Tag: M.W=100-150

Gajeles, Ghellyn; Kim, Se Mi; Yoo, Jong-Cheol; Lee, Kyung-Koo; Lee, Sang Hee published the artcile< Recyclable anhydride catalyst for H2O2 oxidation: N-oxidation of pyridine derivatives>, Category: pyridine-derivatives, the main research area is pyridine oxide green preparation; oxidation pyridine poly maleic anhydride alt octadecene catalyst.

The catalytic efficiency and recyclability of poly(maleic anhydride-alt-1-octadecene) (Od-MA) and poly(maleic anhydride-alt-1-isobutylene) (Bu-MA) were evaluated for use in the development of a metal-free, reusable catalyst for the oxidation of pyridines to pyridine N-oxides, such as I [R = 2-Cl, 3-Br, 2-CO2H, etc.] in the presence of H2O2. The Od-MA catalyst was easily recovered via filtration with recovery yields exceeding 99.8%. The catalyst retained its activity after multiple uses and did not require any treatment for reuse. The Od-MA and H2O2 catalytic system described herein was eco-friendly, operationally simple, and cost-effective; thus, it was industrially applicable. Od-MA and H2O2 could potentially be used in place of percarboxylic acid as an oxidant in a wide range of oxidation reactions.

RSC Advances published new progress about Green chemistry. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Patel, Paresh N.; Desai, Dipen H.; Patel, Nilam C.; Deshmukh, Amar G. published the artcile< Efficient multicomponent processes for synthesis of novel poly-nuclear hetero aryl substituted terpyridine scaffolds: Single crystal XRD study>, Category: pyridine-derivatives, the main research area is naphthalenyl terpyridine preparation uv vis spectra fluorescence; benzothiophenyl terpyridine preparation; acetyl pyridine naphthaldehyde benzothiophene aldehyde multicomponent condensation reaction.

Authors studied the synthesis of novel terpyridine scaffolds from poly-nuclear and hetero-aryl aldehydes by the multicomponent condensation reactions with various acetyl pyridine derivatives in the presence of ammonium hydroxide. Comparative studies of two different processes catalyzed by potassium hydroxide and pyrrolidine have been performed and presented in this report. The structures of all the newly prepared terpyridine mols. have been well established by preforming various spectral anal. and single crystal XRD studies for selected mols. This approach addressed some structural miscellany concerns currently facing in photo-luminescent chem., and the derived hybrid pyridines could be used as suitable precursors for the synthesis of related photo-luminescent systems. The prepared scaffolds as such and their d-block or f-block metal complexes and coordination polymers may provide an efficient candidate for photo-luminescent chem.

Journal of Molecular Structure published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tan, Yee Seng; Tiekink, Edward R. T. published the artcile< Crystal structure of catena-poly{(μ2-N1,N2-bis[(pyridin-4-yl)methyl]ethanediamide-κ2N:N′)-bis(O,O′-di-isopropyldithiophosphato-κ1S)zinc(II)} - acetonitrile (1/1), C26H42N4O6P2S4Zn[n.8901]C2H3N>, Related Products of 3731-53-1, the main research area is crystal structure catenapolypyridinmethylethanediamideisopropyldithiophosphatoacetonitrile.

C28H45N5O6P2S4Zn, monoclinic, P21/c (number 14), a = 7.73670(10) Å, b = 21.56370(10) Å, c = 23.1184(2) Å, β = 99.121(1)°, V = 3808.12(6) Å3, Z = 4, Rgt(F) = 0.0210, wRref(F2) = 0.0580, T = 100(2) K. CCDC number: 1959644. The Zn[S2P(O-iPr)2]2precursor was prepared in high yield from the in situ reaction of Zn(NO3)2·6 H2O (Alfa Aesar; 14.87 g, 0.05 mol), iPrOH (Merck; 16.05 mL, 0.21 mol), P2S5(Sigma-Aldrich; 11.11 g, 0.05 mol) and 50% weight/weight NaOH solution (Merck; 8.80 mL, 0.11 mol). N, N-Bis(pyridin-4-ylmethyl) ethanediamide (4LH2) was prepared in high yield from the 2:1 reaction (reflux) of 4-picolylamine (Aldrich; 2.03 mL, 0.02 mol) and di-Et oxalate (Aldrich; 1.36 mL, 0.01 mol) in ethanol solution (Merck; 5 mL). The title compound was obtained by mixing a suspension of Zn[S2P(O-iPr)2]2(0.50 g, 1.02 mmol) and N,N-bis(pyridin-4-ylmethyl)ethanediamide (0.28 g, 1.04 mmol) in DMF (Merck; 5 mL), followed by stirring for 30 min at 373 K. The solution was filtered, the filtrate taken in acetonitrile (Merck; 1 mL) and transferred to a vial for crystallization Yellow crystals formed after one day.

Zeitschrift fuer Kristallographie – New Crystal Structures published new progress about Crystal structure. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tapanyigit, Ozan; Demirkol, Onur; Guler, Ece; Ersatr, Mehmet; Cam, Muhammet Emin; Giray, Elife Sultan published the artcile< Synthesis and investigation of anti-inflammatory and anticonvulsant activities of novel coumarin-diacylated hydrazide derivatives>, Product Details of C7H7NO2, the main research area is coumarin diacylated hydrazide derivative anticonvulsant anti inflammatory.

A number of novel coumarin derivatives synthesized by the reaction of 3-carbonyl chloride coumarin with some substituted aryl acid hydrazides to investigate their anti-inflammatory and anticonvulsant activities. Carrageenan (0.1 mL of 1%, w/v) was injected subplantarly in the right paw of rats to induce an acute model of inflammation. Anti-inflammatory efficacy was evaluated for 5 h at 3 different dosages 5, 10, 25 mg/kg. After that, the changes in the level of paw edema volumes and percentage inhibition of all groups were observed and the most effective coumarin derivative was found as N′-(2-hyroxybenzoyl)-2-oxo-2H-chromene-3-carbohydrazide. In addition, N′-(2-oxo-2H-chromene-3-carbonyl)nicotinohydrazide, (E)-N′-(3-(4-hydroxyphenyl)acryloyl)-2-oxo-2H-chromene-3-carbohydrazide, and N′-(5-amino-2-hydroxybenzoyl)-2-oxo-2H-chromone-3-carbohydrazide showed their anti-inflammatory effects in a dose-dependent manner. On the other hand, pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was used to investigate the anticonvulsant activities of six newly synthesized coumarin derivatives in mice. Hybrid compound of salicylic acid hydrazide and 3-carbonyl chloride coumarin was found the most promising anticonvulsant agent among all treatment groups according to the onset of seizure and survival rate. Moreover, (E)-N′-cinnamoyl-2-oxo-2H-chromene-3-carbohyrazide and (E)-N′-(3-(4-hyroxyphenyl)acryloyl)-2-oxo-2H-chromene-3-carbohydrazide has potential anticonvulsant efficiency in low doses (30 mg/kg). The anticonvulsant effect of these coumarin derivatives may be through enhanced GABA-mediated inhibition in the brain.

Arabian Journal of Chemistry published new progress about Anti-inflammatory agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hu, Jun-Chao; Sun, Shanshan; Li, Ming-De; Xia, Wu; Wu, Jin; Liu, Hongfang; Wang, Feng published the artcile< A biomimetic self-assembled cobaloxime@CdS/rGO hybrid for boosting photocatalytic H2 production>, Synthetic Route of 3731-53-1, the main research area is biomimetic cobaloxime CdS rGO hybrid photocatalytic hydrogen prduction.

A biomimetic CoPe@CdS/rGO hybrid that self-assembles via the integration of a mol. cobalt catalyst and CdS nano-semiconductor on reduced graphene oxide was constructed for boosting photocatalytic H2 production Photoinduced electron transfer from CdS/rGO to the mol. catalyst occurs and a long-lived charge-separation state forms for high H2 production

Chemical Communications (Cambridge, United Kingdom) published new progress about Attenuated-total-reflectance IR spectroscopy. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Houlihan, Joanna C. C.; Moratti, Stephen C.; Hanton, Lyall R. published the artcile< Formation of a robust, double-walled LiMOF from an L-shaped di-substituted N-heterocyclic adamantane-based ligand>, Related Products of 93-60-7, the main research area is preparation lithium copper zinc heterocyclic adamantane complex; crystal structure lithium copper zinc heterocyclic adamantane complex; lithium copper zinc heterocyclic adamantane MOF.

The properties of adamantane render it an attractive building block towards the synthesis of robust frameworks. This work describes the synthesis of the L-shaped 1,3-bis(3′-carboxypyridine)adamantane (L1) ligand and the corresponding Li(I), Zn(II) and Cu(II) frameworks. Three topol. analogous Li(I) frameworks LiMOF12, LiMOF30 and LiMOF50 are reported, with calculated solvent accessible void volumes of 46, 43 and 36%, resp. The reaction between the carboxylate groups of L1 and the Li(I) cations gave Li-carboxylate rods. The Li-carboxylate rods contributed to the formation of a double-walled MOF with large, open one dimensional channels. The synergistic effect of the double wall, lithium-carboxylate rods and the adamantane core itself, gave a robust network stable up to temperatures of 300-350° and a min. of three months stability in air. Furthermore, complexation of L1 with Cu(BF4)2·H2O and Zn(CF3SO3)2 provided a 2D → 3D interpenetrated network containing a classic dimeric copper paddle-wheel SBU, and an infinite 1D chain which extended into a 3D structure facilitated by hydrogen-bonding interactions, resp.

Dalton Transactions published new progress about Crystal structure. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Keawkim, Kannika; Na Jom, Kriskamol published the artcile< Metabolomics and flavoromics analysis of chemical constituent changes during roasting of germinated Sacha inchi (Plukenetia volubilis L.)>, Related Products of 93-60-7, the main research area is metabolome flavorome roasting browning germination Plukenetia.

This study examined the changes in metabolites together with the flavor profiles of germinated Sacha inchi seeds during roasting by using gas chromatog. The results indicated that roasting partially increased the browning index, amino acid levels, total phenolic content, and antioxidant capacity, but slightly decreased the levels of reducing sugars. Oxidized and rancid compounds were significantly decreased at a 180 °C roasting temperature Pyrazine, furan, and pyrrole were Maillard reaction products that were increased at 180 °C of roasting. Roasting at 145 °C for 45 min after germination for 4 days was determined to be the optimal conditions for roasting germinated Sacha inchi seeds, which reduced the off-flavor and burned taste. The roasted germinated Sacha inchi seed contains higher amino acids than raw seed, which could be used as an alternative source for food products and supplements. In addition, the roasted germinated seeds at 4 days were recommended for food applications.

Food Chemistry: X published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ngo, Khang; Collins-Kautz, Chelsey; Gerstenecker, Stefan; Wagner, Bjoern; Heine, Andreas; Klebe, Gerhard published the artcile< Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?>, Product Details of C6H8N2, the main research area is Protein Induced ligand protonation trypsin thrombin.

Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg. Both recognize basic substrate headgroups via Asp189 at the bottom of the S1 pocket. By crystallog. and isothermal titration calorimetry (ITC), we studied a series of D-Phe/D-DiPhe-Pro-(amino)pyridines. Identical ligand pairs show the same binding poses. Surprisingly, one ligand binds to trypsin in protonated state and to thrombin in unprotonated state at P1 along with differences in the residual solvation pattern. While trypsin binding is mediated by an ordered water mol., in thrombin, water is scattered over three hydration sites. Although having highly similar S1 pockets, our results suggest different electrostatic properties of Asp189 possibly contributing to the selectivity determinant. Thrombin binds a specific Na+ ion next to Asp189, which is absent in trypsin. The electrostatic properties across the S1 pocket are further attenuated by charged Glu192 at the rim of S1 in thrombin, which is replaced by uncharged Gln192 in trypsin.

Journal of Medicinal Chemistry published new progress about Enzyme functional sites, active. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Sonu; Sarmah, Manash P.; Reddy, Yella; Bhatt, Ashish; Kant, Ravi published the artcile< A one-step synthesis of substituted benzo- and pyridine-fused 1H-imidazoles>, Electric Literature of 3731-53-1, the main research area is aryl benzoimidazole preparation; fluoronitrobenzene amine cyclization microwave irradiation; imidazopyridine aryl preparation; amine nitrofluoropyrdine cyclization microwave irradiation.

A one-step microwave accelerated synthesis of substituted benzo- and pyridine-fused 1H-imidazoles were described. Mechanistically, the reaction proceeded by reacting substituted 2-fluoronitrobenzene and substituted arylamine through the formation of N-hydroxy intermediate, which at higher temperature cleaved to afford the desired product. This approach achieved reductions in reaction times, higher yields, cleaner reactions than the previously described synthetic processes.

Synthetic Communications published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Electric Literature of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

El-Marrouki, Dalel; Touchet, Sabrina; Abdelli, Abderrahmen; M’Rabet, Hedi; Efrit, Mohamed Lotfi; Gros, Philippe C. published the artcile< Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor>, SDS of cas: 3731-53-1, the main research area is indole preparation; cinnoline preparation; diketone primary amine Michael; 1,4-diketone; N-heterocycle; cinnoline; indole; indolone.

A straightforward and metal-free strategy for the synthesis of nitrogen-containing heterocyclic moieties, indoles I [R1 = Me, Et; R2 = Bn, CH(Me)Ph, CH2(CH2)2NMe2, etc.], indolones II [R3 = Me, Et, Ph; R4 = Bn, 4-BrC6H4, 4-pyridylmethyl, etc.] and cinnolines III [R5 = Me, Ph, 2-thienyl, etc.; R6 = H, Me] was developed via Michael reaction 1,4-diketones and primary amines. The protocols developed here used mild conditions, were functional-group tolerant, transition-metal-free, proceeded in moderate to good yield.

Beilstein Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, SDS of cas: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem