Tag: M.W=100-150

Patel, P. N.; Desai, D. H.; Patel, N. C. published the artcile< Novel Terpyridine Derivatives of Benzothiazole and Copper(II) Complex: Synthesis and Spectral Studies>, Application In Synthesis of 350-03-8, the main research area is crystal structure copper benzothiazolylterpyridine complex; benzothiazolylterpyridine preparation copper complex.

Novel terpyridine derivatives of benzothiazole were synthesized by simple multicomponent 1-pot reaction of benzothiazole-2-carbaldehyde, ammonium hydroxide, and isomeric acetyl pyridines with isolated yields of 92-98%. All the prepared derivatives were characterized by NMR, IR, and high-resolution mass spectra. A Cu(II) complex was prepared selectively from the terpyridine derivative obtained from 2-acetylpyridine and was characterized by single-crystal x-ray anal. UV-visible spectra were recorded for all the synthesized compounds

Russian Journal of Organic Chemistry published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bennasar, M.-Lluiesa; Zulaica, Ester; Juan, Cecilia; Alonso, Yolanda; Bosch, Joan published the artcile< Addition of Ester Enolates to N-Alkyl-2-fluoropyridinium Salts: Total Synthesis of (±)-20-Deoxycamptothecin and (+)-Camptothecin>, Related Products of 131747-55-2, the main research area is ester enolate addition fluoropyridinium salt; deoxycamptothecin total synthesis; camptothecin total synthesis.

Several 4-substituted dihydropyridones or 2-pyridones have been prepared by nucleophilic addition of α-(methylsulfanyl)ester enolates to N-alkyl-2-fluoropyridinium salts, followed by acid hydrolysis or oxidation with concomitant hydrolysis, of the intermediate 2-fluoro-1,4-dihydropyridine adducts, resp. Addition of the enolate derived from iso-Pr α-(methylsulfanyl)butyrate to N-(quinolylmethyl)-2-fluoropyridinium triflate followed by DDQ treatment gave a pyridone I, from which (±)-20-deoxycamptothecin a known precursor of camptothecin was synthesized by a radical cyclization-desulfurization, with subsequent elaboration of the lactone E ring by chemoselective reduction A similar sequence starting from the enolate of a chiral 2-hydroxybutyric acid derivative (II) provides access to natural (+)-camptothecin.

Journal of Organic Chemistry published new progress about Addition reaction. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Related Products of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Hongyun; Datta Khanal, Hari; Rok Lee, Yong published the artcile< Iodine-Catalyzed Annulations of 2-Amino Carbonyls for Diverse 1-Azaxanthones, Quinolines, and Naphthyridines>, COA of Formula: C6H6N2O, the main research area is amino formylchromone enamine iodine catalyst tandem cycloaddition green chem; azaxanthone preparation; carbonyl aniline enamine iodine catalyst tandem cycloaddition green chem; quinoline preparation; aminonicotinaldehyde enamine iodine catalyst tandem cycloaddition green chem; naphthyridine preparation.

An efficient and facile iodine-catalyzed reaction of 2-amino carbonyls with β-enamino esters or β-enaminones afforded 1-azaxanthones, quinolines and naphthyridines in good to excellent yields. This novel catalytic [4+2] annulation reaction proceeded through a cascade I2-activation, Michael addition, intramol. aldol reaction and aromatization.

Asian Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, COA of Formula: C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gu, Yiting; Shen, Yangyang; Zarate, Cayetana; Martin, Ruben published the artcile< A Mild and Direct Site-Selective sp2 C-H Silylation of (Poly)Azines>, Product Details of C6H4F3N, the main research area is silylation pyridine pyrimidine pyrazine quinoline silyl dioxaborolane reagent; base promoted silylation azine borylsilane regioselective orthogonal process.

A base-mediated protocol that allows for the site-selective sp2 C-H silylation of pyridines, pyrazines, pyridazines, pyrimidines and quinolines by Et3SiBpin is described. The substitution typically proceeds in 4- or 2-position of the pyridine ring. This method is distinguished by its mild conditions, simplicity and excellent site-selective modulation for a diverse set of azines, even in the context of late-stage functionalization, while exhibiting orthogonal reactivity with classical silylation reactions.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (borylsilanes). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Product Details of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Beebeejaun-Boodoo, B. M. P.; Rademeyer, Melanie published the artcile< Coordination polymers and metallocycles of metal halides with n-(aminomethyl)pyridine, n = 3 or 4: Structures and solid-state fluorescence>, Name: Pyridin-4-ylmethanamine, the main research area is cobalt mercury halo aminomethylpyridine coordination polymer metallocycle preparation; crystal structure cobalt mercury halo aminomethylpyridine coordination polymer metallocycle; fluorescence cobalt mercury halo aminomethylpyridine coordination polymer metallocycle.

Coordination polymers and metallocycles formed by the reactions of CoX2 or HgX2, X = Cl-, Br- or I-, with the ditopic organic ligands (L) 3-(aminomethyl)pyridine, 3amp, or 4-(aminomethyl)pyridine, 4amp, are reported. The combination of L = 4amp with CoCl2, CoBr2 or HgI2 yielded one-dimensional coordination polymers of composition [M(L)(X)2]∞, in which the metal ion displays a tetrahedral geometry. Only the combination of L = 3amp with CoCl2 gave a one-dimensional coordination polymer, while the rest of the structures containing this organic ligand were comprised of metallocycles. The metallocyclic rings have a composition [M2(L)2(X)4]n, with n = 1 for L = 3amp and HgBr2, and n = 2 for L = 3amp and CoBr2 or HgI2. Strong N-H. X-M hydrogen bonding interactions are observed in both the coordination polymer and metallocycle structures. The solid-state fluorescence spectra of selected compounds are reported.

Polyhedron published new progress about Coordination polymers Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gilchrist, T. L. published the artcile< Product class 3: arynes>, Safety of 3-Chloro-2-methoxypyridine, the main research area is review aryne preparation organic synthesis.

A review of methods to prepare arynes.

Science of Synthesis published new progress about Alkynes, arynes Role: SPN (Synthetic Preparation), PREP (Preparation). 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Safety of 3-Chloro-2-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Xiaoya; Zhou, Sen; Li, Yuli; Guo, Minjie; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei published the artcile< Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate>, COA of Formula: C7H7NO2, the main research area is indolizine synthesis annulation pyridinium salt bromodifluoroacetate.

Here we present a novel annulation of pyridinium salts with BrCF2CO2Et to access the indolizine derivatives with high efficiency. The α substitution of pyridine plays a key role in determining the reaction pathways. Various types of indolizines can be conveniently accessed from easily available pyridinium salts under mild and simple reaction conditions.

Organic Letters published new progress about Cyclization, regioselective. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Shuni; Yang, Hong; Su, Mingbo; Lian, Fulin; Cong, Zhanqing; Wei, Rongrui; Zhou, Yubo; Li, Xingjun; Zheng, Xingling; Li, Chunpu; Fu, Xuhong; Han, Xu; Shi, Qiongyu; Li, Cong; Zhang, Naixia; Geng, Meiyu; Liu, Hong; Li, Jia; Huang, Xun; Wang, Jiang published the artcile< 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma>, Formula: C6H8N2, the main research area is aminonaphthalene sulfonamide preparation NSD2 inhibitor SAR antitumor apoptosis human; 5-Aminonaphthalene derivatives; HTS; Inhibitor; Methyltransferase; Multiple myeloma; NSD2.

Using high-throughput screening (HTS) with biol. analyzes, a series of 5-aminonaphthalene derivatives such as I [X = CO, SO2; R1 = NHCH2Ph, NHPh, NHCH2(4-FC6H4), etc.; R2 = H, NH2, NMe2, etc.] were designed and synthesized as novel NSD2 inhibitors. Among all the prepared compounds, I [R1 = NHCH2Ph, R2 = NH2] displayed a good NSD2 inhibitory activity (IC50 = 2.7μM) and selectivity against both SET-domain-containing and non-SET-domain-containing methyltransferases. Preliminary research indicated the inhibition mechanism of compound I [X = SO2, R1 = NHCH2Ph, R2 = NH2 (II)] by significantly suppressed the methylation of H3K36me2. Compound II specifically inhibited the proliferation of the human B cell precursor leukemia cell line RS4:11 and the human myeloma cell line KMS11 by inducing cell cycle arrest and apoptosis with little cytotoxicity. It was reported that the anti-cancer effect of compound II was partly achieved by completely suppressing the transcriptional activation of NSD2-targeted genes.

European Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shiao, Min Jen; Shyu, Li Ming; Tarng, Kai Yih; Ma, Ying Tsun published the artcile< A convenient synthesis of halogenated 2-chloropyridines by transformation of halogenated 2-methoxypyridines under Vilsmeier-Haack conditions>, SDS of cas: 13472-84-9, the main research area is Vilsmeir halomethoxypyridine; chlorination halomethoxypyridine; chloropyridine.

The title compounds I (R = Cl; R1 = H, R2 = 3-Cl, 5-Cl, 6-Cl, 3-Br, 5-Br, 6-Br) were conveniently synthesized by reaction of 2-methoxypyridines I (R = OMe) under Vilsmeier-Haack conditions.

Synthetic Communications published new progress about Chlorination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, SDS of cas: 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Qiang; Kurpiewska, Katarzyna; Domling, Alexander published the artcile< SNAr Isocyanide Diversification>, COA of Formula: C6H8N2, the main research area is imino isocyanide preparation; isocyanide amine multicomponent nucleophilic aromatic substitution.

The first-time isocyanide diversification based on nucleophilic aromatic substitution of suitable precursor isocyanides like 1-fluoro-4-isocyano-2-nitrobenzene has been described. The mild conditions allow for easy access to multiple novel isocyanides I (R = morpholin-4-yl, pyrrolidin-1-yl, piperidin-1-yl, etc.) useful in organic synthesis. The resulting isocyanides I are solid and non-noxious, yet react nicely in multicomponent reactions.

European Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem