workflow and subsequent mass spectrometric anal. for anal. of unsaturated, oxidized lipids. Results for hydroxylated fatty acids and triglycerides containing isolated and conjugated C-C bonds will be presented making use of 3-acetylpyridine as a photochem. active compound Photochem. derivatization is performed in nano-electrospray emitter tips in 30 s resulting in the formation of oxetanes without inducing light-triggered oxidation of analytes. Collisional-activation of photoproducts facilitates selective cleavage of oxetane moieties. Resulting fragment ions not only allow the determination of C-C bond locations for isolated and conjugated C-C bonds but also restrict the site of oxidation By registering the mass shift in some fragment ions of +15.99 Da due to hydroxylation, the oxidized sections of lipids can be identified. In order to demonstrate its anal. robustness, the method is applied to determine the structural impact of non-selective ambient oxidation on fatty acids, triglycerides and complex triglyceride mixtures obtained from Sacha inchi oil.

Analyst (Cambridge, United Kingdom) published new progress about C-C bond, double. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Devi, Lalita; Kumar, Prashant; Kant, Ruchir; Rastogi, Namrata published the artcile< Exploiting the umpolung reactivity of diazo groups: direct access to triazolyl-azaarenes from azaarenes>, Name: 3-(Methoxycarbonyl)pyridine, the main research area is triazolyl isoquinoline pyridine phenanthridine preparation; azaarene diazo iodonium triflate tandem electrophilic substitution dipolar cycloaddition.

The present work documents electrophilic substitution of azaarenes, mainly isoquinolines, with hypervalent iodine diazo reagents (HIDR) followed by formal [3+2]-dipolar cycloaddition in a tandem fashion. Other azaarenes viz. pyridines and phenanthridines too could be successfully used in the reaction. The methodol. capitalizes on the umpolung nature of α-aryliodonio diazo compounds for installing a nucleophile, i.e. azaarene, at their α-position. Subsequent ylide formation and intramol. 1,5-cyclization furnished 4,3-fused 1,2,4-triazolyl-azaarenes in good yields. The reaction is notable for its mild conditions, operational simplicity and fairly general scope.

Chemical Communications (Cambridge, United Kingdom) published new progress about [3+2] Cycloaddition reaction. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Name: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Steyer, Daniel J.; Kennedy, Robert T. published the artcile< High-Throughput Nanoelectrospray Ionization-Mass Spectrometry Analysis of Microfluidic Droplet Samples>, Formula: C7H7NO, the main research area is high throughput nanoelectrospray mass spectrometry droplet microfluidics.

Droplet microfluidics enables high-throughput manipulation of fL-μL volume samples. Methods implemented for the chem. anal. of microfluidic droplets have been limited in scope, leaving some applications of droplet microfluidics difficult to perform or out of reach entirely. Nanoelectrospray ionization-mass spectrometry (nESI-MS) is an attractive approach for droplet anal., because it allows rapid, label-free, information-rich anal. with high mass sensitivity and resistance to matrix effects. Previous proof-of-concept systems for the nESI-MS anal. of droplets have been limited by the microfluidics used so that stable, long-term operation needed for high-throughput applications has not been demonstrated. The authors describe a platform for the stable anal. of microfluidic droplet samples by nESI-MS. Continuous infusion of droplets to an nESI emitter was demonstrated for as long as 2.5 h, corresponding to anal. of over 20 000 samples. Stable signal was observed for droplets as small as 65 pL and for throughputs as high as 10 droplets/s. A linear-concentration-based response and sample-to-sample carryover of <3% were also shown. The system is demonstrated for measuring products of in-droplet enzymic reactions. Analytical Chemistry (Washington, DC, United States) published new progress about Droplet microfluidics. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ismail, Hani K. published the artcile< Electrodeposition of a mirror zinc coating from a choline chloride-ethylene glycol-based deep eutectic solvent modified with methyl nicotinate>, Related Products of 93-60-7, the main research area is electrodeposition zinc choline chloride ethylene glycol solvet; deep eutectic solvent modified methyl nicotinate.

A number of studies have reported the effects of additives on metal coatings electrochem. deposited from deep eutectic solvents (DESs). However, no previous study has studied the influences of Me nicotinate (MN) as an additive on the electrodeposition of Zn on a Cu substrate from a DES. The results of this study show that MN significantly develops the Zn deposition in this system compared to the corresponding system in its absence. This is the 1st study to date to show that a mirror Zn coating can be obtained on a Cu substrate using such a mechanism. Various electrochem. methods such as cyclic voltammetry, chronocoulometry, and chronoamperometry were used to understand the electrochem. properties of Zn electrolytes in the absence and presence of MN. These experiments found that the redox reaction currents decline when the additive was included in the Zn electrolyte, and that Zn deposition followed an instantaneous nucleation mechanism in the absence of the additive while in its presence the mechanism was closer to that of progressive growth. Further, the current efficiency decreased from 98.99% in the absence of additive to ∼82% as a result of including the additive in the Zn plating bath, according to electrochem. quartz crystal microbalance (EQCM) data. The resultant roughness, thickness and surface morphol. of the deposited Zn were characterized using at. force microscopy, SEM, and x-ray diffraction, indicating that Me nicotinate, as an additive, functions as a highly influential brightener that gave highly homogeneous and flat Zn deposits.

Journal of Electroanalytical Chemistry published new progress about Chronoamperometry. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Chia-Yu; Stauffer, Tara M.; Strickland, Corey L.; Reader, John C.; Huang, He; Li, Ge; Cooper, Alan B.; Doll, Ronald J.; Ganguly, Ashit K.; Baldwin, John J.; Rokosz, Laura L. published the artcile< Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc>, Formula: C7H10N2, the main research area is piperazine derivative preparation structure farnesyltransferase inhibitor crystal structure.

Farnesyltransferase inhibitors identified from an ECLiPS library were optimized using solution-phase synthesis. X-ray crystallog. of inhibited complexes was used to identify substructures that coordinate to the active site zinc. The x-ray structures were ultimately used to guide the design of second-generation analogs with FTase IC50s of less than 1.0 nM.

Bioorganic & Medicinal Chemistry Letters published new progress about Conformation. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Formula: C7H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Firth, Nicholas C.; Atrash, Butrus; Brown, Nathan; Blagg, Julian published the artcile< MOARF, an Integrated Workflow for Multiobjective Optimization: Implementation, Synthesis, and Biological Evaluation>, Safety of (6-Methylpyridin-3-yl)methanamine, the main research area is MOARF structure activity relationship.

We describe the development and application of an integrated, multiobjective optimization workflow (MOARF) for directed medicinal chem. design. This workflow couples a rule-based mol. fragmentation scheme (SynDiR) with a pharmacophore fingerprint-based fragment replacement algorithm (RATS) to broaden the scope of reconnection options considered in the generation of potential solution structures. Solutions are ranked by a multiobjective scoring algorithm comprising ligand-based (shape similarity) biochem. activity predictions as well as physicochem. property calculations Application of this iterative workflow to optimization of the CDK2 inhibitor Seliciclib (CYC202, R-roscovitine) generated solution mols. in desired physicochem. property space. Synthesis and exptl. evaluation of optimal solution mols. demonstrates CDK2 biochem. activity and improved human metabolic stability.

Journal of Chemical Information and Modeling published new progress about Drug design. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Safety of (6-Methylpyridin-3-yl)methanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elshikh, Mohamed S.; Chen, Tse-Wei; Mani, G.; Chen, Shen-Ming; Huang, Po-Jui; Ali, M. Ajmal; Al-Hemaid, Fahad M.; Al-Mohaimeed, Amal M. published the artcile< Green sonochemical synthesis and fabrication of cubic MnFe2O4 electrocatalyst decorated carbon nitride nanohybrid for neurotransmitter detection in serum samples>, Formula: C7H7NO2, the main research area is neurotransmitter MnFe2o4 electrocatalyst carbon nitride; Bimetal oxides; Graphitic carbon nitride; Hybrid materials; Neurotransmitter detection; Sonochemical synthesis.

The binary nanomaterials and graphitic carbon based hybrid has been developed as an important porous nanomaterial for fabricating electrode with applications in non-enzymic (bio) sensors. We report a fast synthesis of bimetal oxide particles of nano-sized manganese ferrite (MnFe2O4) decorated on graphitic carbon nitride (GCN) via a high-intensity ultrasonic irradiation method for C (30 kHz and 70 W/cm2). The nanocomposites were analyzed by powder X-ray diffraction, XPS, EDS, TEM to ascertain the effects of synthesis parameters on structure, and morphol. The MnFe2O4/GCN modified electrode demonstrated superior electrocatalytic activity toward the neurotransmitter (5-hydroxytryptamine) detection with a high peak intensity at +0.21 V. The appealing application of the MnFe2O4/GCN/GCE as neurotransmitter sensors is presented and a possible sensing mechanism is analyzed. The constructed electrochem. sensor for the detection of 5-hydroxytryptamine (STN) showed a wide working range (0.1-522.6μM), high sensitivity (19.377μA μM-1 cm-2), and nano-molar detection limit (3.1 nM). Moreover, it is worth noting that the MnFe2O4/GCN not only enhanced activity and also promoted the electron transfer rate towards STN detection. The proposed sensor was analyzed for its real-time applications to the detection of STN in rat brain serum, and human blood serum in good satisfactory results was obtained. The results showed promising reproducibility, repeatability, and high stability for neurotransmitter detection in biol. samples.

Ultrasonics Sonochemistry published new progress about Brain. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bori, Jugal; Mahata, Satyajit; Manivannan, Vadivelu published the artcile< A new route for the synthesis of 2,4-bis(2-pyridyl)-6-(pyridyl)pyrimidines: Synthesis and characterization of Co(II), Ni(II) complexes of 2,4,6-tris(2-pyridyl)pyrimidine>, Application In Synthesis of 350-03-8, the main research area is cobalt nickel pyridyl pyrimidine complex preparation crystal structure DFT; EPR spectra cobalt nickel pyridyl pyrimidine complex.

Using 2-acetylpyridine, sodium hydroxide and 2-cyanopyridine, 2,4,6-tris(2-pyridyl)pyrimidine (L1) was synthesized in good yield. Similarly, 2,4-bis(2-pyridyl)-6-(3-pyridyl)pyrimidine (L2) and 2,4-bis(2-pyridyl)-6-(4-pyridyl)pyrimidine (L3) were also synthesized by using resp. acetylpyridine. 2-Acetylpyridine reacted with sodium hydroxide to produce 2-oxo-2-(2-pyridyl)-1-ethanide, which behaves as a nucleophile towards 2-cyanopyridine. All three pyrimidines are potential multidentate ligand and by using L1 complexes of composition [Ni(L1)(H2O)3](NO3)2·4H2O (1), [Ni(L1)2](NO3)2·2H2O (2) and [Co(L1)2](NO3)2·1.5H2O (3) were isolated and structurally characterized. In 1-3, L1 behaves as a tridentate pincer type ligand, DFT calculations performed on L1-L3 indicate that energy difference between HOMO and LUMO is 4.544, 4.643 and 4.533 eV, resp.

Inorganica Chimica Acta published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Jiacheng; Siang Tan, Suan; Kyne, Sara Helen; Chan, Philip Wai Hong published the artcile< Minisci-Type Alkylation of N-Heteroarenes by N-(Acyloxy)phthalimide Esters Mediated by a Hantzsch Ester and Blue LED Light>, Category: pyridine-derivatives, the main research area is alkylated quinoline preparation; quinoline acyloxy phthalimide ester Minisci type alkylation HE mediated; isoquinoline alkylated preparation; acyloxy phthalimide ester isoquinoline Minisci type alkylation HE mediated; pyridine alkylated preparation; phthalimide ester acyloxy pyridine Minisci type alkylation HE mediated.

A synthetic method that enabled the Hantzsch ester (HE)-mediated Minisci-type C2-alkylation of quinolines, isoquinolines and pyridines by N-(acyloxy)phthalimide esters (NHPI) to afford alkylated N-heterocyclic products, e.g., I, under blue LED (light emitting diode) light (456 nm) was described. Achieved under mild reaction conditions at room temperature, the metal-free synthetic protocol was shown to be applicable to primary, secondary and tertiary NHPIs to give the alkylated N-heterocyclic products in yields of 21-99%. On introducing a chiral phosphoric acid, an asym. version of the reaction was also realized and provided product enantiomeric excess (ee) values of 53-99%.

Advanced Synthesis & Catalysis published new progress about Alkylation. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem