Tag: M.W=100-150

Chinna Ayya, Swamy .P.; Varenikov, Andrii; de Ruiter, Graham published the artcile< Chiral Imidazo[1,5-a]pyridine-Oxazolines: A Versatile Family of NHC Ligands for the Highly Enantioselective Hydrosilylation of Ketones>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is chiral imidazopyridineoxazoline bidentate ligand preparation cyclometalation rhodium complex; rhodium imidazopyridineoxazoline bidentate carbene complex preparation catalyst hydrosilylation ketone; alc chiral enantioselective preparation.

Herein the authors report the synthesis and application of a versatile class of N-heterocyclic carbene ligands based on an imidazo[1,5-a]pyridine-3-ylidine backbone that is fused to a chiral oxazoline auxiliary. The key step in the synthesis of these ligands involves the installation of the oxazoline functionality via a microwave-assisted condensation of a cyano-azolium salt with a wide variety of 2-amino alcs. The resulting chiral bidentate NHC-oxazoline ligands form stable complexes with Rh(I) that are efficient catalysts for the enantioselective hydrosilylation of structurally diverse ketones. The corresponding secondary alcs. are isolated in good yields (typically >90%) with good to excellent enantioselectivities (80-95% ee). The reported hydrosilylation occurs at ambient temperatures (40°), with excellent functional group tolerability. Even ketones bearing heterocyclic substituents (e.g., pyridine or thiophene) or complex organic architectures are hydrosilylated efficiently, which is discussed further.

Organometallics published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dolui, Dependu; Mir, Ab Qayoom; Dutta, Arnab published the artcile< Probing the peripheral role of amines in photo- and electrocatalytic H2 production by molecular cobalt complexes>, Formula: C6H8N2, the main research area is peripheral amine photo electrocatalysis hydrogen evolution cobalt complex catalyst.

The incorporation of amine functionality in the periphery of a synthetic cobaloxime core induces excellent photo-(TON 180) and electrocatalytic H2 production (TOF 4330 s-1) in aqueous solution The primary amine group displays a superior influence on the catalysis compared to a secondary amine group with an analogous cobaloxime template.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amino group. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lai, Long-Li; Lin, Pen-Yuan; Wang, Jy-Shih; Hwu, Jih Ru; Shiao, Min-Jen; Tsay, Shwu-Chen published the artcile< Substituent effect on the chlorination of 2-alkoxypyridines to give 2-chloropyridines under Vilsmeier-Haack conditions>, Synthetic Route of 13472-84-9, the main research area is substituent effect chlorination alkoxypyridine.

Various substituted 2-alkoxypyridines were converted into the corresponding 2-chloropyridines in 28-91% yield by use of POCl3 and DMF. Me, halogen, ester and nitro groups displayed an activating effect and an amino group exhibited a deactivating effect.

Journal of Chemical Research, Synopses published new progress about Chlorination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Synthetic Route of 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lan, Chunling Blue; Auclair, Karine published the artcile< Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation>, COA of Formula: C6H8N2, the main research area is amine potassium cyanate ammonium chloride microwave irradiation green chem; urea preparation.

Ammonium chloride promoted the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeded rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it was compatible with other nucleophiles, acid-labile moieties and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatog.

European Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Sen; Sun, Ze-Ying; Zhu, Kongying; Zhao, Wentao; Tang, Xiangyang; Guo, Minjie; Wang, Guangwei published the artcile< Metal-Free Difunctionalization of Pyridines: Selective Construction of N-CF2H and N-CHO Dihydropyridines>, Quality Control of 350-03-8, the main research area is pyridine nitroalkane bromodifluoroacetate regioselective nucleophilic addition; nitroalkyl difluoromethyl dihydropyridine preparation; nitromethylene difluoromethyl dihydropyridine preparation; formyl difluoromethyl dihydropyridine preparation.

A novel nucleophilic addition of N-difluoromethylpyridinium salts with nitroalkanes to synthesize N-CF2H-dihydropyridines and N-CHO-dihydropyridines in a highly efficient and regioselective pathway was reported. This protocol exhibited good functional group tolerance and good to excellent yields.

Organic Letters published new progress about Alkanes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Quality Control of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Youcan; Yin, Zhiping; Wang, Hai; Wu, Xiao-Feng published the artcile< Pd/C-Catalyzed Carbonylative Synthesis of 2-Aminobenzoxazinones from 2-Iodoaryl Azides and Amines>, COA of Formula: C6H8N2, the main research area is amine iodoaryl azide carbon monoxide palladium catalyst carbonylation; aminobenzoxazinone preparation.

A palladium-catalyzed carbonylative procedure for the synthesis of 2-aminobenzoxazinones from 1-azido-2-iodobenzenes and amines has been developed. A broad range of 2-aminobenzoxazinone derivatives, e.g., I were prepared in moderate to excellent yields by using Pd/C as the catalyst under CO atm. Notably, by using organic azides as the substrates, external oxidant usage can be successfully avoided and only forms N2 as the byproduct.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nelson, Todd D.; Crouch, R. David published the artcile< Cu, Ni, and Pd mediated homocoupling reactions in biaryl syntheses: The Ullmann reaction>, Reference of 13472-84-9, the main research area is review Biaryl; review Homocoupling; review Pd; review Reaction; review Syntheses; review Ullmann; review Ni; review Cu; review Reactions; review Mediated.

A review of the article Cu, Ni, and Pd mediated homocoupling reactions in biaryl syntheses: The Ullmann reaction.

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Reference of 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bokosi, Fostino R. B.; Beteck, Richard M.; Mbaba, Mziyanda; Mtshare, Thanduxolo E.; Laming, Dustin; Hoppe, Heinrich C.; Khanye, Setshaba D. published the artcile< Design, synthesis and biological evaluation of mono- and bisquinoline methanamine derivatives as potential antiplasmodial agents>, Product Details of C6H8N2, the main research area is quinoline methanamine preparation antimalarial; Antiplasmodial; Chloroquine-sensitive; Plasmodium falciparum; Quinoline.

Several classes of antimalarial drugs are currently available, although issues of toxicity and the emergence of drug resistant malaria parasites have reduced their overall therapeutic efficiency. Quinoline based antiplasmodial drugs have unequivocally been long-established and continue to inspire the design of new antimalarial agents. Herein, a series of mono- and bisquinoline methanamine derivatives were synthesized through sequential steps; Vilsmeier-Haack, reductive amination, and nucleophilic substitution, and obtained in low to excellent yields. The resulting compounds were investigated for in vitro antiplasmodial activity against the 3D7 chloroquine-sensitive strain of Plasmodium falciparum, and compounds I and II emerged as the most promising with IC50 values of 0.23 and 0.93μM, resp. The most promising compounds were also evaluated in silico by mol. docking protocols for binding affinity to the {0 0 1} fast-growing face of a hemozoin crystal model.

Bioorganic & Medicinal Chemistry Letters published new progress about Amines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Turley, Alexandra E.; Isaacs, Kristin K.; Wetmore, Barbara A.; Karmaus, Agnes L.; Embry, Michelle R.; Krishan, Mansi published the artcile< Incorporating new approach methodologies in toxicity testing and exposure assessment for tiered risk assessment using the RISK21 approach: Case studies on food contact chemicals>, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is food contact chem toxicity risk assessment RISK21 approach; Dibutyltin dichloride; Food additive; High-throughput screening; In-vitro in-vivo extrapolation; RISK21; Sodium (2-pyridylthio)-N-Oxide (pyrithione sodium); ToxCast.

Programs including the ToxCast project have generated large amounts of in vitro high-throughput screening (HTS) data, and best approaches for the interpretation and use of HTS data, including for chem. safety assessment, remain to be evaluated. To fill this gap, we conducted case studies of two indirect food additive chems. where ToxCast data were compared with in vivo toxicity data using the RISK21 approach. Two food contact substances, sodium (2-pyridylthio)-N-oxide and dibutyltin dichloride, were selected, and available exposure data, toxicity data, and model predictions were compiled and assessed. Oral equivalent doses for the ToxCast bioactivity data were determined by in-vitro in-vivo extrapolation (IVIVE). For sodium (2-pyridylthio)-N-oxide, bioactive concentrations in ToxCast assays corresponded to low- and no-observed adverse effect levels in animal studies. For dibutyltin dichloride, the ToxCast bioactive concentrations were below the dose range that demonstrated toxicity in animals; however, this was confounded by the lack of toxicokinetic data, necessitating the use of conservative toxicokinetic parameter estimates for IVIVE calculations This study highlights the potential utility of the RISK21 approach for interpretation of the ToxCast HTS data, as well as the challenges involved in integrating in vitro HTS data into safety assessments.

Food and Chemical Toxicology published new progress about Chemical safety. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ham, Won Seok; Choi, Hoonchul; Zhang, Jianbo; Kim, Dongwook; Chang, Sukbok published the artcile< C2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic Functionalization>, Product Details of C6H4F3N, the main research area is aminopyrimidine preparation DFT; pyrimidine nucleophilic functionalization.

A synthetic platform for site-selective C-H functionalization that affords pyrimidinyl iminium salt intermediates, which then can be transformed into various amine products I (R = azanyl, 5-(trifluoromethyl)-1,2,3,4-tetrahydropyridin-1-yl, methylaminyl, etc.; R1 = H, Ph) in situ. was described. Mechanism-based reagent design allowed for the C2-selective amination of pyrimidines II, opening the new scope of site-selective heteroaryl C-H functionalization. This method is compatible with a broad range of pyrimidines II with sensitive functional groups, and can access complex aminopyrimidines I in high selectivity.

Journal of the American Chemical Society published new progress about Density functional theory. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Product Details of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem