Tag: M.W=100-150

Zhou, BW; Yuan, Y; Jin, HW; Liu, YK in [Zhou, Bingwei; Yuan, Yuan; Jin, Hongwei; Liu, Yunkui] Zhejiang Univ Technol, Coll Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Zhejiang, Peoples R China published I2O5-Mediated Iodocyclization Cascade of N-(1-Arylallyl)pyridine-2-amines with Concomitant C=C Bond Cleavage: A Synthesis of 3-Iodoimidazo[1,2-a]pyridines in 2019.0, Cited 89.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A facile method for the synthesis of 3-iodoimidazo[1,2-a]pyridines has been successfully developed involving an I2O5-mediated iodocyclization cascade of N-(1-arylallyl)pyridin-2-amines with concomitant C=C bond cleavage. Preliminary mechanistic studies reveal that this protocol might undergo an oxidative cyclization/decarboxylation/iodination sequence in which I2O5 is used as both an oxidant and an iodine source. The present protocol has advantages of wide substrate scope, simple operation, and metal-free conditions.

Formula: C6H5NO. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Imidazo[1,2-a]pyridine A(3)-Coupling Catalyzed by a Cu/SiO2 Material WOS:000482836400005 published article about ONE-POT SYNTHESIS; 3-COMPONENT COUPLING REACTION; MULTICOMPONENT SYNTHESIS; COPPER; ALKYNE; 2-AMINOPYRIDINES; CYCLOADDITION; CYCLIZATION; PALLADIUM; ALDEHYDES in [de Salles, Helena D.; Benvenutti, Edilson, V; Schneider, Paulo H.] Univ Fed Rio Grande do Sul, Inst Quim, Av Bento Goncalves 9500, BR-91501970 Porto Alegre, RS, Brazil; [da Silva, Tiago L.] Univ Fed Rio de Janeiro, Inst Quim, Av Athos da Silveira Ramos 149,Bloco A, BR-21941909 Rio de Janeiro, RJ, Brazil; [Radatz, Catia S.] Univ Fed Pelotas UFPeI, CCQFA, BR-96010900 Pelotas, RS, Brazil; [Affeldt, Ricardo F.] Univ Fed Santa Catarina, Ctr Ciencias Fis & Matemat, Dept Quim, BR-88040970 Florianopolis, SC, Brazil in 2019.0, Cited 60.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

In this work, we report the preparation of a copper-silica material (Cu/SiO2) by a sol-gel methodology and its characterization concerning composition and textural properties. The Cu/SiO2 material was successfully applied as a Lewis acid heterogeneous catalyst for the A(3)-coupling from 2-aminopyridine, aldehydes and alkynes to imidazo[1,2-a]pyridines (45-82%). which are relevant pharmacological scaffolds. The synthesis shows a number of advantages, such as easy separation from the reaction media and the minimal formation of metal aqueous wastes. Investigation of the mechanism supports the involvement of the formation of reaction intermediates inside the pores of the mesoporous material prior to 5-exo-dig cyclization.

Product Details of 500-22-1. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Palladium-Catalyzed Decarboxylative Generation and Propargylation of 2-Azaallyl Anions WOS:000475459200017 published article about SUPER-ELECTRON-DONORS; COUPLING REACTION; DOUBLE-BLIND; REGIOSELECTIVITY; VIRIDENOMYCIN; DERIVATIVES; CARBONATES in [Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J.] Sichuan Univ, Key Lab Green Chem & Technol, Coll Chem, Chengdu 610064, Sichuan, Peoples R China; [Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J.] Sichuan Univ, Sino British Mat Res Inst, Coll Phys Sci & Technol, Chengdu 610064, Sichuan, Peoples R China in 2019.0, Cited 43.0. Name: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A palladium-catalyzed decarboxylative propargylation (DcPg) of propargyl 2,2-diphenylglycinate imines was developed. In this process, the nature of the propargyl ester and aryl imine components, as well as the catalyst system and solvent, had a significant impact on the ratio of desired propargylated products vs. allene and/or diene side products that arise via different modes of C-C bond formation. The resulting propargylated products can be transformed readily into useful (Z)-homoallylic amines. Moreover, the regioisomeric diene products could be converted to pharmaceutically-relevant diarylmethyl imines via a two-step Diels-Alder/oxidation process.

Name: 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Tang, SJ; Wei, WJ; Yin, D; Poznik, MC; Chruma, AO or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article 1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors WOS:000526403900042 published article about SUBSTITUTED SACCHARIN DERIVATIVES; SECONDARY SULFONAMIDES; IN-VITRO; CANCER; ISOFORM; SCAFFOLD; POTENT; MODEL in [D’Ascenzio, Melissa; Secci, Daniela; Guglielmi, Paolo; Pierini, Marco] Sapienza Univ Rome, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy; [Carradori, Simone; Zara, Susi] G dAnnunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Cirilli, Roberto] Ist Super Sanita, Ctr Nazl Controllo & Valutaz Farm, I-00161 Rome, Italy; [Poli, Giulio; Tuccinardi, Tiziano] Univ Pisa, Dept Pharm, I-56126 Pisa, Italy; [Angeli, Andrea; Supuran, Claudiu T.] Univ Florence, Neurofarba Dept, Sect Pharmaceut & Nutraceut Sci, I-50019 Florence, Italy; [Angeli, Andrea] Petru Poni Inst Macromol Chem, Ctr Adv Res Bionanoconjugates, Iasi 700487, Romania; [Angeli, Andrea] Petru Poni Inst Macromol Chem, Biopolymers Dept, Iasi 700487, Romania in 2020.0, Cited 44.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

Two series of saccharin/isoxazole and saccharin/isoxazoline hybrids were synthesized by 1,3-dipolar cycloaddition. The new compounds showed to be endowed with potent and selective inhibitory activity against the cancer-related human carbonic anhydrase (hCA) IX and XII isoforms in the nanomolar range, while no affinity was encountered for off-targets, such as hCA I and II. Successive enantioseparation on a milligram scale of the most representative compounds led to the discovery that (S)-isomers were more potent than their corresponding (R)-enantiomers. Lastly, molecular modeling studies were conducted to define those structural requirements that were responsible for the discrimination among selected human isoforms of carbonic anhydrases. Two nanomolar hCA IX and XII inhibitors were also screened for their selective toxicity against non tumoral primary cells (fibroblasts) and against a breast adenocarcinoma cell line (MCF7) in hypoxic environment. The efficacious combination of these compounds with doxorubicin on MCF7 cells was demonstrated after 72 h of treatment.

Recommanded Product: 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact D’Ascenzio, M; Secci, D; Carradori, S; Zara, S; Guglielmi, P; Cirilli, R; Pierini, M; Poli, G; Tuccinardi, T; Angeli, A; Supuran, CT or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article A novel cluster of C-5-curcuminoids: design, synthesis, in vitro antiproliferative activity and DNA binding of bis(arylidene)-4-cyclanone derivatives based on 4-hydroxycyclohexanone scaffold WOS:000481805000030 published article about CIRCULAR-DICHROISM; CURCUMIN; ANTITUMOR; TOXICITY; ANALOGS; 3,5-BIS(ARYLIDENE)-4-PIPERIDONES; CYTOTOXICITY; APOPTOSIS; DELIVERY; CELLS in [Huber, Imre; Perjesi, Pal] Univ Pecs, Dept Pharmaceut Chem, H-7624 Pecs, Hungary; [Zupko, Istvan; Gyovai, Andras] Univ Szeged, Dept Pharmacodynam & Biopharm, H-6720 Szeged, Hungary; [Horvath, Peter; Kiss, Eszter] Semmelweis Univ, Dept Pharmaceut Chem, H-1092 Budapest, Hungary; [Gulyas-Fekete, Gergely; Schmidt, Janos] Univ Pecs, Dept Biochem & Med Chem, H-7624 Pecs, Hungary in 2019.0, Cited 50.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A new series (6) of C-5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is described here with their evaluation for in vitro antiproliferative activities. Evaluation of 31 compounds against human A2780 (ovarian), C33A (cervix) and MDA-MB-231 (breast) cancer cell lines was performed to obtain structure activity relation data. The best performer was (2E,6E)-2,6-bis(3 ‘-nitrobenzylidene)-4-hydroxycyclohexanone (6h) with IC50 values of 0.68 mu M (A2780), 0.69 mu M (C33A) and 0.92 mu M (MDA-MB-231) compared to cisplatin with 1.30 mu M, 3.69 mu M and 19.13 mu M, respectively. According to calculated physicochemical properties some members in series 6, namely (2E,6E)-2,6-bis[(4 ‘-pyridinyl)methylene]-4-hydroxycyclohexanone (6p) [IC50 = 0.76 mu M (A2780), 2.69 mu M (C33A), 1.28 mu M (MDA-MB-231)] seem to have improved bioavailability compared to curcumin. Selected members of series 6 were involved in circular dichroism spectroscopic measurements in order to determine their interaction with natural DNA. Based on these data, we conclude that these derivatives do not bind to DNA in vitro. A proposal is summarized based on mass spectrometric assessment for fingerprint analysis in biological research of such C-5-curcuminoids.

Quality Control of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Huber, I; Zupko, I; Gyovai, A; Horvath, P; Kiss, E; Gulyas-Fekete, G; Schmidt, J; Perjesi, P or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 SYNTHESIS-STUTTGART published article about ORTHO-QUINONE METHIDES; ANTITUMOR AGENTS; DERIVATIVES; PRECURSORS; NUCLEOPHILES; ALKYLATION; ANALOGS in [Osyanin, Vitaly A.; Osipov, Dmitry V.; Melnikova, Irina V.; Korzhenko, Kirill S.; Semenova, Irina A.; Klimochkin, Yuri N.] Samara State Tech Univ, Dept Organ Chem, Fac Chem Technol, 244 Molodogvardeyskaya St, Samara 443100, Russia in 2020.0, Cited 54.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

A new strategy to 2-aminochromanes through catalyst-free cascade reaction of 3-trifluoroacetyl-4H-chromenes and 4H-chromene-3-carbaldehydes with cyclic secondary amines is presented. The reaction proceeds through subsequent 1,4- and 1,2-additions of amine, bimolecular elimination of trifluoroacetamide or formamide, and 6-exotrig cyclization. The latter stage is a very rare example of addition of phenols to enamines. The obtained semicyclic N,O-acetals were applied as useful precursors for the synthesis of other chromanes.

Recommanded Product: 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Osyanin, VA; Osipov, DV; Melnikova, IV; Korzhenko, KS; Semenova, IA; Klimochkin, YN or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Yu, L; Lv, LY; Qiu, ZH; Chen, ZP; Tan, Z; Liang, YF; Li, CJ in WILEY-V C H VERLAG GMBH published article about C-H BONDS; OLEFIN SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; INTERNAL ALKYNES; ALDEHYDES; ALKENYLATION; CARBANIONS; 1,3-DIENES; ALCOHOLS; ALKENES in [Yu, Lin; Lv, Leiyang; Qiu, Zihang; Chen, Zhangpei; Liang, Yu-Feng; Li, Chao-Jun] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Yu, Lin; Lv, Leiyang; Qiu, Zihang; Chen, Zhangpei; Liang, Yu-Feng; Li, Chao-Jun] McGill Univ, FRQNT Ctr Green Chem & Catalysis, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Yu, Lin; Lv, Leiyang; Tan, Ze] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China in 2020.0, Cited 62.0. SDS of cas: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

We have developed an unprecedented Pd-catalyzed formal hydroalkylation of alkynes with hydrazones, which are generated in situ from naturally abundant aldehydes, as both alkylation reagents and hydrogen donors. The hydroalkylation proceeds with high regio- and stereoselectivity to form (Z)-alkenes, which are more difficult to generate compared to (E)-alkenes. The reaction is compatible with a wide range of functional groups, including hydroxy, ester, ketone, nitrile, boronic ester, amine, and halide groups. Furthermore, late-stage modifications of natural products and pharmaceutical derivatives exemplify its unique chemoselectivity, regioselectivity, and synthetic applicability. Mechanistic studies indicate the possible involvement of Pd-hydride intermediates.

SDS of cas: 500-22-1. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 BIOORGAN MED CHEM published article about TRANSITION-STATE ANALOG; CRYSTAL-STRUCTURE; HYDROXY COMPOUNDS; DERIVATIVES; PYRROLIDINE; BINDING; PHOSPHORYLATION; ENANTIOMERS; MECHANISM; ALCOHOLS in [Claret, Eduard Mas; Al Yahyaei, Balqees; Chu, Shuyu; Imperato, Manuel; Lopez, Arnaud; Howlin, Brendan J.; Whelligan, Daniel K.] Univ Surrey, Dept Chem, Guildford GU2 7XH, Surrey, England; [Elliott, Ruan M.] Univ Surrey, Dept Nutr Sci, Sch Biosci & Med, Guildford GU2 7XH, Surrey, England; [Meira, Lisiane B.] Univ Surrey, Dept Clin & Expt Med, Sch Biosci & Med, Guildford GU2 7XH, Surrey, England in 2020.0, Cited 66.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

The DNA repair enzyme AAG has been shown in mice to promote tissue necrosis in response to ischaemic reperfusion or treatment with alkylating agents. A chemical probe inhibitor is required for investigations of the biological mechanism causing this phenomenon and as a lead for drugs that are potentially protective against tissue damage from organ failure and transplantation, and alkylative chemotherapy. Herein, we describe the rationale behind the choice of arylmethylpyrrolidines as appropriate aza-nucleoside mimics for an inhibitor followed by their synthesis and the first use of a microplate-based assay for quantification of their inhibition of AAG. We finally report the discovery of an imidazol-4-ylmethylpyrrolidine as a fragment-sized, weak inhibitor of AAG.

Application In Synthesis of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Claret, EM; Al Yahyaei, B; Chu, SY; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Generation of a Heteropolycyclic and sp(3)-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels-Alder and ROM-RCM Reaction Sequence WOS:000458273900021 published article about DIVERSITY-ORIENTED SYNTHESIS; CHEMICAL SPACE; CYCLIZATION; ACID; DRUG; METATHESIS; COMPLEXITY; MITSUNOBU; ESTERS in [Flagstad, Thomas; Azevedo, Carlos M. G.; Troelsen, Nikolaj S.] Tech Univ Denmark, Dept Chem, Ctr Nanomed & Theranost, Kemitorvet 207, DK-2800 Lyngby, Denmark; EDELRIS, 115 Ave Lacassagne, F-69003 Lyon, France; Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 637551, Singapore; Univ Copenhagen, Dept Immunol & Microbiol, Costerton Biofilm Ctr, DK-2200 Copenhagen, Denmark in 2019.0, Cited 43.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 500-22-1

Efficient access to diverse screening compounds with desirable, lead-like properties can be a bottleneck in early drug discovery and chemical biology. Herein we present an efficient, rapid route to three structurally distinct classes of compounds (A-C) from a single precursor, which in turn is available through a one-pot Petasis 3-component reaction/Diels-Alder cascade reaction. We demonstrate the versatility of the approach through the synthesis of 35 exemplary compounds from the three classes, as well as by the production of 2188 final compounds, which have been included in the Joint European Compound Library of the European Lead Factory.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 CHEM-EUR J published article about FRIEDEL-CRAFTS REACTIONS; PI-ACTIVATED ALCOHOLS; NUCLEOPHILIC-SUBSTITUTION; ALLYLIC ALCOHOLS; MILD; MITSUNOBU; DERIVATIVES; AMINATION; TRIFLATE; AMINES in [Estopina-Duran, Susana; Donnelly, Liam J.; Mclean, Euan B.; Hockin, Bryony M.; Slawin, Alexandra M. Z.; Taylor, James E.] Univ St Andrews, EaStCHEM, Sch Chem, St Andrews KY16 9ST, Fife, Scotland; [Taylor, James E.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England in 2019.0, Cited 58.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

A combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C-O bonds. This method has been applied to the intermolecular substitution of benzylic alcohols to form symmetrical ethers, intramolecular cyclisations of diols to form aryl-substituted tetrahydrofuran and tetrahydropyran derivatives, and intermolecular crossed-etherification reactions between two different alcohols. Mechanistic control experiments have identified a potential catalytic intermediate formed between the aryl boronic acid and oxalic acid.

Product Details of 500-22-1. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem