Tag: M.W=100-150

Beller, Matthias; Magerlein, Wolfgang; Indolese, Adriano F.; Fischer, Christine published the artcile< Efficient palladium-catalyzed alkoxycarbonylation of N-heteroaryl chlorides - A practical synthesis of building blocks for pharmaceuticals and herbicides. [Erratum to document cited in CA135:210917]>, Product Details of C6H6ClNO, the main research area is erratum butyl pyridinecarboxylate preparation; butyl pyridinecarboxylate preparation erratum; heteroaryl chloride alkoxycarbonylation palladium phosphine ligand catalyst erratum; alkoxycarbonylation chloropyridine palladium catalyst erratum.

The correct structures are given for Table 5, entry 3, product; Table 7, entry 1, product; Table 7, entry 2, product; and Table 7, entry 3, product.

Synthesis published new progress about Alkoxycarbonylation. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Product Details of C6H6ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Guohua; Huang, Yang; Wang, Chun; Lu, Linxia; Sun, Tongming; Wang, Miao; Tang, Yanfeng; Shan, Doudou; Wen, Shuijin; Zhu, Jinli published the artcile< A novel coumarin-based fluorescence chemosensor for Al3+ and its application in cell imaging>, Reference of 93-60-7, the main research area is coumarin fluorescence chemosensor aluminum cell imaging; Al(3+); Chemosensor; Coumarin; Live cells.

As an efficient turn-on fluorescent chemosensor for Al3+, a new coumarin derivative (CND) has been designed and synthesized by the condensation of 8-formyl-7-hydroxycoumarin with niacin hydrazide. The spectroscopic studies revealed that the sensor CND exhibited a remarkable fluorescence enhancement towards Al3+ with high selectivity and sensitivity in EtOH-HEPES (95:5, volume/volume, pH = 7.40), which was attributed to the photoinduced electron transfer (PET) and -C:N isomerization mechanism. Fluorescence titration calculations data showed that the detection limit and the association constants of CND for Al3+ are 2.51 × 10-7 M and 9.64 × 104 M-1, resp. The results of experiments, including Job’s plot, 1H NMR titration and ESI-MS, revealed that the stoichiometric binding between CND and Al3+ was 1:1. The studies of the pH dependency of CND for Al3+ detection, and the cell imaging suggested the sensor CND could be promisingly applied for the recognition of Al3+ in biol. cells.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Fluorescence. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oates, Conor L.; Widegren, Magnus B.; Clarke, Matthew L. published the artcile< Manganese-catalysed transfer hydrogenation of esters>, Application In Synthesis of 93-60-7, the main research area is primary alc preparation manganese catalyst; ester reduction ethanol hydrogen transfer agent.

Manganese catalyzed ester reduction using ethanol as a hydrogen transfer agent in place of dihydrogen is reported. High yields can be achieved for a range of substrates using 1 mol% of a Mn(I) catalyst, with an alkoxide promoter. The catalyst is derived from a tridentate P,N,N ligand.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aliphatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Maji, Ankur; Gupta, Shivangi; Maji, Milan; Kundu, Sabuj published the artcile< Well-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is quinoline pyrrole pyridine preparation density functional theory; amino alc ketone manganese complex catalyst.

Herein, authors report a simple, phosphine-free, and inexpensive catalytic system based on a manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles and pyridines from amino alcs. and ketones. Several control experiments, kinetic studies, and DFT calculations were carried out to support the plausible reaction mechanism. Authors also detected two potential intermediates in the catalytic cycle using ESI-MS anal. Based on these studies, a metal-ligand cooperative mechanism was proposed.

Journal of Organic Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chandrashekhar, Vishwas G.; Baumann, Wolfgang; Beller, Matthias; Jagadeesh, Rajenahally V. published the artcile< Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis>, Category: pyridine-derivatives, the main research area is amine preparation; nitrile amine hydrogenative coupling nickel catalyzed.

A homogeneous nickel catalyst for hydrogenative cross coupling of a range of aromatic, heteroaromatic, and aliphatic nitriles with primary and secondary amines or ammonia to give amines was reported. This general hydrogenation protocol was showcased by straightforward and highly selective synthesis of >230 functionalized and structurally diverse amines including pharmaceutically relevant and chiral products, as well as 15N-isotope labeling applications.

Science (Washington, DC, United States) published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Akiu, Mayuko; Tsuji, Takashi; Sogawa, Yoshitaka; Terayama, Koji; Yokoyama, Mika; Tanaka, Jun; Asano, Daigo; Sakurai, Ken; Sergienko, Eduard; Sessions, E. Hampton; Gardell, Stephen J.; Pinkerton, Anthony B.; Nakamura, Tsuyoshi published the artcile< Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition>, Category: pyridine-derivatives, the main research area is nicotinamide phosphoribosyltransferase activator pyrazolyltriazolopyridine pyridinylmethyl urea; CYP inhibition; LogD; NAD(+); NAMPT activators; Triazolopyridines.

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the NAD+ salvage pathway. Since NAD+ plays a pivotal role in many biol. processes including metabolism and aging, activation of NAMPT is an attractive therapeutic target for treatment of diverse array of diseases. Herein, we report the continued optimization of novel urea-containing derivatives which were identified as potent NAMPT activators. Early optimization of HTS hits afforded compound 12 (I) , with a triazolopyridine core, as a lead compound CYP direct inhibition (DI) was identified as an issue of concern, and was resolved through modulation of lipophilicity to culminate in 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea (21, II), which showed potent NAMPT activity accompanied with attenuated CYP DI towards multiple CYP isoforms.

Bioorganic & Medicinal Chemistry Letters published new progress about Biological permeation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yu, Hsien-Cheng; Islam, Shahidul M.; Mankad, Neal P. published the artcile< Cooperative Heterobimetallic Substrate Activation Enhances Catalytic Activity and Amplifies Regioselectivity in 1,4-Hydroboration of Pyridines>, Application of C6H4F3N, the main research area is cooperative catalyst NHC copper iron half sandwich regioselective borylation; pyridine regioselective borylation cooperative copper iron imidazolylidene catalyst; dihydropyridine boronate preparation regioselective hydroboration pyridine cooperative bimetallic catalyst.

Regioselective 1,4-hydroboration of pyridine derivatives and quinoline with pinacolborane is catalyzed efficiently by the heterobinuclear catalyst, (IPr)CuFeCp(CO)2, at only 2 mol % loading, providing access to valuable 1,4-dihydropyridine (1,4-DHP) products. A variety of reactive functional groups are tolerated in the pyridine 3-position, and sufficient catalytic activity was obtained for reduction of sterically hindered cases such as 3,5-disubstituted pyridines and even 4-substituted pyridines. Mechanistic experiments indicate that the superior catalytic activity and 1,4-regioselectivity of the Cu/Fe heterobinuclear catalyst, compared to the corresponding mononuclear Cu catalyst, is derived from biphilic cooperativity of two key catalytic intermediates: electrophilic CpFe(CO)2(Bpin) activates the pyridine substrates toward regioselective nucleophilic addition by (IPr)CuH.

ACS Catalysis published new progress about Boronic acids, esters Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lopez Quezada, Landys; Li, Kelin; McDonald, Stacey L.; Nguyen, Quyen; Perkowski, Andrew J.; Pharr, Cameron W.; Gold, Ben; Roberts, Julia; McAulay, Kathrine; Saito, Kohta; Somersan Karakaya, Selin; Javidnia, Prisca Elis; Porras de Francisco, Esther; Amieva, Manuel Marin; Diaz, Sara Palomo; Mendoza Losana, Alfonso; Zimmerman, Matthew; Liang, Hsin-Pin Ho; Zhang, Jun; Dartois, Veronique; Sans, Stephanie; Lagrange, Sophie; Goullieux, Laurent; Roubert, Christine; Nathan, Carl; Aube, Jeffrey published the artcile< Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis>, Electric Literature of 3811-73-2, the main research area is pyrithione containing cephalosporin Mycobacterium replication; antimycobacterial; cephalosporin; pyrithione; tuberculosis; β-lactamase.

The historical view of β-lactams as ineffective antimycobacterials has given way to growing interest in the activity of this class against Mycobacterium tuberculosis (Mtb) in the presence of a β-lactamase inhibitor. However, most antimycobacterial β-lactams kill Mtb only or best when the bacilli are replicating. Here, a screen of 1904 β-lactams led to the identification of cephalosporins substituted with a pyrithione moiety at C3′ that are active against Mtb under both replicating and nonreplicating conditions, neither activity requiring a β-lactamase inhibitor. Studies showed that activity against nonreplicating Mtb required the in situ release of the pyrithione, independent of the known class A β-lactamase, BlaC. In contrast, replicating Mtb could be killed both by released pyrithione and by the parent β-lactam. Thus, the antimycobacterial activity of pyrithione-containing cephalosporins arises from 2 mechanisms that kill mycobacteria in different metabolic states.

ACS Infectious Diseases published new progress about Blood plasma. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Electric Literature of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kuzuya, Masayuki; Noguchi, Akihiro; Mano, Eiichi; Okuda, Takachiyo published the artcile< The structure-reactivity-chemoselectivity relationship on the reactions of 1-unsubstituted tautomeric 2-pyridones with benzyne>, Product Details of C5H4ClNO, the main research area is tautomerism pyridone reaction benzyne.

The effect of tautomerism of 2-pyridones on the products obtained in reaction with benzyne was studied. Both Diels-Alder and Michael-type adducts were formed. The Diels-Alder reactivities were correlated with HOMO energy levels of the 2-pyridone form; the yields of the Michael-type adducts were associated with the tautomeric equilibrium Substituent effects on the tautomerism were discussed.

Bulletin of the Chemical Society of Japan published new progress about CNDO/2 (molecular orbital method). 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Product Details of C5H4ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vydzhak, Roman N.; Panchishin, Svitlana Ya.; Kachaeva, Maryna V.; Pilyo, Stepan G.; Moskvina, Viktoriia S.; Shablykina, Olga V.; Kozytskiy, Andriy V.; Brovarets, Volodymyr S. published the artcile< Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones>, Application of C6H8N2, the main research area is dihydrochromenopyrrole dione preparation; hydroxyphenyl dihydropyrrolopyrazolone preparation; Chromeno[2,3-c]pyrroles; Combinatorial library; Dihydrochromeno[2,3-c]pyrrole-3,9-diones; Dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones; Multicomponent cyclization.

An efficient and practical synthetic procedure for libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones I [R =H, 6,7-di-Me, 7-F, etc.; R1 = n-Pr, CH2CH2OH, 2-furylmethyl, etc.; Ar = Ph, 4-MeC6H4, 3,4,5-tri-MeOC6H2, etc.] using a multicomponent process was presented. A convenient synthetic procedure for obtaining functionalized 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones II [R2 = H, 3,5-di-Me, 4-Me-5-Cl, etc.; R3 = 4-BrC6H4, 2-OHC6H4, 3-MeO-4-OHC6H3, etc.; R4 = n-Pr, CH2CH2OH, 2-ClC6H4CH2, etc.] via ring-opening strategy was developed. This protocol was found to be compatible with a wide range of substituents and paves the way for the practical synthesis of title compounds with a broad range of substituents under mild condition. The products could be easily isolated by crystallization without the use of chromatog.

Molecular Diversity published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem