Tag: M.W=100-150

Budweg, Svenja; Wei, Zhihong; Jiao, Haijun; Junge, Kathrin; Beller, Matthias published the artcile< Iron-PNP-Pincer-Catalyzed Transfer Dehydrogenation of Secondary Alcohols>, SDS of cas: 350-03-8, the main research area is iron PNP pincer catalyst transfer dehydrogenation secondary alc; ketone preparation mol modeling; homogeneous catalysis; iron; oxidation; pincer ligands; transfer dehydrogenation.

The well-defined iron PNP pincer complex catalyst [Fe(H)(BH4)(CO)(HN{CH2CH2P(iPr)2}2)] was used for the catalytic dehydrogenation of secondary alcs. to give the corresponding ketones. Using acetone as inexpensive hydrogen acceptor enables the oxidation with good to excellent yields. DFT computations indicate an outer-sphere mechanism and support the importance of an acceptor to achieve this transformation under milder conditions.

ChemSusChem published new progress about Dehydrogenation catalysts. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, SDS of cas: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Handa, Sachin; Andersson, Martin P.; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H. published the artcile< HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-catalyzed Cross-Couplings in Water at Room Temperature>, HPLC of Formula: 13472-84-9, the main research area is monophosphine palladium catalyst coupling Suzuki Miyaura; E Factor; Suzuki-Miyaura coupling; green chemistry; ligand design; micellar catalysis.

The new monophosphine ligand HandaPhos was identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki-Miyaura reactions involving highly functionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures Comparisons with existing state-of-the-art ligands and catalysts are discussed herein.

Angewandte Chemie, International Edition published new progress about Cross-coupling reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, HPLC of Formula: 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Deping; Liu, Wenwu; Huang, Yaoguan; Liu, Mingyue; Tian, Caizhi; Lu, Hongyuan; Jia, Hui; Xu, Zihua; Ding, Huaiwei; Zhao, Qingchun published the artcile< Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer>, Quality Control of 3731-53-1, the main research area is beta carboline preparation SAR antitumor human CDK4 inhibitor; CDK4; HCT116; Harmine; β-carboline.

Cyclin-dependent kinase 4 (CDK4), which is involved in dynamic regulation of cell cycle, has gained particularly attention for its role in controlling tumor growth. Increasing evidence showed that β-carboline derivatives have the potential to inhibit CDK4. Herein, on the basis of previous work, authors designed and synthesized a series of novel β-carbolines and evaluated their antitumor activity. Among them, compounds I and II, with the most potent anti-proliferative activity and CDK4 enzymic inhibition activity, were selected for further pharmacol. research in vitro and in vivo. The results in vitro showed that I and II exhibited potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. In vivo, I showed significant tumor growth inhibition in HCT116 tumor xenograft model without causing significant weight loss and toxicity consistent with the acute toxicity test. In addition, silico study showed I and II not only have good biol. actions, but also acceptable predicted ADME and physicochem. properties. Taken together, compounds I and II could be selected for further modification and preclin. evaluation.

Bioorganic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An, Ju Hyeon; Kim, Kyu Dong; Lee, Jun Hee published the artcile< Highly Chemoselective Deoxygenation Of N-Heterocyclic N-Oxides Using Hantzsch Esters As Mild Reducing Agents>, Computed Properties of 93-60-7, the main research area is deoxygenated nitrogen heterocycle green preparation chemoselective; heterocycle nitrogen oxide deoxygenation Hantzsch ester metallaphotocatalyst.

A highly chemoselective room-temperature deoxygenation method applicable to various functionalized N-heterocyclic N-oxides via visible light-mediated metallaphotoredox catalysis using Hantzsch esters as the sole stoichiometric reductant to afford deoxygenated N-heterocycles I [R = 6-OMe, 6-Cl, 2-Ph, etc.], II [R1 = H, 5-Br; X = CH, N] and III [R2 = 3-Ph, 2,6-Cl2, pyridin-2-yl, etc.] were reported. Despite the feasibility of catalyst-free conditions, most of these deoxygenations could be completed within a few minutes using only a tiny amount of a catalyst. This technol. also allowed for multigram-scale reactions even with an extremely low catalyst loading of 0.01 mol %. The scope of this scalable and operationally convenient protocol encompassed a wide range of functional groups, such as amides, carbamates, esters, ketones, nitrile groups, nitro groups and halogens, which provided access to the corresponding compounds I, II and III in good to excellent yields (an average of an 86.8% yield for a total of 45 examples).

Journal of Organic Chemistry published new progress about Amine oxides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroarene). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elawa, Sherif; Mirdell, Robin; Farnebo, Simon; Tesselaar, Erik published the artcile< Skin blood flow response to topically applied methyl nicotinate: Possible mechanisms.>, Synthetic Route of 93-60-7, the main research area is capillary capacity; laser speckle contrast imaging; methyl nicotinate; microcirculation; tissue viability.

BACKGROUND: Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be valuable as a local provocation in the assessment of microcirculation and skin viability. The mechanisms through which MN mediates its vascular effect are not fully known. The aim of this study was to characterize the vasodilatory effects of topically applied MN and to study the involvement of nitric oxide (NO), local sensory nerves, and prostaglandin-mediated pathways. METHODS: MN was applied on the skin of healthy subjects in which NO-mediated (L-NMMA), nerve-mediated (lidocaine/prilocaine), and cyclooxygenase-mediated (NSAID) pathways were selectively inhibited. Microvascular responses in the skin were measured using laser speckle contrast imaging (LSCI). RESULTS: NSAID reduced the MN-induced perfusion increase with 82% (P < .01), whereas lidocaine/prilocaine reduced it with 32% (P < .01). L-NMMA did not affect the microvascular response to MN. CONCLUSION: The prostaglandin pathway and local sensory nerves are involved in the vasodilatory actions of MN in the skin. Skin research and technology : International Society for Skin Imaging (ISSI) published new progress about 93-60-7. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Synthetic Route of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Yinyin; Wang, Yue; Huang, Zhefan; Zhang, Fangjun; Shao, Yinlin published the artcile< tBuOLi-Promoted Hydroboration of Esters and Epoxides>, Computed Properties of 93-60-7, the main research area is ester lactone epoxide hydroboration chemoselective lithium tertbutoxide catalyst; alc preparation.

Com. available and inexpensive lithium tert-butoxide (tBuOLi) acts as a good precatalyst for the hydroboration of esters, lactones, and epoxides using pinacolborane as a borylation agent. Functional groups such as cyano-, nitro-, amino-, vinyl, and alkynyl are unaffected under the presented hydroboration process, representing high chemoselectivity. This transformation has also been effectively applied to the synthesis of key intermediates of Erlotinib and Cinacalcet. Preliminary investigations of the mechanism show that the hydroboration proceeds through the in situ formed BH3 species.

ACS Omega published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Takale, Balaram S.; Thakore, Ruchita R.; Handa, Sachin; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H. published the artcile< A new, substituted palladacycle for ppm level Pd-catalyzed Suzuki-Miyaura cross couplings in water>, Recommanded Product: 3-Chloro-2-methoxypyridine, the main research area is biarene preparation green chem; halide aryl boronic acid Suzuki Miyaura coupling palladium catalyst.

A newly engineered palladacycle that contains substituents on the biphenyl rings along with the ligand HandaPhos is especially well-matched to an aqueous micellar medium, enabling valued Suzuki-Miyaura coupling of aryl halides RX (R = 2-O2NC6H4, 1-benzothiophen-2-yl, 2-fluoropyridin-3-yl, etc.; X = Cl, Br, I) and aryl boronic acids R1B(OH)2 (R1 = 4-ClC6H4, 1-benzofuran-2-yl, pyren-1-yl, etc.) to be run not only in water under mild conditions, but at 300 ppm of Pd catalyst. This general methodol. has been applied to several targets in the pharmaceutical area. Multiple recyclings of the aqueous reaction mixture involving both the same as well as different coupling partners are demonstrated. Low temperature microscopy (cryo-TEM) indicates the nature and size of the particles acting as nanoreactors. Importantly, given the low loadings of Pd invested per reaction, ICP-MS analyses of residual palladium in the products show levels to be expected that are well within FDA allowable limits.

Chemical Science published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Recommanded Product: 3-Chloro-2-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Su, Xuxian; Wang, Wen-Jin; Cao, Qian; Zhang, Hang; Liu, Bin; Ling, Yuyi; Zhou, Xiaotong; Mao, Zong-Wan published the artcile< A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity>, Formula: C6H8N2, the main research area is CAIX ruthenium photosensitizer preparation cancer PDT pyroptosis immunity; anti-tumor immunity; carbonic anhydrase IX targeting; metallodrugs; photodynamic therapy; pyroptosis.

An ideal cancer treatment should not only destroy primary tumors but also improve the immunogenicity of the tumor microenvironment to achieve a satisfactory anti-tumor immune effect. We designed a carbonic anhydrase IX (CAIX)-anchored rhenium(I) photosensitizer, named CA-Re, that not only performs type-I and type-II photodynamic therapy (PDT) with high efficiency under hypoxia (nanomolar-level phototoxicity), but also evokes gasdermin D (GSDMD) mediated pyroptotic cell death to effectively stimulate tumor immunogenicity. CA-Re could disrupt and self-report the loss of membrane integrity simultaneously. This promoted the maturation and antigen-presenting ability of dendritic cells (DCs), and fully activated T cells dependent adaptive immune response in vivo, eventually eliminating distant tumors at the same time as destroying primary tumors. To the best of our knowledge, CA-Re is the first metal complex-based pyroptosis inducer.

Angewandte Chemie, International Edition published new progress about Adaptive immunity. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pramanik, Bapan; Das, Saurav; Das, Debapratim published the artcile< Aggregation-directed High Fidelity Sensing of Picric Acid by a Perylenediimide-based Luminogen>, Related Products of 3731-53-1, the main research area is aggregation directed fluorescent sensor picric acid perylenediimide luminogen; aggregation caused quenching; chemosensor; explosive sensor; perylenediimide; picric acid.

Widespread use of picric acid (PA) in chem. industries and deadly explosives poses dreadful impact on all living creatures as well as the natural environment and has raised global concerns that necessitate the development of fast and efficient sensing platforms. To address this issue, herein, we report a perylenediimide-peptide conjugate, PDI-1 (I), for detection of PA in methanol. The probe displays typical aggregation caused quenching (ACQ) behavior and exhibits a fluorescence “”turn-off”” sensory response towards PA which is unaffected by the presence of other interfering nitroarom. compounds The sensing mechanism involves PA induced aggregation of the probe into higher order tape like structures which leads to quenching of emission. The probe possesses a low detection limit of 5.6 nM or 1.28 ppb and a significantly high Stern-Volmer constant of 6.87×104 M-1. It also exhibits conducting properties in the presence of PA vapors and thus represents a prospective candidate for vapor phase detection of PA. This is, to the best of our knowledge, the first example of a perylenediimide based probe that demonstrates extremely specific, selective and sensitive detection of PA and thus grasps the potential for application in practical scenarios.

Chemistry – An Asian Journal published new progress about Aggregation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bairagi, Pallab Kumar; Goyal, Arpit; Verma, Nishith published the artcile< Methyl nicotinate biomarker of tuberculosis voltammetrically detected on cobalt nanoparticle-dispersed reduced graphene oxide-based carbon film in blood>, Quality Control of 93-60-7, the main research area is methyl nicotinate biomarker graphene oxide carbon cobalt nanoparticle tuberculosis.

Me nicotinate (MN), a metabolite of Mycobacterium tuberculosis, is an important biomarker of tuberculosis (TB). An effective measurement of MN can provide an early detection of TB, before it becomes life threatening. In this study, a cobalt (Co) and reduced graphene oxide (rGO) dispersed N-doped phenolic polymer precursor-based carbon film is used as the biosensor electrode to detect and measure MN in human blood for the first time. The Co nanoparticles are successfully used as the nonbiol. recognition element of MN. Doping of the carbon film with N-heteroatom using melamine increases the film electro-conductivity Using differential pulse voltammetry, the sensor electrode exhibits excellent linearity (0.9925) over 0.05-14 mg L-1MN concentrations (S/N ratio = 3), with high sensitivity (1735.2μA mM-1 cm-2) and low detection limit (0.0004 mM). The sensor also shows good selectivity and high recovery for MN. Most importantly, the sensor successfully confirms its clin. applicability when tested in the synthetic clin. MN solutions (RSD < 6.5%). The method and materials developed in this study have paved a new platform for developing similar biosensors using non-biol. components for chronic diseases such as typhoid and kidney-dysfunction. Sensors and Actuators, B: Chemical published new progress about Blood. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem