Tag: M.W=100-150

Zhang, Jing; Han, Fu-She published the artcile< Pd-Catalyzed Aerobic Oxidative Heck Cross-Coupling for the Straightforward Construction of Indole δ-Lactams>, Related Products of 93-60-7, the main research area is indolyl amide palladium catalyst oxidative Heck coupling regioselective hetereocyclization; fused indolyl lactam preparation; Catalysis; Chemistry; Organic Chemistry.

A co-ligand-prompted Pd-catalyzed 6-exo-trig intramol. cyclization of indolyl amides via the aerobic oxidative Heck cross-coupling. The method provided a general and efficient way for the construction of [6.5.6]-tricyclic indole δ-lactams. A mechanistic study suggests that a Pd(I)/Pd(III) catalytic cycle should be responsible for effective coupling, which represents a mechanistically alternative pathway when compared with the Pd(0)/Pd(II) cycle proposed for other related coupling reactions.

iScience published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Hongmei; Wu, Shaohang; Yao, Jiaxu; Chen, Rui; Pan, Ming; Chen, Weitao; Zhou, Jing; Zhang, Wenjun; Wang, Tao; Chen, Wei published the artcile< An effective surface modification strategy with high reproducibility for simultaneously improving efficiency and stability of inverted MA-free perovskite solar cells>, Computed Properties of 350-03-8, the main research area is perovskite solar cell surface modification high reproducibility efficiency stability.

Perovskite solar cells (PSCs) have become the front-running photovoltaic technol. and have triggered enormous research interest worldwide owing to their ultra-high solar-to-elec. power conversion efficiency and low fabrication costs, but their poor intrinsic stability issues still constitute the main obstacles that hinder their rapid commercialization. Herein, we demonstrate that, by carefully designing the modifier’s mol. structure, a facile, highly reproducible and scalable surface modification strategy can effectively enhance both the stability and efficiency of inverted PSCs. The most efficient modifier (2-acetylpyridine) can not only passivate the surface traps of the perovskite film but also enhance its stability against moisture by forming a hydrophobic capping layer on top. Accordingly, the efficiency of the inverted PSC has been improved from 16.75% to 20.05% for the best-performing one, which is, to our knowledge, among the highest values for inverted MA-free PSCs. More encouragingly, the stability of the modified devices can also be largely enhanced: the devices retained 95%, 90%, and 91% of their initial efficiencies after storage in the dark in ambient air for 2000 h, 85°C thermal aging for 500 h in the dark, and light soaking at 45°C for 500 h, resp.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Electric current-potential relationship. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Computed Properties of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhao, Changgui; Ye, Zhengqing; Ma, Zhi-xiong; Wildman, Scott A.; Blaszczyk, Stephanie A.; Hu, Lihong; Guizei, Ilia A.; Tang, Weiping published the artcile< A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings>, HPLC of Formula: 3731-53-1, the main research area is polycyclic steroid preparation oxidation ring expastion natural product.

The interrogation of complex biol. pathways demands diverse small mol. tool compounds, which can often lead to important therapeutics for the treatment of human diseases. Since natural products are the most valuable source for the discovery of therapeutics, the derivatization of natural products has been extensively investigated to generate mols. for biol. screenings. However, most previous approaches only modified a limited number of functional groups, which resulted in a limited number of skeleta. Here, a general strategy for the preparation of a library of complex small mols. by combining state-of-the-art chem. – the site-selective oxidation of C-H bonds – with reactions that expand rigid, small rings in polycyclic steroids to medium-sized rings is described. This library occupies a unique chem. space compared to selected diverse reference compounds The diversification strategy developed herein for steroids can also be expanded to other types of natural products.

Nature Communications published new progress about Alkylation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Lei; Zhou, Guo-Jun; Yu, You-Zhu; Nojiri, Hiroyuki; Schroder, Christian; Winpenny, Richard E. P.; Zheng, Yan-Zhen published the artcile< Topological Self-Assembly of Highly Symmetric Lanthanide Clusters: A Magnetic Study of Exchange-Coupling ""Fingerprints"" in Giant Gadolinium(III) Cages>, Computed Properties of 73018-09-4, the main research area is gadolinium cage self assembly magnetization exchange interaction crystal structure.

The creation of a perfect hollow nanoscopic sphere of metal centers is clearly an unrealizable synthetic challenge. It is, however, an inspirational challenge from the viewpoint of chem. architecture and also as finite mol. species may provide unique microscopic insight into the origin and onset of phenomena such as topol. spin-frustration effects found in infinite 2D and 3D systems. Herein, we report a series of high-symmetry gadolinium(III) (S = 7/2) polyhedra, Gd20, Gd32, Gd50, and Gd60, to test an approach based on assembling polymetallic fragments that contain different polygons. Structural anal. reveals that the Gd20 cage resembles a dodecahedron; the vertices of the Gd32 polyhedron exactly reveal symmetry Oh; Gd50 displays an unprecedented polyhedron in which an icosidodecahedron Gd30 core is encapsulated by an outer Gd20 dodecahedral shell with approx. Ih symmetry; and the Gd60 shows a truncated octahedron geometry. Exptl. and theor. magnetic studies show that this series produces the expected antiferromagnetic interaction that can be modeled based on classical spins at the Gd sites. From the magnetization analyses, we can roughly correlate the derivative bands to the Gd-O-Gd angles. Such a magneto-structural correlation may be used as “”fingerprints”” to identify these cages.

Journal of the American Chemical Society published new progress about Antiferromagnetic exchange. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Computed Properties of 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Kena; Li, Hui; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng published the artcile< An efficient palladium-catalyzed synthesis of 1-heteroaryl-4-aminopiperidine derivatives from heteroaryl chlorides>, Recommanded Product: 3-Chloro-2-methoxypyridine, the main research area is aminopiperidine heteroaryl preparation Buchwald Hartwig amination palladium.

An efficient protocol for the synthesis of 1-heteroaryl-4-(N-methyl)aminopiperidines starting from heteroaryl chloride derivatives is described. A broad range of 1-heteroaryl-4-(N-Boc-N-methyl)aminopiperidine derivatives, e.g., I and II, were obtained in good to excellent yields using DavePhos as optimal ligand for Pd-catalyzed Buchwald-Hartwig amination reaction. After a mild and efficient acidolysis the amination products could be obtained successfully.

Tetrahedron Letters published new progress about Buchwald-Hartwig reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Recommanded Product: 3-Chloro-2-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chakraborty, Gargi; Sikari, Rina; Das, Siuli; Mondal, Rakesh; Sinha, Suman; Banerjee, Seemika; Paul, Nanda D. published the artcile< Dehydrogenative Synthesis of Quinolines, 2-Aminoquinolines, and Quinazolines Using Singlet Diradical Ni(II)-Catalysts>, Formula: C7H7NO, the main research area is quinoline biomimetic synthesis; aminoquinoline biomimetic synthesis; quinazoline biomimetic synthesis; nickel complex diamine singlet diradical oxidative condensation coupling catalyst.

Simple, straightforward, and atom economic methods for the synthesis of quinolines, 2-aminoquinolines, and quinazolines via biomimetic dehydrogenative condensation/coupling reactions, catalyzed by well-defined inexpensive and easy to prepare singlet diradical Ni(II)-catalysts featuring two antiferromagnetically coupled singlet diradical diamine type ligands are described. Various polysubstituted quinolines, 2-aminoquinolines, and quinazolines were synthesized in moderate to good yields from different low-cost and readily accessible starting materials. Several control experiments were carried out to get insight into the reaction mechanism which shows that the nickel and the coordinated diamine ligands participate in a synergistic way during the dehydrogenation of alcs.

Journal of Organic Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (phenylacetonitriles). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xiong, Yun; Zhang, Pangzhen; Luo, Jiaqian; Johnson, Stuart; Fang, Zhongxiang published the artcile< Effect of processing on the phenolic contents, antioxidant activity and volatile compounds of sorghum grain tea>, Application of C7H7NO2, the main research area is Sorghum tea phenol antioxidant volatile compound.

Sorghum grain is rich in phenolic compounds and may be used to develop functional tea beverages. This work investigated the effect of processing techniques on the phenolic contents, antioxidant activity, and volatile compounds of a white color sorghum (Liberty) grain tea. Significant (P ≤ 0.05) increase of total phenolic content, total flavonoid content and condensed tannin content were observed during the processing, whereas the antioxidant activity was not statistically enhanced. A total of 63 volatile compounds were detected including 5 alcs., 13 alkanes, 2 aldehydes, 2 carboxylic acids, 15 esters, 4 ketones, 3 pyrazines and 1 phenylenediamine, which were affected by the processing techniques. The sorghum tea made from powder form infusion had more abundant volatile compounds compared to whole grain form infusion. The findings of this research have potential to expand human consumption of sorghum grain in the new form of grain tea.

Journal of Cereal Science published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Zhong; He, Jia-Hao; Zhang, Ming; Shi, Zhu-Jun; Tang, Han; Zhou, Xin-Yue; Tian, Jun-Jie; Wang, Xiao-Chen published the artcile< Borane-Catalyzed C3-Alkylation of Pyridines with Imines, Aldehydes, or Ketones as Electrophiles>, Category: pyridine-derivatives, the main research area is C3 selective pyridine preparation regioselective; pyridine imine aldehyde ketone alkylation borane catalyst.

Achieving C3-selective pyridine functionalization is a longstanding challenge in organic chem. The existing methods, including electrophilic aromatic substitution and C-H activation, often require harsh reaction conditions and excess pyridine and generate multiple regioisomers. Herein, authors report a method for borane-catalyzed tandem reactions that result in exclusively C3-selective alkylation of pyridines. These tandem reactions consist of pyridine hydroboration, nucleophilic addition of the resulting dihydropyridine to an imine, an aldehyde, or a ketone, and subsequent oxidative aromatization. Because the pyridine is the limiting reactant and the reaction conditions are mild, this method constitutes a practical tool for late-stage functionalization of structurally complex pharmaceuticals bearing a pyridine moiety.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Bin; Dong, Yue; Lei, Kang; Wang, Jian; Zhao, Liyu; Liu, Min published the artcile< Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors>, COA of Formula: C6H8N2, the main research area is amide pyridine derivative preparation squalene cyclooxygenase CYP51 inhibitor antifungal; 3D QSAR model; Amide-pyridine compounds; Antifungal activity; Dual-target; Molecular docking.

Based on the anal. of the squalene cyclooxygenase (SE) and 14α-demethylase (CYP51) inhibitors pharmacophore feature and the dual-target active sites, a series of compounds with amide-pyridine scaffolds have been designed and synthesized to treat the increasing incidence of drug-resistant fungal infections. In vitro evaluation showed that these compounds have a certain degree of antifungal activity. The most potent compounds 11a, 11b with MIC values in the range of 0.125-2 μg/mL had a broad-spectrum antifungal activity and exhibited excellent inhibitory activity against drug-resistant pathogenic fungi. Preliminary mechanism studies revealed that the compound 11b might play an antifungal role by inhibiting the activity of SE and CYP51. Notably compounds did not show the genotoxicity through plasmid binding assay. Finally, this study of mol. docking, ADME/T prediction and the construction of 3D QSAR model were performed. These results can point out the direction for further optimization of the lead compound

Bioorganic & Medicinal Chemistry published new progress about Drug resistance. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hawash, Mohammed; Kahraman, Deniz Cansen; Ergun, Sezen Guntekin; Cetin-Atalay, Rengul; Baytas, Sultan Nacak published the artcile< Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines>, Quality Control of 3731-53-1, the main research area is indole isoxazole carboxamide preparation antitumor activity physicochem property; Apoptosis; CDK4; Cell cycle arrest; Hepatocellular carcinoma; Indole; Isoxazole.

In this study, a series of indole-3-isoxazole-5-carboxamide derivatives I (R = n-butylamine, 3,4,5-(trimethoxyphenyl)aminyl, morpholin-4-yl, etc.) was designed, synthesized, and evaluated for their anticancer activities. The cytotoxic activity was performed against Huh7, MCF7 and HCT116 cancer cell lines using sulforhodamine B assay. Some compounds I showed potent anticancer activities and three of them were chosen for further evaluation on liver cancer cell lines based on SRB assay and real-time cell growth tracking anal. Compounds I were shown to cause arrest in the G0/G1 phase in Huh7 cells and caused a significant decrease in CDK4 levels. A good correlation was obtained between the theor. predictions of bioavailability using Molinspiration calculation, Lipinski’s rule of five, and exptl. verification. These investigations reveal that indole-isoxazole hybrid system have the potential for the development of novel anticancer agents.

BMC Chemistry published new progress about Amides Role: PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem