Tag: M.W=100-150

An article Synthesis, characterization, biological evaluation, and molecular docking studies of some piperonyl-based 4-thiazolidinone derivatives WOS:000499004600001 published article about CARBONIC-ANHYDRASE; ALPHA-GLUCOSIDASE; IN-VITRO; ACETYLCHOLINESTERASE; INHIBITION; BUTYRYLCHOLINESTERASE; THIAZOLIDIN-4-ONE; ANTIOXIDANT; GLYCOSIDASE; POTENT in [Bilgicli, Hayriye Genc; Akyuz, Busra] Sakarya Univ, Fac Arts & Sci, Dept Chem, TR-54050 Servidan, Sakarya, Turkey; [Taslimi, Parham] Bartin Univ, Dept Biotechnol, Fac Sci, Bartin, Turkey; [Tuzun, Burak] Cumhuriyet Univ, Dept Chem, Fac Sci, Sivas, Turkey; [Gulcin, Ilhami] Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey in 2020.0, Cited 51.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Name: 3-Pyridinecarboxaldehyde

Heterocyclic compounds are of particular importance among pharmacologically active compounds. In this study, some piperonyl-based 4-thiazolidinone derivatives (2a-i) were synthesized and characterized by spectroscopic assays. All molecules were tested as enzyme inhibitory factors. These compounds were effective inhibitors of the enzymes acetylcholinesterase (AChE), alpha-glycosidase (alpha-Gly), and the human carbonic anhydrase I and II isoforms (hCA I and II), with K-i values in the range of 8.90-66.51 nM for alpha-Gly, 94.8-289.5 nM for hCA I, 106.3-304.6 nM for hCA II, and 0.55-2.36 nM for AChE. The synthesized molecules were also studied theoretically. Molecular docking calculations were performed to investigate the interaction between the target protein and molecules. CA inhibitor compounds have been clinically used for almost 60 years as antiglaucoma and diuretic drugs. The inhibition of the AChE enzyme results in the blockage of ACh hydrolysis. On the contrary, the design of inhibitor compounds or/and modulators for AChE is of major interest as it is one of the most popular tools to prevent Alzheimer’s disease.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Bilgicli, HG; Taslimi, P; Akyuz, B; Tuzun, B; Gulcin, I or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Sapijanskaite-Banevic, B; Sovkovaja, B; Vaickelioniene, R; Siugzdaite, J; Mickeviciute, E in MDPI published article about N-ACYLHYDRAZONE DERIVATIVES; ANTIMICROBIAL EVALUATION; 2-AMINOTHIAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; HIGH ANTIBACTERIAL; DESIGN; NMR; ISOMERIZATION; PYRIMIDINE; THIAZOLES in [Sapijanskaite-Banevic, Birute; Sovkovaja, Bozena; Vaickelioniene, Rita] Kaunas Univ Technol, Dept Organ Chem, Radvilenu Rd 19, LT-50254 Kaunas, Lithuania; [Siugzdaite, Jurate] Lithuanian Univ Hlth Sci, Dept Vet Pathobiol, Vet Acad, Tilzes Str 18, LT-47181 Kaunas, Lithuania; [Mickeviciute, Egle] Kaunas Univ Technol, Dept Informat Syst, Studentu Str 50, LT-51368 Kaunas, Lithuania in 2020.0, Cited 52.0. COA of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Thiazole derivatives attract the attention of scientists both in the field of organic synthesis and bioactivity research due to their high biological activity. In the present study, thiazole ring was obtained by the interaction of 1-(4-(bromoacetyl)phenyl)-5-oxopyrrolidine-3-carboxylic acid with thiocarbamide or benzenecarbothioamide, as well as tioureido acid. A series of substituted 1-(3-(1,3-thiazol-2-yl)phenyl)-5-oxopyrrolidines with pyrrolidinone, thiazole, pyrrole, 1,2,4-triazole, oxadiazole and benzimidazole heterocyclic fragments were synthesized and their antibacterial properties were evaluated against Gram-positive strains of Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes and Gram-negative Pseudomonas aeruginosa, Escherichia coli and Salmonella enterica enteritidis. The vast majority of compounds exhibited between twofold and 16-fold increased antibacterial effect against the test-cultures when compared with Oxytetracycline.

COA of Formula: C6H5NO. Welcome to talk about 500-22-1, If you have any questions, you can contact Sapijanskaite-Banevic, B; Sovkovaja, B; Vaickelioniene, R; Siugzdaite, J; Mickeviciute, E or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 3-Pyridinecarboxaldehyde. I found the field of Chemistry very interesting. Saw the article The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of alpha, beta-Unsaturated Carbonyl Compounds published in 2019.0, Reprint Addresses Zhang, SL (corresponding author), Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China.; Zhang, SL (corresponding author), Soochow Univ, Coll Pharmaceut Sci, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China.; Wang, L (corresponding author), Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Shandong, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of alpha, beta-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules.

Recommanded Product: 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Du, FY; Zhou, QF; Fu, XX; Shi, YJ; Chen, YG; Fang, WH; Yang, JY; Chen, GL in ROYAL SOC CHEMISTRY published article about SUPEROXIDE-DISMUTASE; IN-VITRO; STROKE; ISCHEMIA; MUTANT; MICE in [Du, Fangyu; Zhou, Qifan; Shi, Yajie; Chen, Yuanguang; Fang, Wuhong; Chen, Guoliang] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China; [Fu, Xiaoxiao; Yang, Jingyu] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China in 2019.0, Cited 34.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The development of novel neuroprotection agents is of great significance for the treatment of ischemic stroke. In this study, a series of compounds comprising 2,2-dimethylbenzopyran groups and cinnamic acid groups have been synthesized. Preferential combination principles and bioisostere that improved the neuroprotective effect of the compounds were identified for this series via biological activity assay in vitro. Meanwhile, a functional reversal group of the acrylamide amide resulted in the most active compounds. Among them, BN-07 significantly improved the morphology of neurons and obviously increased cell survival rate of primary neurons induced by oxygen glucose deprivation (OGD), superior to clinically used anti-ischemic stroke drug edaravone (Eda). Overall, our findings may provide an alternative strategy for the design of novel anti-ischemic stroke agents with more potency than Eda.

Welcome to talk about 500-22-1, If you have any questions, you can contact Du, FY; Zhou, QF; Fu, XX; Shi, YJ; Chen, YG; Fang, WH; Yang, JY; Chen, GL or send Email.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Sapijanskaite-Banevic, B; Sovkovaja, B; Vaickelioniene, R; Siugzdaite, J; Mickeviciute, E in MDPI published article about N-ACYLHYDRAZONE DERIVATIVES; ANTIMICROBIAL EVALUATION; 2-AMINOTHIAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; HIGH ANTIBACTERIAL; DESIGN; NMR; ISOMERIZATION; PYRIMIDINE; THIAZOLES in [Sapijanskaite-Banevic, Birute; Sovkovaja, Bozena; Vaickelioniene, Rita] Kaunas Univ Technol, Dept Organ Chem, Radvilenu Rd 19, LT-50254 Kaunas, Lithuania; [Siugzdaite, Jurate] Lithuanian Univ Hlth Sci, Dept Vet Pathobiol, Vet Acad, Tilzes Str 18, LT-47181 Kaunas, Lithuania; [Mickeviciute, Egle] Kaunas Univ Technol, Dept Informat Syst, Studentu Str 50, LT-51368 Kaunas, Lithuania in 2020.0, Cited 52.0. COA of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Thiazole derivatives attract the attention of scientists both in the field of organic synthesis and bioactivity research due to their high biological activity. In the present study, thiazole ring was obtained by the interaction of 1-(4-(bromoacetyl)phenyl)-5-oxopyrrolidine-3-carboxylic acid with thiocarbamide or benzenecarbothioamide, as well as tioureido acid. A series of substituted 1-(3-(1,3-thiazol-2-yl)phenyl)-5-oxopyrrolidines with pyrrolidinone, thiazole, pyrrole, 1,2,4-triazole, oxadiazole and benzimidazole heterocyclic fragments were synthesized and their antibacterial properties were evaluated against Gram-positive strains of Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes and Gram-negative Pseudomonas aeruginosa, Escherichia coli and Salmonella enterica enteritidis. The vast majority of compounds exhibited between twofold and 16-fold increased antibacterial effect against the test-cultures when compared with Oxytetracycline.

COA of Formula: C6H5NO. Welcome to talk about 500-22-1, If you have any questions, you can contact Sapijanskaite-Banevic, B; Sovkovaja, B; Vaickelioniene, R; Siugzdaite, J; Mickeviciute, E or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 3-Pyridinecarboxaldehyde. I found the field of Chemistry very interesting. Saw the article The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of alpha, beta-Unsaturated Carbonyl Compounds published in 2019.0, Reprint Addresses Zhang, SL (corresponding author), Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China.; Zhang, SL (corresponding author), Soochow Univ, Coll Pharmaceut Sci, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China.; Wang, L (corresponding author), Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Shandong, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of alpha, beta-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules.

Recommanded Product: 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Du, FY; Zhou, QF; Fu, XX; Shi, YJ; Chen, YG; Fang, WH; Yang, JY; Chen, GL in ROYAL SOC CHEMISTRY published article about SUPEROXIDE-DISMUTASE; IN-VITRO; STROKE; ISCHEMIA; MUTANT; MICE in [Du, Fangyu; Zhou, Qifan; Shi, Yajie; Chen, Yuanguang; Fang, Wuhong; Chen, Guoliang] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China; [Fu, Xiaoxiao; Yang, Jingyu] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China in 2019.0, Cited 34.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The development of novel neuroprotection agents is of great significance for the treatment of ischemic stroke. In this study, a series of compounds comprising 2,2-dimethylbenzopyran groups and cinnamic acid groups have been synthesized. Preferential combination principles and bioisostere that improved the neuroprotective effect of the compounds were identified for this series via biological activity assay in vitro. Meanwhile, a functional reversal group of the acrylamide amide resulted in the most active compounds. Among them, BN-07 significantly improved the morphology of neurons and obviously increased cell survival rate of primary neurons induced by oxygen glucose deprivation (OGD), superior to clinically used anti-ischemic stroke drug edaravone (Eda). Overall, our findings may provide an alternative strategy for the design of novel anti-ischemic stroke agents with more potency than Eda.

Welcome to talk about 500-22-1, If you have any questions, you can contact Du, FY; Zhou, QF; Fu, XX; Shi, YJ; Chen, YG; Fang, WH; Yang, JY; Chen, GL or send Email.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: 3-Pyridinecarboxaldehyde. In 2019.0 BIOORG CHEM published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; DERIVATIVES; APOPTOSIS; AGENTS; ANALOGS in [Riaz, Sharon; Chotana, Ghayoor Abbas; Saleem, Rahman Shah Zaib] Lahore Univ Management Sci, Syed Babar Ali Sch Sci & Engn, Dept Chem & Chem Engn, Lahore 54792, Pakistan; [Iqbal, Maheen; Ullah, Rahim; Zahra, Rida; Faisal, Amir] Lahore Univ Management Sci, Syed Babar Ali Sch Sci & Engn, Dept Biol, Lahore 54792, Pakistan in 2019.0, Cited 45.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A series of forty a-substituted chalcones were synthesized and screened for their antiproliferative activities against HCT116 (colorectal) and HCC1954 (breast) cancer cell lines. Compounds 5a and 5e were found to be the most potent compounds with GI(50) values of 0.63 mu M and 0.725 mu M in HCC1954 cell line and 0.69 mu M and 1.59 mu M in HCT116 cell line, respectively. Both compounds induced a G2/M cell cycle arrest and caused apoptotic cell death in HCT116 cells as shown by the induction of PARP cleavage. The compounds also stabilized p53 in a dose-dependent manner in HCT116 cells following 24-hour treatment. Furthermore, both 5a and 5e were able to overcome multidrug resistance in two MDR-1 overexpressing multidrug resistant cell lines.

Name: 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Riaz, S; Iqbal, M; Ullah, R; Zahra, R; Chotana, GA; Faisal, A; Saleem, RSZ or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Wang, ZZ; Song, T; Yang, Y in [Wang, Zhaozhan; Song, Tao; Yang, Yong] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key CAS Lab Biobased Mat, Qingdao 266101, Shandong, Peoples R China published Additive- and Oxidant-Free Expedient Synthesis of Benzimidazoles Catalyzed by Cobalt Nanocomposites on N-Doped Carbon in 2019.0, Cited 47.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A one-pot direct synthesis of a wide range of biologically active benzimidazoles through coupling of phenylenediamines and aldehydes catalyzed by a highly recyclable nonnoble cobalt nanocomposite was developed. A broad set of benzimidazoles can be efficiently synthesized in high yields and with good functional-group tolerance under additive- and oxidant-free mild conditions. The catalyst can be easily recycled for successive uses, and the process permits gram-scale syntheses of benzimidazoles.

Welcome to talk about 500-22-1, If you have any questions, you can contact Wang, ZZ; Song, T; Yang, Y or send Email.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Pyridinecarboxaldehyde. I found the field of Chemistry very interesting. Saw the article Synthesis and characterization of a novel Fe3O4@SiO2-BenzIm-Fc[Cl]/BiOCl nano-composite and its efficient catalytic activity in the ultrasound-assisted synthesis of diverse chromene analogs published in 2019.0, Reprint Addresses Mohammadi, R (corresponding author), Univ Tabriz, Dept Organ & Biochem, Fac Chem, Tabriz 5166614766, Iran.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

In this study, a novel magnetically recoverable Fe3O4@SiO2-BenzIm-Fc[Cl]/BiOCl nano-composite was synthesized using a simple chemical co-precipitation method. This is the first time that a magnetic nano-catalyst bearing ionic liquid, ferrocene and BiOCl is synthesized. The Fe3O4@SiO2-BenzIm-Fc[Cl]/BiOCl nano-composite was characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX) and field emission scanning electron microscopy (FE-SEM) techniques. The catalytic activities of the novel magnetic nano-composite were evaluated in one-pot three-component synthesis of a wide variety of 2-amino-3-cyano-4H-chromene derivatives under ultrasound irradiation. A simple, facile and highly efficient ultrasound-assisted method was developed to synthesize 4H-chromene derivatives via one-pot, three-component reaction of aldehyde, malononitrile and active phenolic compounds (2-naphthol, 1-naphthol, 3-(dimethylamino)phenol, resorcinol and orcinol) at room temperature. The reaction of aldehyde, malononitrile and orcinol is newly introduced in this paper. The ultrasound-assisted synthesis protocol that was studied in this article exhibits some notable advantages such as short reaction times, operational simplicity, green reaction conditions, high yields and easy work-up and purification steps. In addition, the novel magnetic nano-composite could be easily recovered by an external magnetic field and reused for six-reaction cycles without significant loss of its catalytic activity.

Quality Control of 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem