Tag: M.W=100-150

An article Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines WOS:000470996600117 published article about MULTICOMPONENT REACTIONS; CHEMISTRY; ISOCYANIDES; DISCOVERY; MECHANISM; REVEALS; BIOLOGY; IMINES in [Galli, Ubaldina; Hysenlika, Rejdia; Del Grosso, Erika; Tron, Gian Cesare] Univ Piemonte Orientale, Dipartimento Sci Farmaco, I-28100 Novara, Italy; [Meneghetti, Fiorella] Univ Milan, Dipartimento Sci Farmaceut, I-20133 Milan, Italy; [Pelliccia, Sveva; Novellino, Ettore; Giustiniano, Mariateresa] Univ Napoli Federico II, Dipartimento Farm, I-80131 Naples, Italy in 2019.0, Cited 38.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine derivatives in excellent yields. The imidazole nitrogen atom was able to intercept the nascent nitrilium ion, channeling the reaction toward to the sole formation of imidazopyrazines, suppressing the competitive formation of other possible side products deriving from the reaction with the high-energy nitrilium ion. The number of examples and the variability of the nature of isocyanides, aldehydes, and amine components herein employed, witness the robustness of this novel methodology.

Product Details of 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Galli, U; Hysenlika, R; Meneghetti, F; Del Grosso, E; Pelliccia, S; Novellino, E; Giustiniano, M; Tron, GC or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article An efficient Bi/NH4I-mediated addition reaction for the highly diastereoselective synthesis of homoallylic alcohols in aqueous media WOS:000510956700019 published article about UNACTIVATED ALKYL-HALIDES; GRIGNARD-TYPE ADDITION; C-H BONDS; CARBONYL-COMPOUNDS; ORGANIC-REACTIONS; ALPHA,BETA-UNSATURATED KETONES; QUATERNARY CENTERS; IN-SITU; ORGANOINDIUM REAGENTS; ASYMMETRIC-SYNTHESIS in [Wu, Zhen; Feng, Xue-Xin; Liu, Xuan-Yu; Yang, Jin-Ming; Shen, Zhi-Liang] Nanjing Tech Univ, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China; [Wu, Zhen; Feng, Xue-Xin; Wang, Qing-Dong; Yang, Jin-Ming] Yancheng Teachers Univ, Sch Pharm, Yancheng 224007, Peoples R China; [Rao, Weidong] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Key Lab Biomass Based Green Fuels & Chem, Nanjing 210037, Peoples R China in 2020.0, Cited 113.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

An efficient water-based bismuth-mediated addition reaction of carbonyl compound with cyclic allylic halide was developed. The reactions proceeded smoothly in aqueous DMF in the presence of ammonium iodide to afford the corresponding syn-homoallylic alcohols in moderate to good yields with excellent diastereoselectivities (>99:1 syn:anti). Reversal of product diastereoselectivity was observed when heteroaryl aldehyde possessing an adjacent chelating nitrogen atom was employed as substrate. 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Ascorbic Acid as an Efficient Organocatalyst for the Synthesis of 2-Substituted-2,3-dihydroquinazolin-4(1H)-one and 2-Substituted Quinazolin-4(3H)-one in Water WOS:000506438700016 published article about ONE-POT SYNTHESIS; CUO-CATALYZED SYNTHESIS; HETEROGENEOUS CATALYST; FACILE SYNTHESIS; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; DERIVATIVES; QUINAZOLINONES; 1,2-DIHYDROQUINAZOLIN-4(3H)-ONES; HETEROCYCLES; AMIDATION in [Pariyar, Gyan Chandra] Univ North Bengal, Dept Food Technol, Siliguri, W Bengal, India; [Mitra, Bijeta; Mukherjee, Suvodip; Ghosh, Pranab] Univ North Bengal, Dept Chem, Siliguri, W Bengal, India in 2020.0, Cited 61.0. Name: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

An environmentally benign, robust and straightforward protocol has been developed for the synthesis of a diverse array of 2,3-dihydroquinazolin-4(1H)-ones using 2-aminobenzamide and various aldehydes or ketones. Water, a green solvent was adopted in this methodology replacing hazardous reaction mediums. Further, ascorbic acid, an organocatalyst has been accepted to meet the role of catalyst, thus bypassing the use of noxious metals or hazardous materials, which is another asset of this protocol. The activity of this novel methodology has been further being broadened using an oxidant oxone to synthesize 2-substituted quinazolin-4(3H)-one from aldehyde.

Name: 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Pariyar, GC; Mitra, B; Mukherjee, S; Ghosh, P or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 BIOORG CHEM published article about BIOLOGICAL EVALUATION; INHIBITORY-ACTIVITY; 15-LIPOXYGENASE-1; BIOSYNTHESIS; EXPRESSION; DESIGN; POTENT in [Omar, Yasser M.; Abdel-Moty, Samia G.; Abdu-Allah, Hajjaj H. M.] Assiut Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71526, Egypt in 2020.0, Cited 40.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Formula: C6H5NO

Herin we report the design, synthesis, full characterization and biological investigation of new 15-LOX/COX dual inhibitors based on 1,3-thiazolidin-4-one (15-lipoxygenase pharmacophore) and 1,3,4-thiadiazole (COX pharmacophore) scaffolds. This series of molecular modifications is an extension of a previously reported series to further explore the structural activity relationship. Compounds 3a, 4e, 4n, 4q, 7 and 8 capable of inhibiting 15-LOX at (2.74, 4.2, 3.41, 10.21, 3.71 and 3.36 mu M, respectively) and COX-2 at (0.32, 0.28, 0.28, 0.1, 0.28 and 0.27 mu M, respectively). The results revealed that binding to 15-LOX and COX is sensitive to the bulkiness of the substituents at the 5 positions. 15-LOX bind better with small substituents, while COXs bind better with bulky substituents. Compounds 3a, 4r and 4q showed comparable in vivo anti-inflammatory activity to the reference drug (celecoxib). The ulcer liability test showed no sign of ulceration which ensures the safe gastric profile. Docking study was performed to explore the possible mode of interaction of the new compounds with the active site of human 15-LOX and COX-2. This study discloses some structural features for binding to 15-LOX and COX, thus pave the way to design anti-inflammatory agents with balanced dual inhibition of these enzymes.

Formula: C6H5NO. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Wang, KZ; Jiang, PB; Yang, M; Ma, P; Qin, JH; Huang, XK; Ma, L; Li, R in [Wang, Kaizhi; Jiang, Pengbo; Yang, Ming; Ma, Ping; Qin, Jiaheng; Huang, Xiaokang; Ma, Lei; Li, Rong] Lanzhou Univ, SKLAOC, Lanzhou 730000, Gansu, Peoples R China; [Wang, Kaizhi; Jiang, Pengbo; Yang, Ming; Ma, Ping; Qin, Jiaheng; Huang, Xiaokang; Ma, Lei; Li, Rong] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China published Metal-free nitrogen -doped carbon nanosheets: a catalyst for the direct synthesis of imines under mild conditions in 2019, Cited 77. Recommanded Product: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Herein, a highly stable, porous, multifunctional and metal-free catalyst was developed, which exhibited significant catalytic performance in the oxidation of amines and transfer hydrogenation of nitriles under mild conditions; this could be attributed to the presence of numerous active sites and their outstanding BET surface area. The obtained results showed that most of the yields of imines exceeded 90%, and the cycling performance of the catalyst could be at least seven runs without any decay in the reaction activity, which could be comparable to those of metal catalysts. Subsequently, a kinetic study has demonstrated that the apparent activation energy for the direct synthesis of imines from amines is 67.39 kJ mol(-1), which has been performed to testify that the catalytic performances are rational. Via catalyst characterizations and experimental data, graphitic-N has been proven to be the active site of the catalyst. Hence, this study is beneficial to comprehend the mechanism of action of a metal-free N-doped carbon catalyst in the formation of imines.

Recommanded Product: 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Coumarinylthiazolyl Iminothiazolidinone Hybrids as Potent Urease Inhibitors WOS:000532796500003 published article about COUMARIN DERIVATIVES; DESIGN in [Shams-Ul Mahmood; Saeed, Aamer] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Nazir, Yasir; Ashraf, Zaman] Allama Iqbal Open Univ, Dept Chem, Islamabad 44000, Pakistan; [Abbas, Qamar] Univ Sindh, Dept Physiol, Jamshoro, Pakistan in 2020.0, Cited 26.0. Application In Synthesis of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The present paper is designed to explore the potential of an important class of heterocycles coumarinylthiazolyl iminothiazolidinone to inhibit jack bean urease. The final products 6a-j were prepared by condensation of substituted aldehydes with intermediate 5 in sodium methoxide/methanol mixture. The synthesized compounds were characterized by their FTIR, H-1, C-13 NMR and mass spectral data. The synthesized coumarinylthiazolyl iminothiazolidinone hybrids 6 a-j were evaluated for their potential to inhibit urease activity. All the synthesized derivatives showed remarkable inhibitory activity with IC50 ranging 8 to 34 nM, while IC50 of standard thiourea is 18.5 nM. The compound 5-(2,4-Dichlorobenzylidene)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl imino) thiazolidin-4-one 6 h bearing 2,4-di-chloro substituted phenyl ring exhibited excellent activity with IC50 value 8 nM. In silico molecular docking studies was performed against urease enzyme PDBID 4H9 M and predicted possible binding modes in catalytic site for these active compounds. The thiazole nitrogen in compound 6 h formed a strong hydrogen bonding interaction with side chain Gln635 having distance 2.01 angstrom and rest part of this inhibitor is present close to Val640. The most potent derivative 6 h have highest binding affinity with binding energy -6.178 kcal/mol. It is concluded based upon our results that 6 a and 6 h are most promising compounds from this series and provide a basis for rationale design of most potent urease inhibitors.

Application In Synthesis of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Shams-Ul Mahmood; Nazir, Y; Saeed, A; Abbas, Q; Ashraf, Z or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Bregier, F; Godard, J; Thiais, J; Bouramtane, S; Moulin, A; Champavier, Y; Mailleau, A; Chaleix, V; Sol, V in WORLD SCI PUBL CO INC published article about PHOTODYNAMIC THERAPY; STANNOUS CHLORIDE; DERIVATIVES; SUBSTITUENTS; AGENTS; PDT in [Bregier, Frederique; Godard, Jeremy; Thiais, Jordan; Bouramtane, Soukaina; Moulin, Alexia; Chaleix, Vincent; Sol, Vincent] Univ Limoges, PEIRENE, EA 7500, 123 Ave Albert Thomas, F-87060 Limoges, France; [Champavier, Yves; Mailleau, Alexis] BISCEm, FR3503, GEIST, CBRS, 2 Rue Dr Marcland, F-87025 Limoges, France in 2019.0, Cited 44.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Dihydroporphyrins or chlorins differ from porphyrins only by saturation of a peripheral double bond of the macrocycle. However, this small structural difference leads to a significant increase of the absorption band at approximately 650 nm, which makes them very interesting candidates for photodynamic therapy applications. The reduction of porphyrins bearing two, three or four pyridyl substituents with fin(II) chloride has been developed for the synthesis of dihydroporphyrins in yields of 15-73%. The reduction of 5-(aryl)-10,15,20-tris(2 or 4-pyridyl)porphyrin with fin(II) chloride dihydrate demonstrated good regioselectivity. Porphyrins with one meso-aryl bearing one electron-donating group (EDG) gave 5-aryl-10,15,20-tris(2- or 4-pyridyl)-17,18-dihydroporphyrins in 17-72% yield. Porphyrins with one meso-aryl bearing one or more electron-withdrawing groups (EWG) gave 5-aryl-10,15,20-tris(4-pyridyl)-17,18-dihydroporphyrins or 5-aryl- 10,15,20-tris(4-pyridyl)-7,8-dihydroporphyrins in 15-21% yield and isobacteriochlorin. We have also proven the possibility of functionalizing these compounds to design new regioisomerically pure photosensitizers.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Maskeri, MA; Schrader, ML; Scheidt, KA in WILEY-V C H VERLAG GMBH published article about N-HETEROCYCLIC CARBENE; STEREOSELECTIVE-SYNTHESIS; CONJUGATE ADDITIONS; ENOLATE ADDITIONS; STETTER REACTION; CATALYSIS; ESTERS; HYDROGENATION; ALDEHYDES; COMBINATION in [Maskeri, Mark A.; Schrader, Malte L.; Scheidt, Karl A.] Northwestern Univ, Dept Chem, Ctr Mol Innovat & Drug Discovery, Silverman Hall, Evanston, IL 60208 USA in 2020.0, Cited 85.0. Name: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Combining biological and small-molecule catalysts under a chemoenzymatic manifold presents a series of significant advantages to the synthetic community. We report herein the successful development of a two-step/single flask synthesis of gamma-lactones through the merger of Umpolung catalysis with a ketoreductase-catalyzed dynamic kinetic resolution, reduction, and cyclization. This combined approach delivers highly enantio- and diastereoenriched heterocycles and demonstrates the feasibility of integrating NHC catalysis with enzymatic processes.

Welcome to talk about 500-22-1, If you have any questions, you can contact Maskeri, MA; Schrader, ML; Scheidt, KA or send Email.. Name: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Thiruvengetam, P; Chakravarthy, RD; Chand, DK in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about COPPER(II)-CATALYZED AEROBIC OXIDATION; ORGANIC-SOLVENT-FREE; ROOM-TEMPERATURE; DIOXOMOLYBDENUM(VI) COMPLEXES; OXOPEROXO MOLYBDENUM(VI); SULFOXIDATION REACTIONS; SELECTIVE OXIDATION; SECONDARY ALCOHOLS; HYDROGEN-PEROXIDE; MOLECULAR-OXYGEN in [Thiruvengetam, Prabaharan; Chakravarthy, Rajan Deepan; Chand, Dillip Kumar] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India in 2019, Cited 81. SDS of cas: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A surfactant based oxodiperoxo molybdenum complex, which could activate molecular oxygen, has been employed as a catalyst for controlled oxidation of benzylic alcohols to corresponding carbonyls. The oxidation reactions were carried out under aqueous environment, however, in the absence of any extraneous base or co-catalyst. Sensitive/oxidizable functional groups like cyano, sulfide, hydroxyl, aryl-hydroxyl, alkene (internal/terminal), alkyne (internal/terminal), and acetal were tolerated during the transformations. Such selectivity is attributed to the mild nature of the catalyst. The methodology could also be scaled-up for multi-gram synthesis and the protocol is likely to find practical use since it requires an inexpensive recyclable-catalyst and easily available oxidant (under green conditions). A plausible mechanism is proposed with the help of preliminary computational study. (C) 2019 Elsevier Inc. All rights reserved.

Welcome to talk about 500-22-1, If you have any questions, you can contact Thiruvengetam, P; Chakravarthy, RD; Chand, DK or send Email.. SDS of cas: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy published in 2019. Application In Synthesis of 3-Pyridinecarboxaldehyde, Reprint Addresses Chaudhuri, B (corresponding author), De Montfort Univ, Leicester Sch Pharm, Leicester LE1 9BH, Leics, England.; Jayaprakash, V (corresponding author), Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Bihar, India.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Inhibition of cyclin dependent kinase 4 (Cdk4) prevents cancer cells from entering the early G(0)/G(1) phase of the cell division cycle whereas inhibiting tubulin polymerization blocks cancer cells’ ability to undergo mitosis (M) late in the cell cycle. We had reported earlier that two non-planar and relatively non-toxic fascaplysin derivatives, an indole and a tryptoline, inhibit Cdk4 with IC50 values of 6.2 and 10 mu M, respectively. Serendipitously, we had also found that they inhibited tubulin polymerization. The molecules were efficacious in mouse tumor models. We have now identified Cink4T in a 59-compound quinazolinone library, designed on the basis of ligand-based virtual screening, as a compound that inhibits Cdk4 and tubulin. Its IC50 value for Cdk4 inhibition is 0.47 mu M and >50 mu M for inhibition of Cdk1, Cdk2, Cdk6, Cdk9. Cink4T inhibits tubulin polymerization with an IC50 of 0.6 mu M. Molecular modelling studies on Cink4T with Cdk4 and tubulin crystal structures lend support to these observations. Cancer cell cycle analyses confirm that Cink4T blocks cells at both G(0)/G(1) and M phases as it should if it were to inhibit both Cdk4 and tubulin polymerization. Our results show, for the very first time, that virtual screening can be used to design novel inhibitors that can potently block two crucial phases of the cell division cycle. (C) 2019 Elsevier Masson SAS. All rights reserved.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem