Tag: M.W=100-150

Zeng, Haisu; Wu, Jing; Li, Sihan; Hui, Christina; Ta, Anita; Cheng, Shu-Yuan; Zheng, Shengping; Zhang, Guoqi published the artcile< Copper(II)-Catalyzed Selective Hydroboration of Ketones and Aldehydes>, Application In Synthesis of 350-03-8, the main research area is divalent copper catalyzed chemoselective hydroboration ketone aldehyde; nonanuclear copper complex one pot self assembly preparation.

A novel nonanuclear copper(II) complex obtained by a facile one-pot self-assembly was found to catalyze the hydroboration of ketones and aldehydes with the absence of an activator under mild, solvent-free conditions. The catalyst is air- and moisture-stable, displaying high efficiency (1980 h-1 turnover frequency, TOF) and chemoselectivity on aldehydes over ketones and ketones over imines. This represents a rare example of divalent copper catalyst for the hydroboration of carbonyls.

Organic Letters published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Abramovitch, Rudolph A.; Helmer, Friederike; Liveris, M. published the artcile< Aromatic substitution. XVIII. Kinetics of reactions between some halopyridines and -picolines and their N-oxides with methoxide ion in methanol and in dimethyl sulfoxide. Effect of alkyl groups on rates and orientation in nucleophilic aromatic substitution>, Safety of 3-Chloro-2-methoxypyridine, the main research area is SUBSTITUTION AROM KINETICS; PIRIDINES SUBSTITUTION; KINETICS SUBSTITUTION AROM; AROM SUBSTITUTION KINETICS.

The rates and activation parameters for the reactions of 2-fluoro-, 2-chloro-, 2-bromo-, 2-chloro-3-methyl-, 2-chloro-5-methyl-, 2-bromo-3-methyl-, 2-bromo-5-methyl-, 2,3-dichloro-, 2,5-dichloro-, 2-chloro-3-nitro-, and 2-chloro-5-nitropyridines, and of 2-bromo-, 2-bromo-3-methyl-, and 2-bromo-5-methylpyridine N-oxides with MeOK in methanol were determined and compared. The kinetics of the reaction of 2-bromo-, 2-bromo-3-methyl-, and 2-bromo-5-methyl-pyridine and methoxide ion in Me2SO containing small amounts of methanol were also determined; the rates were very sensitive to the methanol concentration The rates were in the order 2-halo- > 2-halo-3-methyl- > 2-halo-5-methyl-, and were dependent upon Eact when the halogen was Br but upon ΔS when it was Cl. The effects of the β-substituent in the pyridine nucleus upon the orthopara ratios are discussed in terms of their effects upon the energies and entropies of activation. 29 references.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about Activation energy. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Safety of 3-Chloro-2-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chniti, Sami; Kollar, Laszlo; Benyei, Attila; Takacs, Attila published the artcile< Highly Selective Synthesis of 6-Glyoxylamidoquinoline Derivatives via Palladium-Catalyzed Aminocarbonylation>, Application of C6H8N2, the main research area is quinoline amide preparation chemoselective; iodoquinoline amine carbon monoxide aminocarbonylation palladium catalyst; 6-iodoquinoline; aminocarbonylation; carbon monoxide; double carbonylation; palladium.

The aminocarbonylation of 6-iodoquinoline has been investigated in the presence of large series of amine nucleophiles such as tert-butylamine, cyclohexylamine, furfyrlamine, etc. providing an efficient synthetic route for producing various quinoline-6-carboxamide I (R = cyclohexylaminyl, decan-1-aminyl, 4-methylpiperazin-1-yl, etc.) and quinoline-6-glyoxylamide derivatives II. It was shown, after detailed optimization study, that the formation of amides and ketoamides is strongly influenced by the reaction conditions. Performing the reactions at 40 bar of carbon monoxide pressure in the presence of Pd(OAc)2/2 PPh3, the corresponding 2-ketocarboxamides II were formed as major products (up to 63%). When the monodentate triphenylphosphine was replaced by the bidentate XantPhos, the quinoline-6-carboxamide derivatives I were synthesized almost exclusively under atm. conditions (up to 98%). The isolation and characterization of the new carbonylated products I, II of various structures were also accomplished. Furthermore, the structure of three new mono- and double-carbonylated compounds I, I were unambiguously established by using a single-crystal XRD study.

Molecules published new progress about Amides, oxo Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Junaid, Ahmad; Lim, Felicia Phei Lin; Zhou, Yvonne Peijun; Chui, Wai Keung; Dolzhenko, Anton V. published the artcile< Fused heterocyclic systems with an s-triazine ring. 34. Development of a practical approach for the synthesis of 5-aza-isoguanines>, Product Details of C6H8N2, the main research area is azaisoguanine fused triazine preparation; azapurine; purine isostere.; triazine; triazole.

In this article, an attempt to develop a practical method for the preparation of 5-aza-isoguanines is reported. Several synthetic approaches were explored to establish a robust general protocol for the preparation of these compounds The significant difference in the reactivity of the C-5 and C-7 electrophilic centers of 1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines) towards nucleophiles was demonstrated. The most practical and general method for the preparation of 5-aza-isoguanines involved a regioselective reaction of ethoxycarbonyl isothiocyanate with a 5-aminotriazole. The intramol. ring closure of the resulted product followed by the S-methylation afforded 7-methylthio-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-one, which could be effectively aminated with various amines. The resulted 5-aza-isoguanines resemble a known purine nucleoside phosphorylase inhibitor and could be interesting for further investigations as potential anticancer agents.

Molecules published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sepehri, Nima; Iraji, Aida; Yavari, Ali; Asgari, Mohammad Sadegh; Zamani, Saeed; Hosseini, Samanesadat; Bahadorikhalili, Saeed; Pirhadi, Somayeh; Larijani, Bagher; Khoshneviszadeh, Mahsima; Hamedifar, Halleh; Mahdavi, Mohammad; Khoshneviszadeh, Mehdi published the artcile< The natural-based optimization of kojic acid conjugated to different thio-quinazolinones as potential anti-melanogenesis agents with tyrosinase inhibitory activity>, Category: pyridine-derivatives, the main research area is kojic acid thio quinazolinone mol docking antimelanogenesis tyrosinase inhibition; Cytotoxicity; Hyperpigmentation; Kojic acid; Quinazolinone; Tyrosinase inhibitor.

Melanin pigment and melanogenesis are a two-edged sword. Melanin has a radioprotection role while melanogenesis has undesirable effects. Targeting the melanogenesis pathway, a series of kojyl thioether conjugated to different quinazolinone derivatives I (R = c-Pr, Ph, 2-pyridyl, etc.) were designed, synthesized, and evaluated for their inhibitory activity against mushroom tyrosinase. All the synthesized compounds were screened for their anti-tyrosinase activity and all derivatives displayed better potency than kojic acid as the pos. control. In this regard, compounds I (R = pyridin-2-ylmethyl) and I (R = 2-pyridyl) the most active compounds showed an IC50 value of 0.46 and 0.50μM, resp. In kinetic evaluation against tyrosinase, I (R = pyridin-2-ylmethyl) depicted an uncompetitive inhibition pattern. Designed compounds also exhibited mild antioxidant capacity. Moreover, compounds I (R = pyridin-2-ylmethyl) and I (R = 2-pyridyl) achieved good potency against the B16F10 cell line to reduce the melanin content, while showing limited toxicity against malignant cells. The proposed binding mode of new inhibitors evaluated through mol. docking was consistent with the results of structure-activity relationship anal.

Bioorganic & Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

De Kowalewski, D. G.; Contreras, R. H.; De los Santos, C. published the artcile< Carbon-13 and proton NMR spectra of 2-pyridone derivatives>, Category: pyridine-derivatives, the main research area is NMR pyridone derivative; additivity NMR pyridone.

The 13C- and 1H-NMR of substituted pyridines (e.g. I) were studied to determine through additivity properties of 13C shielding constants and of the 13C-1H spin-spin coupling constants, the structure of the ring and of the lateral chains.

Journal of Molecular Structure published new progress about Additivity. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Rongrong; Peng, Qiyao; Wan, Dan; Yu, Chao; Zhang, Yuan; Hou, Yi; Luo, Quan; Li, Xiong; Zhang, Shuihan; Xie, Lin; Ou, Pinghua; Peng, Yongbo published the artcile< Construction of a lysosome-targetable ratiometric fluorescent probe for H2O2 tracing and imaging in living cells and an inflamed model>, HPLC of Formula: 3731-53-1, the main research area is hydrogen peroxide cell lysosome ratiometric fluorescent imaging.

Hydrogen peroxide (H2O2), an important reactive oxygen species (ROS) with unique destructive oxidation properties, can be produced in lysosomes to fight off pathogens. Although many fluorescent probes have been developed for the detection and imaging of H2O2, the development of a ratiometric fluorescent probe for H2O2 detection and imaging in lysosomes and an inflammation model remains rather scarce. Therefore, it is important to develop an efficient tool for monitoring H2O2 in inflamed tissues to evaluate the physiol. and pathol. relationship between inflammation and lysosomal H2O2. In this work, a new naphthalimide-based lysosome-targeting fluorescent probe (NPT-H2O2) for ratiometric detection and imaging was developed in vitro and in vivo. The probe exhibited two wellresolved emission peaks separated by 125 nm, rapid response (<40 s), and high selectivity and sensitivity toward H2O2, as well as low cytotoxicity in vitro. Inspired by prominent features of these results, we further successfully applied NPT-H2O2 for H2O2 imaging with a dual-channel in living cells, demonstrating that our probe NPT-H2O2 was targeted in the lysosomes. Finally, NPT-H2O2 was used for H2O2 detection in inflamed tissues and achieved satisfactory results. We predict that our probe can be used as a powerful tool to reveal the relationship between physiol. and pathol. of inflammation and lysosomal H2O2. RSC Advances published new progress about Absorption spectra. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Xiaonan; Hu, Xuejun; Zhang, Li; Xu, Xi; Sakurai, Takashi published the artcile< Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats>, Product Details of C7H7NO, the main research area is brain injury nicotinamide mononucleotide hypoglycemia neuron survival; Cognitive impairment; Hypoglycemia; Neuronal survival; Nicotinamide mononucleotide; PARP-1; ROS.

Here we investigated whether NMN could reduce brain injury after severe hypoglycemia. We used a rat model of insulin-induced severe hypoglycemia and injected NMN (500 mmg/kg, i.p., one week) following 30 min of severe hypoglycemia, at the time of glucose administration. ROS accumulation, PARP-1 activation, NAD+ and ATP levels in hippocampus were also measured. Cognitive function was assessed using the Morris water maze 6 wk after severe hypoglycemia. The addition of NMN reduced neuron death by 83 ± 3% (P < 0.05) after severe hypoglycemia. The hippocampal LTP was significantly reduced by severe hypoglycemia but showed recovery in the NMN addition group. NMN treatment also attenuated the severe hypoglycemia-induced spatial learning and memory impairment. Mech., we showed that NMN administration decreased ROS accumulation, suppressed PARP-1 activation, and restored levels of NAD+ and ATP in hippocampus. All these protective effects were reversed by 3-acetylpyridine (3-AP), which generates inactive NAD+. In summary, NMN administration following severe hypoglycemia could ameliorate neuronal damage and cognitive impairment caused by severe hypoglycemia. These results suggest that NMN may be a promising therapeutic drug to prevent hypoglycemia-induced brain injury. Brain Research Bulletin published new progress about Biological memory. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheng, Chia-Chung; Yan, Shou-Jen published the artcile< The Friedlander synthesis of quinolines>, Electric Literature of 55279-29-3, the main research area is review Friedlander synthesis quinoline.

A review of the article The Friedlander synthesis of quinolines.

Organic Reactions (Hoboken, NJ, United States) published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Electric Literature of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lee, Jiawen; Fan, Jun; Koh, An-Ping; Joslyn Cheang, Wan-Jun; Yang, Ming-Chung; Su, Ming-Der; So, Cheuk-Wai published the artcile< Amidinato Isopropylmethylamidosilylene-Catalyzed Hydroboration of Carbonyl Compounds>, Product Details of C7H7NO, the main research area is amidinato isopropylmethylamidosilylene catalyzed hydroboration carbonyl compound; borate ester preparation.

This study describes the use of an amidinato isopropylmethylamidosilylene [LSiN(Me)iPr] (1, L = PhC(NtBu)2) to catalyze hydroboration of carbonyl compounds Compound 1 (loading: 5-10 mol%) was an efficient catalyst for the chemoselective hydroboration of aldehydes (average yield = 97%, average TOF = 8.8 h-1) and ketones (average yield = 97%, average TOF = 1.7 h-1) with pinacolborane (HBpin) in C6D6 at 90° to form borate esters. Mechanistic studies show that the Si lone pair electrons on 1 and the B vacant p orbital of HBpin activates the C:O double bond of aldehydes and ketones, the intermediates of which undergoes hydroboration to yield borate esters and regenerate compound 1.

European Journal of Inorganic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem