Tag: M.W=100-150

Grivas, Spiros; Schuisky, Peter published the artcile< Synthesis of imidazonaphthyridines and -quinolines>, Application of C6H6N2O, the main research area is imidazonaphthyridine imidazoquinoline preparation; cyclocondensation aromatic aldehyde aminoimidazolinone.

Four 2-amino-3-methylimidazo[4,5-b][1,x]naphthyridines (x = 5-8), e.g., I, have been obtained from aromatic aldehydes and 2-amino-1-methyl-2-imidazolin-5-one in one step. The N1- and N3-Me isomes of 2-aminoimidazo[4,5-b]quinoline (II and III) were prepared from 2-nitrobenzaldehyde via the isolated E-isomers of imidazolin-5-ones.

Heterocycles published new progress about Cyclocondensation reaction. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Application of C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ceglowski, Michal; Marien, Yoshi W.; Smeets, Sander; De Smet, Lieselot; D′hooge, Dagmar R.; Schroeder, Grzegorz; Hoogenboom, Richard published the artcile< Molecularly Imprinted Polymers with Enhanced Selectivity Based on 4-(Aminomethyl)pyridine-Functionalized Poly(2-oxazoline)s for Detecting Hazardous Herbicide Contaminants>, HPLC of Formula: 3731-53-1, the main research area is molecularly imprinted polymer aminomethylpyridine functionalized polyoxazoline detecting herbicide contaminant; trichlorophenoxyacetate adsorption molecularly imprinted polymer adsorbent.

The detection of hazardous compounds is of importance to control (drinking) water quality. Here, we report the development of poly(2-oxazoline)-based molecularly imprinted polymers (MIPs) for the detection of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). In view of enhanced selectivity of the MIPs, it was hypothesized that incorporation of pyridine groups would lead to stronger interactions with 2,4,5-T. The synthesis of 4-(aminomethyl)pyridine (4-AMP)-functionalized poly(2-methoxycarbonylpropyl-2-oxazoline)s with various degrees of modification was, therefore, investigated via stoichiometric and kinetic control over the functionalization degree. The mol. imprinting of 2,4,5-T is performed by direct amidation of the Me ester side chains with diethylenetriamine. The exptl. data of 2,4,5-T adsorption were interpreted with various models to quantify the adsorption thermodn. and kinetics. The best fit was obtained for a single-site Langmuir model, indicating uniform binding site energies. A further investigation shows that the maximum adsorption capacity is reached at low 4-AMP modification degrees, whereas greater adsorption energies and higher selectivities are observed for higher 4-AMP modification degrees. Finally, the developed 4-AMP-modified MIP adsorbents were successfully used for quantification of 2,4,5-T by direct anal. with ambient mass spectrometry. In comparison with the pure analyte solution, the detection limits decreased by three orders of magnitude.

Chemistry of Materials published new progress about Adsorbents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Leong, Bi-Xiang; Lee, Jiawen; Li, Yan; Yang, Ming-Chung; Siu, Chi-Kit; Su, Ming-Der; So, Cheuk-Wai published the artcile< A Versatile NHC-Parent Silyliumylidene Cation for Catalytic Chemo- and Regioselective Hydroboration>, Application of C7H7NO2, the main research area is silyliumylidene cation catalyzed regioselective hydroboration carbon dioxide carbonyl compound; pyridine derivative regioselective hydroboration silyliumylidene cation catalyst; formoxyborane regioselective preparation; borate ester regioselective preparation; boryldihydropyridine regioselective preparation.

This study describes the 1st use of a Si(II) complex, NHC-parent silyliumylidene cation complex [(IMe)2SiH]I (1, IMe = :C{N(Me)C(Me)}2) as a versatile catalyst in organic synthesis. Complex 1 (loading: 10 mol %) was shown to act as an efficient catalyst (reaction time: 0.08 h, yield: 94%, TOF = 113.2 h-1; reaction time: 0.17 h, yield: 98%, TOF = 58.7 h-1) for the selective reduction of CO2 with pinacolborane (HBpin) to form the primarily reduced formoxyborane [pinBOC(O)H]. The activity is better than the currently available base-metal catalysts used for this reaction. It also catalyzed the chemo- and regioselective hydroboration of carbonyl compounds and pyridine derivatives to form borate esters and N-boryl-1,4-dihydropyridine derivatives with quant. conversions, resp. Mechanistic studies show that the Si(II) center in complex 1 activated the substrates and then mediated the catalytic hydroboration. Complex 1 was slightly converted into the NHC-borylsilyliumylidene complex [(IMe)2SiBpin]I (3) in the catalysis, which was also able to mediate the catalytic hydroboration.

Journal of the American Chemical Society published new progress about Boranes Role: SPN (Synthetic Preparation), PREP (Preparation) (borate esters, boryldihydropyridines). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Jing; Zheng, Jiayi; Peng, Xiaoqian; Dai, Zongren; Liu, Weizhen; Deng, Hong; Xi, Beidou; Lin, Zhang published the artcile< NaCl recovery from organic pollutants-containing salt waste via dual effects of aqueous two-phase systems (ATPS) and crystal regulation with acetone>, Name: 6-Chloropyridin-2-ol, the main research area is sodium chloride recovery acetone organic pollutant industrial salt waste.

A large amount of salt waste accompanied with contaminants (e.g., organic pollutants) is produced in chem. production process, causing serious environmental hazards and waste of salt resources. However, there have been few satisfactory treatments for this hazardous waste until now. In this work, a novel strategy for NaCl recovery and organic pollutants removal from the salt waste containing pyridine derivatives was developed by using acetone in salt waste solution The results showed NaCl was effectively recovered (recovery rate, 99.12%), and the TOC value of its saturated solution was reduced from 806.2 to 145.4 mg/L, below the limits (200 mg/L) for chlorine gas and caustic soda production in chlorine alkali plant. Moreover, no pyridine derivatives can be identified through Fourier transform IR spectroscopy (FTIR) test. Mechanism anal. demonstrated the dual effects of acetone as following: (1) acetone and NaCl formed aqueous two-phase systems (ATPS) to remove organic pollutants; 2) acetone, as a crystal regulator, induced NaCl crystals to recrystallize in cubic morphol. with a smooth surface, which enhanced the removal of pollutants. Besides, the acetone-water phase split facilitated the separation of organic pollutants as well as the reuse of acetone. This work proposes a promising and feasible method for salt waste to remove organic pollutants and recover recrystallized NaCl solids, and also provides new insights into the function of acetone on the crystal regulation of salts.

Journal of Cleaner Production published new progress about Centrifugation. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Name: 6-Chloropyridin-2-ol.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stockmann, Vegar; Fiksdahl, Anne published the artcile< Synthesis of novel 1,7-naphthyridines by Friedlaender condensation of pyridine substrates>, Recommanded Product: 3-Aminoisonicotinaldehyde, the main research area is naphthyridine pyridinyl aryl preparation Friedlaender.

The general ability of appropriate pyridyl compounds (aldehyde or ketone) to undergo Friedlaender condensation to give different 1,7-naphthyridines has been demonstrated. 2-(4-Pyridinyl)-4-methyl-1,7-naphthyridine was prepared from 3-amino-4-acetylpyridine (I) and 4-acetylpyridine (82%). The Friedlaender self-condensation of I is also reported. 2-(3-Aminopyridin-4-yl)-4-methyl-1,7-naphthyridine was obtained in 97% yield. 2-Aryl- and 2,3-diaryl-1,7-naphthyridines were prepared from 3-aminoisonicotinaldehyde (II) and aryl ketones (28-71%). The key substrates I and II are readily available via the improved pyridine nitration method.

Journal of Heterocyclic Chemistry published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Recommanded Product: 3-Aminoisonicotinaldehyde.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tatipaka, Hari Babu; Gillespie, J. Robert; Chatterjee, Arnab K.; Norcross, Neil R.; Hulverson, Matthew A.; Ranade, Ranae M.; Nagendar, Pendem; Creason, Sharon A.; McQueen, Joshua; Duster, Nicole A.; Nagle, Advait; Supek, Frantisek; Molteni, Valentina; Wenzler, Tanja; Brun, Reto; Glynne, Richard; Buckner, Frederick S.; Gelb, Michael H. published the artcile< Substituted 2-Phenylimidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis>, COA of Formula: C5H6FN3, the main research area is phenylimidazopyridine derivative preparation SAR human trypanosomiasis.

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of human African trypanosomiasis, led to the identification of substituted 2-(3-aminophenyl)-oxazolopyridines as a starting point for hit-to-lead medicinal chem. A total of 110 analogs were prepared, which led to the identification of I, a substituted 2-(3-aminophenyl)-imidazopyridine. This compound showed antiparasitic activity in vitro with an EC50 of 2 nM and displayed reasonable druglike properties when tested in a number of in vitro assays. I was orally bioavailable and displayed good plasma and brain exposure in mice. I cured mice infected with Trypanosoma brucei when dosed orally down to 2.5 mg/kg. Given its potent antiparasitic properties and its ease of synthesis, I represents a new lead for the development of drugs to treat human African trypanosomiasis.

Journal of Medicinal Chemistry published new progress about Drug bioavailability. 212268-13-8 belongs to class pyridine-derivatives, and the molecular formula is C5H6FN3, COA of Formula: C5H6FN3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shvydkiy, Nikita V.; Vyhivskyi, Oleksandr; Nelyubina, Yulia V.; Perekalin, Dmitry S. published the artcile< Design of Manganese Phenol Pi-complexes as Shvo-type Catalysts for Transfer Hydrogenation of Ketones>, Formula: C7H7NO, the main research area is manganese phenol pi complex preparation; secondary alc preparation; ketone transfer hydrogenation manganese complex catalyst.

The ability of the manganese pi-complexes to act as Shvo-type catalysts for transfer hydrogenation of ketones to afford secondary alcs. RCH(OH)(R1) [R = Ph, 3-pyridyl, 1-naphthyl, etc.; R1 = Me, n-Pr, Ph, etc.] was explored. DFT calculations suggested that the transfer of hydrogen atoms from the hypothetical intermediate [(C6Me3H2OH)Mn(CO)2H] to acetone had low activation barrier of 10.9 kcal mol-1. Exptl. a number of ketones with various functional groups were successfully reduced in isopropanol in the presence of the complex [(C6Me3H2OH)Mn(CO)3]BF4 (1 mol %) and tBuOK (75 mol %). However, further investigation revealed that the reduction was mainly promoted by base rather than the manganese complex.

ChemCatChem published new progress about Ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mujahed, Shrouq; Hey-Hawkins, Evamarie; Gelman, Dmitri published the artcile< A High-Valent Ru-PCP Pincer Catalyst for Hydrogenation of Carbonyl and Carboxyl Compounds under Molecular Hydrogen>, HPLC of Formula: 350-03-8, the main research area is high valent ruthenium phosphorus carbon PCP pincer catalyst hydrogenation; carbonyl carboxyl nitrile compound hydrogenation catalyst preparation; crystal mol structure ruthenium phosphorus carbon PCP pincer complex; cooperative catalysis; esters; high-valent ruthenium; hydrogenation; pincer complexes.

Low-valent metals traditionally dominate the domain of catalytic hydrogenation. However, metal-ligand cooperating (MLC) catalytic systems, operating through heterolytic H-H bond splitting by a Lewis acidic metal and a basic ligand site, do not require an electron-rich metal. On the contrary, high-valent metals that induce weaker back donation facilitate heterolytic bond activation. Here authors report, for the first time, the efficient hydrogenation of carbonyl and carboxyl compounds under mol. hydrogen catalyzed by a structurally well-defined RuIV catalyst bearing a bifunctional PCP pincer ligand. The catalyst exhibits reactivity toward mol. hydrogen superior to that of the low-valent analog and allows hydrogen activation even at room temperature

Chemistry – A European Journal published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Danqing; Studer, Armido published the artcile< Asymmetric Synthesis of Heterocyclic γ-Amino-Acid and Diamine Derivatives by Three-Component Radical Cascade Reactions>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is asym synthesis heterocyclic amino acid diamine multicomponent radical cascade; Brønsted acids; amino acids; asymmetric synthesis; photochemistry; radicals.

An enantioselective three-component radical reaction of quinolines or pyridines with enamides and α-bromo carbonyl compounds by dual photoredox and chiral Bronsted acid catalysis is presented. A range of valuable chiral γ-amino-acid derivatives are accessible in high chemo-, regio-, and enantioselectivity from simple, readily available starting materials under mild reaction conditions. Using the same strategy, the asym. synthesis of 1,2-diamine derivatives is also reported. Thus, e.g., 4-methylquinoline + N-vinylacetamide + Me bromoacetate → I (88%, 96:4 er).

Angewandte Chemie, International Edition published new progress about Carbonyl compounds (organic), halo carbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent) (quinoline/pyridine + N-vinylacetamide + α-bromo carbonyl compound → γ-amino acid). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hayashi, Mikihiro; Kimura, Takahiro; Oba, Yuta; Takasu, Akinori published the artcile< One-Pot Synthesis of Dual Supramolecular Associative PMMA-Based Copolymers and the Precise Thermal Property Tuning>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is onepot dual supramol associative PMMA copolymer.

Dual supramol. associative polymers have attracted attention for efficient phys. property modification. Herein, a one-pot synthesis of dual supramol. associative poly(Me methacrylate)-based copolymers via reversible addition fragmentation chain transfer (RAFT) copolymerization using a novel methacrylate-type monomer (coded as UP-MA) bearing a urea bond and a pendant pyridine group is demonstrated. UP-MA is synthesized by reacting 4-picolylamine and 2-isocyanatoethyl methacrylate. The subsequent RAFT copolymerization of UP-MA and Me methacrylate (MMA) can be performed by directly adding MMA, a chain transfer agent, and a radical initiator into the reaction solution of UP-MA. The estimated values of radical reactivity ratio (r) for UP-MA and MMA are close to unity, attaining a nearly ideal random sequence of the dual supramol. associative units in the copolymer chain. By blending a metal salt into the random copolymer, coordination bonds between the salt and the pyridine groups are formed, and the urea groups simultaneously form hydrogen bonds, generating a dual supramol. associative network. Precise tuning of the thermal property is realized by changing the fraction of the metal salt and associative groups in the copolymers.

Macromolecular Chemistry and Physics published new progress about Glass transition temperature. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem