Tag: M.W=100-150

Ho, Dang Binh; Gargaro, Samantha; Klake, Raphael K.; Sieber, Joshua D. published the artcile< Development of a Modified System to Provide Improved Diastereocontrol in the Linear-Selective Cu-Catalyzed Reductive Coupling of Ketones and Allenamides>, Formula: C7H7NO, the main research area is chiral gamma lactone preparation; ketone allenamide reductive coupling linear selective copper.

Chiral γ-lactones are prevalent organic architectures found in a large array of natural products. In this work, authors disclose the development of a modified catalytic system utilizing a com. available Cu-phosphite catalyst for the diastereoselective reductive coupling of chiral allenamides and ketones to afford chiral γ-lactone precursors in 80:20 to 99:1 dr.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (allenamides). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Liang; Zhang, Wenpeng; Lin, Feng; Lu, Xinqiang; Chen, Wei; Li, Xingzhou; Zhou, Xinbo; Su, Ruibin; Wang, Lili; Zheng, Zhibing; Li, Song published the artcile< Synthesis and biological evaluation of pyrazolo[3,4-b]pyridine-3-yl pyrimidine derivatives as sGC stimulators for the treatment of pulmonary hypertension>, Application In Synthesis of 131747-55-2, the main research area is pyrazolopyridinyl pyrimidine preparation sGC stimulator; Pulmonary hypertension; Riociguat; pyrazolo[3,4-b]pyridine-3-yl pyrimidine derivatives; sGC stimulators.

A series of new pyrazolo[3,4-b]pyridin-3-yl pyrimidine derivatives I [R = 2-thiophenyl, 3-fluorothiophen-2-yl, 5-methylpyridin-3-yl; R1 = Me, Et, i-Pr; R2 = Me, Et] were synthesized and evaluated for the activation of sGC. Compared with riociguat, compound I [R = 3-fluorothiophen-2-yl; R1 = R2 = Me] exhibited equivalent in vitro activity on preconstricted rat thoracic aorta rings and in Rat heart Langendorff preparation Compound I [R = 3-fluorothiophen-2-yl; R1 = R2 = Me] also showed acceptable PK profiles, which might become a promising candidate for the treatment of pulmonary hypertension.

European Journal of Medicinal Chemistry published new progress about Pulmonary hypertension. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Application In Synthesis of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shokurov, Alexander V.; Meshkov, Ivan N.; Bulach, Veronique; Gorbunova, Yulia G.; Hosseini, Mir Wais; Tsivadze, Aslan Yu.; Arslanov, Vladimir V.; Selektor, Sofia L. published the artcile< Restriction of the rotational relaxation of a butadiyne-bridged porphyrin dimer in ultrathin films>, Application In Synthesis of 3731-53-1, the main research area is porphyrin dimer diazabicyclooctane aminomethylpyridine film preparation dynamic behavior UV.

The dynamic behavior of a porphyrin dimer, based on the covalent linkage of two macrocyclic moieties with a butadiyne connector, was studied in thin films by UV-visible and emission spectroscopies. The degree of π-conjugation through control of intramol. motion was studied without employing extreme conditions such as cryogenic temperatures or high viscosity. By exploiting the propensity of the dimer to bind axial ligands through Zn-N bonds, the coplanar and orthogonal conformations of the dimer may be stabilized in ultrathin films at the air/water interface. Also, using the Langmuir-Blodgett technique, monolayer-thick matrix-free films on solid substrates containing the porphyrin dimer were obtained. In the latter case, the dimer exists in either an exclusively coplanar state or a mixture of conformational states depending on the nature of the axial ligand: 1,4-diazabicyclo[2.2.2]-octane (DABCO) or 4-aminomethylpyridine (AMP).

New Journal of Chemistry published new progress about Lattice dynamics. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application In Synthesis of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hu, Yongke; Xia, Jiawei; Li, Jin; Li, Huaju; Li, Yanxing; Li, Shaozhong; Duanmu, Chuansong; Li, Bindong; Wang, Xin published the artcile< Direct oxidative esterification of alcohols catalyzed by a nitrogen-doped carbon black-supported PdBi bimetallic catalyst under ambient conditions>, Electric Literature of 93-60-7, the main research area is PdBi bimetallic catalyzed oxidative esterification alc; aryl ester preparation PdBi bimetallic catalyzed oxidative esterification.

A highly efficient nitrogen-doped carbon black (NCB)-supported PdBi alloy nanocatalyst has been fabricated via a facile coredn. wet chem. approach. The optimal PdBi/NCB shows outstanding catalytic performance with broad substrate scope, good functional group tolerance towards direct oxidative esterification of alcs. under mild conditions in a heterogeneous catalytic system with air as the sole oxidant. A variety of benzylic and allylic alcs. were smoothly reacted with methanol and even with long-chain aliphatic alcs., providing desired esters in good to excellent yields. Moreover, the as-prepared catalyst is easily recycled and can be reused at least five times without a significant loss of catalytic activity. Superior catalytic activity is mainly attributable to the unique structure of the catalyst, including synergetic electronic effect between Pd and Bi, as well as modulated surface character by acidification and N doping for better active components’ anchoring and dispersion, as well as reactants’ adsorption. This study provides a facial, practical, eco-friendly and efficient catalytic system for oxidative esterification of alcs. and shows promising prospect in industrial production

Journal of Materials Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Electric Literature of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Voisin, Anne Sophie; Bouillon, Alexandre; Lancelot, Jean-Charles; Rault, Sylvain published the artcile< Efficient synthesis of halohydroxypyridines by hydroxydeboronation>, SDS of cas: 96630-88-5, the main research area is halohydroxypyridine preparation regioselective hydroxydeboronation halopyridinylboronic acid ester.

This paper describes a general method for the synthesis of halohydroxypyridines from novel halopyridinylboronic acids and esters recently described by some of us. Halopyridinylboronic acids and esters have been efficiently hydroxydeboronated under mild conditions by employing hydrogen peroxide or meta-chloroperbenzoic acid. These hydroxylations take place regioselectively without other oxidation (N-oxide formation).

Tetrahedron published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 96630-88-5 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, SDS of cas: 96630-88-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Hai; Wang, Liang; Wang, Sai; Dong, Xue; Zhang, Jian; Xiao, Feng-Shou published the artcile< Aerobic Activation of C-H Bond in Amines Over a Nanorod Manganese Oxide Catalyst>, Application of C6H8N2, the main research area is aerobic activation amine nanorod manganese oxide catalyst; amide preparation green chem.

The development of heterogeneous catalysts for the synthesis of pharmaceutically relevant compounds is always important for chem. research. Here, we report a selective aerobic oxidation of aromatic and aliphatic amines to corresponding amides over a nanorod manganese oxide (NR-MnOx) catalyst. The kinetic studies reveal that the NR-MnOx catalyzed amine-to-amide reaction proceeds the oxidative dehydrogenation of the amines into nitriles, followed by hydrolysis of nitrile into amides. The NR-MnOx exhibits fast kinetics and high selectivities in these steps, as well as hinders the byproduct formation. More importantly, the NR-MnOx catalyst is stable and reusable in the continuous recycle tests with water as a sole byproduct, exhibiting superior sustainability and significant advancement to outperform the traditional amide production route in acidic or basic media with toxic byproducts.

ChemCatChem published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An, Yunfei; Dong, Yue; Liu, Min; Han, Jun; Zhao, Liyu; Sun, Bin published the artcile< Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation>, Application In Synthesis of 3731-53-1, the main research area is naphthylamide imidazole preparation antifungal activity mol docking SAR; squalene epoxidase cytochrome P450 enzyme inhibitor; Antifungal activity; Dual-target; Fungal infections; Inhibitors; Organic synthesis.

In the study, a series of active fragments were screened through the method of De Novo Link, and these active fragments with the higher Ludi_Scores were selected, which can show the obvious binding ability with the dual targets (SE, CYP51). Subsequently, three series of target compounds with naphthyl amide scaffolds were constructed by connecting these core fragments, and their structures were synthesized. Most of compounds showed the antifungal activity in the treatment of pathogenic fungi. It was worth noting that compoundsI [R = pyridin-4-ylmethyl] and II [R = methyl] with the excellent broad-spectrum antifungal properties also exhibited the obvious antifungal effects against drug-resistant fungi. Preliminary mechanism study has proved these target compounds can block the biosynthesis of ergosterol by inhibiting the activity of dual targets (SE, CYP51). Furthermore, target compounds I [R = pyridin-4-ylmethyl] and II [R = methyl] with low toxicity side effects also demonstrated the excellent pharmacol. effects in vivo. The mol. docking and ADMET prediction were performed, which can guide the optimization of subsequent lead compounds

European Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application In Synthesis of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Matesanz, Encarna; Alcazar, Jesus; Andres, J. Ignacio; Bartolome, Jose M.; De Bruyn, Marcel; Fernandez, Javier; Van Emelen, Kristof published the artcile< Synthesis of novel aza analogues of 2-substituted-2,3-dihydro-1,4-benzodioxins as potential new scaffolds for drug discovery>, Application of C5H4ClNO, the main research area is benzodioxin aza analog preparation.

New synthesis approaches that have led to a series of novel aza analogs of the 2-substituted-2,3-dihydro-1,4-benzodioxin core, bearing versatile bromomethyl group on the non aromatic oxygenated ring, are described. According to their structures these novel scaffolds can be useful intermediates for the preparation of potential new therapeutic agents.

Tetrahedron Letters published new progress about Cyclization, regioselective. 96630-88-5 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Application of C5H4ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ziolkowska, Dorota; Syrotynska, Iryna; Shyichuk, Alexander; Lamkiewicz, Jan published the artcile< Determination of SLES in personal care products by colloid titration with light reflection measurements>, Quality Control of 3811-73-2, the main research area is sodium laureth sulfate personal care product colloid titration; PDADMAC; PDDA; cationic polymer; polyDADMAC; quantitation of surfactants; turbidity.

The method of colloid titration with poly(diallyldimethylammonium) chloride has been improved to detect the endpoint with an off-vessel light reflectance sensor. The digital color sensor used measures light reflectance by means of light guides, with no immersion into the reaction solution In such a method, the optical signal is free of disturbances caused by sticky flocs in the solution The improved automatic titration set was applied for the determination of sodium laureth sulfate (SLES) in industrial batches and com. personal care products. The sample color and opacity do not disturb the SLES quantification. When the SLES content lies in the range from 5% to 9%, the optimal sample weight is from 6 g to 3 g.

Molecules published new progress about Almond. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Quality Control of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rani, S. Mahil; Brindha, J.; Reji, T. F. Abbs Fen published the artcile< Synthesis, computational studies and antioxidant activity of some 3-(2-alkylamino-4-aminothiazole-5-oyl)pyridines>, Name: 1-(Pyridin-3-yl)ethanone, the main research area is alkylamino aminothiazoloyl pyridine preparation antioxidant DFT HOMO LUMO.

A series of thiazoloylpyridine derivatives I (R = Et, n-Pr, i-Pr, n-Bu, allyl) has been synthesized and analyzed to confirm the structure of the product using IR, 1H and 13C NMR, mass spectra and anal. data. Optimized structural and electronic parameters of all the compounds I have been calculated by using B3LYP/ 6-31G basis set. The Mulliken charges of all atoms have been evaluated. All the synthesized compounds I have been examined for antioxidant activities. The antioxidant activity of 3-(2-alkylamino-4-aminothiazol -5-oyl)pyridines I have been analyzed using DPPH radical scavenging assay. The compounds I (R = Et, n-Pr) possess higher radical scavenging activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Antioxidants. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Name: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem