Tag: M.W=100-150

Grozavu, Alexandru; Hepburn, Hamish B.; Smith, Philip J.; Potukuchi, Harish K.; Lindsay-Scott, Peter J.; Donohoe, Timothy J. published the artcile< The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation>, COA of Formula: C7H7NO2, the main research area is pyridinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; quinolinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; tetrahydropyridine preparation; tetrahydroquinoline preparation.

Aromatic rings are ubiquitous in organic chem. and form the basis of many com. products. Despite the numerous routes available for the preparation of aromatic compounds, there remain few methods that allow their conversion into synthetically useful partially saturated derivatives and even fewer that allow new C-C bonds to be formed at the same time. Here we set out to address this problem and uncover a unique catalytic partial reduction reaction that forms partially saturated azaheterocycles from aromatic precursors. In this reaction, methanol and formaldehyde are used for the reductive functionalization of pyridines and quinolines using catalytic iridium; thus, inexpensive and renewable feedstocks are utilized in the formation of complex N-heterocycles. By harnessing the formation of a nucleophilic enamine intermediate, the C-C bond-forming process reverses the normal pattern of reactivity and allows access to the C3 position of the arene. Mechanistic investigations using D-labeling experiments reveal the source of hydride added to the ring and show the reversible nature of the iridium-hydride addition

Nature Chemistry published new progress about C-C bond formation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barone, Antonella; Cristiano, Maria Chiara; Cilurzo, Felisa; Locatelli, Marcello; Iannotta, Dalila; Di Marzio, Luisa; Celia, Christian; Paolino, Donatella published the artcile< Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is ammonium glycyrrhizate skin drug delivery antiinflammatory activity; Ammonium glycyrrhizate; Anti-inflammatory activity; Colloidal nanocarriers; Topical administration; Ultradeformable liposomes.

Although several nanoformulations, such as ethosomes, are designed to provide a systemic effect through a topical application, there are different limitations to the distribution inside the blood stream. For this reason, ultradeformable liposomes, or transfersomes, are selected to improve the topical delivery of drugs and allow the distribution of payloads in the blood stream because they pass intact through the stratum corneum epidermis barrier, due to the presence of sodium cholate, aqueous cutaneous gradient, and the rapid penetration of transfersomes by cutaneous tight junctions, thus allowing the systemic delivery of different therapeutic cargo in non-occlusive conditions. The aim of this work was the synthesis and physicochem. characterization of the ammonium glycyrrhizinate-loaded ultradeformable liposomes, the evaluation of drug release and permeation through stratum corneum and epidermis barrier. The in vivo anti-inflammatory effect of ammonium glycyrrhizinate-loaded ultradeformable liposomes was tested on human healthy volunteers. The results demonstrated that the ammonium glycyrrhizinate-loaded ultradeformable liposomes decreased the skin inflammation on the human volunteers and the resulting nanoformulations can be used as a potential topical drug delivery system for anti-inflammatory therapy.Parts of these results were presented as a poster communication at the Recent Developments in Pharmaceutical Anal. 2019 (RDPA 2019), Chieti, Italy.

Colloids and Surfaces, B: Biointerfaces published new progress about Anti-inflammatory agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pflegr, Vaclav; Stepankova, Sarka; Svrckova, Katarina; Svarcova, Marketa; Vinsova, Jarmila; Kratky, Martin published the artcile< 5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study>, Application In Synthesis of 93-60-7, the main research area is aryloyl dodecyl oxadiazol amine preparation cholinesterase inhibition docking SAR; dodecyl aryloyl thiadiazol amine preparation acetyl butyrylcholinesterase inhibition docking; hydrazine carboxamide cyclization; 1,3,4-oxadiazole; 1,3,4-thiadiazole; acetylcholinesterase; butyrylcholinesterase; enzyme inhibition; molecular docking.

The compounds 5-aryl-1,3,4-oxadiazoles/thiadiazols decorated with dodecyl linked via nitrogen, sulfur or directly to this heterocycle I [R = Ph, 4-MeC6H4, 4-tBuC6H4, etc.,; X = O, S; Y = NH, S] was designed as potential inhibitors of AChE and BChE. Oxadiazoles/thiadiazols derivatives I were prepared from hydrazides by reaction with dodecyl isocyanate to form hydrazine-1-carboxamides II (yields 67-98%) followed by cyclization using p-toluenesulfonyl chloride and triethylamine in 41-100% yields. The derivatives I were screened for inhibition of AChE and BChE using Ellman’s spectrophotometric method. The compounds I showed a moderate dual inhibition with IC50 values of 12.8-99.2 for AChE and from 53.1μM for BChE. All the heterocycles I were more efficient inhibitors of AChE. The most potent inhibitor, N-dodecyl-5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine I [R =4-pyridyl, X= S, Y = NH] was subjected to advanced reversibility and type of inhibition evaluation. Structure-activity relationships of heterocycles I were identified. Many oxadiazoles I showed lower IC50 values against AChE than established drug rivastigmine. According to mol. docking, the compounds I interact non-covalently with AChE and BChE and block entry into enzyme gorge and catalytic site, resp.

Pharmaceuticals published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Echterhoff, Antje K. C.; Yogendra, Sivathmeehan; Koesters, Jutta; Fischer, Roland; Weigand, Jan J. published the artcile< A versatile protocol for the synthesis of pyrazolyl-substituted pyridinium and guanidinium salts from pyridone and urea derivatives>, HPLC of Formula: 73018-09-4, the main research area is pyridinium pyrazolyl guanidinium triflate preparation crystal structure; tripyridyl phosphite preparation crystal structure.

The trication I was used as a convenient pyrazolyl-transfer reactant to convert 2-pyridone, 4-pyridone and urea derivatives such as benzimidazol-2-one and theobromine to their pyrazolyl substituted triflate salts, e.g., II. The conversion represented a new, efficient and highly functional group-compatible approach that yielded the desired products conveniently and in high yields. Typically the reaction proceeded via exchange of carbonyl oxygen atom of the substrate for pyrazolyl moiety. However, for the structurally related 3-hydroxypyridines, a different reaction pathway occurred giving tripyridyl phosphites, e.g., III which was explained by the lactam-lactim tautomerism of the substrate. The structural arrangements of most of the products were confirmed by X-ray crystallog. anal.

European Journal of Organic Chemistry published new progress about Crystal structure. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, HPLC of Formula: 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xiaojuan; Zhang, Qiang; Zhang, Weigang; Wang, Yi; Pan, Yi published the artcile< Decarboxylative Alkylation of Heteroarenes Using N-Hydroxybenzimidoyl Chloride Esters>, Recommanded Product: 3-(Trifluoromethyl)pyridine, the main research area is heteroarene hydroxybenzimidoyl chloride ester decarboxylative alkylation.

Functionalized N-heteroarenes are highly desired motifs in medicinal chem. and pharmaceutical industry. Minisci-type reactions usually require a protonated N-heteroarene for the alkyl radical to attack. This work describes a leaving-group-assisted redox-active ester to enable direct coupling of an amino acid with N-heteroarenes. The efficient and sustainable photoredox strategy provides rapid access to an alkylated heterocyclic manifold.

Journal of Organic Chemistry published new progress about Alkylation (decarboxylative). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Recommanded Product: 3-(Trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Manuel Ledo, J.; Flores, Henoc; Ramos, Fernando; Freitas, Vera L. S.; Ribeiro da Silva, Maria D. M. C. published the artcile< MatThermochemical study to assess the energetical and structural effects of nitro substituents in methyl benzoate isomers>, Formula: C7H7NO2, the main research area is methyl nitrobenzoate nitro substituent effect thermochem property.

Combined exptl. and computational studies were performed aiming the anal. of energetic properties vs structural characteristics of three Me nitrobenzoate isomers (Me 2-nitrobenzoate, M2NB, Me 3-nitrobenzoate, M3NB, Me 4-nitrobenzoate, M4NB). The exptl. studies include the determination of the enthalpy of formation in the condensed state (crystal and liquid) of the compounds by static combustion, and the determination of enthalpies of phase transition, using Differential Scanning Calorimetry, high temperature Calvet microcalorimetry and the Knudsen effusion method. These data were combined to derive the enthalpy of formation of the Me nitrobenzoate isomers in the gaseous phase, at T = 298.15 K. At the computational level, the gas-phase enthalpy of formation of the Me nitrobenzoate isomers were estimated using theor. approaches, resorting to the G3(MP2)//B3LYP composite method and to appropriate hypothetical gas-phase reactions. The enthalpies of formation obtained exptl. and computationally will be discussed and the energetic-structural synergies for the three Me nitrobenzoate, along with other analogous isomers, will be also analyzed.

Journal of Chemical Thermodynamics published new progress about Combustion. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Luo, Yun-Cheng; Tong, Fei-Fei; Zhang, Yanxia; He, Chun-Yang; Zhang, Xingang published the artcile< Visible-Light-Induced Palladium-Catalyzed Selective Defluoroarylation of Trifluoromethylarenes with Arylboronic Acids>, Application of C6H4F3N, the main research area is trifluoromethylarene arylboronic acid palladium defluoroarylation cross coupling oxidative addition; diaryldifluoromethane preparation selective photochem.

An unprecedented excited-state palladium catalysis strategy for selective defluoroarylation of trifluoromethylarenes with arylboronic acids was reported. This visible-light-induced palladium-catalyzed cross-coupling proceeded under mild reaction conditions and allowed transformation of a variety of arylboronic acids and ArCF3. Preliminary mechanistic studies revealed that the oxidative addition of the C(sp3)-F bond in ArCF3 to excited-state palladium(0) via a single electron transfer pathway is responsible for the C(sp3)-F bond activation.

Journal of the American Chemical Society published new progress about Aralkyl fluorides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Jiancheng; Zheng, Xiangui; Li, Jiongxian; Li, Xiuyan; Lu, K. published the artcile< Electrodeposited Al mesocrystal with high thermal stability and high hardness>, SDS of cas: 93-60-7, the main research area is thermal stability aluminum mesocrystal high hardness electrodeposited.

Mesocrystal, composed of same-oriented nanocrystals separated by organics, is a promising structure for superior chem. and mech. properties, in which the high d. of nanocrystal-organic interfaces plays a crucial role. The stability of the interfaces determines the service temperature and strength of the material. Here, we synthesized aluminum mesocrystal using electrodeposition in ionic liquids with Me nicotinate additive and investigated its thermal and mech. stability. In contrast to the low stability of nanograined metals and nanoporous metals with comparable grain sizes, the Al mesocrystal is found to be stable up to 320°C (0.63 Tm, Tm: the m.p.) and has a recorded high hardness of 2.27 GPa. The high stability originates from the suppression of migration and free diffusion of the interfaces.

Scripta Materialia published new progress about Electrodeposition. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, SDS of cas: 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tyagi, Adish; Karmakar, Gourab; Mandal, B. P.; Dutta Pathak, Dipa; Wadawale, Amey; Kedarnath, G.; Srivastava, A. P.; Jain, Vimal K. published the artcile< Di-tert-butyltin(IV) 2-pyridyl and 4,6-dimethyl-2-pyrimidyl thiolates: versatile single source precursors for the preparation of SnS nanoplatelets as anode material for lithium ion batteries>, Computed Properties of 3811-73-2, the main research area is pyrimidylthiolate tin sulfide nanoplatelet lithium ion battery anode.

New air and moisture stable di-tert-butyltin complexes derived from 2-mercaptopyridine (HSpy), [tBu2Sn(Spy)2], [tBu2Sn(Cl)(Spy)] and 4,6-dimethyl-2-mercaptopyrimidine (HSpymMe2) [tBu2Sn(Cl)(SpymMe2)], have been prepared and utilized as single-source mol. precursors for the preparation of orthorhombic SnS nanoplatelets by a hot injection method and thin films by aerosol assisted chem. vapor deposition (AACVD). The complexes were characterized by NMR (1H, 13C, 119Sn) and elemental anal. and their structures were unambiguously established by the single crystal X-ray diffraction technique. Thermolysis of these complexes in oleylamine (OAm) produced SnS nanoplatelets. The morphologies, elemental compositions, phase purity and crystal structures of the resulting Oam-capped nanoplatelets were determined by electron microscopy (SEM, TEM), energy dispersive X-ray spectroscopy (EDS) and pXRD, while the band gaps of the nanoplatelets were evaluated by diffuse reflectance spectroscopy (DRS) and were blue shifted relative to the bulk material. The morphol. and preferential growth of the nanoplatelets were found to be significantly altered by the nature of the mol. precursor employed. The synthesized SnS nanoplatelets were evaluated for their performance as anode material for lithium ion batteries (LIBs). A cell comprised of an SnS electrode could be cycled for 50 cycles. The rate capability of SnS was investigated at different current densities in the range 0.1 to 0.7 A g-1 which revealed that the initial capacity could be regained.

Dalton Transactions published new progress about Battery anodes. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Computed Properties of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Juma, Jamil A. published the artcile< The effect of organic additives in electrodeposition of Co from deep eutectic solvents>, Application In Synthesis of 93-60-7, the main research area is cobalt chloride organic additive deep eutectic solvent electrodeposition.

A range of organic/ inorganic additives have traditionally been added to electroplating solutions to improve brightness and encourage leveling. A limited number of studies have shown that some brighteners function in ionic liquids In this study the effect of four additives; nicotinic acid (NA), Me nicotinate (MN), 5,5-di-Me hydantoin (DMH) and boric acid (BH), have been measured on the electrodeposition of cobalt in the 1choline chloride (ChCl): 2 ethylene glycol (EG) based deep eutectic solvent (DES). In general the addition of these additives causes the deposition potential of Co to be shifted to more neg. over-potentials. No apparent change in speciation and coordination environment around the CoII center was observed The surface morphol. was significantly changed by the addition of each of the additives, suggesting that they function by modifying the double layer. The nucleation and growth mechanism of Co deposition was found to change in the presence of these additives. Flat, shiny and high uniform cobalt layers were obtained with the additives whereas in their absence the deposit was black and dull. The additives significantly increased the hardness of the cobalt deposit and this was shown to be related to the crystal structure of the deposit which was determined using XRD.

Arabian Journal of Chemistry published new progress about Brightening agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem