Tag: M.W=100-150

Zheng, Yan-Long; Newman, Stephen G. published the artcile< Methyl Esters as Cross-Coupling Electrophiles: Direct Synthesis of Amide Bonds>, Application In Synthesis of 93-60-7, the main research area is methyl ester amine nickel catalyzed cross coupling amide preparation.

Amide bond formation and transition metal-catalyzed cross-coupling are two of the most frequently used chem. reactions in organic synthesis. Recently, an overlap between these two reaction families was identified when Pd and Ni catalysts were demonstrated to cleave the strong C-O bond present in esters via oxidative addition When simple Me and Et esters are used, this transformation provides a powerful alternative to classical amide bond formations, which commonly feature stoichiometric activating agents. Thus far, few redox-active catalysts have been demonstrated to activate the C(acyl)-O bond of alkyl esters, which makes it difficult to perform informed screening when a challenging reaction needs optimization. We demonstrate that Ni catalysts bearing diverse NHC, phosphine, and nitrogen-containing ligands can all be used to activate Me esters and enable their use in direct amide bond formation.

ACS Catalysis published new progress about Aliphatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vijeta, Arjun; Reisner, Erwin published the artcile< Carbon nitride as a heterogeneous visible-light photocatalyst for the Minisci reaction and coupling to H2 production>, Computed Properties of 93-60-7, the main research area is heterogeneous Minisci hydrogen evolution reaction photocatalyst.

Cyanamide functionalized carbon nitride powder is reported as a photocatalyst for direct Minisci-type coupling of heteroarenes with ethers, alcs., and amides using atm. oxygen as the oxidant at room temperature This mild protocol displays broad substrate scope, good functional group tolerance and the catalyst can be easily isolated and reused for several cycles. It thereby addresses the two major limitations of previously reported photoredox-mediated Minisci reactions: (i) use of expensive and potentially harmful non-recyclable photocatalysts, and (ii) requirement of a stoichiometric amount of strong chem. oxidant. Finally, using platinum as a co-catalyst with the carbon nitride allows this light-mediated reaction to generate two value-added products under an anaerobic atm. – functionalized heteroarenes and H2 fuel.

Chemical Communications (Cambridge, United Kingdom) published new progress about Hydrogen evolution reaction catalysts. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pinkerton, Anthony B.; Sessions, E. Hampton; Hershberger, Paul; Maloney, Patrick R.; Peddibhotla, Satyamaheshwar; Hopf, Meghan; Sergienko, Eduard; Ma, Chen-Ting; Smith, Layton H.; Jackson, Michael R.; Tanaka, Jun; Tsuji, Takashi; Akiu, Mayuko; Cohen, Steven E.; Nakamura, Tsuyoshi; Gardell, Stephen J. published the artcile< Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators>, Reference of 3731-53-1, the main research area is urea nicotinamide phosphoribosyltransferase activator; NAD(+) booster; NAMPT; NAMPT activators; Ureas.

NAD+ is a crucial cellular factor that plays multifaceted roles in wide ranging biol. processes. Low levels of NAD+ have been linked to numerous diseases including metabolic disorders, cardiovascular disease, neurodegeneration, and muscle wasting disorders. A novel strategy to boost NAD+ is to activate nicotinamide phosphoribosyltransferase (NAMPT), the putative rate-limiting step in the NAD+ salvage pathway. We previously showed that NAMPT activators increase NAD+ levels in vitro and in vivo. Herein we describe the optimization of our NAMPT activator prototype (SBI-0797812) leading to the identification of 1-(4-((4-chlorophenyl)sulfonyl)phenyl)-3-(oxazol-5-ylmethyl)urea (34) that showed far more potent NAMPT activation and improved oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about Cardiovascular disease. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Reference of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yu, Xudong; Guo, Jiangbo; Peng, Pan; Shen, Fengjuan; Li, Yajuan; Geng, Lijun; Wang, Tao published the artcile< Self-assembly induced hydrogelation approach as novel means of selective and visual sensing picric acid>, Formula: C6H8N2, the main research area is hydrogel picric acid sugar derivative isomer hydrogen bonding.

Picric acid is a kind of dangerous and toxic nitroarom. explosive chems. and causes great concern in safety, health and environment issues. However, the visual and selective sensing of picric acid in pure water is still a challenge in recent years. In this work, two novel isomeric sugar-based derivatives denoted as NGs (NG1 and NG2) with different terminal groups (pyridyl segments) have been designed and synthesized. We demonstrate the preparation of picric acid assisted supramol. hydrogels driven by hydrogen bonding interaction, which endows the visual and direct recognition for picric acid via fast and selective gelation approach without expensive equipment. The binding mechanism of NGs with PA both in solutions and gels and the isomeric effect on the gelation properties are studied in detail by several techniques. At last, NG2 based test strips are also developed to detect tiny amount of PA in water in a contact mode.

Applied Surface Science published new progress about Carbohydrates Role: TEM (Technical or Engineered Material Use), USES (Uses) (deriv). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aryal, Gyan H.; Rana, Ganesh R.; Guo, Fei; Hunter, Kenneth W.; Huang, Liming published the artcile< Heparin sensing based on multisite-binding induced highly ordered perylene nanoaggregates>, HPLC of Formula: 3731-53-1, the main research area is perylene nanoaggregate heparin fluorescent sensor.

Highly ordered perylene nanoaggregates with ultra-low fluorescence were employed for the selective and sensitive fluorescence sensing of heparin. A supramol. host-guest complex was used as a displacement probe to improve the sensitivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Fluorescence. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tamang, Sem Raj; Singh, Arpita; Bedi, Deepika; Bazkiaei, Adineh Rezaei; Warner, Audrey A.; Glogau, Keeley; McDonald, Corey; Unruh, Daniel K.; Findlater, Michael published the artcile< Polynuclear lanthanide-diketonato clusters for the catalytic hydroboration of carboxamides and esters>, Category: pyridine-derivatives, the main research area is amine preparation; carboxamide hydroboration lanthanide diketonato cluster catalyst; tetramethyl dioxaborolane preparation.

The direct deoxygenation of carboxamides RC(O)N(R1)R2 [R = H, Ph, thiophen-2-yl, naphthalen-2-yl, etc.; R1 = H, Me, Et, (CH2)4CH3, iso-Pr, Ph, benzyl; R2 = H, Me, Et, isopropyl; R1R2 = (CH2)5, (CH2)2O(CH2)2] using earth-abundant lanthanum catalysts in the presence of HBpin presents good to excellent yields with broad substrate scope and functional group/heteroatom tolerance. Moreover, this method is also effective in catalyzing the hydroboration of esters R3C(O)OR4 [R3 = Ph, cyclohexyl, (CH2)6CH3, pyridin-3-yl, etc.; R4 = Me, Et, naphthalen-2-yl, 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl, etc.]. Finally, selective cleavage of the amide group bonds (C-N vs. C-O) could be achieved based on the nature of the nitrogen substituents. Catalytic reduction of carboxamides into their corresponding amines RCH2N(R1)R2 is attractive but extremely challenging transformation, which often meets with limited success; the valuable amine products drive ongoing research in this area.

Nature Catalysis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Datong; Pan, Fei; Gao, Li; Tao, Yongxin; Kong, Yong published the artcile< An ionic-based carbon dot for enantioselective discrimination of nonaromatic amino alcohols>, Synthetic Route of 3731-53-1, the main research area is fluorescent sensor amino alc copper binding energy chiral recognition.

Here, ionized chiral carbon dots, (S,S)-C-dots-1 (λex = 430 nm, λem = 480 nm), were synthesized via a facile route with relatively high quantum yield (~24.4%) and used as a fluorescent chiral sensor. One of the advantages of the synthetic process is that it avoids the loss of the chiral center. That is, the chiral bromo compound can directly form an ionic pair with the pyridyl group, which is derived from the amine precursor in the first step. Furthermore, (S,S)-C-dots-1 shows clear discrimination toward different configurations of nonaromatic amino alcs. in the presence of Cu(II). When the (R)-isomer is added to a solution of (S,S)-C-dots-1 + Cu(II), it shows much higher fluorescent intensity than the (S)-isomer. The values of IR/IS are 2.9 and 2.3 for 2-aminobutan-1-ol and 2-aminopropan-1-ol, resp. In summary, we believe that this work can expand the synthetic routes and potential applications of functional carbon dots in the field of enantioselective sensing.

Analyst (Cambridge, United Kingdom) published new progress about Amino alcohols Role: ANT (Analyte), PEP (Physical, Engineering or Chemical Process), PRP (Properties), ANST (Analytical Study), PROC (Process). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Kaige; Liu, Chunlin; Zhang, Wei; Wang, Kangni; Liu, Wenlong published the artcile< Pyroelectricity and fieldinduced spin-flop in 4-(aminomethyl)pyridinium manganese chloride dihydrate>, Quality Control of 3731-53-1, the main research area is aminomethyl pyridinium manganese chloride dihydrate pyroelectricity spinflop; ferroelectric; pyroelectric; single crystal; spin-flop.

Large single crystals of (4-(Aminomethyl)pyridinium)2 MnCl4 • 2H2O (1) were grown by slow evaporation of solution The crystal structure was solved to be Pi, which belongs to the ̅central sym. space group. But small pyroelec. current was detected, as well as a ferroelec. hysteresis loop. The pyroelec. and the ferroelec. properties were attributed to the strain caused by defects. Temperature-dependent magnetic curves and the M-H curve show that 1 is antiferromagnetic ordering below 2.5 K. A field-induced spin-flop is observed in the antiferromagnetic ordering state.

Royal Society Open Science published new progress about Antiferromagnetic films. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto published the artcile< The reactions of some halogenated pyridines with methoxide and methanethiolate ions in dimethylformamide>, Application of C6H6ClNO, the main research area is pyridine dihalo substitution methoxide alkanethiolate; halopyridine substitution methoxide alkanethiolate; substitution dihalopyridine methoxide alkanethiolate; mercaptopyridine; alkylthiopyridine.

Dihalopyridines I (R = 2-Br, R1 = 5-, 6-Br; R = 2-, 5-Cl, R1 = 3-Cl) reacted with NaSR2 (R2 = Me, CHMe2) in DMF to give 73-96% mono- or bis-substitution products I (R = SR2) or I (R = R1 = SR2), depending upon reaction conditions. The dihalo compounds reacted with NaOMe to give 72-93% I (R = OMe), but bis-substitution occurred easily only for I (R = 2-Br, R1 = 6-Br; R = 5-Cl, R1 = 3-Cl). Some I [R(R1) = OMe, R1(R) = SMe] were prepared by further reaction of monosubstitution products. I (R = R1 = SCHMe2 were fragmented by Na-HMPA to give I (R = R1 = SH), which were isolated as I (R = R1 = SMe) in 63-80% yield.

Tetrahedron published new progress about Nucleophilic aromatic substitution reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Application of C6H6ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mihajlovic-Lalic, Ljiljana E.; Stankovic, Dalibor; Novakovic, Irena; Grguric-Sipka, Sanja published the artcile< (Electro)chemical and antimicrobial characterization of novel Ru(II) bipyridine complexes with acetylpyridine analogs>, Related Products of 350-03-8, the main research area is ruthenium bipyridine acetylpyridine complex preparation antibacterial antifungal antioxidant; DNA intercalation ruthenium bipyridine acetylpyridine complex.

Three ruthenium-bipyridine complexes (1-3) carrying acetylpyridine ligand unit were synthesized in methanol via the reaction of [RuCl2(bpy)2] with corresponding acetylpyridine (2-, 3-, and 4-acpy). Obtained complexes were characterized by (1H and 13C) NMR and IR spectroscopy, MS spectrometry, UV-visible spectrophotometry, and cyclic voltammetry. Their structural characterization revealed bidentate coordination mode for 2-acpy while 3- and 4-acpy acted as monodentate ligands. The electrochem. profile of newly synthesized compounds was studied by cyclic voltammetry which confirmed their electrochem. activity. Voltammetric responses within the -1.20 < Ep < 1.50 v range of potentials were summarized in two major events: Ru(II)→Ru(III) oxidation spotted at apparatus ΔEp = 0.65 v and successive reductions of bpy units located from -0.79 v to 0.47 v (vs. Ag/AgCl (3 M) electrode). The DNA-binding activity of the complexes was evaluated by both UV-visible spectrophotometry and cyclic voltammetry indicating DNA-intercalation with a slight contribution of electrostatic interactions. Furthermore, antimicrobial activity was tested against bacterial and fungal strains, for which moderate activity was observed Assessment of in vitro toxicity against freshly hatched nauplii of Artemia salina as well as radical scavenging capacity was evaluated. The test compounds showed neither toxicity nor antioxidant activity. Journal of Coordination Chemistry published new progress about Antibacterial agents. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Related Products of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem