Tag: M.W=100-150

Pang, Maofu; Shi, Le-Le; Xie, Yufang; Geng, Tianyi; Liu, Lan; Liao, Rong-Zhen; Tung, Chen-Ho; Wang, Wenguang published the artcile< Cobalt-Catalyzed Selective Dearomatization of Pyridines to N-H 1,4-Dihydropyridines>, Computed Properties of 93-60-7, the main research area is pyridine cobalt catalyst chemoselective regioselective dearomatization; dihydropyridine preparation.

Catalytic reduction of pyridines to N-H 1,4-dihydropyridines was exceptionally challenging because they are essential intermediates to form tetrahydropyridines. Using a facile dihydrogen source H3N·BH3 to activate the pyridine ring in situ, was achieved by selective transfer hydrogenation of nicotinate derivatives to N-H 1,4-dihydropyridines by cobalt-amido cooperative catalysis. The reactions operated smoothly under mild conditions to produce a variety of N-H 1,4-dihydropyridines with high chemo- and regioselectivity. This catalytic method also provides a practical protocol to regenerate Hantzsch analogs after delivery of H2.

ACS Catalysis published new progress about Chemoselectivity. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Haw-Tyng; Zhu, Li; Ward, Matthew D.; Wang, Tao; Chen, Bo; Chaloux, Brian L.; Wang, Qianqian; Biswas, Arani; Gray, Jennifer L.; Kuei, Brooke; Cody, George D.; Epshteyn, Albert; Crespi, Vincent H.; Badding, John V.; Strobel, Timothy A. published the artcile< Nanoarchitecture through Strained Molecules: Cubane-Derived Scaffolds and the Smallest Carbon Nanothreads>, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is cubane derived scaffold carbon nanothread.

Relative to the rich library of small-mol. organics, few examples of ordered extended (i.e., nonmol.) hydrocarbon networks are known. In particular, sp3 bonded, diamond-like materials represent appealing targets because of their desirable mech., thermal, and optical properties. While many covalent organic frameworks (COFs)-extended, covalently bonded, and porous structures-have been realized through mol. architecture with exceptional control, the design and synthesis of dense, covalent-extended solids has been a longstanding challenge. We report the preparation of a sp3-bonded, low-dimensional hydrocarbon synthesized via high-pressure, solid-state diradical polymerization of cubane (C8H8), which is a saturated, but immensely strained, cage-like mol. Exptl. measurements show that the obtained product is crystalline with 3-dimensional order that appears to largely preserve the basic structural topol. of the cubane mol. precursor and exhibits high hardness (comparable to fused quartz) and thermal stability ≤300°. Among the plausible theor. candidate structures, 1-dimensional carbon scaffolds comprising 6- and 4-membered rings that pack within a pseudosquare lattice provide the best agreement with exptl. data. These diamond-like mol. rods with extraordinarily small thickness are among the smallest members in the carbon nanothread family, and calculations indicate 1 of the stiffest 1-dimensional systems known. These results present opportunities for the synthesis of purely sp3-bonded extended solids formed through the strain release of saturated mols., as opposed to only unsaturated precursors.

Journal of the American Chemical Society published new progress about Compression. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

McCann, Scott D.; Reichert, Elaine C.; Arrechea, Pedro Luis; Buchwald, Stephen L. published the artcile< Development of an Aryl Amination Catalyst with Broad Scope Guided by Consideration of Catalyst Stability>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is dialkylbiaryl monosphosphine ligand preparation amination coupling catalyst.

The authors have developed a new dialkylbiaryl monophosphine ligand, GPhos, that supports a palladium catalyst capable of promoting carbon-nitrogen cross-coupling reactions between a variety of primary amines and aryl halides; in many cases, these reactions can be carried out at room temperature The reaction development was guided by the idea that the productivity of catalysts employing BrettPhos-like ligands is limited by their lack of stability at room temperature Specifically, it was hypothesized that primary amine and N-heteroaromatic substrates can displace the phosphine ligand, leading to the formation of catalytically dormant palladium complexes that reactivate only upon heating. This notion was supported by the synthesis and kinetic study of a putative off-cycle Pd complex. Consideration of this off-cycle species, together with the identification of substrate classes that are not effectively coupled at room temperature using previous catalysts, led to the design of a new dialkylbiaryl monophosphine ligand. An Ot-Bu substituent was added ortho to the dialkylphosphino group of the ligand framework to improve the stability of the most active catalyst conformer. To offset the increased size of this substituent, the authors also removed the para i-Pr group of the non-phosphorus-containing ring, which allowed the catalyst to accommodate binding of even very large α-tertiary primary amine nucleophiles. In comparison to previous catalysts, the GPhos-supported catalyst exhibits better reactivity both under ambient conditions and at elevated temperatures Its use allows for the coupling of a range of amine nucleophiles, including (1) unhindered, (2) five-membered-ring N-heterocycle-containing, and (3) α-tertiary primary amines, each of which previously required a different catalyst to achieve optimal results.

Journal of the American Chemical Society published new progress about Amination. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ismael, Aya; Gevorgyan, Ashot; Skrydstrup, Troels; Bayer, Annette published the artcile< Renewable Solvents for Palladium-Catalyzed Carbonylation Reactions>, Related Products of 93-60-7, the main research area is aryl bromide boronic acid palladium renewable solvent carbonylative coupling; ketone aryl preparation; amine aryl bromide palladium renewable solvent aminocarbonylation catalyst; amide preparation; alkoxide aryl bromide palladium renewable solvent alkoxycarbonylation catalyst; ester preparation.

Solvents constitute the largest component for many chem. processes and substitution of nonrenewable solvents is a longstanding goal for green chem. Here, we show that Pd-catalyzed carbonylative couplings, such as carbonylative cross-couplings, aminocarbonylations, and alkoxycarbonylations, can be successfully realized using renewable solvents. The present research covers not only well-established renewable solvents, such as 2-methyltetrahydrofuran (2MeTHF), limonene, and di-Me carbonate, but also recently introduced biomass-derived 1,1-diethoxyethane, isosorbide di-Me ether, eucalyptol, rose oxide, γ-terpinene, and α-pinene. The carbonylative coupling of boronic acids and aryl bromides works well in limonene. Aminocarbonylation gave excellent results in di-Me carbonate, α-pinene, and limonene, while alkoxycarbonylation was successful in 2MeTHF, α-pinene, γ-terpinene, and di-Me carbonate. The developed methods based on renewable solvents can be used for the synthesis of com. drug Trimetozine and an analog of Itopride.

Organic Process Research & Development published new progress about Alkoxycarbonylation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumari, Renu; Singh, R. T. published the artcile< Studies on the effect of dielectric constants of aquo-DMF solvent- system of the solvolysis products of nicotinates>, Reference of 93-60-7, the main research area is dimethyl formamide nicotinate solvolysis dielec constant.

From the enhancement observed in ΔG* values with simultaneous decrease in the values of ΔH and ΔS* of the reaction, it is concluded that the organic co-solvent DMF (DMF) acts as entropy controller and enthalpy stimulator solvent for alkali catalyzed solvolysis of Me nicotinate. Form the evaluated values of water mols. associated with the activated complex of the reaction which are found to increase with increase in the temperature of the reaction, it is inferred that the bimol. mechanistic path is changed to unimol. in presence of the organic component (DMF) of the reaction media. The numerical value of Iso-Kinetic temperature of the reaction which comes to be nearly 287.5 (below 300) indicates that there is weak but considerable solvent-solute interaction in the aquo-DMF solvent system.

Journal of Ultra Chemistry published new progress about Activation energy. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Dong; Wang, Zhentao; Liu, Zhenlin; Huang, Mindong; Hu, Jianyong; Yu, Peng published the artcile< Strategic C-C Bond-Forming Dearomatization of Pyridines and Quinolines>, Recommanded Product: 3-(Methoxycarbonyl)pyridine, the main research area is regioselective diastereoselective tetrahydropyridine tetrahydroquinoline preparation one pot aromatization; dearomative double nucleophilic addition pyridine quinoline.

A one-pot protocol for the dearomative double nucleophilic addition to pyridines and quinolines, providing convenient, regioselective and diastereoselective access to tetrahydropyridines and tetrahydroquinolines under reductant-free conditions is described. This method also offers a new strategy for the general dearomatization of nitrogen heteroaromatics

Organic Letters published new progress about Crystal structure. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Recommanded Product: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Groman, Aleksandra; Stolarczyk, Elobieta; Mucha, Mariola published the artcile< Purity determination of the starting materials used in the synthesis of pharmaceutical substances>, Electric Literature of 350-03-8, the main research area is bosentan imatinib ethylene glycol acetylpyridine GCFID.

High requirements for the API quality mean that the quality control of the starting material is crucial in the manufacturing process of drug substances. Three sensitive methods for the purity determination of the following starting materials: ethylene glycol (method I), 3-acetylpyridine (method II) and 4-chloromethyl-5- methyl-1,3-dioxol-2-one (method III) used in the syntheses of selected drug substances were developed using GC-FID techniques. All the methods were validated according to the International Conference on Harmonization guidelines. The correlation coefficient values were found to be about 0.99. The calculated RSD values from the replicate injections in the range of 20-120% of the nominal concentration ensured the precision of the methods.

Acta Poloniae Pharmaceutica published new progress about Drugs. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Zhong; He, Jia-Hao; Zhang, Ming; Shi, Zhu-Jun; Tang, Han; Zhou, Xin-Yue; Tian, Jun-Jie; Wang, Xiao-Chen published the artcile< Borane-Catalyzed C3-Alkylation of Pyridines with Imines, Aldehydes, or Ketones as Electrophiles>, Product Details of C7H7NO2, the main research area is C3 selective pyridine preparation regioselective; pyridine imine aldehyde ketone alkylation borane catalyst.

Achieving C3-selective pyridine functionalization is a longstanding challenge in organic chem. The existing methods, including electrophilic aromatic substitution and C-H activation, often require harsh reaction conditions and excess pyridine and generate multiple regioisomers. Herein, authors report a method for borane-catalyzed tandem reactions that result in exclusively C3-selective alkylation of pyridines. These tandem reactions consist of pyridine hydroboration, nucleophilic addition of the resulting dihydropyridine to an imine, an aldehyde, or a ketone, and subsequent oxidative aromatization. Because the pyridine is the limiting reactant and the reaction conditions are mild, this method constitutes a practical tool for late-stage functionalization of structurally complex pharmaceuticals bearing a pyridine moiety.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Siegel, David J.; Howarth, Alexis N.; Traver, Joseph R.; Hillesheim, Patrick C.; Zeller, Matthias; Mirjafari, Arsalan published the artcile< 2,2'-[Methylenebis(sulfanediyl)]bis(pyridine 1-oxide)>, Electric Literature of 3811-73-2, the main research area is pyridine N oxide compound synthesis crystal structure.

The title compound, C11H10N2O2S2, crystallizes with one complete mol. in the asym. unit. In the crystal, weak hydrogen bonding is observed between the N-oxide moieties and several C-H units.

IUCrData published new progress about Crystal structure. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Electric Literature of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Valipour, Mehdi; Chippindale, Ann M.; Kouzeli, Aynaz; Irannejad, Hamid published the artcile< A new and facile synthesis of N-benzyl-N'-acylureas via reaction of dibenzoylhydrazine carboxamide and benzylamines>, Application In Synthesis of 3731-53-1, the main research area is benzyl acylurea preparation; dibenzoylhydrazine carboxamide benzylamine amination.

Herein, a new method of synthesis of N-acylureas I (Ar = Ph, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, pyridin-3-yl, pyridin-4-yl) via reaction of N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide and various benzylamines ArCH2NH2 was reported. Preparation of N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide was performed by the treatment of 3-methylthio-5,6-bis(4-methoxyphenyl)-1,2,4-triazine with Oxone which leads to oxidation and triazine ring cleavage in high yield (82%). Five benzylamine derivatives I containing different electron donating and withdrawing substituents were used in this study. Yields for the conversion of dibenzoylhydrazine carboxamide to N-acylureas I were in the range of 40-55%.

Synthetic Communications published new progress about Amides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application In Synthesis of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem