Tag: M.W=100-150

Galico, Diogo A.; Ramdani, Rayan; Murugesu, Muralee published the artcile< Phonon-assisted molecular upconversion in a holmium(III)-based molecular cluster-aggregate>, Reference of 73018-09-4, the main research area is holmium gadolinium ytterbium mol cluster aggregate upconversion emission spectra.

Upconversion (UC) is a fascinating process in which higher energy photons can be emitted from excitation by lower energy photons. The current challenge remains in downscaling and effectively achieving upconversion with lanthanide ions at the mol. scale. Here, using a rationally designed mol. cluster-aggregate (MCA), we demonstrate for the first time HoIII ion mol. upconversion. The synthesized MCA exhibits identifiable HoIII green and red UC emissions with a uniquely enhanced red to green ratio as well as a conventional near-IR (NIR) emission. A combined rigid spherical cluster core with reduced mol. vibrations, ideally matched donor and acceptor excited levels via a phonon-assisted mechanism, led to an upconversion quantum yield of 5.24 x 10-6%.

Nanoscale published new progress about Aggregates. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Reference of 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aretz, Christopher D.; Morwitzer, M. Jane; Sanford, Austin G.; Hogan, Alicia M.; Portillo, Madelene V.; Kharade, Sujay V.; Kramer, Meghan; McCarthey, James B.; Trigueros, Renata Rusconi; Piermarini, Peter M.; Denton, Jerod S.; Hopkins, Corey R. published the artcile< Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)-N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel>, Safety of Pyridin-4-ylmethanamine, the main research area is nitrophenylsulfonylpiperazinylpyridinylmethylaniline preparation Kir1 potassium channel inhibitor Aedes; Kir channels; Zika; larvae; vector-borne diseases.

Mosquito-borne arboviral diseases such as Zika, dengue fever, and chikungunya are transmitted to humans by infected adult female Aedes aegypti mosquitoes and affect a large portion of the world’s population. The Kir1 channel in Ae. aegypti (AeKir1) is an important ion channel in the functioning of mosquito Malpighian (renal) tubules and one that can be manipulated in order to disrupt excretory functions in mosquitoes. We have previously reported the discovery of various scaffolds that are active against the AeKir1 channel. Herein we report the synthesis and biol. characterization of a new 2-nitro-5-(4-(phenylsulfonyl) piperazin-1-yl)-N-(pyridin-4-ylmethyl)anilines scaffold as inhibitors of AeKir1. This new scaffold is more potent in vitro compared to the previously reported scaffolds, and the mols. kill mosquito larvae.

ACS Infectious Diseases published new progress about Aedes aegypti. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Safety of Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Obradors, Carla; List, Benjamin published the artcile< Azine Activation via Silylium Catalysis>, Synthetic Route of 3796-23-4, the main research area is heteroarene silyl ketene acetal silylium phosphoramidimidate catalyst regioselective addition; silyl alkyl heteroarene preparation oxidation; alkyl heteroarene preparation.

A direct, catalytic and selective functionalization of azines via silylium activation was described. The catalyst design enabled mild conditions and a remarkable functional group tolerance in a one-pot setup.

Journal of the American Chemical Society published new progress about Acetals, ketene, silyl Role: RCT (Reactant), RACT (Reactant or Reagent). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Synthetic Route of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tiecco, M.; Testaferri, L.; Tingoli, M.; Chianelli, D.; Montanucci, M. published the artcile< A convenient synthesis of bipyridines by nickel-phosphine complex-mediated homo coupling of halopyridines>, Category: pyridine-derivatives, the main research area is coupling halopyridine; bipyridine methoxy; pyridine halo coupling; nickel phosphine complex coupling catalyst.

Coupling of 2-bromopyridine in DMF in the presence of Ni(PPh3)4, prepared in situ from NiCl2, PPh3, and Zn, gave 68% 2,2′-bipyridine. Among the 10 other compounds similarly prepared were: 4,4′-biquinoline and 2,2′-dimethoxy-3,3′-bipyridine.

Synthesis published new progress about Coupling reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Qi; Zard, Samir Z. published the artcile< Modular route to azaindanes>, Electric Literature of 131747-55-2, the main research area is xanthate ester radical cyclization; azaindane preparation.

A convergent radical based route to azaindanes, e.g., I, is described, relying on the degenerative addition transfer of various substituted S-(pyridylmethyl)-O-Et dithiocarbonates (xanthates) to functional alkenes followed by radical cyclization onto the pyridine ring activated by protonation with trifluoroacetic acid. In one case, a richly decorated cyclohepta[b]pyridine could be assembled swiftly by allowing the first adduct to N-phenylmaleimide to undergo addition to N-allylphthalimide prior to cyclization.

Organic Letters published new progress about Heterocyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation) (azaindanes). 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Electric Literature of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dai, Q.; Wang, H.; Wang, Y.; Xiao, M.; Jin, H.; Li, M.; Xia, T. published the artcile< Enhancing the sensory attributes and antioxidant properties of snus by mixing it with tea>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is tea beverage snus antioxidant sensory property.

In the present work, we investigated the chem. and volatile compositions of three tea-containing snus samples, after which their acceptability on the aromatic and taste coordination was evaluated by a professional panel. Results showed that the tea-containing snus samples exhibited better acceptability on the aroma and taste coordination profiles. Dahongpao tea (DT)-containing snus (DT-snus) exhibited the best acceptability of aromatic coordination, whereas the most favorable taste coordination was exhibited by Keemun black tea (KBT)-containing snus (KBT-snus). The antioxidant activity determined by the DPPH and ABTS assays revealed that Lu’an Guapian tea (LGT)-containing snus (LGT-snus) exhibited the highest free-radical scavenging ability. LGT-snus was also found to have the highest content of total polyphenols, amino acids, and caffeine. The highest levels of total flavonoids and soluble sugars were found in DT-snus and KBT-snus, resp. There were 88, 68, and 74 volatiles found in DT-snus, LGT-snus, and KBT-snus, resp., among which, nitrogenous compounds constituted the major category. High levels of nicotine, megastigmatrienone, neophytadiene, nicotyrine, and cotinine, which are the major volatiles in snus, were detected in the tea-containing snus samples. The mixing of tea introduced the flavor profiles of the volatiles present in the original tea into the tea-containing snus samples. Benzaldehyde, β-ionone, hexanoic acid, 3-(Z)-hexenyl ester, pyrazines, and nerolidol from LGT; furfural, benzeneethanol, nerolidol, linalool, and cedrol from DT; and nonanal, geraniol, cis-jasmone, benzenemethanol, and Me salicylate from KBT were found in high concentrations in the corresponding tea-containing snus samples.

International Food Research Journal published new progress about Acids Role: ANT (Analyte), FFD (Food or Feed Use), PRP (Properties), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Guanglong; Xiao, Keya; Shi, Man; Shuai, Jing; Xu, Zhiping; Li, Zhong; Cheng, Jiagao published the artcile< Study on 4-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine Derivatives: Design, Synthesis, Insecticidal Assay and Binding Mode Studies>, HPLC of Formula: 3731-53-1, the main research area is oxotetrahydro pyrazolopyrimidine preparation insecticide docking SAR; GABA receptor; fipronil; insecticidal activity; phenylpyrazole; scaffold hopping.

A series of 4-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesized based on the fipronil low energy conformation by scaffold hopping strategy. Physicochem. properties calculation, insecticidal assay and binding mode studies were also performed. It was found that the target compounds displayed lower insecticidal activities than fipronil. The differences in binding modes between these compounds and fipronil may be the major reason for reduced insecticidal activities.

Chemistry & Biodiversity published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Ke; Iqbal, Sarah; Hernandez, Pamela; Park, HaJeung; LoGrasso, Philip V.; Feng, Yangbo published the artcile< Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives [Erratum to document cited in CA162:029776]>, Product Details of C7H10N2, the main research area is aminopyrazole JNK3 enzyme inhibitor preparation structure neurodegeneration erratum.

On page S4, Section 2.1, Line 1 of the supporting Inforamtion is incorrect; The correct information is given.

Journal of Medicinal Chemistry published new progress about Drug metabolism. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Product Details of C7H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Amu; Liu, Ya-Zhou; Shen, Zhongke; Qiao, Zeen; Ma, Xiaofeng published the artcile< Regioselective Synthesis of Pyrazolo[1,5-a]pyridine via TEMPO-Mediated [3 + 2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds>, Safety of 3-(Trifluoromethyl)pyridine, the main research area is pyridiniumamine trimethylbenzenesulfonate alkene TEMPO catalyst regioselective annulation aromatization; pyrazolopyridine preparation.

A TEMPO-mediated [3 + 2] annulation-aromatization protocol for the preparation of pyrazolo[1,5-a]pyridines from N-aminopyridines and α,β-unsaturated compounds were developed. The procedure offered multisubstituted pyrazolo[1,5-a]pyridines in good to excellent yield with high and predictable regioselectivity. The modification of marketed drugs including Loratadine, Abiraterone and Metochalcone, a one-pot three-step gram scale synthesis of key intermediate for the preparation of Selpercatinib were demonstrated. Mechanism studies showed that TEMPO served both as a Lewis acid and as an oxidant.

Organic Letters published new progress about [3+2] Cycloaddition reaction (regioselective). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Safety of 3-(Trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Yuxing; Chen, Jiean; Huang, Yong published the artcile< N-Heterocyclic Carbene-Catalyzed 1,4-Alkylacylation of 1,3-Enynes>, Computed Properties of 350-03-8, the main research area is allenone preparation; enyne aldehyde radical precursor alkylacylation heterocyclic carbene catalyst.

The radical relay coupling reaction recently emerged as a powerful synthetic strategy for producing tetrasubstituted allenes R(R1CHR2)C=C=C(R3)C(O)R4 (R = H, Me; R1 = trifluoromethyl, 1,1-difluoro-2-methoxy-2-oxoethyl, 3-cyanopropyl, etc.; R2 = Me, Ph, thiophen-3-yl, pyridin-3-yl, etc.; R3 = hexyl, cyclopropyl, Ph, 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butyl, etc.; R4 = Ph, furan-2-yl, pyridin-3-yl, etc.). However, bond-forming processes involving the allenyl radical intermediate are mostly limited to those promoted by transition metals. In this report, a ketyl radical generated from single-electron oxidation of the Breslow intermediate, which is an excellent coupling partner of allenyl radicals is described. An organocatalytic 1,4-alkylacylation of 1,3-enynes RCH=C(R2)CCR3 occurred smoothly in the presence of an aldehyde R4CHO, a radical precursor, and an N-heterocyclic carbene catalyst. This transformation showed remarkable tolerance to both aromatic and aliphatic aldehydes, enyne substitution, and diversified radical precursors.

Organic Letters published new progress about Acylation. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Computed Properties of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem