Tag: M.W=100-150

Jeon, Jinwon; He, Yu-Tao; Shin, Sanghoon; Hong, Sungwoo published the artcile< Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes>, COA of Formula: C7H7NO2, the main research area is phosphine oxide pyridinyl preparation; pyridinium alkenyloxy alkenylamino preparation trifluoromethylation phosphinylation regioselective migration; fluoroalkyl functionalized pyridine preparation; alkenes; heterocycles; photochemistry; radicals; reaction mechanisms.

The photocatalyzed ortho-selective migration on a pyridyl ring has been achieved for the site-selective trifluoromethylative pyridylation of unactivated alkenes. The overall process was initiated by the selective addition of a CF3 radical to the alkene moiety of N-(alkenyloxy)pyridinium salts I [X = O, Z = (CH2)3, R1 = H, 2-Me, 3-MeO2C, 4-Ph, etc., R2 = H, Me; X = O, Z = CH2, CH2CH2, (CH2)4, R1 = 4-MeO2C, R2 = H; X = NTs, Z = CH2, CH2CH2, R1 = H, 4-MeO2C, R2 = H; etc.] to provide a nucleophilic alkyl radical intermediate, which enabled an intramol. endo addition exclusively to the ortho-position of the pyridinium salt to afford the corresponding functionalized pyridines II. Both secondary and tertiary alkyl radicals were well-suited for addition to the C2-position of pyridinium salts to ultimately provide synthetically valuable C2-fluoroalkyl functionalized pyridines. Moreover, the method was successfully applied to the reaction with P-centered radicals. The utility of this transformation was further demonstrated by the late-stage functionalization of complex bioactive mols.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grivas, Spiros; Ronne, Erik published the artcile< Synthesis of four isomeric imidazonaphthyridines; three novel ring systems>, HPLC of Formula: 55279-29-3, the main research area is imidazonaphthyridine; Friedlaender reaction creatinine aminopyridinecarbaldehyde.

The novel 2-amino-1-Me derivatives of imidazo[4,5-b][1,x]naphthyridine, for example, I and II, were prepared via the Friedlaender reaction from the corresponding aminopyridinecarbaldehydes and creatinine in 65-85% yields. The ring systems I, II and their isomers were not reported previously.

Journal of Chemical Research, Synopses published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, HPLC of Formula: 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Timmer, Brian J. J.; Kravchenko, Oleksandr; Liu, Tianqi; Zhang, Biaobiao; Sun, Licheng published the artcile< Off-Set Interactions of Ruthenium-bda Type Catalysts for Promoting Water-Splitting Performance>, COA of Formula: C7H7NO2, the main research area is ruthenium catalyst water splitting performance catalytic activity; homogeneous catalysis; kinetics; noncovalent interactions; ruthenium; water splitting.

O-O bond formation with Ru(bda)L2-type catalysts is well-known to proceed through a bimol. reaction pathway, limiting the potential application of these catalysts at low concentrations Herein, we achieved high efficiencies with mononuclear catalysts, with TOFs of 460±32 s-1 at high catalyst loading and 31±3 s-1 at only 1 μM catalyst concentration, by simple structural considerations on the axial ligands. Kinetic and DFT studies show that introduction of an off-set in the interaction between the two catalytic units reduces the kinetic barrier of the second-order O-O bond formation, maintaining high catalytic activity even at low catalyst concentrations The results herein furthermore suggest that π-π interactions may only play a minor role in the observed catalytic activity, and that asymmetry can also rationalize high activity observed for Ru(bda)(isoq)2 type catalysts and offer inspiration to overcome the limitations of 2nd order catalysis.

Angewandte Chemie, International Edition published new progress about Bond formation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Das, Jagadish; Vellakkaran, Mari; Banerjee, Debasis published the artcile< Nickel-Catalyzed Alkylation of Ketone Enolates: Synthesis of Monoselective Linear Ketones>, Product Details of C7H7NO, the main research area is ketone alc nickel monoselective alkylation catalyst; linear ketone preparation green chem.

Herein we have developed a Ni-catalyzed protocol for the synthesis of linear ketones. Aryl, alkyl, and heteroaryl ketones as well as alcs. yielded the monoselective ketones in up to 90% yield. The catalytic protocol was successfully applied in to a gram-scale synthesis. For a practical utility, applications of a steroid derivative, oleyl alc., and naproxen alc. were employed. Preliminary catalytic investigations involving the isolation of a Ni intermediate and defined Ni-H species as well as a series of deuterium-labeling experiments were performed.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mandal, Rajorshi; Garai, Abhijit; Peli, Simone; Datta, Prasanta K.; Biradha, Kumar published the artcile< Photoinduced bending of single crystals of a linear bis-olefin via water-templated solid-state [2+2] photopolymerization reaction>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is photocycloaddition photopolymerization crystal bending; photoactuators; photochemistry; photoinduced bending; solid-state [2+2] photopolymerization.

The single crystals of two structural isomers of bis-olefinic mols. were shown to have contrasting properties in terms of their photoreactivity: one exhibits an excellent ability to form polymers, accompanied with bending of crystals upon irradiation, while the other is photostable. The photoreactive crystal is a first example in which [2+2] polymerization leads to bending of the crystals, with implications for the design of photoactuators. The hydrate formation ability of one of these mol. isomers promotes the solid-state reactivity in its crystal, as the H2O mols. act as a template to bring the olefin mols. into the required arrangement for [2+2] polymerization Further, the crystals of the polymer exhibited better flexibility and smoothed surfaces compared to those of the monomers. In addition, under UV-light the diene emits bluish violet light while the polymer emits green light, indicating that the luminescence property can be tuned through photoirradiation

Chemistry – A European Journal published new progress about [2+2] Photocycloaddition reaction. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rawat, Manish; Rawat, Diwan S. published the artcile< Cu2O-Decorated Marigold Hollow Alumina Microsphere Nanoparticles as a Robust and Efficient Catalyst for the Synthesis of Isoquinolones>, Electric Literature of 350-03-8, the main research area is copper oxide decorated marigold hollow alumina microsphere catalyst preparation; isoquinolone green preparation.

A novel Cu2O-decorated marigold hollow alumina microsphere nanocatalytic system for the synthesis of isoquinolones I [R1 = H, 7-Me, 6-F; R2 = Ph, 4-ClC6H4, 2-thienyl, etc.] using 2-bromobenzonitriles and ketones under neat condition was reported. The prepared nanocatalyst was well characterized by SEM, high-resolution transmission electron microscopy, powder X-ray diffraction, energy-dispersive X-ray anal., XPS and Brunauer-Emmett-Teller techniques. The present method was facile and showed better green chem. metrics such as low E-factor, high reaction mass efficiency, and high turnover number and could be reused for five cycles without any loss in its catalytic activity.

ACS Sustainable Chemistry & Engineering published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schirrmacher, Ralf; Wangler, Bjorn; Schirrmacher, Esther; August, Thorsten; Rosch, Frank published the artcile< Dimethylpyridin-4-ylamine-catalysed alcoholysis of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride: An effective route to O6-substituted guanine derivatives from alcohols with poor nucleophilicity>, Name: 2-Fluoro-3-(hydroxymethyl)pyridine, the main research area is dimethylpyridinylamine catalyzed alcoholysis nucleophilicity aminotrimethylpurinylammonium chloride; guanine alc derivative preparation.

Dimethylpyridin-4-ylamine (DMAP)-catalyzed reactions of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride with fluoropyridine methoxides and various other alkoxides in DMSO at 60 °C gave the corresponding coupling products in moderate to good yields between 20-87%. Under these reaction conditions, fluorinated O6-substituted Guanine derivatives have been synthesized which could not be obtained via known analogous literature procedures. The resp. yields of known O6-substituted guanine derivatives could be significantly improved by using this method. The efficient use of DMAP as an excellent nucleophilic catalyst in the syntheses of O6-substituted Guanine derivatives has thus been demonstrated.

Synthesis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Name: 2-Fluoro-3-(hydroxymethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Manteau, Baptiste; Genix, Pierre; Brelot, Lydia; Vors, Jean-Pierre; Pazenok, Sergiy; Giornal, Florence; Leuenberger, Charlotte; Leroux, Frederic R. published the artcile< A General Approach to (Trifluoromethoxy)pyridines: first X-ray Structure Determinations and Quantum Chemistry Studies>, Reference of 73018-09-4, the main research area is general approach synthesis Trifluoromethoxy pyridines crystal structure; ab initio energy profiles rotation trifluoromethoxy methoxy pyridines.

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallog. structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies.

European Journal of Organic Chemistry published new progress about Anomeric effect. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Reference of 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Gongming; Li, Zhipeng; Liu, Yuhan; Guo, Donghui; Sheng, Xijun; Wang, Jian published the artcile< Organocatalytic Higher-Order [8+2] Cycloaddition for the Assembly of Atropoenantiomeric 3-Arylindolizines>, Application of C6H4F3N, the main research area is arylindolizine preparation enantioselective; ylide ynal cycloaddition organocatalyst.

An unprecedented atroposelective [8+2] cycloaddition reaction between pyridinium/isoquinolinium ylides and ynals was presented. It was worth noting that this protocol represented a new example of the organocatalyzed atropoenantioselective higher-order cycloaddition reaction, providing various axial chiral 3-arylindolizines, e.g., I in good yields and high enantioselectivities. In addition, the obtained axially chiral 3-aryldolizines also provided many opportunities for structural transformations and potential drug discovery.

Organic Letters published new progress about Alkynes, internal Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wei, Xiao-Jing; Abdiaj, Irini; Sambiagio, Carlo; Li, Chenfei; Zysman-Colman, Eli; Alcazar, Jesus; Noel, Timothy published the artcile< Visible-Light-Promoted Iron-Catalyzed C(sp2)-C(sp3) Kumada Cross-Coupling in Flow>, Related Products of 13472-84-9, the main research area is Kumada cross coupling aryl chloride Grignard reagent iron catalyst; visible light Kumada cross coupling iron catalyst mechanism flow; Kumada coupling; cross-coupling; flow chemistry; iron catalysis; photocatalysis.

A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application. The mechanism was studied using radical clock experiments, kinetic measurements, DFT and other techniques.

Angewandte Chemie, International Edition published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Related Products of 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem