Tag: M.W=100-150

Li, Bin; Yong, Guoping published the artcile< The positional isomeric effects induced various phosphorescence: Switchable properties through acid-base vapor stimulation>, Category: pyridine-derivatives, the main research area is positional isomer phosphorescence switchable acid base vapor; chloroimidazopyridinylpyridinylpropenone preparation.

Three novel positional isomers, namely (E)-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)-1-(pyridin-2-yl)prop-2-en-1-one , (E)-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)-1-(pyridin-3-yl)prop-2-en-1-one and (E)-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one, were obtained through a mild approach. Powder x-ray diffraction patterns demonstrate their various stacking structures, attributed to positional isomeric effects. Furthermore, these positional isomers exhibit different phosphorescent colors and quantum yields. These positional isomers also reveal reversible phosphorescent color switching in the response to acid-base vapor stimuli. The present work provides a promising approach for synthesizing organic materials and a new access to develop dynamic functional materials which can be reversibly switched between different phosphorescence based on external acid-base vapor stimuli.

Journal of Molecular Structure published new progress about Acids Role: RGT (Reagent), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Soczewka, Piotr; Tribouillard-Tanvier, Deborah; di Rago, Jean-Paul; Zoladek, Teresa; Kaminska, Joanna published the artcile< Targeting copper homeostasis improves functioning of vps13δ yeast mutant cells, a model of VPS13-related diseases>, Name: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is CCC2 VPS13A CTR1 cox11 Parkinson Menke Wilson disease; CCC2; CTR1; FET3; VPS13; copper homeostasis; disulfiram; elesclomol; pyrithione; yeast model, neurodegeneration.

Ion homeostasis is crucial for organism functioning, and its alterations may cause diseases. For example, copper insufficiency and overload are associated with Menkes andWilsons diseases, respectivley, and iron imbalance is observed in Parkinsons and Alzheimers diseases. To better understand human diseases, Saccharomyces cerevisiae yeast are used as a model organism. In our studies, we used the vps13δ yeast strain as a model of rare neurol. diseases caused by mutations in VPS13A-D genes. In this work, we show that overexpression of genes encoding copper transporters, CTR1, CTR3, and CCC2, or the addition of copper salt to the medium, improved functioning of the vps13δ mutant. We show that their mechanism of action, at least partially, depends on increasing iron content in the cells by the copper-dependent iron uptake system. Finally, we present that treatment with copper ionophores, disulfiram, elesclomol, and sodium pyrithione, also resulted in alleviation of the defects observed in vps13δ cells. Our study points at copper and iron homeostasis as a potential therapeutic target for further investigation in higher eukaryotic models of VPS13-related diseases.

International Journal of Molecular Sciences published new progress about Alzheimer disease. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Name: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kamga, Justin; Leonte, Denisa; Ambassa, Pantaleon; Mbaveng, Armelle T.; Fotso, Ghislain W.; Coman, Fana-Maria; Ngadjui, Bonaventure T.; Kuete, Victor; Zaharia, Valentin; Ngameni, Bathelemy published the artcile< Heterocycles 45.Synthesis, characterization and biological evaluation of 3-indolyl-1-pyridyl-2-propenones as anticancer agents>, Reference of 350-03-8, the main research area is acetylpyridine indolyl carbaldehyde diastereoselective Claisen Schmidt condensation; indolyl pyridyl propenone preparation antitumor cytotoxicity.

A series of seven indolyl pyridyl propenones I [R = H, Me, Et, etc.; Ar = 3-pyridyl, 4-pyridyl] were synthesized via Claisen-Schmidt condensation with 68.8-91.8% yields. All the synthesized compounds I were purified and characterized by m.ps., IR, 1H NMR, 13C NMR and HRMS. The cytotoxicity of the synthesized indolyl pyridyl propenones I and doxorubicin, used as pos. control, was determined in a panel of nine human cancer cell lines including both sensitive and drug-resistant phenotypes, as well as in normal AML12 hepatocytes. Compounds I [R = Et, allyl; Ar = 4-pyridyl] and [R = Me; Ar = 3-pyridyl] displayed half maximal inhibitory concentration (IC50) values below 100μM in all tested cancer cell lines meanwhile, other compounds displayed selective activities.

Farmacia (Bucharest, Romania) published new progress about Antitumor agents. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Reference of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kehner, Rebecca A.; Hewitt, Matthew Christian; Bayeh-Romero, Liela published the artcile< Expanding Zirconocene Hydride Catalysis: In Situ Generation and Turnover of ZrH Catalysts Enabling Catalytic Carbonyl Reductions>, Electric Literature of 350-03-8, the main research area is zirconium hydride in situ preparation zirconocene dichloride hydrosilane; ketone aldehyde enone ynone lactone reduction zirconium hydride catalyst.

Despite the wide use and popularity of metal hydride catalysis, methods utilizing zirconium hydride catalysts remain underexplored. Here, authors report the development of a mild method for the in situ prepatation. and use of zirconium hydride catalysts. This robust method requires only 2.5-5 mol % of zirconocene dichloride in combination with a hydrosilane as the stoichiometric reductant and does not necessitate careful air- or moisture-free technique. A key finding of this study concerns an amine-mediated ligand exchange en route to the active zirconocene hydride catalyst. Mechanistic investigation supports the intermediacy of an oxo-bridged dimer precatalyst. The application of this method to the reduction of a wide variety of carbonyl-containing substrates, including ketones, aldehydes, enones, ynones, and lactones is demonstrated with up to 92% yield and exhibiting broad functional group tolerability. These findings open up alternative avenues for the catalytic application of chlorozirconocenes, potentially serving as the foundation for broader applications of zirconium hydride catalysis.

ACS Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vezzu, Keti; Nawn, Graeme; Pagot, Gioele; Negro, Enrico; Nale, Angeloclaudio; Bang, Yannick Herve; Conti, Fosca; Cavinato, Gianni; Di Noto, Vito published the artcile< Relaxation phenomena and conductivity mechanisms in anion-exchange membranes derived from polyketone>, Safety of Pyridin-4-ylmethanamine, the main research area is relaxation conductivity anion exchange membrane polyketone.

A polyketone-b-poly[N-(4 Me-methylpyridium)-ethylenepyrrole+][X-], with X- = I- or OH-, was studied as an example of anion-exchange membrane with potential applications in fuel cells. The polyketone starting material PK and the functionalized polyketones Pyr-FPKmI and Pyr-FPKmOH were studied via Broadband Elec. Spectroscopy (BES) to understand the conductivity mechanism. BES signals are collected in the frequency range of 10-2 – 107 Hz and from -100° to 120°. BES measurements reveal up to three interdomain polarizations phenomena, one electrode polarization event and two β dielec. relaxation modes for both wet Pyr-FPKmI and Pyr-FPKmOH. Ion conductivity for Pyr-FPKmI and Pyr-FPKmOH is 0.0086 and 0.0105 S cm-1 at 80°, resp. The overall conductivity mechanism is attributed to the superposition of two conduction pathways, via delocalization bodies and via interdomain percolation pathways, which are associated with two different phys. phenomena.

Electrochimica Acta published new progress about Anion exchange membranes. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Safety of Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kasting, Gerald B.; Miller, Matthew A.; Xu, Lijing; Yu, Fang; Jaworska, Joanna published the artcile< In Vitro Human Skin Absorption of Solvent-deposited Solids: Niacinamide and Methyl Nicotinate>, Application of C7H7NO2, the main research area is niacinamide methyl nicotinate skin absorption; Absorption; Disposition; Passive diffusion/transport; Percutaneous; Permeability; Skin; Transdermal; pathways.

A quant. understanding of the dose dependence of topical delivery is important to cosmetic and dermatol. product development and to risk assessment for hazardous chems. contacting the skin. Despite considerable research, predictive capability in this area remains limited. To this end we conducted an exptl. skin absorption study of two closely related skin care agents, niacinamide (nicotinamide, NA) and Me nicotinate (MN), and analyzed the results quant. using a transient diffusion model described sep. (Yu et al. submitted for publication). Radiolabeled test compounds were solvent-deposited onto ex vivo human skin mounted in Franz diffusion cells over a dose range exceeding 4.5 orders of magnitude, and permeation was measured over a 1-4 day period. At low doses, the permeation rate of NA was approx. 60-fold lower than that of its lower melting, more lipophilic analog, MN; at high doses an even greater difference was observed The difference can be qual. explained based on higher lipid solubility and lower crystallinity of MN relative to NA. Dissolution-limited mass transfer through a lipid layer at the SC surface is suggested. Relevance of the results to practical skin care formulations was confirmed by a parallel study of NA in an o/w emulsion.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Crystallinity. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schubert, Steffen; Bauer, Andrea; Hillen, Uwe; Werfel, Thomas; Geier, Johannes; Brans, Richard; IVDK published the artcile< Occupational contact dermatitis in painters and varnishers: Data from the Information Network of Departments of Dermatology ( IVDK ), 2000 to 2019>, Category: pyridine-derivatives, the main research area is occupational contact dermatitis paints varnish human; allergic contact dermatitis; epoxy resin; face dermatitis; methylchloroisothiazolinone; methylisothiazolinone; occupational dermatitis; painter; patch test; varnisher.

Painters and varnishers (“”painters””) are exposed to various contact allergens and skin irritants, and therefore, are at risk for developing occupational dermatitis (OD). To describe the spectrum of occupational sensitizations in painters and revise the corresponding current patch test recommendations. Retrospective anal. of Information Network of Departments of Dermatol. (IVDK) data from 2000 to 2019 with focus on male painters with OD, ages 20-59 years (n = 557) in comparison to age-matched male painters without OD (n = 422) and male OD patients who have had never worked as painters (n = 13 862). Male painters with OD have a significantly higher rate of allergic contact dermatitis and face dermatitis than male patients with OD who work in other professions. Pos. patch tests to epoxy resin, methylisothiazolinone (MI), and methylchloroisothiazolinone (MCI)/MI were significantly more frequent in painters with OD than in the other groups. Epoxy resin sensitization was significantly associated with face dermatitis. Epoxy resin, MI, and MCI/MI represent the most important occupational sensitizers in painters. In addition to baseline, resins and glues, and industrial biocides series, the patients′ own workplace materials should be tested in painters with suspected OD.

Contact Dermatitis published new progress about Alcohols, C16-18, ethoxylated Role: ADV (Adverse Effect, Including Toxicity), BIOL (Biological Study). 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Heath, Julie A.; Mehrotra, Mukund M.; Chi, Shannon; Yu, Jin-Chen; Hutchaleelaha, Athiwat; Hollenbach, Stanley J.; Giese, Neill A.; Scarborough, Robert M.; Pandey, Anjali published the artcile< Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor>, SDS of cas: 56622-54-9, the main research area is PDGF receptor inhibitor thiourea derivative structure activity cancer.

4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivatives such as 14 (CT53986) have been identified to be potent and selective inhibitors of the phosphorylation of PDGFR. SAR-investigations are described in the arylamine segment, C-7 appendage, and the thiourea moiety. Bioisosteres of thiourea (cyanoguanidine), and of quinazoline (quinoline-3-carbonitrile) were synthesized and are compared for their in vitro inhibitory activity. PK profiles of the optimized compounds in rat, dog, and cynomolgus monkey are described.

Bioorganic & Medicinal Chemistry Letters published new progress about c-Kit proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, SDS of cas: 56622-54-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hao, Pengfei; Guo, Chunyu; Wang, Meidan; Shen, Junju; Fu, Yunlong published the artcile< Lattice Water Controlled Photo- and Thermochromism of N-Protonated Carbomethoxypyridinium Iodoargentate Hybrids>, Quality Control of 93-60-7, the main research area is lattice water controlled photochromism thermochromism protonated carbomethoxypyridinium iodoargentate hybrid; silver iodide protonated carbomethoxypyridinium preparation crystal structure; thermochromism hydration dehydration induced protonated carbomethoxypyridinium iodoargentate; photochromism intermol charge transfer protonated carbomethoxypyridinium iodoargentate.

Two iodoargentate hybrids, {[HNOM][AgI2]·H2O} (1) and {[HINOM][AgI2]·H2O} (2) (HNOM+ = N-protonated 3-carbomethoxypyridinium; HINOM+ = N-protonated 4-carbomethoxypyridinium), were designed and prepared, which were constructed from typical [AgI2]- inorganic chains and cationic H-bonding supramol. networks (1-dimensional for 1 and three-dimensional for 2) of lattice H2O and positional isomeric N-protonated carbomethoxypyridinium. Two hybrids exhibit sensitive photochromism based on intermol. electron transfer (ET) and thermochromism due to reversible hydration and dehydration and the consequent variation of intermol. charge transfer (CT). Also, loss of lattice H2O gives rise to improved photochromic dehydrated form 1T and optically inert dehydrated form 2T, suggesting a delicate modulating effect of lattice contraction on the intermol. CT and ET as well as consequently photoresponsive behaviors.

Inorganic Chemistry published new progress about Charge transfer interaction (hydration/dehydration induced). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sen, Subhabrata; Barman, Dhiraj; Khan, Haya; Das, Ranajit; Maiti, Debajit published the artcile< Cu(II)-Catalyzed Multicomponent Reaction of Pyridine Derivatives/Isoquinolines with Iodonium Ylide and 1,4-Quinones Using Mechanochemistry>, Application of C6H4F3N, the main research area is isoindolopyridine preparation green chem regioselective mechanochem DFT photoluminescence anticancer; pyridine iodonium ylide quinone multicomponent reaction copper catalyst; isoindoloisoquinoline preparation green chem regioselective mechanochem DFT photoluminescence anticancer; isoquinoline iodonium ylide quinone multicomponent reaction copper catalyst.

An efficient copper-catalyzed solvent-free multicomponent reaction for pyridine derivatives such as 3-methylpyridine, pyridine-3-carbonitrile, 3-(trifluoromethyl)pyridine, etc. Ph iodonium di-Me malonate, and 1,4-quinones such as benzoquinone, p-methylbenzoquinone, anthraquinone and naphthoquinone is developed via a room-temperature ball milling technique. The reported protocol provides a sustainable synthesis of isoindolo[2,1-a]pyridine/isoquinoline class of mols., e.g., I (R = F, H) and e.g., II in good to excellent yield in a mixer mill (RETSCH MM400) engaging the com. available copper acetate (Cu(OAc)2) as a catalyst without the use of organic solvents. It tolerates a myriad of electron-rich and electron-deficient functionalities on the pyridine moiety. The scalability of the protocol was illustrated by successfully performing the reaction in the gram scale. The photoluminescence and related cellular study revealed that these can be used as a fluorescent chromophore-based cellular probe. A clean reaction profile and a facile exptl. setup that is devoid of anhydrous reaction conditions and toxic organic solvents have established the advantages of this strategy over the reported process.

Journal of Organic Chemistry published new progress about Antitumor agents. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem